β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment

γ-Secretase and Presenilin Mediate Cleavage and Phosphorylation of Vascular Endothelial Growth Factor Receptor-1

(2011) Jun Cai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Robust Central Reduction of Amyloid-  in Humans with an Orally Available, Non-Peptidic  -Secretase Inhibitor

(2011) P. C. May et al.   JOURNAL OF NEUROSCIENCE

Placenta Growth Factor-1 Exerts Time-Dependent Stabilization of Adherens Junctions Following VEGF-Induced Vascular Permeability

(2011) Jun Cai et al.   PLoS One

PEDF Regulates Vascular Permeability by a γ-Secretase-Mediated Pathway

(2011) Jun Cai et al.   PLoS One

Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration

(2011) J.-D. Ding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secretases as therapeutic targets for Alzheimer’s disease

(2010) Ha-Na Woo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions

(2010) David W. Klaver et al.   BIOLOGICAL CHEMISTRY

Design and Synthesis of Potent and Selective BACE-1 Inhibitors

(2010) Catarina Björklund et al.   JOURNAL OF MEDICINAL CHEMISTRY

The secretases: enzymes with therapeutic potential in Alzheimer disease

(2010) Bart De Strooper et al.   Nature Reviews Neurology

Design and synthesis of cell potent BACE-1 inhibitors: Structure–activity relationship of P1′ substituents

(2009) Jennifer M. Sealy et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of Ligand-Induced Proteolytic Cleavage and Ectodomain Shedding of VEGFR-1/FLT1 in Leukemic Cancer Cells

(2009) N. Rahimi et al.   CANCER RESEARCH

The  -Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential

(2009) R. Vassar et al.   JOURNAL OF NEUROSCIENCE

Regulation of Adult Hematopoietic Stem Cells Fate for Enhanced Tissue-specific Repair

(2009) Nilanjana Sengupta et al.   MOLECULAR THERAPY

Anti-sphingosine-1-phosphate monoclonal antibodies inhibit angiogenesis and sub-retinal fibrosis in a murine model of laser-induced choroidal neovascularization

(2008) Sergio Caballero et al.   EXPERIMENTAL EYE RESEARCH

γ-Secretase: a multifaceted regulator of angiogenesis

(2008) Michael E. Boulton et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE