Some Metabolites Act as Second Messengers in Yeast Chronological Aging

Lipid metabolism and transport define longevity of the yeast Saccharomyces cerevisiae

(2018) Vladimir I Titorenko   Frontiers in Bioscience-Landmark

Yeast Cells Exposed to Exogenous Palmitoleic Acid Either Adapt to Stress and Survive or Commit to Regulated Liponecrosis and Die

(2018) Karamat Mohammad et al.   Oxidative Medicine and Cellular Longevity

Caloric restriction extends yeast chronological lifespan via a mechanism linking cellular aging to cell cycle regulation, maintenance of a quiescent state, entry into a non-quiescent state and survival in the non-quiescent state

(2017) Anna Leonov et al.   Oncotarget

Conceptualizing Eukaryotic Metabolic Sensing and Signaling

(2017) Sunil Laxman   JOURNAL OF THE INDIAN INSTITUTE OF SCIENCE

External and internal triggers of cell death in yeast

(2016) Claudio Falcone et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The slim, the fat, and the obese: guess who lives the longest?

(2016) Xiaobo Li et al.   CURRENT GENETICS

Unraveling the role of the Target of Rapamycin signaling in sphingolipid metabolism

(2016) Vitor Teixeira et al.   PROGRESS IN LIPID RESEARCH

TOR Complexes and the Maintenance of Cellular Homeostasis

(2016) Sandra Eltschinger et al.   TRENDS IN CELL BIOLOGY

Chronological Lifespan in Yeast Is Dependent on the Accumulation of Storage Carbohydrates Mediated by Yak1, Mck1 and Rim15 Kinases

(2016) Lu Cao et al.   PLoS Genetics

Communications between Mitochondria, the Nucleus, Vacuoles, Peroxisomes, the Endoplasmic Reticulum, the Plasma Membrane, Lipid Droplets, and the Cytosol during Yeast Chronological Aging

(2016) Pamela Dakik et al.   Frontiers in Genetics

Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density

(2016) Yong Pan et al.   Aging-US

Autophagy mediates pharmacological lifespan extension by spermidineand resveratrol

(2016) Eugenia Morselli et al.   Aging-US

Polyamines in aging and disease

(2016) Nadège Minois et al.   Aging-US

The longevity in the yeast Saccharomyces cerevisiae: A comparison of two approaches for assessment the lifespan

(2015) Mateusz Molon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Stratification of yeast cells during chronological aging by size points to the role of trehalose in cell vitality

(2015) Andrea Svenkrtova et al.   BIOGERONTOLOGY

A Protein Restriction-Dependent Sulfur Code for Longevity

(2015) Hong Seok Shim et al.   CELL

Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits

(2015) Christopher Hine et al.   CELL

A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging

(2015) Mark A. McCormick et al.   Cell Metabolism

Acetyl Coenzyme A: A Central Metabolite and Second Messenger

(2015) Federico Pietrocola et al.   Cell Metabolism

Calorie restriction and methionine restriction in control of endogenous hydrogen sulfide production by the transsulfuration pathway

(2015) Christopher Hine et al.   EXPERIMENTAL GERONTOLOGY

A Genome Scale Screen for Mutants with Delayed Exit from Mitosis: Ire1-Independent Induction of Autophagy Integrates ER Homeostasis into Mitotic Lifespan

(2015) Ata Ghavidel et al.   PLoS Genetics

ATG13

(2014) Sebastian Alers et al.   Autophagy

The Search for Antiaging Interventions: From Elixirs to Fasting Regimens

(2014) Rafael de Cabo et al.   CELL

Mechanism of liponecrosis, a distinct mode of programmed cell death

(2014) Vincent R Richard et al.   CELL CYCLE

Nucleocytosolic Depletion of the Energy Metabolite Acetyl-Coenzyme A Stimulates Autophagy and Prolongs Lifespan

(2014) Tobias Eisenberg et al.   Cell Metabolism

Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A

(2014) Guillermo Mariño et al.   MOLECULAR CELL

Methionine Restriction Activates the Retrograde Response and Confers Both Stress Tolerance and Lifespan Extension to Yeast, Mouse and Human Cells

(2014) Jay E. Johnson et al.   PLoS One

Lifespan Extension by Methionine Restriction Requires Autophagy-Dependent Vacuolar Acidification

(2014) Christoph Ruckenstuhl et al.   PLoS Genetics

Reducing sphingolipid synthesis orchestrates global changes to extend yeast lifespan

(2013) Jun Liu et al.   AGING CELL

Sphingolipids and lifespan regulation

(2013) Xinhe Huang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Macromitophagy, neutral lipids synthesis, and peroxisomal fatty acid oxidation protect yeast from “liponecrosis”, a previously unknown form of programmed cell death

(2013) Sara Sheibani et al.   CELL CYCLE

Epigenetic Silencing Mediates Mitochondria Stress-Induced Longevity

(2013) Elizabeth A. Schroeder et al.   Cell Metabolism

Molecular mechanisms linking the evolutionary conserved TORC1-Sch9 nutrient signalling branch to lifespan regulation inSaccharomyces cerevisiae

(2013) Erwin Swinnen et al.   FEMS YEAST RESEARCH

A network of interorganellar communications underlies cellular aging

(2013) Anna Leonov et al.   IUBMB LIFE

Crosstalk between mitochondrial stress signals regulates yeast chronological lifespan

(2013) Elizabeth A. Schroeder et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Independent and Additive Effects of Glutamic Acid and Methionine on Yeast Longevity

(2013) Ziyun Wu et al.   PLoS One

Time line of redox events in aging postmitotic cells

(2013) Nicolas Brandes et al.   eLife

Molecular mechanisms of Saccharomyces cerevisiae stress adaptation and programmed cell death in response to acetic acid

(2013) Sergio Giannattasio et al.   Frontiers in Microbiology

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespan

(2012) Michelle T. Burstein et al.   CELL CYCLE

Acetic acid and acidification accelerate chronological and replicative aging in yeast

(2012) Mario G. Mirisola et al.   CELL CYCLE

pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast

(2012) Christopher Murakami et al.   CELL CYCLE

Mitochondrial Respiratory Thresholds Regulate Yeast Chronological Life Span and its Extension by Caloric Restriction

(2012) Alejandro Ocampo et al.   Cell Metabolism

Replicative and Chronological Aging in Saccharomyces cerevisiae

(2012) Valter D. Longo et al.   Cell Metabolism

Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae

(2012) Joe R. Delaney et al.   EXPERIMENTAL GERONTOLOGY

Nutritional Control of Growth and Development in Yeast

(2012) J. R. Broach   GENETICS

Yeast Colonies: A Model for Studies of Aging, Environmental Adaptation, and Longevity

(2012) Libuše Váchová et al.   Oxidative Medicine and Cellular Longevity

Down-Regulating Sphingolipid Synthesis Increases Yeast Lifespan

(2012) Xinhe Huang et al.   PLoS Genetics

Integration of peroxisomes into an endomembrane system that governs cellular aging

(2012) Adam Beach et al.   Frontiers in Physiology

Caloric Restriction Extends Yeast Chronological Lifespan by Altering a Pattern of Age-Related Changes in Trehalose Concentration

(2012) Pavlo Kyryakov et al.   Frontiers in Physiology

Driving the Cell Cycle Through Metabolism

(2011) Ling Cai et al.   Annual Review of Cell and Developmental Biology

Sch9 partially mediates TORC1 signaling to control ribosomal RNA synthesis

(2011) Yuehua Wei et al.   CELL CYCLE

Acetic acid effects on aging in budding yeast: Are they relevant to aging in higher eukaryotes?

(2011) William C. Burhans et al.   CELL CYCLE

In search of housekeeping pathways that regulate longevity

(2011) Adam Beach et al.   CELL CYCLE

A genomic analysis of chronological longevity factors in budding yeast

(2011) Christopher R. Burtner et al.   CELL CYCLE

The Tor and cAMP-dependent protein kinase signaling pathways coordinately control autophagy inSaccharomyces cerevisiae

(2010) Joseph S. Stephan et al.   Autophagy

A molecular mechanism of chronological aging in yeast

(2010) Christopher R. Burtner et al.   CELL CYCLE

Life in the midst of scarcity: adaptations to nutrient availability in Saccharomyces cerevisiae

(2010) Bart Smets et al.   CURRENT GENETICS

Gene regulatory changes in yeast during life extension by nutrient limitation

(2010) Jinqing Wang et al.   EXPERIMENTAL GERONTOLOGY

Lessons on longevity from budding yeast

(2010) Matt Kaeberlein   NATURE

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Peroxisome Metabolism and Cellular Aging

(2010) Vladimir I. Titorenko et al.   TRAFFIC

Effect of calorie restriction on the metabolic history of chronologically aging yeast

(2009) Alexander A. Goldberg et al.   EXPERIMENTAL GERONTOLOGY

Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis

(2009) A. Huber et al.   GENES & DEVELOPMENT

Regulation of RNA Polymerase III Transcription InvolvesSCH9-dependent andSCH9-independent Branches of the Target of Rapamycin (TOR) Pathway

(2009) JaeHoon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy

(2009) J. S. Stephan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of trehalose on protein structure

(2009) Nishant Kumar Jain et al.   PROTEIN SCIENCE

Tor1/Sch9-Regulated Carbon Source Substitution Is as Effective as Calorie Restriction in Life Span Extension

(2009) Min Wei et al.   PLoS Genetics

Measuring Replicative Life Span in the Budding Yeast

(2009) Kristan K. Steffen et al.   Jove-Journal of Visualized Experiments

Replicative Aging in Yeast: The Means to the End

(2008) K.A. Steinkraus et al.   Annual Review of Cell and Developmental Biology

Quantitative evidence for conserved longevity pathways between divergent eukaryotic species

(2008) E. D. Smith et al.   GENOME RESEARCH

Yeast Yak1 kinase, a bridge between PKA and stress-responsive transcription factors, Hsf1 and Msn2/Msn4

(2008) Peter Lee et al.   MOLECULAR MICROBIOLOGY

Caffeine extends yeast lifespan by targeting TORC1

(2008) Valeria Wanke et al.   MOLECULAR MICROBIOLOGY