Targeting the undruggable: exploiting neomorphic features of fusion oncoproteins in childhood sarcomas for innovative therapies

Rhabdomyosarcoma

(2019) Stephen X. Skapek et al.   Nature Reviews Disease Primers

USP19 deubiquitinates EWS-FLI1 to regulate Ewing sarcoma growth

(2019) Maria E. Gierisch et al.   Scientific Reports

Targeting the IGF1R/PI3K/AKT pathway sensitizes Ewing sarcoma to BET bromodomain inhibitors

(2019) Sudan N Loganathan et al.   MOLECULAR CANCER THERAPEUTICS

Trabectedin Inhibits EWS-FLI1 and Evicts SWI/SNF from Chromatin in a Schedule-dependent Manner

(2019) Matt L. Harlow et al.   CLINICAL CANCER RESEARCH

Immune targeting of autocrine IGF2 hampers rhabdomyosarcoma growth and metastasis

(2019) Carla De Giovanni et al.   BMC CANCER

INFORM2 exploratory multinational phase I/II combination study of nivolumab and entinostat in children and adolescents with refractory high-risk malignancies: INFORM2 NivEnt.

(2019) Cornelis Martinus van Tilburg et al.   JOURNAL OF CLINICAL ONCOLOGY

Targeted inhibition of histone deacetylase leads to suppression of Ewing sarcoma tumor growth through an unappreciated EWS-FLI1/HDAC3/HSP90 signaling axis

(2019) Yan Ma et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Immunogenic neoantigens derived from gene fusions stimulate T cell responses

(2019) Wei Yang et al.   NATURE MEDICINE

Evaluation of entinostat alone and in combination with standard‐of‐care cytotoxic agents against rhabdomyosarcoma xenograft models

(2019) Raushan T. Kurmasheva et al.   PEDIATRIC BLOOD & CANCER

EWS–FLI1 modulated alternative splicing of ARID1A reveals novel oncogenic function through the BAF complex

(2019) Saravana P Selvanathan et al.   NUCLEIC ACIDS RESEARCH

Small molecule inhibition of lysine-specific demethylase 1 (LSD1) and histone deacetylase (HDAC) alone and in combination in Ewing sarcoma cell lines

(2019) Darcy Welch et al.   PLoS One

Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes

(2019) Julian Musa et al.   Nature Communications

The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma

(2018) Matthew J. McBride et al.   CANCER CELL

The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma

(2018) Ana Banito et al.   CANCER CELL

Supersulfated low-molecular weight heparin synergizes with IGF1R/IR inhibitor to suppress synovial sarcoma growth and metastases

(2018) Giuliana Cassinelli et al.   CANCER LETTERS

EWS/ETS-driven Ewing Sarcoma requires BET bromodomain proteins

(2018) Paradesi Naidu Gollavilli et al.   CANCER RESEARCH

Preclinical Evaluation of Vemurafenib as Therapy for BRAFV600E Mutated Sarcomas

(2018) Sarina Gouravan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synovial Sarcoma: Current Concepts and Future Perspectives

(2018) Silvia Stacchiotti et al.   JOURNAL OF CLINICAL ONCOLOGY

Oncogenic fusion proteins adopt the insulin-like growth factor signaling pathway

(2018) Haim Werner et al.   Molecular Cancer

Targeting Histone Deacetylase Activity to Arrest Cell Growth and Promote Neural Differentiation in Ewing Sarcoma

(2018) Bárbara Kunzler Souza et al.   MOLECULAR NEUROBIOLOGY

Epigenome-based cancer risk prediction: rationale, opportunities and challenges

(2018) Martin Widschwendter et al.   Nature Reviews Clinical Oncology

Ewing sarcoma

(2018) Thomas G. P. Grünewald et al.   Nature Reviews Disease Primers

Epigenome editing of microsatellite repeats defines tumor-specific enhancer functions and dependencies

(2018) Gaylor Boulay et al.   GENES & DEVELOPMENT

ADVL1513: Results of a phase 1 trial of entinostat, an oral histone deacetylase inhibitor, in pediatric patients with recurrent or refractory solid tumors.

(2018) Suman Malempati et al.   JOURNAL OF CLINICAL ONCOLOGY

Efficacy and safety of lurbinectedin (PM1183) in Ewing sarcoma: Final results from a phase 2 study.

(2018) Vivek Subbiah et al.   JOURNAL OF CLINICAL ONCOLOGY

Preclinical Evaluation of Nintedanib, a Triple Angiokinase Inhibitor, in Soft-Tissue Sarcoma: Potential Therapeutic implication for Synovial Sarcoma

(2018) Parag P Patwardhan et al.   MOLECULAR CANCER THERAPEUTICS

Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors

(2018) Nathaniel D. Anderson et al.   SCIENCE

The combination of epigenetic drugs SAHA and HCI-2509 synergistically inhibits EWS-FLI1 and tumor growth in Ewing sarcoma

(2018) Daniel Jose García-Domínguez et al.   Oncotarget

A Combination CDK4/6 and IGF1R Inhibitor Strategy for Ewing Sarcoma

(2018) Lillian M. Guenther et al.   CLINICAL CANCER RESEARCH

A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation

(2018) Brittany C. Michel et al.   NATURE CELL BIOLOGY

The HDAC3–SMARCA4–miR-27a axis promotes expression of the PAX3:FOXO1 fusion oncogene in rhabdomyosarcoma

(2018) Narendra Bharathy et al.   Science Signaling

Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma

(2018) Gerard L Brien et al.   eLife

Canonical WNT/β-Catenin Signaling Plays a Subordinate Role in Rhabdomyosarcomas

(2018) Nada Ragab et al.   Frontiers in Pediatrics

SHCBP1 promotes synovial sarcoma cell metastasis via targeting TGF-β1/Smad signaling pathway and is associated with poor prognosis

(2017) Changliang Peng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

PAX3-FOXO1 is essential for tumour initiation and maintenance but not recurrence in a human myoblast model of rhabdomyosarcoma

(2017) Puspa R Pandey et al.   JOURNAL OF PATHOLOGY

Death by HDAC Inhibition in Synovial Sarcoma Cells

(2017) Aimée N. Laporte et al.   MOLECULAR CANCER THERAPEUTICS

Targeting genomic rearrangements in tumor cells through Cas9-mediated insertion of a suicide gene

(2017) Zhang-Hui Chen et al.   NATURE BIOTECHNOLOGY

Fusions in solid tumours: diagnostic strategies, targeted therapy, and acquired resistance

(2017) Alison M. Schram et al.   Nature Reviews Clinical Oncology

Cell-to-cell heterogeneity of EWSR1-FLI1 activity determines proliferation/migration choices in Ewing sarcoma cells

(2017) G-A Franzetti et al.   ONCOGENE

Exosomes: Therapy delivery tools and biomarkers of diseases

(2017) Lucio Barile et al.   PHARMACOLOGY & THERAPEUTICS

Identification of two types of GGAA-microsatellites and their roles in EWS/FLI binding and gene regulation in Ewing sarcoma

(2017) Kirsten M. Johnson et al.   PLoS One

Role for the EWS domain of EWS/FLI in binding GGAA-microsatellites required for Ewing sarcoma anchorage independent growth

(2017) Kirsten M. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PAX3–FOXO1 Establishes Myogenic Super Enhancers and Confers BET Bromodomain Vulnerability

(2017) Berkley E. Gryder et al.   Cancer Discovery

Inhibition of porcupine prolongs metastasis free survival in a mouse xenograft model of Ewing sarcoma

(2017) Masanori Hayashi et al.   Oncotarget

The neoepitope landscape in pediatric cancers

(2017) Ti-Cheng Chang et al.   Genome Medicine

CRISPR/Cas9 in Genome Editing and Beyond

(2016) Haifeng Wang et al.   Annual Review of Biochemistry

Coinhibitory Pathways in Immunotherapy for Cancer

(2016) Susanne H. Baumeister et al.   Annual Review of Immunology

Lurbinectedin Inactivates the Ewing Sarcoma Oncoprotein EWS-FLI1 by Redistributing It within the Nucleus

(2016) Matt L. Harlow et al.   CANCER RESEARCH

Activation of Wnt/ -Catenin in Ewing Sarcoma Cells Antagonizes EWS/ETS Function and Promotes Phenotypic Transition to More Metastatic Cell States

(2016) E. A. Pedersen et al.   CANCER RESEARCH

Vorinostat in refractory soft tissue sarcomas – Results of a multi-centre phase II trial of the German Soft Tissue Sarcoma and Bone Tumour Working Group (AIO)

(2016) Thomas Schmitt et al.   EUROPEAN JOURNAL OF CANCER

Proteasomal Degradation of the EWS-FLI1 Fusion Protein Is Regulated by a Single Lysine Residue

(2016) Maria E. Gierisch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Englerin A Inhibits EWS-FLI1 DNA Binding in Ewing Sarcoma Cells

(2016) Vittorio Caropreso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RGD liposome-protamine-siRNA (LPR) nanoparticles targeting PAX3-FOXO1 for alveolar rhabdomyosarcoma therapy

(2016) Venkatesh Rengaswamy et al.   JOURNAL OF CONTROLLED RELEASE

The Bromodomain BET Inhibitor JQ1 Suppresses Tumor Angiogenesis in Models of Childhood Sarcoma

(2016) H. K. Bid et al.   MOLECULAR CANCER THERAPEUTICS

Preclinical Justification of pbi-shRNA EWS/FLI1 Lipoplex (LPX) Treatment for Ewing's Sarcoma

(2016) Donald D. Rao et al.   MOLECULAR THERAPY

Chinese scientists to pioneer first human CRISPR trial

(2016) David Cyranoski   NATURE

Driving CAR T-cells forward

(2016) Hollie J. Jackson et al.   Nature Reviews Clinical Oncology

Targeting the cancer epigenome for therapy

(2016) Peter A. Jones et al.   NATURE REVIEWS GENETICS

EWS-FLI1-mediated suppression of the RAS-antagonist Sprouty 1 (SPRY1) confers aggressiveness to Ewing sarcoma

(2016) F Cidre-Aranaz et al.   ONCOGENE

Initial testing (stage 1) of tazemetostat (EPZ-6438), a novel EZH2 inhibitor, by the Pediatric Preclinical Testing Program

(2016) Raushan T. Kurmasheva et al.   PEDIATRIC BLOOD & CANCER

Panobinostat-A Potential Treatment for Metastasized Ewing Sarcoma? A Case Report

(2016) Annemiek M. van Maldegem et al.   PEDIATRIC BLOOD & CANCER

CRISPR/Cas9 therapeutics: a cure for cancer and other genetic diseases

(2016) Faheem Ahmed Khan et al.   Oncotarget

Advances in sarcoma diagnostics and treatment

(2016) Amanda R. Dancsok et al.   Oncotarget

Targeting the epigenetic readers in Ewing Sarcoma inhibits the oncogenic transcription factor EWS/Fli1

(2016) Camille Jacques et al.   Oncotarget

Identification of SHCBP1 as a novel downstream target gene of SS18-SSX1 and its functional analysis in progression of synovial sarcoma

(2016) Changliang Peng et al.   Oncotarget

The fusion protein SS18-SSX1 employs core Wnt pathway transcription factors to induce a partial Wnt signature in synovial sarcoma

(2016) Luisa Cironi et al.   Scientific Reports

Targeting EZH2-mediated methylation of H3K27 inhibits proliferation and migration of Synovial Sarcoma in vitro

(2016) Jacson K. Shen et al.   Scientific Reports

A phase II study of SB939, a novel pan-histone deacetylase inhibitor, in patients with translocation-associated recurrent/metastatic sarcomas—NCIC-CTG IND 200†

(2015) Q. S.-C. Chu et al.   ANNALS OF ONCOLOGY

SLFN11 Is a Transcriptional Target of EWS-FLI1 and a Determinant of Drug Response in Ewing Sarcoma

(2015) S.-W. Tang et al.   CLINICAL CANCER RESEARCH

Targeting hedgehog signalling by arsenic trioxide reduces cell growth and induces apoptosis in rhabdomyosarcoma

(2015) KAREN A. BOEHME et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite

(2015) Thomas G P Grünewald et al.   NATURE GENETICS

RNA helicase A activity is inhibited by oncogenic transcription factor EWS-FLI1

(2015) Hayriye Verda Erkizan et al.   NUCLEIC ACIDS RESEARCH

Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing

(2015) Saravana P. Selvanathan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a novel synthetic lethality of combined inhibition of hedgehog and PI3K signaling in rhabdomyosarcoma

(2015) Ulrike Graab et al.   Oncotarget

The PARP inhibitor olaparib enhances the sensitivity of Ewing sarcoma to trabectedin

(2015) José Luis Ordóñez et al.   Oncotarget

Inhibiting phosphorylation of the oncogenic PAX3-FOXO1 reduces alveolar rhabdomyosarcoma phenotypes identifying novel therapy options

(2015) J M Loupe et al.   Oncogenesis

IGF-1R Inhibition Activates a YES/SFK Bypass Resistance Pathway: Rational Basis for Co-Targeting IGF-1R and Yes/SFK Kinase in Rhabdomyosarcoma

(2015) Xiaolin Wan et al.   NEOPLASIA

EWS/FLI1 Target Genes and Therapeutic Opportunities in Ewing Sarcoma

(2015) Florencia Cidre-Aranaz et al.   Frontiers in Oncology

GLI inhibitor GANT-61 diminishes embryonal and alveolar rhabdomyosarcoma growth by inhibiting Shh/AKT-mTOR axis

(2015) Ritesh K. Srivastava et al.   Oncotarget

A phase 2 trial of R1507, a monoclonal antibody to the insulin-like growth factor-1 receptor (IGF-1R), in patients with recurrent or refractory rhabdomyosarcoma, osteosarcoma, synovial sarcoma, and other soft tissue sarcomas: Results of a Sarcoma Alliance

(2014) Alberto S. Pappo et al.   CANCER

PLK1 Phosphorylates PAX3-FOXO1, the Inhibition of Which Triggers Regression of Alveolar Rhabdomyosarcoma

(2014) V. Thalhammer et al.   CANCER RESEARCH

Reversible LSD1 Inhibition Interferes with Global EWS/ETS Transcriptional Activity and Impedes Ewing Sarcoma Tumor Growth

(2014) S. Sankar et al.   CLINICAL CANCER RESEARCH

Lineage of origin in rhabdomyosarcoma informs pharmacological response

(2014) J. Abraham et al.   GENES & DEVELOPMENT

Brd4 activates P-TEFb for RNA polymerase II CTD phosphorylation

(2014) Friederike Itzen et al.   NUCLEIC ACIDS RESEARCH

The landscape and therapeutic relevance of cancer-associated transcript fusions

(2014) K Yoshihara et al.   ONCOGENE

Regulation of FAS Exon Definition and Apoptosis by the Ewing Sarcoma Protein

(2014) Maria Paola Paronetto et al.   Cell Reports

Classification of Rhabdomyosarcoma and Its Molecular Basis

(2013) David M. Parham et al.   ADVANCES IN ANATOMIC PATHOLOGY

A phase II trial of panobinostat in patients with advanced pretreated soft tissue sarcoma. A study from the French Sarcoma Group

(2013) P A Cassier et al.   BRITISH JOURNAL OF CANCER

SRC Signaling Is Crucial in the Growth of Synovial Sarcoma Cells

(2013) S. Michels et al.   CANCER RESEARCH

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

(2013) Jakob Lovén et al.   CELL

Reversible Disruption of mSWI/SNF (BAF) Complexes by the SS18-SSX Oncogenic Fusion in Synovial Sarcoma

(2013) Cigall Kadoch et al.   CELL

Loss of SS18-SSX1 Inhibits Viability and Induces Apoptosis in Synovial Sarcoma

(2013) Emily E. Carmody Soni et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Simultaneous targeting of insulin-like growth factor-1 receptor and anaplastic lymphoma kinase in embryonal and alveolar rhabdomyosarcoma: A rational choice

(2013) J. Carlijn van Gaal et al.   EUROPEAN JOURNAL OF CANCER

Characterization of Wnt/β-catenin signaling in rhabdomyosarcoma

(2013) Srinivas R Annavarapu et al.   LABORATORY INVESTIGATION

Small Molecule Inhibition of PAX3-FOXO1 through AKT Activation Suppresses Malignant Phenotypes of Alveolar Rhabdomyosarcoma

(2013) M. Jothi et al.   MOLECULAR CANCER THERAPEUTICS

Pre-clinical efficacy of PU-H71, a novel HSP90 inhibitor, alone and in combination with bortezomib in Ewing sarcoma

(2013) Srikanth R. Ambati et al.   Molecular Oncology

Systems biology of Ewing sarcoma: a network model of EWS-FLI1 effect on proliferation and apoptosis

(2013) Gautier Stoll et al.   NUCLEIC ACIDS RESEARCH

Downregulation of IGFBP2 is associated with resistance to IGF1R therapy in rhabdomyosarcoma

(2013) Z Kang et al.   ONCOGENE

The Polycomb group (PcG) protein EZH2 supports the survival of PAX3-FOXO1 alveolar rhabdomyosarcoma by repressing FBXO32 (Atrogin1/MAFbx)

(2013) R Ciarapica et al.   ONCOGENE

SS18-SSX fusion protein-induced Wnt/β-catenin signaling is a therapeutic target in synovial sarcoma

(2013) M Trautmann et al.   ONCOGENE

JARID2 is a direct target of the PAX3-FOXO1 fusion protein and inhibits myogenic differentiation of rhabdomyosarcoma cells

(2013) Z S Walters et al.   ONCOGENE

Cetuximab promotes anticancer drug toxicity in rhabdomyosarcomas with EGFR amplification in vitro

(2013) YUKI YAMAMOTO et al.   ONCOLOGY REPORTS

Cyclin-Dependent Kinase 4 Phosphorylates and Positively Regulates PAX3-FOXO1 in Human Alveolar Rhabdomyosarcoma Cells

(2013) Lingling Liu et al.   PLoS One

Targeting the Wnt Pathway in Synovial Sarcoma Models

(2013) W. Barham et al.   Cancer Discovery

An adaptive Src–PDGFRA–Raf axis in rhabdomyosarcoma

(2012) Jinu Abraham et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Carnitine palmitoyltransferase 1A (CPT1A): a transcriptional target of PAX3-FKHR and mediates PAX3-FKHR–dependent motility in alveolar rhabdomyosarcoma cells

(2012) Lingling Liu et al.   BMC CANCER

Impairment of p53 acetylation by EWS-Fli1 chimeric protein in Ewing Family Tumors

(2012) Yan Li et al.   CANCER LETTERS

Targeting the EWSR1-FLI1 Oncogene-Induced Protein Kinase PKC-  Abolishes Ewing Sarcoma Growth

(2012) D. Surdez et al.   CANCER RESEARCH

AKT and PAX3-FKHR cooperation enforces myogenic differentiation blockade in alveolar rhabdomyosarcoma cell

(2012) Mathivanan Jothi et al.   CELL CYCLE

EWS-FLI-1-Targeted Cytotoxic T-cell Killing of Multiple Tumor Types Belonging to the Ewing Sarcoma Family of Tumors

(2012) C. H. Evans et al.   CLINICAL CANCER RESEARCH

FGFR4 Blockade Exerts Distinct Antitumorigenic Effects in Human Embryonal versus Alveolar Rhabdomyosarcoma

(2012) L. E. S. Crose et al.   CLINICAL CANCER RESEARCH

A Phase I Trial and Pharmacokinetic Study of Sorafenib in Children with Refractory Solid Tumors or Leukemias: A Children's Oncology Group Phase I Consortium Report

(2012) B. C. Widemann et al.   CLINICAL CANCER RESEARCH

Evaluation of arsenic trioxide by the pediatric preclinical testing program with a focus on Ewing sarcoma

(2012) Malcolm A. Smith et al.   PEDIATRIC BLOOD & CANCER

Acetylation Increases EWS-FLI1 DNA Binding and Transcriptional Activity

(2012) Silke Schlottmann et al.   Frontiers in Oncology

CAPER-α alternative splicing regulates the expression of vascular endothelial growth factor165 in Ewing sarcoma cells

(2011) Gangxiong Huang et al.   CANCER

Hedgehog signal inhibitor forskolin suppresses cell proliferation and tumor growth of human rhabdomyosarcoma xenograft

(2011) Hiroaki Yamanaka et al.   JOURNAL OF PEDIATRIC SURGERY

Prevalence and prognostic influence of genomic changes of EGFR pathway markers in synovial sarcoma

(2011) Hao-Wei Teng et al.   JOURNAL OF SURGICAL ONCOLOGY

The Effect of SYT-SSX and Extracellular Signal-Regulated Kinase (ERK) on Cell Proliferation in Synovial Sarcoma

(2011) Wenjuan Cai et al.   PATHOLOGY & ONCOLOGY RESEARCH

Betulinic acid induces apoptosis and inhibits hedgehog signalling in rhabdomyosarcoma

(2010) M Eichenmüller et al.   BRITISH JOURNAL OF CANCER

Sorafenib induces growth inhibition and apoptosis in human synovial sarcoma cells via inhibiting the RAF/MEK/ERK signaling pathway

(2010) Chang-Liang Peng et al.   CANCER BIOLOGY & THERAPY

Inhibition of the transcriptional function of p53 by EWS–Fli1 chimeric protein in Ewing Family Tumors

(2010) Yan Li et al.   CANCER LETTERS

Genome-Wide Identification of PAX3-FKHR Binding Sites in Rhabdomyosarcoma Reveals Candidate Target Genes Important for Development and Cancer

(2010) L. Cao et al.   CANCER RESEARCH

Synthetic siRNA targeting the breakpoint of EWS/Fli-1 inhibits growth of Ewing sarcoma xenografts in a mouse model

(2010) Iori Takigami et al.   INTERNATIONAL JOURNAL OF CANCER

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

p21 Downregulation is an important component of PAX3/FKHR oncogenicity and its reactivation by HDAC inhibitors enhances combination treatment

(2010) R M Hecker et al.   ONCOGENE

Synovial Sarcoma is a Stem Cell Malignancy

(2010) Norifumi Naka et al.   STEM CELLS

Glycogen synthase kinase 3 regulates PAX3–FKHR-mediated cell proliferation in human alveolar rhabdomyosarcoma cells

(2009) Fu-Yue Zeng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ewing Sarcoma Fusion Protein EWSR1/FLI1 Interacts with EWSR1 Leading to Mitotic Defects in Zebrafish Embryos and Human Cell Lines

(2009) L. J. Embree et al.   CANCER RESEARCH

GLI1 Is a Direct Transcriptional Target of EWS-FLI1 Oncoprotein

(2009) Elspeth Beauchamp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brd4 Marks Select Genes on Mitotic Chromatin and Directs Postmitotic Transcription

(2009) Anup Dey et al.   MOLECULAR BIOLOGY OF THE CELL

A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma

(2009) Hayriye V Erkizan et al.   NATURE MEDICINE

O-GlcNAcylation is involved in the transcriptional activity of EWS-FLI1 in Ewing's sarcoma

(2009) R Bachmaier et al.   ONCOGENE

EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation

(2009) G. H. S. Richter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Differential roles of SS18–SSX fusion gene and insulin-like growth factor-1 receptor in synovial sarcoma cell growth

(2008) Maria Törnkvist et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phosphorylation of Ewing's sarcoma protein (EWS) and EWS-Fli1 in response to DNA damage

(2008) Iva V. Klevernic et al.   BIOCHEMICAL JOURNAL

Alveolar rhabdomyosarcoma: Is the cell of origin a mesenchymal stem cell?

(2008) Elizabeth Charytonowicz et al.   CANCER LETTERS

Phosphorylation Regulates Transcriptional Activity of PAX3/FKHR and Reveals Novel Therapeutic Possibilities

(2008) R. Amstutz et al.   CANCER RESEARCH

Histone Deacetylase Inhibitors Reverse SS18-SSX-Mediated Polycomb Silencing of the Tumor Suppressor Early Growth Response 1 in Synovial Sarcoma

(2008) J. M. Lubieniecka et al.   CANCER RESEARCH

The Oncoprotein SS18-SSX1 Promotes p53 Ubiquitination and Degradation by Enhancing HDM2 Stability

(2008) P. D'Arcy et al.   MOLECULAR CANCER RESEARCH

Alteration of cyclin D1 transcript elongation by a mutated transcription factor up-regulates the oncogenic D1b splice isoform in cancer

(2008) G. Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microsatellites as EWS/FLI response elements in Ewing's sarcoma

(2008) K. Gangwal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of proteins interacting with protein arginine methyltransferase 8: The Ewing sarcoma (EWS) protein binds independent of its methylation state

(2008) Steffen Pahlich et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Effects of PAX3-FKHR on malignant phenotypes in alveolar rhabdomyosarcoma

(2007) Ken Kikuchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS