A functional unfolded protein response is required for chronological aging in Saccharomyces cerevisiae

Is Gcn4-induced autophagy the ultimate downstream mechanism by which hormesis extends yeast replicative lifespan?

(2019) Zih-Jie Shen et al.   CURRENT GENETICS

Endoplasmic Reticulum Stress Coping Mechanisms and Lifespan Regulation in Health and Diseases

(2019) Sarah R. Chadwick et al.   Frontiers in Cell and Developmental Biology

Heat shock transcriptional factor mediates mitochondrial unfolded protein response

(2018) Naoki Koike et al.   CURRENT GENETICS

Targeting PERK signaling with the small molecule GSK2606414 prevents neurodegeneration in a model of Parkinson's disease

(2018) Gabriela Mercado et al.   NEUROBIOLOGY OF DISEASE

Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast

(2018) Carine Beaupere et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

(Un)folding mechanisms of adaptation to ER stress: lessons from aneuploidy

(2018) Carine Beaupere et al.   CURRENT GENETICS

Pathways of cellular proteostasis in aging and disease

(2017) Courtney L. Klaips et al.   JOURNAL OF CELL BIOLOGY

Generic membrane-spanning features endow IRE1α with responsiveness to membrane aberrancy

(2017) Nozomu Kono et al.   MOLECULAR BIOLOGY OF THE CELL

Acetic Acid Causes Endoplasmic Reticulum Stress and Induces the Unfolded Protein Response in Saccharomyces cerevisiae

(2017) Nozomi Kawazoe et al.   Frontiers in Microbiology

Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence

(2017) Annika Höhn et al.   Redox Biology

Endoplasmic reticulum stress: The cause and solution to Huntington's disease?

(2016) Yuwei Jiang et al.   BRAIN RESEARCH

Proteostasis impairment in ALS

(2016) Céline Ruegsegger et al.   BRAIN RESEARCH

Model systems of protein-misfolding diseases reveal chaperone modifiers of proteotoxicity

(2016) Marc Brehme et al.   Disease Models & Mechanisms

A Toolbox for Rapid Quantitative Assessment of Chronological Lifespan and Survival inSaccharomyces cerevisiae

(2016) Sarah R. Chadwick et al.   TRAFFIC

Intestinal IRE1 Is Required for Increased Triglyceride Metabolism and Longer Lifespan under Dietary Restriction

(2016) Nuno Miguel Luis et al.   Cell Reports

Water-Transfer Slows Aging in Saccharomyces cerevisiae

(2016) Aviv Cohen et al.   PLoS One

The unfolded protein response in neurodegenerative diseases: a neuropathological perspective

(2015) Wiep Scheper et al.   ACTA NEUROPATHOLOGICA

Sir2 links the unfolded protein response and the heat shock response in a stress response network

(2015) Esther Weindling et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments

(2015) J. Kirstein et al.   EMBO JOURNAL

The ImageJ ecosystem: An open platform for biomedical image analysis

(2015) Johannes Schindelin et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

High-throughput analysis of yeast replicative aging using a microfluidic system

(2015) Myeong Chan Jo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterotypic Signals from Neural HSF-1 Separate Thermotolerance from Longevity

(2015) Peter M. Douglas et al.   Cell Reports

A Genome Scale Screen for Mutants with Delayed Exit from Mitosis: Ire1-Independent Induction of Autophagy Integrates ER Homeostasis into Mitotic Lifespan

(2015) Ata Ghavidel et al.   PLoS Genetics

PERK Limits Drosophila Lifespan by Promoting Intestinal Stem Cell Proliferation in Response to ER Stress

(2015) Lifen Wang et al.   PLoS Genetics

Hexosamine Pathway Metabolites Enhance Protein Quality Control and Prolong Life

(2014) Martin S. Denzel et al.   CELL

Age-Dependent Decrease in Chaperone Activity Impairs MANF Expression, Leading to Purkinje Cell Degeneration in Inducible SCA17 Mice

(2014) Su Yang et al.   NEURON

Late-Onset of Spinal Neurodegeneration in Knock-In Mice Expressing a Mutant BiP

(2014) Hisayo Jin et al.   PLoS One

HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span

(2014) N. A. Baird et al.   SCIENCE

Integration of UPRER and Oxidative Stress Signaling in the Control of Intestinal Stem Cell Proliferation

(2014) Lifen Wang et al.   PLoS Genetics

Lifespan Extension Conferred by Endoplasmic Reticulum Secretory Pathway Deficiency Requires Induction of the Unfolded Protein Response

(2014) Vyacheslav M. Labunskyy et al.   PLoS Genetics

High-Resolution Profiling of Stationary-Phase Survival Reveals Yeast Longevity Factors and Their Genetic Interactions

(2014) Erika Garay et al.   PLoS Genetics

XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity

(2013) Rebecca C. Taylor et al.   CELL

Characterization of global gene expression during assurance of lifespan extension by caloric restriction in budding yeast

(2013) Kyung-Mi Choi et al.   EXPERIMENTAL GERONTOLOGY

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains

(2013) R. Volmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crosstalk between the UPR and autophagy pathway contributes to handling cellular stress in neurodegenerative disease

(2012) René L. Vidal et al.   Autophagy

Acetic acid and acidification accelerate chronological and replicative aging in yeast

(2012) Mario G. Mirisola et al.   CELL CYCLE

Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy

(2012) Rene L. Vidal et al.   HUMAN MOLECULAR GENETICS

Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase

(2012) Eric M. Rubenstein et al.   JOURNAL OF CELL BIOLOGY

Kar2p availability defines distinct forms of endoplasmic reticulum stress in living cells

(2012) Patrick Lajoie et al.   MOLECULAR BIOLOGY OF THE CELL

SCS3 and YFT2 Link Transcription of Phospholipid Biosynthetic Genes to ER Stress and the UPR

(2012) Robyn D. Moir et al.   PLoS Genetics

Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways

(2011) Thanyarat Promlek et al.   MOLECULAR BIOLOGY OF THE CELL

Endoplasmic reticulum stress regulation of the Kar2p/BiP chaperone alleviates proteotoxicity via dual degradation pathways

(2011) Chia-Ling Hsu et al.   MOLECULAR BIOLOGY OF THE CELL

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Unfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response

(2011) B. M. Gardner et al.   SCIENCE

ER stress and hormetic regulation of the aging process

(2010) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Assessment of chronological lifespan dependent molecular damages in yeast lacking mitochondrial antioxidant genes

(2010) Ayse Banu Demir et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A molecular mechanism of chronological aging in yeast

(2010) Christopher R. Burtner et al.   CELL CYCLE

Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity

(2010) S. Henis-Korenblit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BiP Binding to the ER-Stress Sensor Ire1 Tunes the Homeostatic Behavior of the Unfolded Protein Response

(2010) David Pincus et al.   PLOS BIOLOGY

A Microarray-Based Genetic Screen for Yeast Chronological Aging Factors

(2010) Mirela Matecic et al.   PLoS Genetics

ER and aging—Protein folding and the ER stress response

(2009) Nirinjini Naidoo   AGEING RESEARCH REVIEWS

Dysfunction of the unfolded protein response increases neurodegeneration in aged rat hippocampus following proteasome inhibition

(2009) María Paz Gavilán et al.   AGING CELL

Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response

(2009) Sebastian Schuck et al.   JOURNAL OF CELL BIOLOGY

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

(2009) A. Ben-Zvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Comprehensive Characterization of Genes Required for Protein Folding in the Endoplasmic Reticulum

(2009) M. C. Jonikas et al.   SCIENCE

Lipid-Induced ER Stress: Synergistic Effects of Sterols and Saturated Fatty Acids

(2009) Ludovic Pineau et al.   TRAFFIC

Quantifying Yeast Chronological Life Span by Outgrowth of Aged Cells

(2009) Christopher Murakami et al.   Jove-Journal of Visualized Experiments

Measuring Replicative Life Span in the Budding Yeast

(2009) Kristan K. Steffen et al.   Jove-Journal of Visualized Experiments

Real-Time Redox Measurements during Endoplasmic Reticulum Stress Reveal Interlinked Protein Folding Functions

(2008) Philip I. Merksamer et al.   CELL

Heat shock response relieves ER stress

(2008) Yu Liu et al.   EMBO JOURNAL

Mitochondrial dysfunction leads to reduced chronological lifespan and increased apoptosis in yeast

(2008) An M. Aerts et al.   FEBS LETTERS

Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity

(2008) M. L. Duennwald et al.   GENES & DEVELOPMENT

Aging Impairs the Unfolded Protein Response to Sleep Deprivation and Leads to Proapoptotic Signaling

(2008) N. Naidoo et al.   JOURNAL OF NEUROSCIENCE

Messenger RNA targeting to endoplasmic reticulum stress signalling sites

(2008) Tomás Aragón et al.   NATURE

A comprehensive strategy enabling high-resolution functional analysis of the yeast genome

(2008) David K Breslow et al.   NATURE METHODS

Polyglutamine neurodegeneration: protein misfolding revisited

(2008) Aislinn J. Williams et al.   TRENDS IN NEUROSCIENCES

Decreased enzyme activities of chaperones PDI and BiP in aged mouse livers

(2007) Jonathan E. Nuss et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS