Glioblastoma-synthesized G-CSF and GM-CSF contribute to growth and immunosuppression: Potential therapeutic benefit from dapsone, fenofibrate, and ribavirin

Autophagy suppression sensitizes glioma cells to IMP dehydrogenase inhibition-induced apoptotic death

(2017) Andjelka M. Isakovic et al.   EXPERIMENTAL CELL RESEARCH

Bone marrow response as a potential biomarker of outcomes in glioblastoma patients

(2017) Eugene J. Vaios et al.   JOURNAL OF NEUROSURGERY

Assessing blood granulocyte colony-stimulating factor as a potential biomarker of acute traumatic brain injury in mice and humans

(2016) William A. Banks et al.   BRAIN BEHAVIOR AND IMMUNITY

Tumor-associated GM-CSF overexpression induces immunoinhibitory molecules via STAT3 in myeloid-suppressor cells infiltrating liver metastases

(2016) M Thorn et al.   CANCER GENE THERAPY

CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells

(2016) Alan L. Chang et al.   CANCER RESEARCH

Induction of protumoral CD11chighmacrophages by glioma cancer stem cells through GM-CSF

(2016) Yasuhiro Kokubu et al.   GENES TO CELLS

Neutrophils in cancer development and progression: Roles, mechanisms, and implications (Review)

(2016) Xu Zhang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

High Pretreatment Neutrophil-to-Lymphocyte Ratio Predicts Poor Survival in Patients With Glioblastoma Treated With Radiation Therapy and Temozolomide

(2016) T. Yoshitake et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

G-CSF–Induced Suppressor IL-10+Neutrophils Promote Regulatory T Cells That Inhibit Graft-Versus-Host Disease in a Long-Lasting and Specific Way

(2016) Suelen Martins Perobelli et al.   JOURNAL OF IMMUNOLOGY

Radiotherapy induces an immediate inflammatory reaction in malignant glioma: a clinical microdialysis study

(2016) Pedram Tabatabaei et al.   JOURNAL OF NEURO-ONCOLOGY

The brain tissue response to surgical injury and its possible contribution to glioma recurrence

(2016) Lauriane Hamard et al.   JOURNAL OF NEURO-ONCOLOGY

Association between treatment-related lymphopenia and overall survival in elderly patients with newly diagnosed glioblastoma

(2016) Joe S. Mendez et al.   JOURNAL OF NEURO-ONCOLOGY

A prospective comparative clinical study of peripheral blood counts and indices in patients with primary brain tumors

(2016) VS Madhugiri et al.   Journal of Postgraduate Medicine

Steroid-sparing effect and toxicity of dapsone treatment in giant cell arteritis

(2016) Kim Heang Ly et al.   MEDICINE

Reactive astrocytes potentiate tumor aggressiveness in a murine glioma resection and recurrence model

(2016) Onyinyechukwu Okolie et al.   NEURO-ONCOLOGY

Elevated levels of polymorphonuclear myeloid-derived suppressor cells in patients with glioblastoma highly express S100A8/9 and arginase and suppress T cell function

(2016) Paul R. Gielen et al.   NEURO-ONCOLOGY

Use of an anti-viral drug, Ribavirin, as an anti-glioblastoma therapeutic

(2016) F Volpin et al.   ONCOGENE

Inhibition of radiation-induced glioblastoma invasion by genetic and pharmacological targeting of MDA-9/Syntenin

(2016) Timothy P. Kegelman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Stem Cell-Secreted Macrophage Migration Inhibitory Factor Stimulates Myeloid Derived Suppressor Cell Function and Facilitates Glioblastoma Immune Evasion

(2016) Balint Otvos et al.   STEM CELLS

NETs in cancer

(2016) Marzena Garley et al.   TUMOR BIOLOGY

Toward a noncytotoxic glioblastoma therapy: blocking MCP-1 with the MTZ Regimen

(2016) Michael Salacz et al.   OncoTargets and Therapy

Prognostic models to predict survival in patients with advanced non-small cell lung cancer treated with first-line chemo- or targeted therapy

(2016) Rossana Berardi et al.   Oncotarget

Glioma Recurrence following Surgery: Peritumoral or Perilesional?

(2016) Boudewijn van der Sanden et al.   Frontiers in Neurology

Necrotic cells influence migration and invasion of glioblastoma via NF-κB/AP-1-mediated IL-8 regulation

(2016) So-Hee Ahn et al.   Scientific Reports

Granulocyte colony-stimulating factor reprograms bone marrow stromal cells to actively suppress B lymphopoiesis in mice

(2015) R. B. Day et al.   BLOOD

Pre-treatment neutrophil to lymphocyte ratio may be a useful tool in predicting survival in early triple negative breast cancer patients

(2015) Mirco Pistelli et al.   BMC CANCER

Pre-treatment neutrophil-to-lymphocyte ratio is associated with neutrophil and T-cell infiltration and predicts clinical outcome in patients with glioblastoma

(2015) Sheng Han et al.   BMC CANCER

Stem Cell Transfusion Restores Immune Function in Radiation-Induced Lymphopenic C57BL/6 Mice

(2015) V. Kapoor et al.   CANCER RESEARCH

Fenofibrate Attenuates Neutrophilic Inflammation in Airway Epithelia: Potential Drug Repurposing for Cystic Fibrosis

(2015) Amanda J. Stolarz et al.   CTS-Clinical and Translational Science

High neutrophil-to-lymphocyte ratio predicts poor clinical outcome in patients with castration-resistant prostate cancer treated with docetaxel chemotherapy

(2015) Akihisa Yao et al.   INTERNATIONAL JOURNAL OF UROLOGY

G-CSF and GM-CSF in Neutropenia

(2015) Hrishikesh M. Mehta et al.   JOURNAL OF IMMUNOLOGY

Pre-radiation lymphocyte harvesting and post-radiation reinfusion in patients with newly diagnosed high grade gliomas

(2015) Jian L. Campian et al.   JOURNAL OF NEURO-ONCOLOGY

Granulocyte-Macrophage Colony Stimulating Factor Exerts Protective and Immunomodulatory Effects in Cortical Trauma

(2015) Matthew L. Kelso et al.   JOURNAL OF NEUROIMMUNOLOGY

Survival in Patients With Severe Lymphopenia Following Treatment With Radiation and Chemotherapy for Newly Diagnosed Solid Tumors

(2015) Stuart A. Grossman et al.   Journal of the National Comprehensive Cancer Network

Pretreatment Neutrophil–Lymphocyte Ratio

(2015) Fangyuan Gao et al.   MEDICINE

Immunosuppressive mechanisms in glioblastoma: Fig. 1.

(2015) Edjah K. Nduom et al.   NEURO-ONCOLOGY

Neutrophil to lymphocyte ratio is a strong predictor of tumor recurrence in early colon cancers: A propensity score-matched analysis

(2015) Gennaro Galizia et al.   SURGERY

Fenofibrate induces G0/G1 phase arrest by modulating the PPARα/FoxO1/p27kip pathway in human glioblastoma cells

(2015) Dong-feng Han et al.   TUMOR BIOLOGY

Circulating CD14+HLA-DR−/low myeloid-derived suppressor cell is an indicator of poor prognosis in patients with ESCC

(2015) Haitao Huang et al.   TUMOR BIOLOGY

The immunobiology of myeloid-derived suppressor cells in cancer

(2015) Morteza Motallebnezhad et al.   TUMOR BIOLOGY

Enhanced neutrophil activity is associated with shorter time to tumor progression in glioblastoma patients

(2015) Afsar Rahbar et al.   OncoImmunology

Erlotinib augmentation with dapsone for rash mitigation and increased anti-cancer effectiveness

(2015) R. E. Kast   SpringerPlus

Phase II randomized study of whole-brain radiation therapy with or without concurrent temozolomide for brain metastases from breast cancer

(2014) K. I. Cao et al.   ANNALS OF ONCOLOGY

Molecular Pathways: Myeloid Complicity in Cancer

(2014) I. M. Stromnes et al.   CLINICAL CANCER RESEARCH

Enhanced immunosuppression by therapy-exposed glioblastoma multiforme tumor cells

(2014) Astrid Authier et al.   INTERNATIONAL JOURNAL OF CANCER

Characterization of fenofibrate-mediated anti-proliferative pro-apoptotic effects on high-grade gliomas and anti-invasive effects on glioma stem cells

(2014) Emanuela Binello et al.   JOURNAL OF NEURO-ONCOLOGY

Factors impacting survival following second surgery in patients with glioblastoma in the temozolomide treatment era, incorporating neutrophil/lymphocyte ratio and time to first progression

(2014) Mairéad G. McNamara et al.   JOURNAL OF NEURO-ONCOLOGY

Granulocyte-Macrophage Colony-Stimulating Factor Is Neuroprotective in Experimental Traumatic Brain Injury

(2014) Sandy R. Shultz et al.   JOURNAL OF NEUROTRAUMA

Blood neutrophil–lymphocyte ratio predicts survival in locally advanced cancer stomach treated with neoadjuvant chemotherapy FOLFOX 4

(2014) Lamiss Mohamed Abd el Aziz   MEDICAL ONCOLOGY

Molecular Mechanisms of Fenofibrate-Induced Metabolic Catastrophe and Glioblastoma Cell Death

(2014) Anna Wilk et al.   MOLECULAR AND CELLULAR BIOLOGY

Human Astrocytes: Secretome Profiles of Cytokines and Chemokines

(2014) Sung S. Choi et al.   PLoS One

Platelet-derived growth factor in glioblastoma—driver or biomarker?

(2014) Bengt Westermark   UPSALA JOURNAL OF MEDICAL SCIENCES

Sustained CD4+T cell-driven lymphopenia without a compensatory IL-7/IL-15 response among high-grade glioma patients treated with radiation and temozolomide

(2014) Susannah Ellsworth et al.   OncoImmunology

Review: dermatitis herpetiformis

(2013) Fernanda Berti Rocha Mendes et al.   ANAIS BRASILEIROS DE DERMATOLOGIA

Dapsone in dermatology and beyond

(2013) Gottfried Wozel et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

GM-CSF Promotes the Immunosuppressive Activity of Glioma-Infiltrating Myeloid Cells through Interleukin-4 Receptor- 

(2013) G. Kohanbash et al.   CANCER RESEARCH

Glioblastoma Stem Cells Are Regulated by Interleukin-8 Signaling in a Tumoral Perivascular Niche

(2013) D. W. Infanger et al.   CANCER RESEARCH

Myeloid-derived suppressor cells in glioma

(2013) Masoud Mirghorbani et al.   Expert Review of Neurotherapeutics

The association of pre-treatment neutrophil to lymphocyte ratio with overall survival in patients with glioblastoma multiforme

(2013) R. M. Bambury et al.   JOURNAL OF NEURO-ONCOLOGY

Postoperative ischemic changes following brain metastasis resection as measured by diffusion-weighted magnetic resonance imaging

(2013) Jens Gempt et al.   JOURNAL OF NEUROSURGERY

Post-Traumatic Hypoxia Is Associated with Prolonged Cerebral Cytokine Production, Higher Serum Biomarker Levels, and Poor Outcome in Patients with Severe Traumatic Brain Injury

(2013) Edwin B. Yan et al.   JOURNAL OF NEUROTRAUMA

Cytokine Patterns in Brain Tumour Progression

(2013) Radu Albulescu et al.   MEDIATORS OF INFLAMMATION

External Validation of the Derived Neutrophil to Lymphocyte Ratio as a Prognostic Marker on a Large Cohort of Pancreatic Cancer Patients

(2013) Joanna Szkandera et al.   PLoS One

Bone marrow suppression or active proliferation? An analysis of neutropenia after pegylated interferon treatment of patients with chronic hepatitis C

(2013) Ya-Li Liu et al.   SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES

Immunomonitoring and prognostic relevance of neutrophils in clinical trials

(2013) Frede Donskov   SEMINARS IN CANCER BIOLOGY

Optimum Ribavirin Exposure Overcomes Racial Disparity in Efficacy of Peginterferon and Ribavirin Treatment for Hepatitis C Genotype 1

(2012) Runyan Jin et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Neutrophil Chemotaxis within a Competing Gradient of Chemoattractants

(2012) Donghyuk Kim et al.   ANALYTICAL CHEMISTRY

The Rationale of Targeting Neutrophils with Dapsone during Glioblastoma Treatment

(2012) Richard E. Kast et al.   Anti-Cancer Agents in Medicinal Chemistry

Why dapsone stops seizures and may stop neutrophils’ delivery of VEGF to glioblastoma

(2012) R. E. Kast et al.   BRITISH JOURNAL OF NEUROSURGERY

Granulocyte-colony stimulating factor promotes proliferation, migration and invasion in glioma cells

(2012) Juntao Wang et al.   CANCER BIOLOGY & THERAPY

Role of radiation-induced granulocyte colony-stimulating factor in recovery from whole body gamma-irradiation

(2012) Vijay K. Singh et al.   CYTOKINE

Myeloid-derived Suppressor Cells (MDSCs) in Gliomas and Glioma-Development

(2012) Gary Kohanbash et al.   IMMUNOLOGICAL INVESTIGATIONS

ROS accumulation and IGF-IR inhibition contribute to fenofibrate/PPARα -mediated inhibition of Glioma cell motility in vitro

(2012) Justyna Drukala et al.   Molecular Cancer

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(2012) Penelope Korkolopoulou et al.   MOLECULAR MEDICINE

The hematopoietic cytokine granulocyte-macrophage colony stimulating factor is important for cognitive functions

(2012) Markus Krieger et al.   Scientific Reports

Dapsone Inhibits IL-8 Secretion From Human Bronchial Epithelial Cells Stimulated With Lipopolysaccharide and Resolves Airway Inflammation in the Ferret

(2011) Soichiro Kanoh et al.   CHEST

Neutrophil Degranulation and Immunosuppression in Patients with GBM: Restoration of Cellular Immune Function by Targeting Arginase I

(2011) T. R. Sippel et al.   CLINICAL CANCER RESEARCH

Prognostic significance of IL-8-STAT-3 pathway in astrocytomas: Correlation with IL-6, VEGF and microvessel morphometry

(2011) Christina Piperi et al.   CYTOKINE

Granulocyte–macrophage colony-stimulating factor as an autocrine survival-growth factor in human gliomas

(2011) Roberto P. Revoltella et al.   CYTOKINE

Subcutaneous injection containing IL-3 and GM-CSF ameliorates stab wound-induced brain injury in rats

(2011) Tasuku Nishihara et al.   EXPERIMENTAL NEUROLOGY

Normal human monocytes exposed to glioma cells acquire myeloid-derived suppressor cell-like properties

(2011) Jennifer C. Rodrigues et al.   NEURO-ONCOLOGY

Characteristics of the Alternative Phenotype of Microglia/Macrophages and its Modulation in Experimental Gliomas

(2011) Konrad Gabrusiewicz et al.   PLoS One

Ribavirin for the treatment of chronic hepatitis C virus infection: a review of the proposed mechanisms of action

(2011) Jan Paeshuyse et al.   Current Opinion in Virology

A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils

(2010) S. Massena et al.   BLOOD

The Cytokine Response to Human Traumatic Brain Injury: Temporal Profiles and Evidence for Cerebral Parenchymal Production

(2010) Adel Helmy et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

IL-8 is a mediator of NF-κB induced invasion by gliomas

(2010) Baisakhi Raychaudhuri et al.   JOURNAL OF NEURO-ONCOLOGY

Systemic immune suppression in glioblastoma: the interplay between CD14+HLA-DRlo/neg monocytes, tumor factors, and dexamethasone

(2010) Michael P. Gustafson et al.   NEURO-ONCOLOGY

Endogenous brain protection by granulocyte-colony stimulating factor after ischemic stroke

(2009) Sevgi Sevimli et al.   EXPERIMENTAL NEUROLOGY

Reduction in programmed cell death and improvement in functional outcome of transient focal cerebral ischemia after administration of granulocyte-macrophage colony-stimulating factor in rats

(2009) TaeHo Kong et al.   JOURNAL OF NEUROSURGERY

Deregulation of a STAT3-Interleukin 8 Signaling Pathway Promotes Human Glioblastoma Cell Proliferation and Invasiveness

(2008) N. de la Iglesia et al.   JOURNAL OF NEUROSCIENCE