Activin type II receptor signaling in cardiac aging and heart failure

Heart failure subgroups: HFrEF, HFmrEF, and HFpEF with or without mitral regurgitation

(2018) Thomas F Lüscher   EUROPEAN HEART JOURNAL

Activin A and Late Postpartum Cardiac Dysfunction Among Women With Hypertensive Disorders of PregnancyNovelty and Significance

(2018) Sajid Shahul et al.   HYPERTENSION

Heart Failure With Preserved, Borderline, and Reduced Ejection Fraction

(2017) Kevin S. Shah et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Frailty in Older Adults Undergoing Aortic Valve Replacement

(2017) Jonathan Afilalo et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Treatment of Sarcopenia with Bimagrumab: Results from a Phase II, Randomized, Controlled, Proof-of-Concept Study

(2017) Daniel Rooks et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy

(2017) Frederic Morvan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Opposite effects of Activin type 2 receptor ligands on cardiomyocyte proliferation during development and repair

(2017) Deepika Dogra et al.   Nature Communications

Targeted myocardial delivery of GDF11 gene rejuvenates the aged mouse heart and enhances myocardial regeneration after ischemia–reperfusion injury

(2016) Guo-Qing Du et al.   BASIC RESEARCH IN CARDIOLOGY

Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease

(2016) Marissa J. Schafer et al.   Cell Metabolism

Aptamer-Based Proteomic Profiling Reveals Novel Candidate Biomarkers and Pathways in Cardiovascular DiseaseClinical Perspective

(2016) Debby Ngo et al.   CIRCULATION

Development and Validation of a Protein-Based Risk Score for Cardiovascular Outcomes Among Patients With Stable Coronary Heart Disease

(2016) Peter Ganz et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension

(2016) Alexander M.K. Rothman et al.   JOURNAL OF CLINICAL INVESTIGATION

Myostatin inhibitor ACE-031 treatment of ambulatory boys with Duchenne muscular dystrophy: Results of a randomized, placebo-controlled clinical trial

(2016) Craig Campbell et al.   MUSCLE & NERVE

Cardioprotection and lifespan extension by the natural polyamine spermidine

(2016) Tobias Eisenberg et al.   NATURE MEDICINE

Neurohormonal activation in heart failure with reduced ejection fraction

(2016) Justin Hartupee et al.   Nature Reviews Cardiology

GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration

(2015) Marc A. Egerman et al.   Cell Metabolism

GDF11 Does Not Rescue Aging-Related Pathological HypertrophyNovelty and Significance

(2015) Shavonn C. Smith et al.   CIRCULATION RESEARCH

Association of growth differentiation factor 11/8, putative anti-ageing factor, with cardiovascular outcomes and overall mortality in humans: analysis of the Heart and Soul and HUNT3 cohorts

(2015) Kristoff A. Olson et al.   EUROPEAN HEART JOURNAL

Integrated Analysis of Contractile Kinetics, Force Generation, and Electrical Activity in Single Human Stem Cell-Derived Cardiomyocytes

(2015) Jan David Kijlstra et al.   Stem Cell Reports

Regulation and actions of activin A and follistatin in myocardial ischaemia–reperfusion injury

(2014) Yi Chen et al.   CYTOKINE

Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle

(2014) M. Sinha et al.   SCIENCE

Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy

(2013) Francesco S. Loffredo et al.   CELL

Activin signaling as an emerging target for therapeutic interventions

(2012) Kunihiro Tsuchida et al.   Cell Communication and Signaling

Secretory Products From Epicardial Adipose Tissue of Patients With Type 2 Diabetes Mellitus Induce Cardiomyocyte Dysfunction

(2012) Sabrina Greulich et al.   CIRCULATION

The aging myostatin null phenotype: reduced adiposity, cardiac hypertrophy, enhanced cardiac stress response, and sexual dimorphism

(2012) Melissa F Jackson et al.   JOURNAL OF ENDOCRINOLOGY

Role of satellite cells versus myofibers in muscle hypertrophy induced by inhibition of the myostatin/activin signaling pathway

(2012) S.-J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prodomains regulate the synthesis, extracellular localisation and activity of TGF-β superfamily ligands

(2011) Craig A. Harrison et al.   GROWTH FACTORS

Structure of Myostatin·Follistatin-like 3

(2011) Jennifer N. Cash et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New insights into the mechanisms of activin action and inhibition

(2011) Kelly L. Walton et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

SUMO1-dependent modulation of SERCA2a in heart failure

(2011) Changwon Kho et al.   NATURE

A Crucial Role of Activin A-Mediated Growth Hormone Suppression in Mouse and Human Heart Failure

(2011) Noritoshi Fukushima et al.   PLoS One

Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction

(2010) Sih Min Tan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival

(2010) Xiaolan Zhou et al.   CELL

C/EBPβ Controls Exercise-Induced Cardiac Growth and Protects against Pathological Cardiac Remodeling

(2010) Pontus Boström et al.   CELL

Epidemiology and risk profile of heart failure

(2010) Anh L. Bui et al.   Nature Reviews Cardiology

Effects of myostatin deletion in aging mice

(2009) Michael R. Morissette et al.   AGING CELL

Activin A and Follistatin-Like 3 Determine the Susceptibility of Heart to Ischemic Injury

(2009) Yuichi Oshima et al.   CIRCULATION

Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging

(2009) Dao-Fu Dai et al.   CIRCULATION

The Structure of FSTL3·Activin A Complex

(2008) Robin Stamler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY