Article
Endocrinology & Metabolism
Mei-Xue Dong, You-Dong Wei, Ling Hu
Summary: Dementia is common in late stage PD patients. Metabolomics analysis identified lipid metabolites that were decreased in PDD patients compared to healthy controls and PDND patients. These metabolites could serve as candidate biomarkers for PDD diagnosis, indicating dysregulation of lipid metabolism in PD dementia pathogenesis.
METABOLIC BRAIN DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Saba Abdi, Amani Ahmed Alghamdi, Nouf Nasser Abduallah AlGhunaim, Reem Muteb Almutairi, Farid Shokry Ataya, Mohammed Ghouse Ahmed Ansari, Syed Danish Hussain, Mohammad Masoud, Abir Alamro, Othman T. Almutairi, Nasser M. Al-Daghri, Taim Abdullah Muayqil
Summary: This study investigated the genetic risk factors for Alzheimer's disease (AD) in Arab populations. The findings suggest that genetic variants in ApoE and CLU may influence susceptibility to AD among Saudi Arabian participants.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2022)
Article
Clinical Neurology
Jia-Li Pu, Chong-Yao Jin, Zhong-Xuan Wang, Yi Fang, Yao-Lin Li, Nai-Jia Xue, Ran Zheng, Zhi-Hao Lin, Yi-Qun Yan, Xiao-Li Si, Ying Chen, Yi Liu, Zhe Song, Ya-Ping Yan, Jun Tian, Xin-Zhen Yin, Bao-Rong Zhang
Summary: The study indicates that patients with Parkinson's disease who carry the APOE ε4 allele may experience faster motor progression, especially in those with high amyloid beta burden. This suggests a potential link between APOE ε4 and rapid motor decline in PD.
MOVEMENT DISORDERS
(2022)
Article
Genetics & Heredity
Jian-Yong Wang, Lei Cui, Hong-Yi Shi, Ling-Hao Chen, Ren-Wei Jin, Xiao-Xia Jiang, Zhu-Ling Chen, Jian-Hong Zhu, Xiong Zhang
Summary: This study found that the single nucleotide polymorphisms (SNPs) of the DNMT1 gene are associated with the risk of Parkinson's disease (PD). Among them, rs9305012 is significantly associated with PD risk, and rs9305012/C is a protective allele. The haplotypes of the 4 tag-SNPs show significant differences between PD patients and controls. The ACC module composed of the 3 alleles is the highest-risk haplotype associated with PD.
FRONTIERS IN GENETICS
(2023)
Article
Geriatrics & Gerontology
Yuda Huang, Yongzhi Shan, Wen Qin, Guoguang Zhao
Summary: This study investigated the modulation of APOE on cerebral atrophy and its role in the conversion from cognitive normal (CN) to dementia using a voxel-wise whole-brain perspective. The results revealed that APOE epsilon 4 carriers showed faster-accelerated atrophy in the left hippocampus compared to noncarriers, and both CN2D epsilon 4 carriers and noncarriers exhibited a faster atrophic speed than CN epsilon 4 carriers. These findings were replicated in a sub-sample with strict demographic matching.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Wen-Yi Yang, Si-Si Jiang, Jia-Li Pu, Chong-Yao Jin, Ting Gao, Ran Zheng, Jun Tian, Bao-Rong Zhang
Summary: This study found that single nucleotide polymorphisms rs11655081 (ARSG) and rs61973742 (NALCN) may be associated with Parkinson's disease (PD). The C allele of rs11655081 may increase the risk of PD, whereas the G allele of rs61973742 may be a protective factor.
FRONTIERS IN NEUROLOGY
(2022)
Article
Endocrinology & Metabolism
Lei Wu, Yan Zhang, Hong Zhao, Guodong Rong, Peijun Huang, Fang Wang, Ting Xu
Summary: This study found that APOE gene polymorphisms are associated with CAD with or without T2DM and have an influence on lipid profiles in both T2DM and CAD patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Neurosciences
Ryul Kim, Sangmin Park, Dallah Yoo, Young Ju Suh, Jin-Sun Jun, Beomseok Jeon
Summary: The presence of the APOE ε4 allele was associated with accelerated cognitive decline in male Parkinson's disease patients, but not in female patients. When data from both genders were combined, male patients with the APOE ε4 allele showed a faster rate of cognitive decline compared to female patients with the APOE ε4 allele and those without the allele.
JOURNAL OF PARKINSONS DISEASE
(2021)
Article
Ophthalmology
Yuyu Chou, Zixi Sun, Ye Wang, Yuhan Wang, Jin Ma, Dianxi Zhang, Yong Zhong
Summary: This study elucidated the potential role of genetic polymorphisms of apolipoprotein E (APOE) in nonarteritic anterior ischemic optic neuropathy (NAION) and revealed the association between APOE and NAION-induced ocular impairments.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Neurosciences
Hui-Hui Fan, Qing Guo, Jing Zheng, Yi-Zhi Lian, Shi-Shi Huang, Yue Sun, Ming Zou, Jian-Hong Zhu, Xiong Zhang
Summary: The study found a significant association between a specific SNP of the ALDH1A1 gene and Parkinson's disease susceptibility, as well as multiple haplotypes linked to PD risk. Interaction analyses suggested that specific genotype combinations may increase protection against PD, while the mRNA expression of ALDH1A1 in PD patients showed a trend of reduction.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Gastroenterology & Hepatology
Aleksandra Glapa-Nowak, Mariusz Szczepanik, Barbara Iwanczak, Jaroslaw Kwiecien, Anna Barbara Szaflarska-Poplawska, Urszula Grzybowska-Chlebowczyk, Marcin Osiecki, Marcin Dziekiewicz, Andrzej Stawarski, Jaroslaw Kierkus, Tomasz Banasiewicz, Aleksandra Banaszkiewicz, Jaroslaw Walkowiak
Summary: APOE polymorphisms are associated with the risk of developing IBD and the clinical expression of IBD, but the clinical relevance of the differences identified is rather modest.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Antonela Blazekovic, Kristina Gotovacjercic, Fran Borovecki
Summary: The study aimed to assess differences in 3'UTR variants of the SNCA gene in a cohort of PD patients and control subjects from Croatia, identifying a significantly higher occurrence of a particular variant in the PD population which has not been reported previously. Further research is needed to explore the role of these variants in PD development and their impact on disease pathology.
Article
Clinical Neurology
Jorge J. Llibre-Guerra, Jing Li, Yuting Qian, Juan de Jesus Llibre-Rodriguez, Ivonne Z. Jimenez-Velazquez, Daisy Acosta, Aquiles Salas, Juan Carlos Llibre-Guerra, Adolfo Valvuerdi, Amal Harrati, Jordan Weiss, Mao-Mei Liu, William H. Dow
Summary: This study investigated the role of the major susceptibility gene for Alzheimer's disease, APOE, in diverse Hispanic populations. The study found that APOEε4 carriers had higher dementia prevalence and lower memory performance in all subsamples.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Madia Lozupone, Bruno Pietro Imbimbo, Claudia Balducci, Filomena Lo Vecchio, Paola Bisceglia, Raffaela Rita Latino, Maurizio Leone, Vittorio Dibello, Vincenzo Solfrizzi, Antonio Greco, Antonio Daniele, Mark Watling, Davide Seripa, Francesco Panza
Summary: This article discusses the role of human apolipoprotein E (apoE) in the pathophysiology of Alzheimer's disease (AD), describing its impact on brain homeostasis, neuroinflammation, blood-brain barrier permeability, glial function, synaptogenesis, oral/gut microbiota, neural networks, amyloid beta deposition, and tau-mediated neurodegeneration. It also provides updates on different therapeutic approaches targeting apoE in AD treatment.
ALZHEIMERS & DEMENTIA
(2023)
Article
Psychiatry
Hyojung Paik, Junehawk Lee, Chan-Seok Jeong, Jun Sung Park, Jeong Ho Lee, Nadav Rappoport, Younghoon Kim, Hee-Young Sohn, Chulman Jo, Jimin Kim, Seong Beom Cho
Summary: Observations have confirmed the comorbidity between heart diseases and cognitive impairment. Genetic variants in APOB and ADIPOQ genes were found to have a pleiotropic effect on both diseases. Integrating healthcare records and genetic evidence can help understand the molecular underpinnings of heart disease and associated cognitive impairment.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Biotechnology & Applied Microbiology
P. Kwiatkowski, M. Kurzawski, L. Lopusiewicz, A. Pruss, M. Sienkiewicz, I Wojciechowska-Koszko, B. Dolegowska
Summary: In this study, lymphocytes isolated from whole blood infected with TA-treated Staphylococcus aureus demonstrated significantly higher expression of immune-related genes. Further research is needed to understand the impact of these changes on immune responses.
LETTERS IN APPLIED MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mateusz Kurzawski, Sylwia Szelag-Pieniek, Joanna Lapczuk-Romanska, Maciej Wrzesinski, Stefan Oswald, Marek Drozdzik
Summary: This study compared mRNA expression and protein abundance of drug-metabolizing enzymes in organ donor livers and non-tumorous tissue from metastatic livers. Higher protein abundance in metastatic livers was observed for CYP2C9, CYP2D6, and UGT2B7. Significant correlations between mRNA and protein content were found for most enzymes.
PHARMACOLOGICAL REPORTS
(2022)
Article
Environmental Sciences
Malgorzata Smiarowska, Boguslaw Brzuchalski, Elzbieta Grzywacz, Damian Malinowski, Anna Machoy-Mokrzynska, Anna Pierzchlinska, Monika Bialecka
Summary: This study aimed to evaluate the differences in catechol-O-methyltransferase (COMT) and dopamine receptor D2 (DRD2) gene polymorphisms in children born of high prenatal alcohol exposure (hPAE) with attention deficit hyperactivity disorder (ADHD), with or without morphological fetal alcohol spectrum disorders (FASD). The study also assessed whether genetic predisposition affects the response and safety of methylphenidate (MPH) treatment. The results showed that the analyzed COMT and DRD2 gene polymorphisms seemed to play no role in MPH efficacy in hPAE children with ADHD, while carriers of the low-activity COMT (Met158) variant may be more intolerant to MPH. MPH treatment was found to be effective in ADHD independent of FASD, although higher doses were required for the ADHD-FASD variant to be successful.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Genetics & Heredity
Boleslaw Banach, Andrzej Modrzejewski, Zygmunt Juzyszyn, Mateusz Kurzawski, Tomasz Sroczynski, Andrzej Pawlik
Summary: Recent studies found no significant association between genetic variants of SLCO1B3 and ABCC3 genes and susceptibility to cholesterol gallstone disease or gallstone composition.
Article
Biochemistry & Molecular Biology
Marek Drozdzik, Joanna Lapczuk-Romanska, Christoph Wenzel, Lukasz Skalski, Sylwia Szelag-Pieniek, Mariola Post, Marta Syczewska, Mateusz Kurzawski, Stefan Oswald
Summary: The protein abundances of drug transporters in hepatitis C virus-infected liver samples are influenced by the functional state of the liver.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Pawel Kwiatkowski, Aleksandra Tabis, Karol Fijalkowski, Helena Masiuk, Lukasz Lopusiewicz, Agata Pruss, Monika Sienkiewicz, Marcin Wardach, Mateusz Kurzawski, Sebastian Guenther, Jacek Bania, Barbara Dolegowska, Iwona Wojciechowska-Koszko
Summary: The study investigated the effects of a rotating magnetic field (RMF) on gene expression and toxin production of Staphylococcus aureus. Results showed that RMF had no significant influence on gene expression when bacteria were cultured with a subinhibitory concentration of trans-anethole (TA). However, exposure to 50 Hz RMF without TA increased the expression of certain genes and decreased the expression of others. Additionally, the combination of TA and RMF led to increased production of one toxin and reduced production of others.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Kaja Michalczyk, Patrycja Kapczuk, Grzegorz Witczak, Mateusz Bosiacki, Mateusz Kurzawski, Dariusz Chlubek, Aneta Cymbaluk-Ploska
Summary: The study confirmed older age, post-menopausal status, and type 2 diabetes as independent risk factors for endometrial cancer, while high cadmium and low cobalt levels were associated with the disease risk. Polymorphisms in GSTP1 and SLC11A2 genes did not show any association with endometrial cancer risk, but high cadmium and nickel levels were significantly associated with specific genotypes in the SLC1A2 gene, and high cadmium levels with GSTP1.
Article
Genetics & Heredity
Alina Jurewicz, Andrzej Bohatyrewicz, Maciej Pawlak, Maciej Tarnowski, Mateusz Kurzawski, Anna Machoy-Mokrzynska, Mariusz Kaczmarczyk, Anna Lubkowska, Monika Chudecka, Agnieszka Maciejewska-Skrendo, Katarzyna Leznicka
Summary: This study aimed to investigate the possible association between COMT and OPRM1 genotypes and pain perception in patients undergoing total hip replacement and total knee replacement. The results showed no significant genetic associations between variants of COMT and OPRM1 and pain thresholds/pain tolerance in the study group, and no relationship between specific genetic variants and subjective pain perception using the visual analog scale.
Article
Medicine, Research & Experimental
Pawel Kwiatkowski, Mateusz Kurzawski, Wirginia Kukula-Koch, Agata Pruss, Monika Sienkiewicz, Wojciech Plazinski, Barbara Dolegowska, Iwona Wojciechowska-Koszko
Summary: Previous studies have shown that trans-anethole (TA) can reduce staphyloxanthin (STX) production in Staphylococcus aureus. However, the impact of TA on the biosynthetic pathway of this carotenoid pigment has not yet been studied. This preliminary study evaluated the influence of TA on the expression of genes encoding STX pathway enzymes and identified STX and its intermediates. The results showed that TA treatment led to a significant reduction in the majority of compounds involved in the biosynthetic pathway of STX.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Marek Drozdzik, Joanna Lapczuk-Romanska, Christoph Wenzel, Lukasz Skalski, Sylwia Szelag-Pieniek, Mariola Post, Arkadiusz Parus, Marta Syczewska, Mateusz Kurzawski, Stefan Oswald
Summary: Hepatic drug metabolizing enzymes (DMEs) play a crucial role in drug pharmacokinetics and can be affected by liver diseases. This study analyzed hepatitis C liver samples of different functional states and found that the protein abundances and mRNA levels of specific CYP and UGT enzymes were altered. The severity of the disease was associated with significant up-regulation or down-regulation of certain enzymes, indicating that hepatitis C virus infection impacts DMEs protein abundances in the liver.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Kaja Michalczyk, Patrycja Kapczuk, Grzegorz Witczak, Piotr Tousty, Mateusz Bosiacki, Mateusz Kurzawski, Dariusz Chlubek, Aneta Cymbaluk-Ploska
Summary: Several studies have found a relationship between metallothionein (MT) polymorphisms and the development of various diseases, including cancer. This study aimed to investigate the influence of MT polymorphisms on the development of endometrial lesions, including endometrial cancer. The study analyzed tissue samples from 140 patients with different endometrial conditions and found that MT2 concentration was significantly different between uterine fibromas and normal endometrial tissue samples, but not between endometrial cancer and benign endometrium samples. Menopause status did not affect MT2 concentration. There were no significant associations between MT1A, MT2A, and MT1L polymorphisms and MT2 concentration.
Article
Biotechnology & Applied Microbiology
Magdalena Peruzynska, Anna Nowak, Radoslaw Birger, Paula Ossowicz-Rupniewska, Maciej Konopacki, Rafal Rakoczy, Lukasz Kucharski, Karolina Wenelska, Adam Klimowicz, Marek Drozdzik, Mateusz Kurzawski
Summary: This study evaluated the antiproliferative properties of the ethanolic extract of Epilobium angustifolium (EAE) on normal human fibroblasts and selected cancer cell lines. Bacterial cellulose membranes were used as a carrier for the controlled release of the plant extract. The BC membranes loaded with EAE significantly reduced cell viability in the HT-29 cell line and increased apoptotic/dead cell numbers.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biology
Kaja Michalczyk, Patrycja Kupnicka, Grzegorz Witczak, Piotr Tousty, Mateusz Bosiacki, Mateusz Kurzawski, Dariusz Chlubek, Aneta Cymbaluk-Ploska
Summary: This study is the first to evaluate blood cadmium and lead levels in different uterine pathologies and the risk of endometrial cancer. The results showed a correlation between blood cadmium concentration and endometrial cancer risk, but no relationship with lead concentration.
Article
Allergy
Damian Malinowski, Monika Bialecka, Piotr Bojko, Adriana Kiszkielis, Marek Drozdzik, Mateusz Kurzawski
Summary: This study conducted a confirmation study on SNPs in 9 gene regions in Polish psoriatic patients and controls, and found that certain genetic variants were associated with psoriasis. However, these genetic variants did not affect treatment outcomes.
POSTEPY DERMATOLOGII I ALERGOLOGII
(2022)
Meeting Abstract
Pharmacology & Pharmacy
M. Drozdzik, J. Lapczuk-Romanska, C. Wenzel, S. Szelag-Pieniek, Post, L. Skalski, M. Kurzawski, S. Oswald
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
