EWS-FLI1-mediated suppression of the RAS-antagonist Sprouty 1 (SPRY1) confers aggressiveness to Ewing sarcoma

Targeting FGFR Signaling in Cancer

(2015) M. Touat et al.   CLINICAL CANCER RESEARCH

Deep Sequencing in Conjunction with Expression and Functional Analyses Reveals Activation of FGFR1 in Ewing Sarcoma

(2015) K. Agelopoulos et al.   CLINICAL CANCER RESEARCH

Ewing Sarcoma: Current Management and Future Approaches Through Collaboration

(2015) Nathalie Gaspar et al.   JOURNAL OF CLINICAL ONCOLOGY

Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite

(2015) Thomas G P Grünewald et al.   NATURE GENETICS

Epigenome Mapping Reveals Distinct Modes of Gene Regulation and Widespread Enhancer Reprogramming by the Oncogenic Fusion Protein EWS-FLI1

(2015) Eleni M. Tomazou et al.   Cell Reports

EWS/FLI1 Target Genes and Therapeutic Opportunities in Ewing Sarcoma

(2015) Florencia Cidre-Aranaz et al.   Frontiers in Oncology

EWS-FLI1 Utilizes Divergent Chromatin Remodeling Mechanisms to Directly Activate or Repress Enhancer Elements in Ewing Sarcoma

(2014) Nicolò Riggi et al.   CANCER CELL

Blocking the road, stopping the engine or killing the driver? Advances in targeting EWS/FLI-1 fusion in Ewing sarcoma as novel therapy

(2014) Heinrich Kovar   EXPERT OPINION ON THERAPEUTIC TARGETS

Correlation of Sprouty1 and Jagged1 With Aggressive Prostate Cancer Cells With Different Sensitivities to Androgen Deprivation

(2014) Naoki Terada et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Human Sprouty1 suppresses growth, migration, and invasion in human breast cancer cells

(2014) Ahmed H. Mekkawy et al.   TUMOR BIOLOGY

Genomic Landscape of Ewing Sarcoma Defines an Aggressive Subtype with Co-Association of STAG2 and TP53 Mutations

(2014) F. Tirode et al.   Cancer Discovery

The expression of the Sprouty 1 protein inversely correlates with growth, proliferation, migration and invasion of ovarian cancer cells

(2014) Samar Masoumi-Moghaddam et al.   Journal of Ovarian Research

Lysophosphatidic acid (LPA) signalling in cell migration and cancer invasion: A focussed review and analysis of LPA receptor gene expression on the basis of more than 1700 cancer microarrays

(2013) Semjon Willier et al.   BIOLOGY OF THE CELL

Oncogenic ETS fusions deregulate E2F3 target genes in Ewing sarcoma and prostate cancer

(2013) Sven Bilke et al.   GENOME RESEARCH

BCL11B Is Up-Regulated by EWS/FLI and Contributes to the Transformed Phenotype in Ewing Sarcoma

(2013) Elizabeth T. Wiles et al.   PLoS One

Lysyl Oxidase Is Downregulated by the EWS/FLI1 Oncoprotein and Its Propeptide Domain Displays Tumor Supressor Activities in Ewing Sarcoma Cells

(2013) Noelia Agra et al.   PLoS One

Understanding the Biology of Bone Sarcoma from Early Initiating Events through Late Events in Metastasis and Disease Progression

(2013) Limin Zhu et al.   Frontiers in Oncology

Targeting the EWSR1-FLI1 Oncogene-Induced Protein Kinase PKC-  Abolishes Ewing Sarcoma Growth

(2012) D. Surdez et al.   CANCER RESEARCH

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma

(2012) Sophie Postel-Vinay et al.   NATURE GENETICS

Prospects and challenges for the development of new therapies for Ewing sarcoma

(2012) Patrick J. Grohar et al.   PHARMACOLOGY & THERAPEUTICS

STEAP1 Is Associated with the Invasive and Oxidative Stress Phenotype of Ewing Tumors

(2011) T. G. P. Grunewald et al.   MOLECULAR CANCER RESEARCH

Sprouty1 is a candidate tumor-suppressor gene in medullary thyroid carcinoma

(2011) A Macià et al.   ONCOGENE

Basic fibroblast growth factor in the bone microenvironment enhances cell motility and invasion of Ewing's sarcoma family of tumours by activating the FGFR1–PI3K–Rac1 pathway

(2010) S Kamura et al.   BRITISH JOURNAL OF CANCER

The molecular pathogenesis of Ewing sarcoma

(2010) Carlos Mackintosh et al.   CANCER BIOLOGY & THERAPY

DNA methylation and aberrant expression of Sprouty1 in human prostate cancer

(2010) Bernard Kwabi-Addo et al.   Epigenetics

p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal

(2010) Z. Zhao et al.   GENES & DEVELOPMENT

Primary Disseminated Multifocal Ewing Sarcoma: Results of the Euro-EWING 99 Trial

(2010) Ruth Ladenstein et al.   JOURNAL OF CLINICAL ONCOLOGY

The EWS/FLI1 oncogenic protein inhibits expression of the Wnt inhibitor DICKKOPF-1 gene and antagonizes β-catenin/TCF-mediated transcription

(2009) Diego Navarro et al.   CARCINOGENESIS

Fibroblast growth factor-2 modulates melanoma adhesion and migration through a syndecan-4-dependent mechanism

(2008) Georgia Chalkiadaki et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

DAX1, a direct target of EWS/FLI1 oncoprotein, is a principal regulator of cell-cycle progression in Ewing's tumor cells

(2008) E García-Aragoncillo et al.   ONCOGENE