The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6

Twin enzymes, divergent control: The cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally

(2020) Isabelle M. Capell-Hattam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase

(2019) Ngee Kiat Chua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A VCP inhibitor substrate trapping approach (VISTA) enables proteomic profiling of endogenous ERAD substrates

(2018) Edmond Y. Huang et al.   MOLECULAR BIOLOGY OF THE CELL

Identification and Characterization of Prescription Drugs that Change Levels of the Cholesterol Precursors 7-Dehydrocholesterol and Desmosterol

(2018) Phillip A. Wages et al.   JOURNAL OF LIPID RESEARCH

Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD

(2018) Mark L. Schultz et al.   Nature Communications

N-terminal acetylation and the N-end rule pathway control degradation of the lipid droplet protein PLIN2

(2018) Kha The Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol increases protein levels of the E3 ligase MARCH6, and thereby stimulates protein degradation

(2018) Laura J. Sharpe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1

(2018) Sam A Menzies et al.   eLife

Role of CYP51 in the Regulation of T3 and FSH-Induced Steroidogenesis in Female Mice

(2017) Juan Liu et al.   ENDOCRINOLOGY

A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis

(2017) Ngee Kiat Chua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation regulates activity of 7-dehydrocholesterol reductase (DHCR7), a terminal enzyme of cholesterol synthesis

(2017) Anika V. Prabhu et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation

(2017) Yong-Jian Wang et al.   NATURE CELL BIOLOGY

The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy

(2017) Yong Tae Kwon et al.   TRENDS IN BIOCHEMICAL SCIENCES

Lanosterol Modulates TLR4-Mediated Innate Immune Responses in Macrophages

(2017) Elisa Araldi et al.   Cell Reports

The Role of Cholesterol in Cancer

(2016) Omer F. Kuzu et al.   CANCER RESEARCH

Hepatic cytochromes P450: structural degrons and barcodes, posttranslational modifications and cellular adapters in the ERAD-endgame

(2016) Sung-Mi Kim et al.   DRUG METABOLISM REVIEWS

Novel phenotypes and loci identified through clinical genomics approaches to pediatric cataract

(2016) Nisha Patel et al.   HUMAN GENETICS

Cholesterol-mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis

(2016) Anika V. Prabhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Next-generation Sequencing in the Diagnosis of Metabolic Disease Marked by Pediatric Cataract

(2016) Rachel L. Gillespie et al.   OPHTHALMOLOGY

DHCR7: A vital enzyme switch between cholesterol and vitamin D production

(2016) Anika V. Prabhu et al.   PROGRESS IN LIPID RESEARCH

The Regulatory Domain of Squalene Monooxygenase Contains a Re-entrant Loop and Senses Cholesterol via a Conformational Change

(2015) Vicky Howe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally

(2015) Winnie Luu et al.   JOURNAL OF LIPID RESEARCH

A MARCH6 and IDOL E3 ubiquitin ligase circuit uncouples cholesterol synthesis from lipoprotein uptake in hepatocytes

(2015) Anke Loregger et al.   MOLECULAR AND CELLULAR BIOLOGY

Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways

(2015) Matthew A Mitsche et al.   eLife

Contribution of Clinically Derived Mutations inERG11to Azole Resistance in Candida albicans

(2014) Stephanie A. Flowers et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Squalene mono-oxygenase, a key enzyme in cholesterol synthesis, is stabilized by unsaturated fatty acids

(2014) Julian Stevenson et al.   BIOCHEMICAL JOURNAL

The sterol-based transcriptional control of human 7-dehydrocholesterol reductase (DHCR7): Evidence of a cooperative regulatory program in cholesterol synthesis

(2014) Anika V. Prabhu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cholesterol in brain disease: sometimes determinant and frequently implicated

(2014) M. G. Martin et al.   EMBO REPORTS

The E3 Ubiquitin Ligase MARCH6 Degrades Squalene Monooxygenase and Affects 3-Hydroxy-3-Methyl-Glutaryl Coenzyme A Reductase and the Cholesterol Synthesis Pathway

(2014) N. Zelcer et al.   MOLECULAR AND CELLULAR BIOLOGY

Personalized Diagnosis and Management of Congenital Cataract by Next-Generation Sequencing

(2014) Rachel L. Gillespie et al.   OPHTHALMOLOGY

Quality control of inner nuclear membrane proteins by the Asi complex

(2014) O. Foresti et al.   SCIENCE

Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis

(2013) Winnie Luu et al.   JOURNAL OF LIPID RESEARCH

FoxO4 interacts with the sterol regulatory factor SREBP2 and the hypoxia inducible factor HIF2α at the CYP51 promoter

(2013) Jun Zhu et al.   JOURNAL OF LIPID RESEARCH

Desmosterol and DHCR24: Unexpected new directions for a terminal step in cholesterol synthesis

(2013) Eser J. Zerenturk et al.   PROGRESS IN LIPID RESEARCH

Nitric oxide-based protein modification: formation and site-specificity of protein S-nitrosylation

(2013) Izabella Kovacs et al.   Frontiers in Plant Science

The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1)

(2011) Eser J. Zerenturk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Akt acutely activates the cholesterogenic transcription factor SREBP-2

(2011) Winnie Luu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cholesterol-Dependent Degradation of Squalene Monooxygenase, a Control Point in Cholesterol Synthesis beyond HMG-CoA Reductase

(2011) Saloni Gill et al.   Cell Metabolism

A Meta-Analysis of Low-Density Lipoprotein Cholesterol, Non-High-Density Lipoprotein Cholesterol, and Apolipoprotein B as Markers of Cardiovascular Risk

(2011) Allan D. Sniderman et al.  

Cytochrome P450s in the synthesis of cholesterol and bile acids - from mouse models to human diseases

(2011) Gregor Lorbek et al.   FEBS Journal

Mouse Knockout of the Cholesterogenic Cytochrome P450 Lanosterol 14α-Demethylase (Cyp51) Resembles Antley-Bixler Syndrome

(2011) Rok Keber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of HMG-CoA reductase in mammals and yeast

(2011) John S. Burg et al.   PROGRESS IN LIPID RESEARCH

Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase

(2010) Youngah Jo et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Malformation syndromes caused by disorders of cholesterol synthesis

(2010) Forbes D. Porter et al.   JOURNAL OF LIPID RESEARCH

Dual Mechanisms of CYP3A Protein Regulation by Proinflammatory Cytokine Stimulation in Primary Hepatocyte Cultures

(2009) C.-M. Lee et al.   DRUG METABOLISM AND DISPOSITION

Protein Tyrosine Nitration: Selectivity, Physicochemical and Biological Consequences, Denitration, and Proteomics Methods for the Identification of Tyrosine-Nitrated Proteins

(2009) Nicolas Abello et al.   JOURNAL OF PROTEOME RESEARCH

Regulation of Cholesterologenesis by the Oxysterol Receptor, LXRα

(2008) Yongjun Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mode of Action of Fenarimol Against Leishmania Spp.

(2008) Einat Zeiman et al.   JOURNAL OF PARASITOLOGY