APP mutations in the Aβ coding region are associated with abundant cerebral deposition of Aβ38

Neocortical Variation of Aβ Load in Fully Expressed, Pure Alzheimer's Disease

(2017) Chiara Cupidi et al.   JOURNAL OF ALZHEIMERS DISEASE

Cerebrospinal Fluid Levels ofβ-Amyloid 1-42, but Not of Tau, Are Fully Changed Already 5 to 10 Years Before the Onset of Alzheimer Dementia

(2012) Peder Buchhave   ARCHIVES OF GENERAL PSYCHIATRY

The levels of water-soluble and triton-soluble Aβ are increased in Alzheimer's disease brain

(2012) Jessica M. McDonald et al.   BRAIN RESEARCH

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

(2012) Lucía Chávez-Gutiérrez et al.   EMBO JOURNAL

Lysine 624 of the Amyloid Precursor Protein (APP) Is a Critical Determinant of Amyloid β Peptide Length

(2011) Thomas L. Kukar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New lexicon and criteria for the diagnosis of Alzheimer's disease

(2011) Giorgio Giaccone et al.   LANCET NEUROLOGY

Potent amyloidogenicity and pathogenicity of Aβ43

(2011) Takashi Saito et al.   NATURE NEUROSCIENCE

Neuropathology of the recessive A673V APP mutation: Alzheimer disease with distinctive features

(2010) Giorgio Giaccone et al.   ACTA NEUROPATHOLOGICA

Iowa Variant of Familial Alzheimer’s Disease

(2010) Yasushi Tomidokoro et al.   AMERICAN JOURNAL OF PATHOLOGY

Hereditary Cerebral Hemorrhage With Amyloidosis Associated With the E693K Mutation of APP

(2010) Orso Bugiani et al.   ARCHIVES OF NEUROLOGY

The presence of sodium dodecyl sulphate-stable Aβ dimers is strongly associated with Alzheimer-type dementia

(2010) Jessica M. Mc Donald et al.   BRAIN

Current status on Alzheimer disease molecular genetics: from past, to present, to future

(2010) K. Bettens et al.   HUMAN MOLECULAR GENETICS

Aberrant Amyloid Precursor Protein (APP) Processing in Hereditary Forms of Alzheimer Disease Caused by APP Familial Alzheimer Disease Mutations Can Be Rescued by Mutations in the APP GxxxG Motif

(2010) Lisa-Marie Munter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Revising the definition of Alzheimer's disease: a new lexicon

(2010) Bruno Dubois et al.   LANCET NEUROLOGY

Worldwide distribution of PSEN1 Met146Leu mutation: A large variability for a founder mutation

(2010) A. C. Bruni et al.   NEUROLOGY

Variations in the neuropathology of familial Alzheimer’s disease

(2009) Claire Shepherd et al.   ACTA NEUROPATHOLOGICA

Molecular genetic analysis of Down syndrome

(2009) David Patterson   HUMAN GENETICS

Combined CSF tau, p-tau181 and amyloid-β 38/40/42 for diagnosing Alzheimer’s disease

(2009) Volker Welge et al.   JOURNAL OF NEURAL TRANSMISSION

Aβ43 is more frequent than Aβ40 in amyloid plaque cores from Alzheimer disease brains

(2009) Hedvig Welander et al.   JOURNAL OF NEUROCHEMISTRY

 -Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of  -Carboxyl Terminal Fragment

(2009) M. Takami et al.   JOURNAL OF NEUROSCIENCE

Comparison of Aβ levels in the brain of familial and sporadic Alzheimer's disease

(2009) E. Hellström-Lindahl et al.   NEUROCHEMISTRY INTERNATIONAL

A Recessive Mutation in the APP Gene with Dominant-Negative Effect on Amyloidogenesis

(2009) G. Di Fede et al.   SCIENCE

Inter-laboratory comparison of neuropathological assessments of β-amyloid protein: a study of the BrainNet Europe consortium

(2008) Irina Alafuzoff et al.   ACTA NEUROPATHOLOGICA

Clinical and Neuropathological Features of the Arctic APP Gene Mutation Causing Early-Onset Alzheimer Disease

(2008) Hans Basun et al.   ARCHIVES OF NEUROLOGY

Enzymatic Characteristics of I213T Mutant Presenilin-1/γ-Secretase in Cell Models and Knock-in Mouse Brains

(2008) Masafumi Shimojo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Independent Generation of Aβ42 and Aβ38 Peptide Species by γ-Secretase

(2008) Eva Czirr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

A novel PSEN2 mutation associated with a peculiar phenotype

(2008) P. Piscopo et al.   NEUROLOGY