Stress and ageing in yeast

Is Gcn4-induced autophagy the ultimate downstream mechanism by which hormesis extends yeast replicative lifespan?

(2019) Zih-Jie Shen et al.   CURRENT GENETICS

α‐Synuclein toxicity in yeast and human cells is caused by cell cycle re‐entry and autophagy degradation of ribonucleotide reductase 1

(2019) Belém Sampaio‐Marques et al.   AGING CELL

Dose dependent gene expression is dynamically modulated by the history, physiology and age of yeast cells

(2019) Amparo Pascual-Ahuir et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Endosome and Golgi‐associated degradation (EGAD) of membrane proteins regulates sphingolipid metabolism

(2019) Oliver Schmidt et al.   EMBO JOURNAL

Regulation of the unfolded protein response in yeast by oxidative stress

(2019) Angel Guerra‐Moreno et al.   FEBS LETTERS

The DNA damage response activates respiration and thereby enlarges dNTP pools to promote cell survival in budding yeast

(2019) Pengli Bu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct segregation patterns of yeast cell-peripheral proteins uncovered by a method for protein segregatome analysis

(2019) Shinju Sugiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A functional unfolded protein response is required for chronological aging in Saccharomyces cerevisiae

(2019) Sarah R. Chadwick et al.   CURRENT GENETICS

Endoplasmic Reticulum Stress Coping Mechanisms and Lifespan Regulation in Health and Diseases

(2019) Sarah R. Chadwick et al.   Frontiers in Cell and Developmental Biology

A Futile Battle? Protein Quality Control and the Stress of Aging

(2018) Ryo Higuchi-Sanabria et al.   DEVELOPMENTAL CELL

Low doses of DNA damaging agents extend Saccharomyces cerevisiae chronological lifespan by promoting entry into quiescence

(2018) Emily M. Ross et al.   EXPERIMENTAL GERONTOLOGY

Oxidative stress and aging: Learning from yeast lessons

(2018) Elis Eleutherio et al.   Fungal Biology

Some Metabolites Act as Second Messengers in Yeast Chronological Aging

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ER stress-induced reactive oxygen species (ROS) are detrimental for the fitness of a thioredoxin reductase mutant

(2018) Paraskevi Kritsiligkou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

From the unfolded protein response to metabolic diseases – lipids under the spotlight

(2018) Nurulain Ho et al.   JOURNAL OF CELL SCIENCE

Spermidine in health and disease

(2018) Frank Madeo et al.   SCIENCE

Heritable stress response dynamics revealed by single-cell genealogy

(2018) Meenakshi Chatterjee et al.   Science Advances

Heat-induced longevity in budding yeast requires respiratory metabolism and glutathione recycling

(2018) Marina Musa et al.   Aging-US

DNA protein crosslink proteolysis repair: From yeast to premature ageing and cancer in humans

(2018) John Fielden et al.   DNA REPAIR

Microfluidic technologies for yeast replicative lifespan studies

(2017) Kenneth L. Chen et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Caloric restriction alleviates alpha-synuclein toxicity in aged yeast cells by controlling the opposite roles of Tor1 and Sir2 on autophagy

(2017) Ana Guedes et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Caloric restriction extends yeast chronological lifespan via a mechanism linking cellular aging to cell cycle regulation, maintenance of a quiescent state, entry into a non-quiescent state and survival in the non-quiescent state

(2017) Anna Leonov et al.   Oncotarget

Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy

(2017) Paolo Grumati et al.   eLife

Acetic Acid Causes Endoplasmic Reticulum Stress and Induces the Unfolded Protein Response in Saccharomyces cerevisiae

(2017) Nozomi Kawazoe et al.   Frontiers in Microbiology

Redox signaling: An evolution from free radicals to aging

(2016) Henry Jay Forman   FREE RADICAL BIOLOGY AND MEDICINE

Cardioprotection and lifespan extension by the natural polyamine spermidine

(2016) Tobias Eisenberg et al.   NATURE MEDICINE

Selective sorting and destruction of mitochondrial membrane proteins in aged yeast

(2016) Adam L Hughes et al.   eLife

Surviving in the cold: yeast mutants with extended hibernating lifespan are oxidant sensitive

(2016) Lucie Postma et al.   Aging-US

Mitochondria to nucleus signaling and the role of ceramide in its integration into the suite of cell quality control processes during aging

(2015) S.M. Jazwinski   AGEING RESEARCH REVIEWS

Increased reactive oxygen species production during reductive stress: The roles of mitochondrial glutathione and thioredoxin reductases

(2015) Paavo Korge et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Reductive stress impairs myoblasts mitochondrial function and triggers mitochondrial hormesis

(2015) François Singh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging

(2015) Mark A. McCormick et al.   Cell Metabolism

The endoplasmic reticulum: structure, function and response to cellular signaling

(2015) Dianne S. Schwarz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Metabolic Cycles in Yeast Share Features Conserved among Circadian Rhythms

(2015) Helen C. Causton et al.   CURRENT BIOLOGY

Endoplasmic Reticulum Stress-Activated Cell Reprogramming in Oncogenesis

(2015) E. Chevet et al.   Cancer Discovery

Determination of protein carbonyls in plasma, cell extracts, tissue homogenates, isolated proteins: Focus on sample preparation and derivatization conditions

(2015) Daniela Weber et al.   Redox Biology

Endoplasmic Reticulum Stress, Genome Damage, and Cancer

(2015) Naomi Dicks et al.   Frontiers in Oncology

Tor-Sch9 deficiency activates catabolism of the ketone body-like acetic acid to promote trehalose accumulation and longevity

(2014) Jia Hu et al.   AGING CELL

Autophagy is required for extension of yeast chronological life span by rapamycin

(2014) Ashley L. Alvers et al.   Autophagy

Organelle-Based Aggregation and Retention of Damaged Proteins in Asymmetrically Dividing Cells

(2014) Chuankai Zhou et al.   CELL

How the Nucleus Copes with Proteotoxic Stress

(2014) Yoko Shibata et al.   CURRENT BIOLOGY

Essential Genetic Interactors of SIR2 Required for Spatial Sequestration and Asymmetrical Inheritance of Protein Aggregates

(2014) Jia Song et al.   PLoS Genetics

A sphingolipid-dependent diffusion barrier confines ER stress to the yeast mother cell

(2014) Lori Clay et al.   eLife

Mitochondrial inheritance in yeast

(2013) Benedikt Westermann   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The effect of bicarbonate on menadione-induced redox cycling and cytotoxicity: potential involvement of the carbonate radical

(2013) Naif Aljuhani et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

DNA replication stress-induced loss of reproductive capacity inS. cerevisiaeand its inhibition by caloric restriction

(2013) Martin Weinberger et al.   CELL CYCLE

ER stress suppresses DNA double-strand break repair and sensitizes tumor cells to ionizing radiation by stimulating proteasomal degradation of Rad51

(2013) Tohru Yamamori et al.   FEBS LETTERS

Yeast sirtuins and the regulation of aging

(2013) Margaret B. Wierman et al.   FEMS YEAST RESEARCH

Cellular redox homeostasis, reactive oxygen species and replicative ageing inSaccharomyces cerevisiae

(2013) Anita Ayer et al.   FEMS YEAST RESEARCH

Yeast replicative aging: a paradigm for defining conserved longevity interventions

(2013) Brian M. Wasko et al.   FEMS YEAST RESEARCH

Cellular responses toL-serine inSaccharomyces cerevisiae: roles of general amino acid control, compartmentalization, and aspartate synthesis

(2013) Johnny C.-Y. Lee et al.   FEMS YEAST RESEARCH

Reactive oxygen species, ageing and the hormesis police

(2013) Paula Ludovico et al.   FEMS YEAST RESEARCH

Ribosomal DNA and cellular senescence: new evidence supporting the connection between rDNA and aging

(2013) Austen R. D. Ganley et al.   FEMS YEAST RESEARCH

Superoxide radicals have a protective role during H2O2 stress

(2013) Geoffrey W. Thorpe et al.   MOLECULAR BIOLOGY OF THE CELL

Maintenance of Mitochondrial Morphology by Autophagy and Its Role in High Glucose Effects on Chronological Lifespan ofSaccharomyces cerevisiae

(2013) May T. Aung-Htut et al.   Oxidative Medicine and Cellular Longevity

Endoplasmic Reticulum Structure and Interconnections with Other Organelles

(2013) A. R. English et al.   Cold Spring Harbor Perspectives in Biology

Aging Yeast Cells Undergo a Sharp Entry into Senescence Unrelated to the Loss of Mitochondrial Membrane Potential

(2013) Steffen Fehrmann et al.   Cell Reports

Saccharomyces cerevisiae Genes Involved in Survival of Heat Shock

(2013) Stefanie Jarolim et al.   G3-Genes Genomes Genetics

Mitochondrial dynamics in yeast cell death and aging

(2012) Ralf J. Braun et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The retrograde response: When mitochondrial quality control is not enough

(2012) S. Michal Jazwinski   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nuclear envelope morphology constrains diffusion and promotes asymmetric protein segregation in closed mitosis

(2012) Barbara Boettcher et al.   JOURNAL OF CELL BIOLOGY

The essential iron-sulfur protein Rli1 is an important target accounting for inhibition of cell growth by reactive oxygen species

(2012) Alawiah Alhebshi et al.   MOLECULAR BIOLOGY OF THE CELL

An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast

(2012) Adam L. Hughes et al.   NATURE

Yno1p/Aim14p, a NADPH-oxidase ortholog, controls extramitochondrial reactive oxygen species generation, apoptosis, and actin cable formation in yeast

(2012) M. Rinnerthaler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Down-Regulating Sphingolipid Synthesis Increases Yeast Lifespan

(2012) Xinhe Huang et al.   PLoS Genetics

Oxidative Stress and Programmed Cell Death in Yeast

(2012) Gianluca Farrugia et al.   Frontiers in Oncology

Mitochondrial quality control during inheritance is associated with lifespan and mother-daughter age asymmetry in budding yeast

(2011) José Ricardo McFaline-Figueroa et al.   AGING CELL

Molecular targets of oxidative stress

(2011) Simon V. Avery   BIOCHEMICAL JOURNAL

Acetic acid effects on aging in budding yeast: Are they relevant to aging in higher eukaryotes?

(2011) William C. Burhans et al.   CELL CYCLE

Mitochondria regulate autophagy by conserved signalling pathways

(2011) Martin Graef et al.   EMBO JOURNAL

Glutathione revisited: a vital function in iron metabolism and ancillary role in thiol-redox control

(2011) Chitranshu Kumar et al.   EMBO JOURNAL

Changes in reactive oxygen species begin early during replicative aging of Saccharomyces cerevisiae cells

(2011) Yuen T. Lam et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Response to Heat Shock and Oxidative Stress in Saccharomyces cerevisiae

(2011) K. A. Morano et al.   GENETICS

Life Span Extension and H2O2 Resistance Elicited by Caloric Restriction Require the Peroxiredoxin Tsa1 in Saccharomyces cerevisiae

(2011) Mikael Molin et al.   MOLECULAR CELL

Sensitivity of antioxidant-deficient yeast to hypochlorite and chlorite

(2011) Magdalena Kwolek-Mirek et al.   YEAST

Replicative Age Induces Mitotic Recombination in the Ribosomal RNA Gene Cluster of Saccharomyces cerevisiae

(2011) Derek L. Lindstrom et al.   PLoS Genetics

Glucose deprivation causes oxidative stress and stimulates aggresome formation and autophagy in cultured cardiac myocytes

(2010) Paola Marambio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A molecular mechanism of chronological aging in yeast

(2010) Christopher R. Burtner et al.   CELL CYCLE

Apoptosis in yeast: triggers, pathways, subroutines

(2010) D Carmona-Gutierrez et al.   CELL DEATH AND DIFFERENTIATION

With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging

(2010) Pankaj Kapahi et al.   Cell Metabolism

Role of TOR signaling in aging and related biological processes in Drosophila melanogaster

(2010) Subhash D. Katewa et al.   EXPERIMENTAL GERONTOLOGY

The critical role of glutathione in maintenance of the mitochondrial genome

(2010) Anita Ayer et al.   FREE RADICAL BIOLOGY AND MEDICINE

Endoplasmic reticulum is a major target of cadmium toxicity in yeast

(2010) Aurélie Gardarin et al.   MOLECULAR MICROBIOLOGY

Asymmetrically inherited multidrug resistance transporters are recessive determinants in cellular replicative ageing

(2010) Amr Eldakak et al.   NATURE CELL BIOLOGY

Mitochondrial fusion and fission in cell life and death

(2010) Benedikt Westermann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

YEASTRACT: providing a programmatic access to curated transcriptional regulatory associations in Saccharomyces cerevisiae through a web services interface

(2010) D. Abdulrehman et al.   NUCLEIC ACIDS RESEARCH

Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity

(2010) A. Mesquita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Genome-Wide Screen in Saccharomyces cerevisiae Identifies Vacuolar Protein Sorting, Autophagy, Biosynthetic, and tRNA Methylation Genes Involved in Life Span Regulation

(2010) Paola Fabrizio et al.   PLoS Genetics

Role of chromatin states in transcriptional memory

(2009) Sharmistha Kundu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Genetic basis of arsenite and cadmium tolerance in Saccharomyces cerevisiae

(2009) Michael Thorsen et al.   BMC GENOMICS

Mitochondrial Dysfunction Leads to Nuclear Genome Instability via an Iron-Sulfur Cluster Defect

(2009) Joshua R. Veatch et al.   CELL

Transcriptional memory at the nuclear periphery

(2009) Jason H Brickner   CURRENT OPINION IN CELL BIOLOGY

Mitochondria-Anchored Receptor Atg32 Mediates Degradation of Mitochondria via Selective Autophagy

(2009) Koji Okamoto et al.   DEVELOPMENTAL CELL

The Shock of Aging: Molecular Chaperones and the Heat Shock Response in Longevity and Aging – A Mini-Review

(2009) Stuart K. Calderwood et al.   GERONTOLOGY

Glutathione Participates in the Regulation of Mitophagy in Yeast

(2009) Maika Deffieu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polζ-dependent mechanism

(2009) Federica Madia et al.   JOURNAL OF CELL BIOLOGY

Methionine sulphoxide reductases protect iron-sulphur clusters from oxidative inactivation in yeast

(2009) T. C. Sideri et al.   MICROBIOLOGY-SGM

Function and biogenesis of iron–sulphur proteins

(2009) Roland Lill   NATURE

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

A protein microarray-based analysis ofS-nitrosylation

(2009) Matthew W. Foster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maturation of Iron-Sulfur Proteins in Eukaryotes: Mechanisms, Connected Processes, and Diseases

(2008) Roland Lill et al.   Annual Review of Biochemistry

Reactive oxygen species and yeast apoptosis

(2008) Gabriel G. Perrone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

An Unconventional Diacylglycerol Kinase That Regulates Phospholipid Synthesis and Nuclear Membrane Growth

(2008) Gil-Soo Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutathione is necessary to ensure benefits of calorie restriction during ageing in Saccharomyces cerevisiae

(2008) Sérgio C. Mannarino et al.   MECHANISMS OF AGEING AND DEVELOPMENT

A mechanism for asymmetric segregation of age during yeast budding

(2008) Zhanna Shcheprova et al.   NATURE

Reconciling the chemistry and biology of reactive oxygen species

(2008) Christine C Winterbourn   Nature Chemical Biology

Life Span Extension by Calorie Restriction Depends on Rim15 and Transcription Factors Downstream of Ras/PKA, Tor, and Sch9

(2008) Min Wei et al.   PLoS Genetics

Hsf1 Activation Inhibits Rapamycin Resistance and TOR Signaling in Yeast Revealed by Combined Proteomic and Genetic Analysis

(2008) Sricharan Bandhakavi et al.   PLoS One

Does age influence loss of heterozygosity?

(2007) Laurie L. Carr et al.   EXPERIMENTAL GERONTOLOGY