Targeting Age-Related Pathways in Heart Failure

The N 6 -Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy

(2019) Lisa E. Dorn et al.   CIRCULATION

Activin type II receptor signaling in cardiac aging and heart failure

(2019) Jason D. Roh et al.   Science Translational Medicine

Longterm Exercise-Derived Exosomal miR-342-5p: A Novel Exerkine for Cardioprotection

(2019) Zuoxu Hou et al.   CIRCULATION RESEARCH

Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association

(2019) Emelia J. Benjamin et al.   CIRCULATION

Cellular Senescence in the Lung Across the Age Spectrum

(2019) Pavan Parikh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction

(2019) Anna Walaszczyk et al.   AGING CELL

Aged-senescent cells contribute to impaired heart regeneration

(2019) Fiona C. Lewis-McDougall et al.   AGING CELL

Heart Failure With Preserved Ejection Fraction In Perspective

(2019) Marc A. Pfeffer et al.   CIRCULATION RESEARCH

Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest

(2019) Sangkyun Cho et al.   DEVELOPMENTAL CELL

Stem Cell-Derived Exosomes Prevent Aging-Induced Cardiac Dysfunction through a Novel Exosome/lncRNA MALAT1/NF-κB/TNF-α Signaling Pathway

(2019) Bao Zhu et al.   Oxidative Medicine and Cellular Longevity

Senescent cell clearance by the immune system: Emerging therapeutic opportunities

(2019) Larissa G.P. Langhi Prata et al.   SEMINARS IN IMMUNOLOGY

Loss of Super-Enhancer-Regulated circRNA Nfix Induces Cardiac Regeneration After Myocardial Infarction in Adult Mice

(2019) Senlin Huang et al.   CIRCULATION

CCN1-Induced Cellular Senescence Promotes Heart Regeneration

(2019) Teng Feng et al.   CIRCULATION

Cellular senescence in cardiac diseases

(2019) Ippei Shimizu et al.   Journal of Cardiology

Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy

(2019) Jaecheol Lee et al.   NATURE

From discoveries in ageing research to therapeutics for healthy ageing

(2019) Judith Campisi et al.   NATURE

Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity

(2019) Xudong Zhu et al.   CIRCULATION RESEARCH

From molecular promise to preclinical results: HDAC inhibitors in the race for healthy aging drugs

(2019) Rebecca L McIntyre et al.   EMBO Molecular Medicine

Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis

(2019) Venkata Naga Srikanth Garikipati et al.   Nature Communications

Identification and characterization of Cardiac Glycosides as senolytic compounds

(2019) Francisco Triana-Martínez et al.   Nature Communications

Risk Factors And Epigenetic Markers Of Left Ventricular Diastolic Dysfunction With Preserved Ejection Fraction In A Community-Based Elderly Chinese Population

(2019) Wei Wang et al.   Clinical Interventions in Aging

Cardiomyocyte-specific deletion of Sirt1 gene sensitizes myocardium to ischaemia and reperfusion injury

(2018) Lin Wang et al.   CARDIOVASCULAR RESEARCH

Gata4-Dependent Differentiation of c-Kit+Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart

(2018) Bryan D. Maliken et al.   CIRCULATION

Circulating ANGPTL2 Levels Increase in Humans and Mice Exhibiting Cardiac Dysfunction

(2018) Zhe Tian et al.   CIRCULATION JOURNAL

CRISPR-Mediated Gene Editing to Assess the Roles of Tet2 and Dnmt3a in Clonal Hematopoiesis and Cardiovascular DiseaseNovelty and Significance

(2018) Soichi Sano et al.   CIRCULATION RESEARCH

Cellular senescence in tissue repair: every cloud has a silver lining

(2018) Maximina H. Yun   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Senescent cells: a therapeutic target for cardiovascular disease

(2018) Bennett G. Childs et al.   JOURNAL OF CLINICAL INVESTIGATION

Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome

(2018) Soichi Sano et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

lncRNA ENSMUST00000134285 Increases MAPK11 Activity, Regulating Aging-Related Myocardial Apoptosis

(2018) Xiao Chun Yang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Short-Duration Swimming Exercise after Myocardial Infarction Attenuates Cardiac Dysfunction and Regulates Mitochondrial Quality Control in Aged Mice

(2018) Dajun Zhao et al.   Oxidative Medicine and Cellular Longevity

Histone deacetylase activity governs diastolic dysfunction through a nongenomic mechanism

(2018) Mark Y. Jeong et al.   Science Translational Medicine

The Lncrna, H19 Mediates the Protective Effect of Hypoxia Postconditioning Against Hypoxia–Reoxygenation Injury to Senescent Cardiomyocytes by Targeting MicroRNA-29b-3p

(2018) Xuan Zhang et al.   SHOCK

Short Telomeres Induce p53 and Autophagy and Modulate Age-Associated Changes in Cardiac Progenitor Cell Fate

(2018) Collin Matsumoto et al.   STEM CELLS

Epidemiology of Left Ventricular Systolic Dysfunction and Heart Failure in the Framingham Study

(2018) Ramachandran S. Vasan et al.   JACC-Cardiovascular Imaging

Exercise induces new cardiomyocyte generation in the adult mammalian heart

(2018) Ana Vujic et al.   Nature Communications

Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration

(2018) Wei Huang et al.   Nature Communications

TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging

(2018) Guoliang Lyu et al.   Nature Communications

Epigenetic Modifications in Cardiovascular Aging and Diseases

(2018) Weiqi Zhang et al.   CIRCULATION RESEARCH

Heart-Breaking Telomeres

(2018) Paula Martínez et al.   CIRCULATION RESEARCH

Mitochondrial quality control mechanisms as molecular targets in cardiac ageing

(2018) Anna Picca et al.   Nature Reviews Cardiology

Cardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescence

(2018) Natalie A. Gude et al.   Nature Reviews Cardiology

Telomere shortening is a hallmark of genetic cardiomyopathies

(2018) Alex C. Y. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancing the precision of genetic lineage tracing using dual recombinases

(2017) Lingjuan He et al.   NATURE MEDICINE

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

(2017) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure

(2017) Qiming Duan et al.   Science Translational Medicine

Cardiomyocyte‐Specific Telomere Shortening is a Distinct Signature of Heart Failure in Humans

(2017) Maryam Sharifi‐Sanjani et al.   Journal of the American Heart Association

Current insights into LMNA cardiomyopathies: Existing models and missing LINCs

(2017) Daniel Brayson et al.   Nucleus

Current insights into LMNA cardiomyopathies: Existing models and missing LINCs

(2017) Daniel Brayson et al.   Nucleus

An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers

(2017) Sophia E. Airhart et al.   PLoS One

Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease

(2016) Marissa J. Schafer et al.   Cell Metabolism

Ketones Step to the Plate: A Game Changer for Metabolic Remodeling in Heart Failure?

(2016) Stephen C. Kolwicz et al.   CIRCULATION

Failing Heart and Starving Brain

(2016) Heinrich Taegtmeyer   CIRCULATION

Normalization of NAD+Redox Balance as a Therapy for Heart FailureClinical Perspective

(2016) Chi Fung Lee et al.   CIRCULATION

Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure

(2016) Kenneth C. Bedi et al.   CIRCULATION

The Failing Heart Relies on Ketone Bodies as a Fuel

(2016) Gregory Aubert et al.   CIRCULATION

The Role of Exercise in Cardiac Aging

(2016) Jason Roh et al.   CIRCULATION RESEARCH

Epigenetic control of exercise training-induced cardiac hypertrophy by miR-208

(2016) U. P. R. Soci et al.   CLINICAL SCIENCE

Amelioration of premature aging in mtDNA mutator mouse by exercise: the interplay of oxidative stress, PGC-1α, p53, and DNA damage. A hypothesis

(2016) Adeel Safdar et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Effect of Caloric Restriction or Aerobic Exercise Training on Peak Oxygen Consumption and Quality of Life in Obese Older Patients With Heart Failure With Preserved Ejection Fraction

(2016) Dalane W. Kitzman et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Postnatal telomere dysfunction induces cardiomyocyte cell-cycle arrest through p21 activation

(2016) Esther Aix et al.   JOURNAL OF CELL BIOLOGY

Preclinical Development of a MicroRNA-Based Therapy for Elderly Patients With Myocardial Infarction

(2016) Shashi Kumar Gupta et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Essential Role for Premature Senescence of Myofibroblasts in Myocardial Fibrosis

(2016) Kathleen Meyer et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow

(2016) Li Wang et al.   NATURE

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

ANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism

(2016) Zhe Tian et al.   Nature Communications

Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs

(2016) Antonia Piazzesi et al.   Cell Reports

Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy

(2016) Angela V. Hafner et al.   Aging-US

CircRNA accumulation in the aging mouse brain

(2016) Hannah Gruner et al.   Scientific Reports

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Changes in mid-life fitness predicts heart failure risk at a later age independent of interval development of cardiac and noncardiac risk factors: The Cooper Center Longitudinal Study

(2015) Ambarish Pandey et al.   AMERICAN HEART JOURNAL

Dynamics of Cell Generation and Turnover in the Human Heart

(2015) Olaf Bergmann et al.   CELL

Mosaic Deficiency in Mitochondrial Oxidative Metabolism Promotes Cardiac Arrhythmia during Aging

(2015) Olivier R. Baris et al.   Cell Metabolism

Using Exercise to Measure and Modify Cardiac Function

(2015) Colin Platt et al.   Cell Metabolism

miR-222 Is Necessary for Exercise-Induced Cardiac Growth and Protects against Pathological Cardiac Remodeling

(2015) Xiaojun Liu et al.   Cell Metabolism

GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration

(2015) Marc A. Egerman et al.   Cell Metabolism

Genetic lineage tracing identifies in situ Kit-expressing cardiomyocytes

(2015) Qiaozhen Liu et al.   CELL RESEARCH

GDF11 Does Not Rescue Aging-Related Pathological HypertrophyNovelty and Significance

(2015) Shavonn C. Smith et al.   CIRCULATION RESEARCH

Exercise Training as Therapy for Heart Failure: Current Status and Future Directions

(2015) J. L. Fleg et al.   Circulation-Heart Failure

Age-associated pro-inflammatory remodeling and functional phenotype in the heart and large arteries

(2015) Mingyi Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

So! What's aging? Is cardiovascular aging a disease?

(2015) Edward G. Lakatta   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection

(2015) E. H. Blackburn et al.   SCIENCE

What do we know about the cardiac benefits of exercise?

(2015) Xin Wei et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Resident c-kit+ cells in the heart are not cardiac stem cells

(2015) Nishat Sultana et al.   Nature Communications

Moderate exercise training attenuates aging-induced cardiac inflammation, hypertrophy and fibrosis injuries of rat hearts

(2015) Po-Hsiang Liao et al.   Oncotarget

Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice

(2015) Adeel Safdar et al.   Skeletal Muscle

Mitohormesis

(2014) Jeanho Yun et al.   Cell Metabolism

Regulation of Akt Signaling by Sirtuins

(2014) Vinodkumar B. Pillai et al.   CIRCULATION RESEARCH

Aging and epigenetic drift: a vicious cycle

(2014) Jean-Pierre Issa   JOURNAL OF CLINICAL INVESTIGATION

c-kit+ cells minimally contribute cardiomyocytes to the heart

(2014) Jop H. van Berlo et al.   NATURE

Age-related mutations associated with clonal hematopoietic expansion and malignancies

(2014) Mingchao Xie et al.   NATURE MEDICINE

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reprogramming Suppresses Premature Senescence Phenotypes of Werner Syndrome Cells and Maintains Chromosomal Stability over Long-Term Culture

(2014) Akira Shimamoto et al.   PLoS One

Existing cardiomyocytes generate cardiomyocytes at a low rate after birth in mice

(2014) S. R. Ali et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

(2014) L. Katsimpardi et al.   SCIENCE

Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle

(2014) M. Sinha et al.   SCIENCE

Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease

(2014) Ralf Gilsbach et al.   Nature Communications

Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling

(2014) Rebecca C. Schugar et al.   Molecular Metabolism

Inhibition of DNA methylation reverses norepinephrine-induced cardiac hypertrophy in rats

(2013) DaLiao Xiao et al.   CARDIOVASCULAR RESEARCH

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy

(2013) Francesco S. Loffredo et al.   CELL

BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure

(2013) Priti Anand et al.   CELL

Association of physical activity and heart failure with preserved vs. reduced ejection fraction in the elderly: the Framingham Heart Study

(2013) Elisabeth Kraigher-Krainer et al.   EUROPEAN JOURNAL OF HEART FAILURE

MicroRNA-34a regulates cardiac ageing and function

(2013) Reinier A. Boon et al.   NATURE

Role of telomere dysfunction in cardiac failure in Duchenne muscular dystrophy

(2013) Foteini Mourkioti et al.   NATURE CELL BIOLOGY

Treatment of HCV Infection by Targeting MicroRNA

(2013) Harry L.A. Janssen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Association of telomere shortening in myocardium with heart weight gain and cause of death

(2013) Masanori Terai et al.   Scientific Reports

Phosphoinositide 3-Kinase p110α Is a Master Regulator of Exercise-Induced Cardioprotection and PI3K Gene Therapy Rescues Cardiac Dysfunction

(2012) Kate L. Weeks et al.   Circulation-Heart Failure

Aberrant DNA methylation profiles in the premature aging disorders Hutchinson-Gilford Progeria and Werner syndrome

(2012) Holger Heyn et al.   Epigenetics

Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism

(2012) Matthew L. Steinhauser et al.   NATURE

Functional screening identifies miRNAs inducing cardiac regeneration

(2012) Ana Eulalio et al.   NATURE

Mammalian heart renewal by pre-existing cardiomyocytes

(2012) Samuel E. Senyo et al.   NATURE

MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure

(2011) Geert C. van Almen et al.   AGING CELL

Distinct Epigenomic Features in End-Stage Failing Human Hearts

(2011) Mehregan Movassagh et al.   CIRCULATION

Exercise Protects Against Myocardial Ischemia–Reperfusion Injury via Stimulation of β 3 -Adrenergic Receptors and Increased Nitric Oxide Signaling: Role of Nitrite and Nitrosothiols

(2011) John W. Calvert et al.   CIRCULATION RESEARCH

Extending life span by increasing oxidative stress

(2011) Michael Ristow et al.   FREE RADICAL BIOLOGY AND MEDICINE

Exercise Increases Mitochondrial PGC-1α Content and Promotes Nuclear-Mitochondrial Cross-talk to Coordinate Mitochondrial Biogenesis

(2011) Adeel Safdar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient Regenerative Potential of the Neonatal Mouse Heart

(2011) E. R. Porrello et al.   SCIENCE

Exercise training leads to a reduction of elevated myostatin levels in patients with chronic heart failure

(2011) Karsten Lenk et al.   European Journal of Preventive Cardiology

Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria

(2010) Dao-Fu Dai et al.   AGING CELL

C/EBPβ Controls Exercise-Induced Cardiac Growth and Protects against Pathological Cardiac Remodeling

(2010) Pontus Boström et al.   CELL

Prelamin A Acts to Accelerate Smooth Muscle Cell Senescence and Is a Novel Biomarker of Human Vascular Aging

(2010) Cassandra D. Ragnauth et al.   CIRCULATION

Cardiovascular Effects of 1 Year of Progressive and Vigorous Exercise Training in Previously Sedentary Individuals Older Than 65 Years of Age

(2010) Naoki Fujimoto et al.   CIRCULATION

Cellular senescence: putting the paradoxes in perspective

(2010) Judith Campisi   CURRENT OPINION IN GENETICS & DEVELOPMENT

Global Cardiovascular Reserve Dysfunction in Heart Failure With Preserved Ejection Fraction

(2010) Barry A. Borlaug et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres

(2010) Roderick J O'Sullivan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Effects of myostatin deletion in aging mice

(2009) Michael R. Morissette et al.   AGING CELL

Physical Exercise Prevents Cellular Senescence in Circulating Leukocytes and in the Vessel Wall

(2009) Christian Werner et al.   CIRCULATION

Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging

(2009) Dao-Fu Dai et al.   CIRCULATION

Relationship Between Cardiac Rehabilitation and Long-Term Risks of Death and Myocardial Infarction Among Elderly Medicare Beneficiaries

(2009) Bradley G. Hammill et al.   CIRCULATION

Impact of exercise training on myostatin expression in the myocardium and skeletal muscle in a chronic heart failure model

(2009) Karsten Lenk et al.   EUROPEAN JOURNAL OF HEART FAILURE

Efficacy and Safety of Exercise Training in Patients With Chronic Heart Failure

(2009) Christopher M. O’Connor et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

p66Shc protein, oxidative stress, and cardiovascular complications of diabetes: the missing link

(2009) Pietro Francia et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Antioxidants prevent health-promoting effects of physical exercise in humans

(2009) M. Ristow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for Cardiomyocyte Renewal in Humans

(2009) Olaf Bergmann et al.   SCIENCE

Telomere biology in cardiovascular disease: the TERC-/- mouse as a model for heart failure and ageing

(2008) L. S.M. Wong et al.   CARDIOVASCULAR RESEARCH

Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice

(2008) Rusty L. Montgomery et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of Physical Exercise on Myocardial Telomere-Regulating Proteins, Survival Pathways, and Apoptosis

(2008) Christian Werner et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

(2008) Zoltan Arany et al.   NATURE

LNA-mediated microRNA silencing in non-human primates

(2008) Joacim Elmén et al.   NATURE

DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice

(2008) Marc Vermulst et al.   NATURE GENETICS

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS