Small molecule inhibition of lysine-specific demethylase 1 (LSD1) and histone deacetylase (HDAC) alone and in combination in Ewing sarcoma cell lines

Catalytic inhibition of KDM1A in Ewing sarcoma is insufficient as a therapeutic strategy

(2019) Antonio Romo-Morales et al.   PEDIATRIC BLOOD & CANCER

Irinotecan and temozolomide in recurrent Ewing sarcoma: an analysis in 51 adult and pediatric patients

(2018) E. Palmerini et al.   ACTA ONCOLOGICA

ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia

(2018) Tamara Maes et al.   CANCER CELL

Therapeutic targeting of KDM1A/LSD1 in Ewing sarcoma with SP-2509 engages the endoplasmic reticulum stress response

(2018) Kathleen I. Pishas et al.   MOLECULAR CANCER THERAPEUTICS

LSD1 activates a lethal prostate cancer gene network independently of its demethylase function

(2018) Archana Sehrawat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors

(2018) Jay H. Kalin et al.   Nature Communications

Cell-to-cell heterogeneity of EWSR1-FLI1 activity determines proliferation/migration choices in Ewing sarcoma cells

(2017) G-A Franzetti et al.   ONCOGENE

Inhibition of the oncogenic fusion protein EWS-FLI1 causes G2-M cell cycle arrest and enhanced vincristine sensitivity in Ewing’s sarcoma

(2017) Stefan K. Zöllner et al.   Science Signaling

Concomitant epigenetic targeting of LSD1 and HDAC synergistically induces mitochondrial apoptosis in rhabdomyosarcoma cells

(2017) Tinka Haydn et al.   Cell Death & Disease

Inhibition of the oncogenic fusion protein EWS-FLI1 causes G2-M cell cycle arrest and enhanced vincristine sensitivity in Ewing’s sarcoma

(2017) Stefan K. Zöllner et al.   Science Signaling

A phase I trial of panobinostat and epirubicin in solid tumors with a dose expansion in patients with sarcoma

(2016) S. Thomas et al.   ANNALS OF ONCOLOGY

Identification of clinically achievable combination therapies in childhood rhabdomyosarcoma

(2016) Elliot Kahen et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Pharmacological Inhibition of the Histone Lysine Demethylase KDM1A Suppresses the Growth of Multiple Acute Myeloid Leukemia Subtypes

(2016) John P. McGrath et al.   CANCER RESEARCH

Transcriptional Selectivity of Epigenetic Therapy in Cancer

(2016) Takahiro Sato et al.   CANCER RESEARCH

Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia

(2016) Zizhen Feng et al.   Journal of Hematology & Oncology

Reversible lysine-specific demethylase 1 antagonist HCI-2509 inhibits growth and decreases c-MYC in castration- and docetaxel-resistant prostate cancer cells

(2016) S Gupta et al.   PROSTATE CANCER AND PROSTATIC DISEASES

A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC

(2015) Helai P. Mohammad et al.   CANCER CELL

Identification of Synergistic, Clinically Achievable, Combination Therapies for Osteosarcoma

(2015) Diana Yu et al.   Scientific Reports

Reversible LSD1 Inhibition Interferes with Global EWS/ETS Transcriptional Activity and Impedes Ewing Sarcoma Tumor Growth

(2014) S. Sankar et al.   CLINICAL CANCER RESEARCH

Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells

(2014) W Fiskus et al.   LEUKEMIA

The Genomic Landscape of Pediatric Ewing Sarcoma

(2014) B. D. Crompton et al.   Cancer Discovery

Genomic Landscape of Ewing Sarcoma Defines an Aggressive Subtype with Co-Association of STAG2 and TP53 Mutations

(2014) F. Tirode et al.   Cancer Discovery

The Genomic Landscape of the Ewing Sarcoma Family of Tumors Reveals Recurrent STAG2 Mutation

(2014) Andrew S. Brohl et al.   PLoS Genetics

A phase II trial of panobinostat in patients with advanced pretreated soft tissue sarcoma. A study from the French Sarcoma Group

(2013) P A Cassier et al.   BRITISH JOURNAL OF CANCER

Feasibility and dose discovery analysis of zoledronic acid with concurrent chemotherapy in the treatment of newly diagnosed metastatic osteosarcoma: A report from the Children’s Oncology Group

(2013) Robert E. Goldsby et al.   EUROPEAN JOURNAL OF CANCER

Characterization and Drug Resistance Patterns of Ewing's Sarcoma Family Tumor Cell Lines

(2013) William A. May et al.   PLoS One

Study Reanalysis Using a Mechanism-Based Pharmacokinetic/Pharmacodynamic Model of Pramlintide in Subjects with Type 1 Diabetes

(2012) Jing Fang et al.   AAPS Journal

Randomized Controlled Trial of Interval-Compressed Chemotherapy for the Treatment of Localized Ewing Sarcoma: A Report From the Children's Oncology Group

(2012) Richard B. Womer et al.   JOURNAL OF CLINICAL ONCOLOGY

Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma

(2012) S Sankar et al.   ONCOGENE

Children's Oncology Group's 2013 blueprint for research: Bone tumors

(2012) Richard Gorlick et al.   PEDIATRIC BLOOD & CANCER

Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers

(2010) Shinya Hayami et al.   INTERNATIONAL JOURNAL OF CANCER

LSD1 Is a Subunit of the NuRD Complex and Targets the Metastasis Programs in Breast Cancer

(2009) Yan Wang et al.   CELL

A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma

(2009) Hayriye V Erkizan et al.   NATURE MEDICINE