Emerging roles of N- and C-terminally truncated Aβ species in Alzheimer’s disease

Amyloid-β Immunotherapy for Alzheimer's Disease - Is It Now A Long Shot…?

(2019) Francesco Panza et al.   ANNALS OF NEUROLOGY

N-Terminal Truncated Aβ4 - 42 Is a Substrate for Neprilysin Degradation in vitro and in vivo

(2019) Karen Hornung et al.   JOURNAL OF ALZHEIMERS DISEASE

18F-FDG-PET Detects Drastic Changes in Brain Metabolism in the Tg4–42 Model of Alzheimer’s Disease

(2019) Caroline Bouter et al.   Frontiers in Aging Neuroscience

Presenilins and γ-Secretase in Membrane Proteostasis

(2019) Naoto Oikawa et al.   Cells

The new genetic landscape of Alzheimer’s disease: from amyloid cascade to genetically driven synaptic failure hypothesis?

(2019) Pierre Dourlen et al.   ACTA NEUROPATHOLOGICA

A distinct brain beta amyloid signature in cerebral amyloid angiopathy compared to Alzheimer’s disease

(2019) Eleni Gkanatsiou et al.   NEUROSCIENCE LETTERS

Preliminary Results of a Trial of Atabecestat in Preclinical Alzheimer’s Disease

(2019) David Henley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Randomized Trial of Verubecestat for Prodromal Alzheimer’s Disease

(2019) Michael F. Egan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Analysis of Motor Function in the Tg4-42 Mouse Model of Alzheimer’s Disease

(2019) Jannek M. Wagner et al.   Frontiers in Behavioral Neuroscience

Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression

(2019) Filip Liebsch et al.   Nature Communications

Aβ truncated species: Implications for brain clearance mechanisms and amyloid plaque deposition

(2018) Erwin Cabrera et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Interplay between Copper, Neprilysin, and N-Truncation of β-Amyloid

(2018) Mariusz Mital et al.   INORGANIC CHEMISTRY

Synaptic Alterations in Mouse Models for Alzheimer Disease—A Special Focus on N-Truncated Abeta 4-42

(2018) Katharina Dietrich et al.   MOLECULES

Synergistic Effect on Neurodegeneration by N-Truncated Aβ4−42 and Pyroglutamate Aβ3−42 in a Mouse Model of Alzheimer's Disease

(2018) Jose S. Lopez-Noguerola et al.   Frontiers in Aging Neuroscience

White matter changes in Alzheimer’s disease: a focus on myelin and oligodendrocytes

(2018) Sara E. Nasrabady et al.   Acta Neuropathologica Communications

Pyroglutamate and Isoaspartate modified Amyloid-Beta in ageing and Alzheimer’s disease

(2018) Maria Luisa Moro et al.   Acta Neuropathologica Communications

Enriched environment enhances β‐adrenergic signaling to prevent microglia inflammation by amyloid‐β

(2018) Huixin Xu et al.   EMBO Molecular Medicine

Mass spectrometry analysis of the diversity of Aβ peptides: difficulties and future perspectives for AD biomarker discovery

(2018) Natalia V. Zakharova et al.   Expert Review of Proteomics

Aβ38 in the Brains of Patients with Sporadic and Familial Alzheimer's Disease and Transgenic Mouse Models

(2018) Jochim Reinert et al.   JOURNAL OF ALZHEIMERS DISEASE

Are N- and C-terminally Truncated Aβ species key pathological triggers in Alzheimer’s disease?

(2018) Julie Dunys et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The metalloprotease ADAMTS4 generates N-truncated Aβ4–x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer’s disease

(2018) Susanne Walter et al.   ACTA NEUROPATHOLOGICA

Oligopeptides Generated by Neprilysin Degradation of β-Amyloid Have the Highest Cu(II) Affinity in the Whole Aβ Family

(2018) Karolina Bossak-Ahmad et al.   INORGANIC CHEMISTRY

Dipeptidyl-Peptidase Activity of Meprin β Links N-truncation of Aβ with Glutaminyl Cyclase-Catalyzed pGlu-Aβ Formation

(2018) Dagmar Schlenzig et al.   JOURNAL OF ALZHEIMERS DISEASE

Safety, tolerability and efficacy of the glutaminyl cyclase inhibitor PQ912 in Alzheimer’s disease: results of a randomized, double-blind, placebo-controlled phase 2a study

(2018) Philip Scheltens et al.   Alzheimers Research & Therapy

Decoding the synaptic dysfunction of bioactive human AD brain soluble Aβ to inspire novel therapeutic avenues for Alzheimer’s disease

(2018) Shaomin Li et al.   Acta Neuropathologica Communications

Pyroglutamate–amyloid-β peptide expression in Drosophila leads to caspase-dependent and endoplasmic reticulum stress–related progressive neurodegeneration

(2017) Leo Tsuda et al.   HUMAN MOLECULAR GENETICS

Short Aβ peptides attenuate Aβ42 toxicity in vivo

(2017) Brenda D. Moore et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glutaminyl Cyclase Inhibitor PQ912 Improves Cognition in Mouse Models of Alzheimer’s Disease—Studies on Relation to Effective Target Occupancy

(2017) Torsten Hoffmann et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

N-truncated Aβ4–x peptides in sporadic Alzheimer’s disease cases and transgenic Alzheimer mouse models

(2017) Oliver Wirths et al.   Alzheimers Research & Therapy

The role of astrocytes in amyloid production and Alzheimer's disease

(2017) Georgia R. Frost et al.   Open Biology

Physiological Concentrations of Amyloid Beta Regulate Recycling of Synaptic Vesicles via Alpha7 Acetylcholine Receptor and CDK5/Calcineurin Signaling

(2017) Vesna Lazarevic et al.   Frontiers in Molecular Neuroscience

Distinct deposition of amyloid-β species in brains with Alzheimer’s disease pathology visualized with MALDI imaging mass spectrometry

(2017) Nobuto Kakuda et al.   Acta Neuropathologica Communications

Diversity of Amyloid-beta Proteoforms in the Alzheimer’s Disease Brain

(2017) Norelle C. Wildburger et al.   Scientific Reports

Amyloid Plaque in the Human Brain Can Decompose from Aβ(1-40/1-42) by Spontaneous Nonenzymatic Processes

(2016) Brian Lyons et al.   ANALYTICAL CHEMISTRY

Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence

(2016) Ayano Kimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Probing amyloid-β pathology in transgenic Alzheimer's disease (tgArcSwe) mice using MALDI imaging mass spectrometry

(2016) Louise Carlred et al.   JOURNAL OF NEUROCHEMISTRY

Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site

(2016) Caroline Schönherr et al.   Molecular Neurodegeneration

Immunotherapy targeting pyroglutamate-3 Aβ: prospects and challenges

(2016) Holger Cynis et al.   Molecular Neurodegeneration

Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer’s disease and transgenic mouse models

(2016) Jochim Reinert et al.   Acta Neuropathologica Communications

pGluAβ increases accumulation of Aβ in vivo and exacerbates its toxicity

(2016) Oyinkan Sofola-Adesakin et al.   Acta Neuropathologica Communications

Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis

(2015) Kirsten L. Viola et al.   ACTA NEUROPATHOLOGICA

Amyloid β Protein and Alzheimer’s Disease: When Computer Simulations Complement Experimental Studies

(2015) Jessica Nasica-Labouze et al.   CHEMICAL REVIEWS

Sequential Amyloid-β Degradation by the Matrix Metalloproteases MMP-2 and MMP-9

(2015) Mar Hernandez-Guillamon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Astrocytes and microglia but not neurons preferentially generate N-terminally truncated Aβ peptides

(2015) Timo Jan Oberstein et al.   NEUROBIOLOGY OF DISEASE

Focusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer’s disease

(2014) Thomas A. Bayer et al.   ACTA NEUROPATHOLOGICA

The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes

(2014) Hoang S. Nhan et al.   ACTA NEUROPATHOLOGICA

Pyroglutamylated amyloid-β is associated with hyperphosphorylated tau and severity of Alzheimer’s disease

(2014) Markus Mandler et al.   ACTA NEUROPATHOLOGICA

Insights into the molecular interactions between aminopeptidase and amyloid beta peptide using molecular modeling techniques

(2014) Maruti J. Dhanavade et al.   AMINO ACIDS

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

(2014) Robert Vassar et al.   JOURNAL OF NEUROCHEMISTRY

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Abundance of Aβ5-x like immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer’s disease

(2014) Erika Guzmán et al.   Molecular Neurodegeneration

Study on Aβ34 biology and detection in transgenic mice brains

(2014) Céline Caillava et al.   NEUROBIOLOGY OF AGING

Identification and quantification of amyloid beta-related peptides in human plasma using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

(2014) Naoki KANEKO et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Familial Alzheimer’s mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage site

(2014) Wen Chen et al.   Nature Communications

Truncated and modified amyloid-beta species

(2014) Markus P Kummer et al.   Alzheimers Research & Therapy

β-site amyloid precursor protein-cleaving enzyme 1(BACE1) inhibitor treatment induces Aβ5-X peptides through alternative amyloid precursor protein cleavage

(2014) Erik Portelius et al.   Alzheimers Research & Therapy

APP Homodimers Transduce an Amyloid-β-Mediated Increase in Release Probability at Excitatory Synapses

(2014) Hilla Fogel et al.   Cell Reports

Understanding Amyloid Fibril Nucleation and Aβ Oligomer/Drug Interactions from Computer Simulations

(2013) Phuong Nguyen et al.   ACCOUNTS OF CHEMICAL RESEARCH

N-truncated amyloid β (Aβ) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits

(2013) Yvonne Bouter et al.   ACTA NEUROPATHOLOGICA

γ-Secretase inhibitors and modulators

(2013) Todd E. Golde et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Pyroglutamate-Modified Amyloid Beta Peptides: Emerging Targets for Alzheimer´s Disease Immunotherapy

(2013) Roxanna Perez-Garmendia et al.   Current Neuropharmacology

γ-Secretase Associated with Lipid Rafts

(2013) Nobutaka Matsumura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Intermediate Steps in Amyloid Beta (Aβ) Production under Near-native Conditions

(2013) Fredrik Olsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deleterious effects of soluble amyloid-β oligomers on multiple steps of synaptic vesicle trafficking

(2013) Joohyun Park et al.   NEUROBIOLOGY OF DISEASE

Bapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformation

(2013) Luke A. Miles et al.   Scientific Reports

The Genetics of Alzheimer Disease

(2013) R. E. Tanzi   Cold Spring Harbor Perspectives in Medicine

Cerebrospinal Aβ11-x and 17-x levels as indicators of mild cognitive impairment and patients’ stratification in Alzheimer’s disease

(2013) J-D Abraham et al.   Translational Psychiatry

APP mutations in the Aβ coding region are associated with abundant cerebral deposition of Aβ38

(2012) Maria Luisa Moro et al.   ACTA NEUROPATHOLOGICA

The genetics and neuropathology of Alzheimer’s disease

(2012) Gerard D. Schellenberg et al.   ACTA NEUROPATHOLOGICA

Intracellular accumulation of aggregated pyroglutamate amyloid beta: convergence of aging and Aβ pathology at the lysosome

(2012) Line De Kimpe et al.   AGE

β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment

(2012) Jun Cai et al.   EMBO Molecular Medicine

A comparative analysis of the aggregation behavior of amyloid-β peptide variants

(2012) Annelies Vandersteen et al.   FEBS LETTERS

The Metalloprotease Meprin β Generates Amino Terminal-truncated Amyloid β Peptide Species

(2012) Jessica Bien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyroglutamate Amyloid β (Aβ) Aggravates Behavioral Deficits in Transgenic Amyloid Mouse Model for Alzheimer Disease

(2012) Jessica L. Wittnam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β

(2012) Justin M. Nussbaum et al.   NATURE

Passive Immunization against Pyroglutamate-3 Amyloid-ß Reduces Plaque Burden in Alzheimer-Like Transgenic Mice: A Pilot Study

(2012) Jeffrey L. Frost et al.   Neurodegenerative Diseases

A Plaque-Specific Antibody Clears Existing β-amyloid Plaques in Alzheimer's Disease Mice

(2012) Ronald B. DeMattos et al.   NEURON

BACE1 Inhibition Induces a Specific Cerebrospinal Fluid β-Amyloid Pattern That Identifies Drug Effects in the Central Nervous System

(2012) Niklas Mattsson et al.   PLoS One

Overlapping profiles of Abeta peptides in the Alzheimer's disease and pathological aging brains

(2012) Brenda D Moore et al.   Alzheimers Research & Therapy

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

Pyroglutamate Amyloid-β (Aβ): A Hatchet Man in Alzheimer Disease

(2011) Sadim Jawhar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Hippocampal Neurodegeneration in Transgenic Mice Expressing Small Amounts of Truncated A  Is Induced by Pyroglutamate-A  Formation

(2011) A. Alexandru et al.   JOURNAL OF NEUROSCIENCE

Pyroglutamate-Aβ 3 and 11 colocalize in amyloid plaques in Alzheimer's disease cerebral cortex with pyroglutamate-Aβ 11 forming the central core

(2011) Christopher P. Sullivan et al.   NEUROSCIENCE LETTERS

Distinct glutaminyl cyclase expression in Edinger–Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Aβ pathology in Alzheimer’s disease

(2010) Markus Morawski et al.   ACTA NEUROPATHOLOGICA

Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer’s disease

(2010) Erik Portelius et al.   ACTA NEUROPATHOLOGICA

Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory

(2010) Daniela Puzzo et al.   ANNALS OF NEUROLOGY

Identification of Low Molecular Weight Pyroglutamate Aβ Oligomers in Alzheimer Disease

(2010) Oliver Wirths et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of Glutaminyl Cyclase, the Enzyme Responsible for Pyroglutamate Aβ Formation, Induces Behavioral Deficits, and Glutaminyl Cyclase Knock-out Rescues the Behavioral Phenotype in 5XFAD Mice

(2010) Sadim Jawhar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct cerebrospinal fluid amyloid β peptide signatures in sporadic and PSEN1 A431E-associated familial Alzheimer's disease

(2010) Erik Portelius et al.   Molecular Neurodegeneration

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

(2010) Jorge J Palop et al.   NATURE NEUROSCIENCE

APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy

(2009) Henning Breyhan et al.   ACTA NEUROPATHOLOGICA

Intraneuronal pyroglutamate-Abeta 3–42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model

(2009) Oliver Wirths et al.   ACTA NEUROPATHOLOGICA

Pyroglutamate Formation Influences Solubility and Amyloidogenicity of Amyloid Peptides

(2009) Dagmar Schlenzig et al.   BIOCHEMISTRY

Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer’s disease cases

(2009) Oliver Wirths et al.   JOURNAL OF NEURAL TRANSMISSION

Aminopeptidase A contributes to the N-terminal truncation of amyloid β-peptide

(2009) Jean Sevalle et al.   JOURNAL OF NEUROCHEMISTRY

Picomolar Amyloid-  Positively Modulates Synaptic Plasticity and Memory in Hippocampus

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

Amyloid beta mediates memory formation

(2009) A. Garcia-Osta et al.   LEARNING & MEMORY

Amyloid-β as a positive endogenous regulator of release probability at hippocampal synapses

(2009) Efrat Abramov et al.   NATURE NEUROSCIENCE

Oligodendrocytes are a Novel Source of Amyloid Peptide Generation

(2009) Stephen D. Skaper et al.   NEUROCHEMICAL RESEARCH

Synaptic transmission block by presynaptic injection of oligomeric amyloid beta

(2009) H. Moreno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease

(2009) M. Britschgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloidogenic Processing of Amyloid Precursor Protein: Evidence of a Pivotal Role of Glutaminyl Cyclase in Generation of Pyroglutamate-Modified Amyloid-β†

(2008) Holger Cynis et al.   BIOCHEMISTRY

Independent Generation of Aβ42 and Aβ38 Peptide Species by γ-Secretase

(2008) Eva Czirr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein

(2008) Vivian Y. H. Hook et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology

(2008) Stephan Schilling et al.   NATURE MEDICINE