From the unfolded protein response to metabolic diseases – lipids under the spotlight
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Title
From the unfolded protein response to metabolic diseases – lipids under the spotlight
Authors
Keywords
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Journal
JOURNAL OF CELL SCIENCE
Volume 131, Issue 3, Pages jcs199307
Publisher
The Company of Biologists
Online
2018-02-13
DOI
10.1242/jcs.199307
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Note: Only part of the references are listed.- Activation of the Unfolded Protein Response by Lipid Bilayer Stress
- (2017) Kristina Halbleib et al. MOLECULAR CELL
- ER stress and the unfolded protein response in neurodegeneration
- (2017) Claudio Hetz et al. Nature Reviews Neurology
- Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe
- (2017) Nicholas R Guydosh et al. eLife
- Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes
- (2016) Zobair M. Younossi et al. HEPATOLOGY
- A Eukaryotic Sensor for Membrane Lipid Saturation
- (2016) Roberto Covino et al. MOLECULAR CELL
- Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies
- (2016) Giovanni Musso et al. NATURE REVIEWS DRUG DISCOVERY
- Lack of phosphatidylethanolamine N-methyltransferase alters hepatic phospholipid composition and induces endoplasmic reticulum stress
- (2015) Xia Gao et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis
- (2015) Jonathan Y. Xia et al. Cell Metabolism
- Lipid-dependent regulation of the unfolded protein response
- (2015) Romain Volmer et al. CURRENT OPINION IN CELL BIOLOGY
- Crystal structures reveal transient PERK luminal domain tetramerization in endoplasmic reticulum stress signaling
- (2015) M. Carrara et al. EMBO JOURNAL
- Phosphatidylethanolamine Is a Key Regulator of Membrane Fluidity in Eukaryotic Cells
- (2015) Rosie Dawaliby et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Palmitate induces cisternal ER expansion via the activation of XBP-1/CCTα-mediated phospholipid accumulation in RAW 264.7 cells
- (2015) Seong Keun Kim et al. Lipids in Health and Disease
- CHOP links endoplasmic reticulum stress to NF-κB activation in the pathogenesis of nonalcoholic steatohepatitis
- (2015) Jeffrey A. Willy et al. MOLECULAR BIOLOGY OF THE CELL
- Ceramide as a Mediator of Non-Alcoholic Fatty Liver Disease and Associated Atherosclerosis
- (2015) Takhar Kasumov et al. PLoS One
- A Synthetic Biology Approach Identifies the Mammalian UPR RNA Ligase RtcB
- (2014) Yanyan Lu et al. MOLECULAR CELL
- Lipid landscapes and pipelines in membrane homeostasis
- (2014) Joost C.M. Holthuis et al. NATURE
- Activation of the endoplasmic reticulum unfolded protein response by lipid disequilibrium without disturbed proteostasis in vivo
- (2014) N. S. Hou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphoregulation of Ire1 RNase splicing activity
- (2014) Filippo Prischi et al. Nature Communications
- Ire1 Has Distinct Catalytic Mechanisms for XBP1/HAC1 Splicing and RIDD
- (2014) Arvin B. Tam et al. Cell Reports
- Specificity in endoplasmic reticulum-stress signaling in yeast entails a step-wise engagement of HAC1 mRNA to clusters of the stress sensor Ire1
- (2014) Eelco van Anken et al. eLife
- Physiological roles of regulated Ire1 dependent decay
- (2014) Dina S. Coelho et al. Frontiers in Genetics
- Oleate rescues INS-1E β-cells from palmitate-induced apoptosis by preventing activation of the unfolded protein response
- (2013) Dietlind Sommerweiss et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The role of phospholipids in the biological activity and structure of the endoplasmic reticulum
- (2013) Thomas A. Lagace et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- A Lipid E-MAP Identifies Ubx2 as a Critical Regulator of Lipid Saturation and Lipid Bilayer Stress
- (2013) Michal A. Surma et al. MOLECULAR CELL
- Targeting the unfolded protein response in disease
- (2013) Claudio Hetz et al. NATURE REVIEWS DRUG DISCOVERY
- NAFLD, NASH and liver cancer
- (2013) Gregory A. Michelotti et al. Nature Reviews Gastroenterology & Hepatology
- Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains
- (2013) R. Volmer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sphingolipid Homeostasis in the Endoplasmic Reticulum and Beyond
- (2013) D. K. Breslow Cold Spring Harbor Perspectives in Biology
- Dyslipidemia in Obesity: Mechanisms and Potential Targets
- (2013) Boudewijn Klop et al. Nutrients
- IRE1α-XBP1s Induces PDI Expression to Increase MTP Activity for Hepatic VLDL Assembly and Lipid Homeostasis
- (2012) Shiyu Wang et al. Cell Metabolism
- Silencing of Lipid Metabolism Genes through IRE1α-Mediated mRNA Decay Lowers Plasma Lipids in Mice
- (2012) Jae-Seon So et al. Cell Metabolism
- Proteasome Dysfunction Mediates Obesity-Induced Endoplasmic Reticulum Stress and Insulin Resistance in the Liver
- (2012) T. Otoda et al. DIABETES
- Overexpression of Sphingosine Kinase 1 Prevents Ceramide Accumulation and Ameliorates Muscle Insulin Resistance in High-Fat Diet-Fed Mice
- (2012) C. R. Bruce et al. DIABETES
- The Sphingosine-1-Phosphate Analog FTY720 Reduces Muscle Ceramide Content and Improves Glucose Tolerance in High Fat-Fed Male Mice
- (2012) Clinton R. Bruce et al. ENDOCRINOLOGY
- CHOP is a multifunctional transcription factor in the ER stress response
- (2012) H. Nishitoh JOURNAL OF BIOCHEMISTRY
- Regulation of sphingolipid synthesis through Orm1 and Orm2 in yeast
- (2012) M. Liu et al. JOURNAL OF CELL SCIENCE
- Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cells
- (2012) Sharon Epstein et al. JOURNAL OF LIPID RESEARCH
- The Membrane Stress Response Buffers Lethal Effects of Lipid Disequilibrium by Reprogramming the Protein Homeostasis Network
- (2012) Guillaume Thibault et al. MOLECULAR CELL
- C16 ceramide is crucial for triacylglycerol-induced apoptosis in macrophages
- (2012) E Aflaki et al. Cell Death & Disease
- The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis
- (2012) Philipp Kimmig et al. eLife
- Structural and functional basis for RNA cleavage by Ire1
- (2011) Alexei V Korennykh et al. BMC BIOLOGY
- The contribution of endoplasmic reticulum stress to liver diseases
- (2011) Lily Dara et al. HEPATOLOGY
- Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways
- (2011) Thanyarat Promlek et al. MOLECULAR BIOLOGY OF THE CELL
- Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity
- (2011) Suneng Fu et al. NATURE
- Regulation of glucose homeostasis through a XBP-1–FoxO1 interaction
- (2011) Yingjiang Zhou et al. NATURE MEDICINE
- Selective activation of the transcription factor ATF6 mediates endoplasmic reticulum proliferation triggered by a membrane protein
- (2011) J. Maiuolo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
- (2011) P. Walter et al. SCIENCE
- Unfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response
- (2011) B. M. Gardner et al. SCIENCE
- Endoplasmic reticulum stress, obesity and diabetes
- (2011) Miriam Cnop et al. TRENDS IN MOLECULAR MEDICINE
- Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy
- (2010) S Lépine et al. CELL DEATH AND DIFFERENTIATION
- Decrease in Membrane Phospholipid Unsaturation Induces Unfolded Protein Response
- (2010) Hiroyuki Ariyama et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lipid map of the mammalian cell
- (2010) G. van Meer et al. JOURNAL OF CELL SCIENCE
- Induction of Liver Steatosis and Lipid Droplet Formation in ATF6α-Knockout Mice Burdened with Pharmacological Endoplasmic Reticulum Stress
- (2010) Keisuke Yamamoto et al. MOLECULAR BIOLOGY OF THE CELL
- Orm1 and Orm2 are conserved endoplasmic reticulum membrane proteins regulating lipid homeostasis and protein quality control
- (2010) S. Han et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Modulation of Lipid-Induced ER Stress by Fatty Acid Shape
- (2010) Julie Deguil et al. TRAFFIC
- From Sugar to Fat
- (2009) Laurie H. Glimcher et al. Annals of the New York Academy of Sciences
- The Development of a Metabolic Disease Phenotype in CTP:Phosphoethanolamine Cytidylyltransferase-deficient Mice
- (2009) Morgan D. Fullerton et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Elimination of the CDP-ethanolamine Pathway Disrupts Hepatic Lipid Homeostasis
- (2009) Roberta Leonardi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hepatic Lipid Partitioning and Liver Damage in Nonalcoholic Fatty Liver Disease
- (2009) Zheng Zheng Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response
- (2009) Sebastian Schuck et al. JOURNAL OF CELL BIOLOGY
- In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles
- (2009) A. J. Schindler et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Comprehensive Characterization of Genes Required for Protein Folding in the Endoplasmic Reticulum
- (2009) M. C. Jonikas et al. SCIENCE
- Lipid-Induced ER Stress: Synergistic Effects of Sterols and Saturated Fatty Acids
- (2009) Ludovic Pineau et al. TRAFFIC
- Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal
- (2009) Naim Alkhouri et al. Expert Review of Gastroenterology & Hepatology
- Dephosphorylation of Translation Initiation Factor 2α Enhances Glucose Tolerance and Attenuates Hepatosteatosis in Mice
- (2008) Seiichi Oyadomari et al. Cell Metabolism
- Protection from High Fat Diet-induced Increase in Ceramide in Mice Lacking Plasminogen Activator Inhibitor 1
- (2008) Charmi Shah et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Initiation and execution of lipotoxic ER stress in pancreatic -cells
- (2008) D. A. Cunha et al. JOURNAL OF CELL SCIENCE
- Membrane phospholipid synthesis and endoplasmic reticulum function
- (2008) Paolo Fagone et al. JOURNAL OF LIPID RESEARCH
- Association of Hypertension, Diabetes, Dyslipidemia, and Metabolic Syndrome with Obesity: Findings from the National Health and Nutrition Examination Survey, 1999 to 2004
- (2008) Ninh T. Nguyen et al. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
- Membrane lipids: where they are and how they behave
- (2008) Gerrit van Meer et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The role of FoxO in the regulation of metabolism
- (2008) D N Gross et al. ONCOGENE
- Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1
- (2008) A.-H. Lee et al. SCIENCE
- A Lipid-mediated Quality Control Process in the Golgi Apparatus in Yeast
- (2007) Ludovic Pineau et al. MOLECULAR BIOLOGY OF THE CELL
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