The Pleiotropic Effects of the GM-CSF Rheostat on Myeloid Cell Differentiation and Function: More Than a Numbers Game

A GMCSF-Neuroantigen Tolerogenic Vaccine Elicits Systemic Lymphocytosis of CD4+ CD25high FOXP3+ Regulatory T Cells in Myelin-Specific TCR Transgenic Mice Contingent Upon Low-Efficiency T Cell Antigen Receptor Recognition

(2019) Cody D. Moorman et al.   Frontiers in Immunology

Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model

(2019) Ziv Erlich et al.   NATURE IMMUNOLOGY

The influence of genetics on therapeutic developments in pulmonary alveolar proteinosis

(2019) Ilaria Campo   CURRENT OPINION IN PULMONARY MEDICINE

GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation

(2019) Michael Dougan et al.   IMMUNITY

GM-CSF targeted immunomodulation affects host response to M. tuberculosis infection

(2018) Sulayman Benmerzoug et al.   Scientific Reports

Mavrilimumab, a Fully Human Granulocyte-Macrophage Colony-Stimulating Factor Receptor α Monoclonal Antibody

(2018) Gerd R. Burmester et al.   Arthritis & Rheumatology

Monocytic Myeloid-Derived Suppressor Cells in Chronic Infections

(2018) Anca Dorhoi et al.   Frontiers in Immunology

Mathematical Analysis of Cytokine-Induced Differentiation of Granulocyte-Monocyte Progenitor Cells

(2018) Bronson R. Weston et al.   Frontiers in Immunology

GM-CSF Quantity Has a Selective Effect on Granulocytic vs. Monocytic Myeloid Development and Function

(2018) Li Sun et al.   Frontiers in Immunology

GM-CSF Culture Revisited: Preparation of Bulk Populations of Highly Pure Dendritic Cells from Mouse Bone Marrow

(2018) Dongbin Jin et al.   JOURNAL OF IMMUNOLOGY

Graft-versus-host disease, but not graft-versus-leukemia immunity, is mediated by GM-CSF–licensed myeloid cells

(2018) Sonia Tugues et al.   Science Translational Medicine

The life and death of immune cell types: the role of BCL-2 anti-apoptotic molecules

(2017) Emma M Carrington et al.   IMMUNOLOGY AND CELL BIOLOGY

Tumor-recruited M2 macrophages promote gastric and breast cancer metastasis via M2 macrophage-secreted CHI3L1 protein

(2017) Yulei Chen et al.   Journal of Hematology & Oncology

GM-CSF Promotes Chronic Disability in Experimental Autoimmune Encephalomyelitis by Altering the Composition of Central Nervous System–Infiltrating Cells, but Is Dispensable for Disease Induction

(2017) Patrick C. Duncker et al.   JOURNAL OF IMMUNOLOGY

Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization

(2017) Eleni Vergadi et al.   JOURNAL OF IMMUNOLOGY

Glioblastoma-synthesized G-CSF and GM-CSF contribute to growth and immunosuppression: Potential therapeutic benefit from dapsone, fenofibrate, and ribavirin

(2017) Richard E Kast et al.   TUMOR BIOLOGY

Role of Granulocyte-Macrophage Colony-Stimulating Factor Production by T Cells during Mycobacterium tuberculosis Infection

(2017) Alissa C. Rothchild et al.   mBio

A Randomized Phase IIb Study of Mavrilimumab and Golimumab in Rheumatoid Arthritis

(2017) Michael E. Weinblatt et al.   Arthritis & Rheumatology

O -glycans and O -glycosylation sites of recombinant human GM-CSF derived from suspension-cultured rice cells, and their structural role

(2016) Jihye Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+ Macrophages or Monocyte-Derived Dendritic Cells

(2016) Shinelle Menezes et al.   IMMUNITY

GM-CSF: From Growth Factor to Central Mediator of Tissue Inflammation

(2016) Burkhard Becher et al.   IMMUNITY

The anti-apoptotic Bcl-2 family protein A1/Bfl-1 regulates neutrophil survival and homeostasis and is controlled via PI3K and JAK/STAT signaling

(2016) J Vier et al.   Cell Death & Disease

Distinct Transcriptional Programs Control Cross-Priming in Classical and Monocyte-Derived Dendritic Cells

(2016) Carlos G. Briseño et al.   Cell Reports

RORC1 Regulates Tumor-Promoting “Emergency” Granulo-Monocytopoiesis

(2015) Laura Strauss et al.   CANCER CELL

The divergent roles of macrophages in solid organ transplantation

(2015) Sahar Salehi et al.   Current Opinion in Organ Transplantation

GM-CSF: An immune modulatory cytokine that can suppress autoimmunity

(2015) Palash Bhattacharya et al.   CYTOKINE

The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity

(2015) Andrew L. Croxford et al.   IMMUNITY

GM-CSF Mouse Bone Marrow Cultures Comprise a Heterogeneous Population of CD11c+MHCII+ Macrophages and Dendritic Cells

(2015) Julie Helft et al.   IMMUNITY

Monocyte-Derived Dendritic Cells Promote Th Polarization, whereas Conventional Dendritic Cells Promote Th Proliferation

(2015) Kevin V. Chow et al.   JOURNAL OF IMMUNOLOGY

Targeting GM-CSF in inflammatory diseases

(2015) Ian P. Wicks et al.   Nature Reviews Rheumatology

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy

(2015) Joel D. Leverson et al.   Science Translational Medicine

MOR103, a human monoclonal antibody to granulocyte–macrophage colony-stimulating factor, in the treatment of patients with moderate rheumatoid arthritis: results of a phase Ib/IIa randomised, double-blind, placebo-controlled, dose-escalation trial

(2014) Frank Behrens et al.   ANNALS OF THE RHEUMATIC DISEASES

Development and Function of Dendritic Cell Subsets

(2014) Alexander Mildner et al.   IMMUNITY

GM-CSF-Responsive Monocyte-Derived Dendritic Cells Are Pivotal in Th17 Pathogenesis

(2014) H.-J. Ko et al.   JOURNAL OF IMMUNOLOGY

Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages

(2014) Christoph Schneider et al.   NATURE IMMUNOLOGY

The Closely Related CD103+ Dendritic Cells (DCs) and Lymphoid-Resident CD8+ DCs Differ in Their Inflammatory Functions

(2014) Zhijun Jiao et al.   PLoS One

Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages

(2014) Meera Rath et al.   Frontiers in Immunology

Transgenic Expression of GM-CSF in T Cells Causes Disseminated Histiocytosis

(2013) Annemarie E. van Nieuwenhuijze et al.   AMERICAN JOURNAL OF PATHOLOGY

Increased Frequency of Myeloid-derived Suppressor Cells during Active Tuberculosis and after RecentMycobacterium tuberculosisInfection Suppresses T-Cell Function

(2013) Nelita du Plessis et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting

(2013) Miriam Merad et al.   Annual Review of Immunology

Interleukin-4- and Interleukin-13-Mediated Alternatively Activated Macrophages: Roles in Homeostasis and Disease

(2013) Steven J. Van Dyken et al.   Annual Review of Immunology

Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences

(2013) F. O. Martinez et al.   BLOOD

Myeloid-derived suppressor cell development is regulated by a STAT/IRF-8 axis

(2013) Jeremy D. Waight et al.   JOURNAL OF CLINICAL INVESTIGATION

Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF

(2013) Martin Guilliams et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SOCS-1 Mediates Ubiquitylation and Degradation of GM-CSF Receptor

(2013) Severa Bunda et al.   PLoS One

Regulation of dendritic cell development by GM-CSF: molecular control and implications for immune homeostasis and therapy

(2012) L. van de Laar et al.   BLOOD

Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer

(2012) Lauren J. Bayne et al.   CANCER CELL

The inflammatory cytokine, GM-CSF, alters the developmental outcome of murine dendritic cells

(2012) Yifan Zhan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

GM-CSF Controls Nonlymphoid Tissue Dendritic Cell Homeostasis but Is Dispensable for the Differentiation of Inflammatory Dendritic Cells

(2012) Melanie Greter et al.   IMMUNITY

Defining GM-CSF- and Macrophage-CSF-Dependent Macrophage Responses by In Vitro Models

(2012) D. C. Lacey et al.   JOURNAL OF IMMUNOLOGY

GM-CSF Priming Drives Bone Marrow-Derived Macrophages to a Pro-Inflammatory Pattern and Downmodulates PGE2 in Response to TLR2 Ligands

(2012) Carlos Arterio Sorgi et al.   PLoS One

Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization

(2012) A. Arranz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of systemic and local myeloid cell subpopulations by bone marrow cell-derived granulocyte-macrophage colony-stimulating factor in experimental inflammatory arthritis

(2011) Andrew D. Cook et al.   ARTHRITIS AND RHEUMATISM

GM-CSF increases cross-presentation and CD103 expression by mouse CD8+ spleen dendritic cells

(2011) Yifan Zhan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CISH is induced during DC development and regulates DC-mediated CTL activation

(2011) Mohammad Alam Miah et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Differentiation of Inflammatory Dendritic Cells Is Mediated by NF- B1-Dependent GM-CSF Production in CD4 T Cells

(2011) I. K. Campbell et al.   JOURNAL OF IMMUNOLOGY

The Acquisition of Antigen Cross-Presentation Function by Newly Formed Dendritic Cells

(2011) P. Sathe et al.   JOURNAL OF IMMUNOLOGY

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

(2011) Xiang-Ping Yang et al.   NATURE IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

Direct evidence that GM-CSF inhalation improves lung clearance in pulmonary alveolar proteinosis

(2011) Kazumasa Ohashi et al.   RESPIRATORY MEDICINE

Granulocyte/Macrophage Colony–Stimulating Factor Causes a Paradoxical Increase in the BH3-Only Pro-Apoptotic Protein Bim in Human Neutrophils

(2010) Andrew S. Cowburn et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Myeloid-derived suppressor cells in transplantation

(2010) Nahzli Dilek et al.   Current Opinion in Organ Transplantation

Tumor-Induced Tolerance and Immune Suppression Depend on the C/EBPβ Transcription Factor

(2010) Ilaria Marigo et al.   IMMUNITY

Interleukin-4 induced interferon regulatory factor (Irf) 4 participates in the regulation of alternative macrophage priming

(2010) Carol El Chartouni et al.   IMMUNOBIOLOGY

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

(2010) Takashi Satoh et al.   NATURE IMMUNOLOGY

BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs

(2010) E. M. Carrington et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of GM-CSF signaling in cell-based tumor immunization

(2009) S. Zarei et al.   BLOOD

The concerted action of GM-CSF and Flt3-ligand on in vivo dendritic cell homeostasis

(2009) D. Kingston et al.   BLOOD

Migrating monocytes recruited to the spleen play an important role in control of blood stage malaria

(2009) A.-M. Sponaas et al.   BLOOD

The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease

(2009) T. R. Hercus et al.   BLOOD

Induction of Bim limits cytokine-mediated prolonged survival of neutrophils

(2009) N Andina et al.   CELL DEATH AND DIFFERENTIATION

Modulation of pulmonary DC function by vaccine-encoded GM-CSF enhances protective immunity against Mycobacterium tuberculosis infection

(2009) Jonathan K. Nambiar et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Innate Immune CD11b+Gr-1+ Cells, Suppressor Cells, Affect the Immune Response during Theiler's Virus-Induced Demyelinating Disease

(2009) J. L. Bowen et al.   JOURNAL OF IMMUNOLOGY

GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on Type I interferon signaling

(2009) Andrew J. Fleetwood et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Role of GM-CSF in tolerance induction by mobilized hematopoietic progenitors

(2008) H. Kared et al.   BLOOD

The Signal Transducer STAT5 Inhibits Plasmacytoid Dendritic Cell Development by Suppressing Transcription Factor IRF8

(2008) Eiji Esashi et al.   IMMUNITY

Enhancing the clinical activity of granulocyte-macrophage colony-stimulating factor-secreting tumor cell vaccines

(2008) Masahisa Jinushi et al.   IMMUNOLOGICAL REVIEWS