Controlling Cholesterol Synthesis beyond 3-Hydroxy-3-methylglutaryl-CoA Reductase (HMGCR)

MicroRNAs in Metabolic Disease

(2013) Carlos Fernández-Hernando et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway

(2013) Alexander Mazein et al.   BIOCHEMICAL PHARMACOLOGY

An algorithm for rapid computational construction of metabolic networks: A cholesterol biosynthesis example

(2013) Aleš Belič et al.   COMPUTERS IN BIOLOGY AND MEDICINE

Alternative splicing in the regulation of cholesterol homeostasis

(2013) Marisa W. Medina et al.   CURRENT OPINION IN LIPIDOLOGY

Proteomic Analysis of Two Metabolic Proteins with Potential to Translocate to Plasma Membrane Associated with Tumor Metastasis Development and Drug Targets

(2013) Ting Xue et al.   JOURNAL OF PROTEOME RESEARCH

Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells

(2013) Jonathan J Hulce et al.   NATURE METHODS

Liver-Specific Deletion of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Causes Hepatic Steatosis and Death

(2012) Shuichi Nagashima et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Sterols regulate 3β-hydroxysterol Δ24-reductase (DHCR24) via dual sterol regulatory elements: Cooperative induction of key enzymes in lipid synthesis by Sterol Regulatory Element Binding Proteins

(2012) Eser J. Zerenturk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses

(2012) Nathanael J. Spann et al.   CELL

What dictates the accumulation of desmosterol in the developing brain?

(2012) Maurice Jansen et al.   FASEB JOURNAL

Accumulation of squalene is associated with the clustering of lipid droplets

(2012) Minh T. Ta et al.   FEBS Journal

Cholesterol through the Looking Glass

(2012) Ika Kristiana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identifying a static nonlinear structure in a biological system using noisy, sparse data

(2012) Joshua R. Porter et al.   JOURNAL OF THEORETICAL BIOLOGY

Targeting C4-Demethylating Genes in the Cholesterol Pathway Sensitizes Cancer Cells to EGF Receptor Inhibitors via Increased EGF Receptor Degradation

(2012) Anna Sukhanova et al.   Cancer Discovery

The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1)

(2011) Eser J. Zerenturk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Akt acutely activates the cholesterogenic transcription factor SREBP-2

(2011) Winnie Luu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease

(2011) L Lim et al.   CELL DEATH AND DIFFERENTIATION

Cholesterol-Dependent Degradation of Squalene Monooxygenase, a Control Point in Cholesterol Synthesis beyond HMG-CoA Reductase

(2011) Saloni Gill et al.   Cell Metabolism

Genome-wide Localization of SREBP-2 in Hepatic Chromatin Predicts a Role in Autophagy

(2011) Young-Kyo Seo et al.   Cell Metabolism

Metabolically Regulated Endoplasmic Reticulum-associated Degradation of 3-Hydroxy-3-methylglutaryl-CoA Reductase

(2011) Gil S. Leichner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cross-talk between the Androgen Receptor and the Liver X Receptor

(2011) James Robert Krycer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in the human SC4MOL gene encoding a methyl sterol oxidase cause psoriasiform dermatitis, microcephaly, and developmental delay

(2011) Miao He et al.   JOURNAL OF CLINICAL INVESTIGATION

PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse

(2011) P. V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Coordinately Regulated Alternative Splicing of Genes Involved in Cholesterol Biosynthesis and Uptake

(2011) Marisa Wong Medina et al.   PLoS One

Regulation of HMG-CoA reductase in mammals and yeast

(2011) John S. Burg et al.   PROGRESS IN LIPID RESEARCH

Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells

(2010) Kenji Ishimoto et al.   BIOCHEMICAL JOURNAL

Activation of TM7SF2 promoter by SREBP-2 depends on a new sterol regulatory element, a GC-box, and an inverted CCAAT-box

(2010) Gianluca Schiavoni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Divergent interactions involving the oxidosqualene cyclase and the steroid-3-ketoreductase in the sterol biosynthetic pathway of mammals and yeasts

(2010) Silvia Taramino et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase

(2010) Youngah Jo et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Sterol-induced Dislocation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase from Endoplasmic Reticulum Membranes into the Cytosol through a Subcellular Compartment Resembling Lipid Droplets

(2010) Isamu Z. Hartman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Malformation syndromes caused by disorders of cholesterol synthesis

(2010) Forbes D. Porter et al.   JOURNAL OF LIPID RESEARCH

Common genetic determinants of vitamin D insufficiency: a genome-wide association study

(2010) Thomas J Wang et al.   LANCET

Suppression of 2,3-Oxidosqualene Cyclase by High Fat Diet Contributes to Liver X Receptor-α-mediated Improvement of Hepatic Lipid Profile

(2009) Huaixin Dang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of FoxO4 overexpression on cholesterol biosynthesis, triacylglycerol accumulation, and glucose uptake

(2009) Jun Zhu et al.   JOURNAL OF LIPID RESEARCH

Disruption of the gene encoding 3β-hydroxysterol Δ14-reductase (Tm7sf2) in mice does not impair cholesterol biosynthesis

(2008) Anna M. Bennati et al.   FEBS Journal

Regulation of Cholesterologenesis by the Oxysterol Receptor, LXRα

(2008) Yongjun Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Selective Alzheimer's Disease Indicator-1 Gene (Seladin-1/DHCR24) Is a Liver X Receptor Target Gene

(2008) Y. Wang et al.   MOLECULAR PHARMACOLOGY