Is Gcn4-induced autophagy the ultimate downstream mechanism by which hormesis extends yeast replicative lifespan?

The role of autophagy in the regulation of yeast life span

(2018) Jessica K. Tyler et al.   Annals of the New York Academy of Sciences

Ssd1 and Gcn2 suppress global translation efficiency in replicatively aged yeast while their activation extends lifespan

(2018) Zheng Hu et al.   eLife

Pleiotropic responses to methionine restriction

(2017) Gene P. Ables et al.   EXPERIMENTAL GERONTOLOGY

Alterations of the translation apparatus during aging and stress response

(2017) Yulia Gonskikh et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Nup100 regulatesSaccharomyces cerevisiaereplicative life span by mediating the nuclear export of specific tRNAs

(2016) Christopher L. Lord et al.   RNA

Autophagy mediates pharmacological lifespan extension by spermidineand resveratrol

(2016) Eugenia Morselli et al.   Aging-US

Balancing mitochondrial biogenesis and mitophagy to maintain energy metabolism homeostasis

(2015) K Palikaras et al.   CELL DEATH AND DIFFERENTIATION

A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging

(2015) Mark A. McCormick et al.   Cell Metabolism

Altering nuclear pore complex function impacts longevity and mitochondrial function inS. cerevisiae

(2015) Christopher L. Lord et al.   JOURNAL OF CELL BIOLOGY

A Genome Scale Screen for Mutants with Delayed Exit from Mitosis: Ire1-Independent Induction of Autophagy Integrates ER Homeostasis into Mitotic Lifespan

(2015) Ata Ghavidel et al.   PLoS Genetics

A lifespan-extending form of autophagy employs the vacuole-vacuole fusion machinery

(2014) Fusheng Tang et al.   Autophagy

Keeping the eIF2 alpha kinase Gcn2 in check

(2014) Beatriz A. Castilho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging

(2012) Joe R. Delaney et al.   AGING CELL

Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4

(2008) Kristan K. Steffen et al.   CELL