Article
Immunology
Nadejda Beliakova-Bethell, Kathirvel Maruthai, Ruijie Xu, Liliana C. M. Salvador, Ankita Garg
Summary: The study shows that long after recovery from CoV2 infection, M-MDSC suppresses immune responses to CoV2 antigens. This finding suggests that M-MDSC may serve as novel regulators of CoV2-specific T cell responses and should be targeted to enhance vaccine responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Yin Celeste Cheuk, Shihao Xu, Dong Zhu, Yongsheng Luo, Tian Chen, Juntao Chen, Jiawei Li, Yi Shi, Yi Zhang, Ruiming Rong
Summary: The supernatant derived from myeloid-derived suppressor cells (MDSCs) inhibits the transforming growth factor beta 1 (TGF-beta 1)-induced myofibroblastic differentiation of mesenchymal stem cells (MSCs) through IL-15. This finding provides a new perspective for the development of treatment strategies for renal fibrosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biology
Yunyun Zou, Nobuhiko Kamada, Seung-Yong Seong, Sang-Uk Seo
Summary: This study explores the phenotypic and functional heterogeneity of myeloid-derived suppressor cells (MDSCs) in tumor-bearing hosts. It identifies CD115(-) monocytic MDSCs as a distinct subtype with the potential to differentiate into OLFM4(hi) polymorphonuclear MDSCs. CD115(-) monocytic MDSCs increase in the blood and bone marrow as tumors progress, while preferentially differentiating into tumor-associated macrophages in the tumor mass.
COMMUNICATIONS BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Yuki Masuda, Yoshiaki Nakayama, Ryohei Shimizu, Kenta Naito, Eri Miyamoto, Akihiro Tanaka, Morichika Konishi
Summary: This study investigated the effects of YM-2A, a compound extracted from Grifola frondosa, on the immunosuppressive potential of MDSCs. The results showed that YM-2A selectively reduced the accumulation of M-MDSCs in tumor-bearing mice and promoted the differentiation of M-MDSCs into immunostimulatory M1 macrophages, thus enhancing the efficacy of cancer immunotherapy.
Article
Biotechnology & Applied Microbiology
Richard Hopkins, Wenwei Xiang, Damien Marlier, Veonice Bijin Au, Qianting Ching, Lynn Xue Wu, Rujun Guan, Bernett Lee, Whay-Kuang Chia, Who-Whong Wang, Joseph Wee, Joanna Ng, Rachael Cheong, Shuting Han, Axel Chu, Chit Lai Chee, Timothy Shuen, Michael Podinger, Alexander Lezhava, Han Chong Toh, John E. Connolly
Summary: Late-stage EBV-positive NPC poses a challenge in treatment, but a combination of chemotherapy and EBVST immunotherapy has shown promising response rates. Analysis of EBV DNA plasma concentrations and peripheral monocyte levels can help predict overall survival in patients.
Review
Immunology
Hui Zhang, Qi-Wei Li, Yuan-Yuan Li, Xue Tang, Ling Gu, Han-Min Liu
Summary: Pulmonary hypertension (PH) is characterized by increased pulmonary vascular resistance and pressure, and the relationship between myeloid-derived suppressor cells (MDSCs) and PH has been studied. MDSCs are a group of cells that can suppress T-cell responses and potentially exacerbate the development of diseases. Understanding the relationship between MDSCs and PH can help identify potential therapeutic targets for the treatment of PH.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jiawei Li, Juntao Chen, Mingnan Zhang, Chao Zhang, Renyan Wu, Tianying Yang, Yue Qiu, Jingjing Liu, Tongyu Zhu, Yi Zhang, Ruiming Rong
Summary: The study found that mTOR deficiency enhances the immunosuppressive function of monocytic MDSCs and prolongs the survival time of mouse cardiac transplantation, mainly manifested as promoting MDSC differentiation, increasing intracellular autophagy levels, and inhibiting T cell activation and inducing regulatory T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Ru Li, Mousumi Beto Mukherjee, Jun Lin
Summary: In this review, the effects of cytokines and chemokines on myeloid-derived suppressor cells in cancer metastasis are summarized. Cytokines and chemokines in the tumor microenvironment alter the functional properties of MDSCs and are involved in their production, infiltration, and immunosuppressive functions. The manipulation of MDSCs by tumors through cytokine and chemokine signaling is discussed, as well as potential treatment strategies targeting these signaling pathways to combat the immunosuppressive activities of MDSCs and improve disease outcomes.
Article
Oncology
Latika Singh, Eric S. Muise, Anannya Bhattacharya, Jeff Grein, Sarah Javaid, Peter Stivers, Jun Zhang, Yujie Qu, Barbara Joyce-Shaikh, Andrey Loboda, Chunsheng Zhang, Michael Meehl, Derek Y. Chiang, Sheila H. Ranganath, Michael Rosenzweig, Philip E. Brandish
Summary: MDSCs, specifically monocytic MDSCs, generated by coculture with SK-MEL-5 cells exhibit low levels of HLA-DR and high levels of CD33 and CD11b, suppressing CD8(+) T-cell proliferation and IFN gamma secretion. Targeting ILT3 on M-MDSCs impaired their suppressor phenotype and combination with anti-PD1 enhanced T-cell activation.
MOLECULAR CANCER RESEARCH
(2021)
Article
Immunology
Jie Shen, Mengyu Zhang, Ke Zhang, Yahan Qin, Meifang Liu, Shujuan Liang, Daquan Chen, Meiyu Peng
Summary: This study found that Angelica polysaccharide (APS) promoted the proliferation, differentiation, and immunosuppressive function of myeloid-derived suppressor cells (MDSC) through the STAT1 and STAT3 signaling pathways. In vivo, APS increased the proportion of MDSC in mice, suggesting that its clinical application should consider the possible side effects of increasing MDSC quantity and function.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Yan-Fang Xing, Jia-Rong Cai, Jun-Jian Qin, Wen-Ying Zhou, Can-Ming Li, Xing Li
Summary: In this study, it was found that monocyte-derived suppressor cells (MDSCs) were elevated in end-stage renal disease (ESRD) patients undergoing hemodialysis, and were strongly associated with increased risk of cardiovascular and cerebrovascular diseases. MDSCs in hemodialysis patients showed enhanced recruitment to atherosclerotic lesions and promoted the migration of endothelial cells through depletion of local L-arginine. Plasma levels of IFN-gamma, TNF-alpha, and IL-6 were elevated in hemodialysis patients compared to healthy controls, with MDSC levels positively correlated with IL-6 levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Yoshiaki Nagatani, Yohei Funakoshi, Hirotaka Suto, Yoshinori Imamura, Masanori Toyoda, Naomi Kiyota, Kimihiro Yamashita, Hironobu Minami
Summary: MDSC are divided into M-MDSC, G-MDSC, and I-MDSC subsets, with M-MDSC and G-MDSC suppressing T cell activation while I-MDSC has no suppressive effect. High levels of IL-1RA and arginase were detected in M-MDSC and G-MDSC cultures, with no inhibitory molecules found in I-MDSC cultures. The population of functional MDSC was significantly increased in cancer patients compared to healthy donors.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2021)
Article
Medical Laboratory Technology
Ari Ahn, Chan-Jeoung Park, Min-sun Kim, Young-Uk Cho, Seongsoo Jang, Mi Hyun Bae, Jung-Hee Lee, Je-Hwan Lee, Kyung-Nam Koh, Ho Joon Im
Summary: Myeloid-derived suppressor cells (MDSCs) are heterogeneous populations that suppress tumor-specific T-cell responses and are increased in several hematologic malignancies, including chronic myeloid leukemia (CML). In CML patients, differences in levels and prognostic significance of MDSCs are evaluated according to clinical status. High levels of peripheral blood granulocytic MDSCs (gMDSCs) are associated with better prognosis, while monocytic MDSCs (mMDSCs) may be related to malignant conditions and poor prognosis.
ANNALS OF LABORATORY MEDICINE
(2021)
Article
Immunology
Miriam Simon-Fuentes, Silvia Sanchez-Ramon, Lidia Fernandez-Paredes, Barbara Alonso, Kissy Guevara-Hoyer, Miguel A. Vega, Angel L. Corbi, Angeles Dominguez-Soto
Summary: Common variable immunodeficiency disorders (CVID) is a primary immune deficiency characterized by hypogammaglobulinemia and impaired antibody responses. Intravenous Immunoglobulin (IVIg), a preparation of highly purified poly-specific IgG, exerts immunoregulatory and anti-inflammatory actions on peripheral blood monocytes, leading to an acquisition of an anti-inflammatory gene profile and altered proportions of monocyte subsets. CD14+ MDSC-like cells may contribute to the immunoregulatory effects of IVIg in CVID and other inflammatory disorders.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Sara Falck-Jones, Sindhu Vangeti, Meng Yu, Ryan Falck-Jones, Alberto Cagigi, Isabella Badolati, Bjorn Osterberg, Maximilian Julius Lautenbach, Eric Ahlberg, Ang Lin, Rico Lepzien, Inga Szurgot, Klara Lenart, Fredrika Hellgren, Holden Maecker, Jorgen Salde, Jan Albert, Niclas Johansson, Max Bell, Karin Lore, Anna Farnert, Anna Smed-Sorensen
Summary: The frequency of M-MDSCs is elevated in the blood of patients with COVID-19, suppressing T cells and strongly associated with disease severity.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemical Research Methods
Minghan Chen, Brandon D. Amos, Layne T. Watson, John J. Tyson, Young Cao, Clifford A. Shaffer, Michael W. Trosset, Cihan Oguz, Gisella Kakoti
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
(2019)
Article
Biochemistry & Molecular Biology
Chu Chen, Ian P. Whitney, Anand Banerjee, Carlos Sacristan, Palak Sekhri, David M. Kern, Adrienne Fontan, Geert J. P. L. Kops, John J. Tyson, Iain M. Cheeseman, Ajit P. Joglekar
Article
Biology
John J. Tyson, Teeraphan Laomettachit, Pavel Kraikivski
JOURNAL OF THEORETICAL BIOLOGY
(2019)
Article
Biochemical Research Methods
Mansooreh Ahmadian, John J. Tyson, Yang Cao
BMC BIOINFORMATICS
(2019)
Review
Oncology
Robert Clarke, John J. Tyson, Ming Tan, William T. Baumann, Lu Jin, Jianhua Xuan, Yue Wang
ENDOCRINE-RELATED CANCER
(2019)
Article
Mathematical & Computational Biology
Jenna E. Gallegos, Neil R. Adames, Mark F. Rogers, Pavel Kraikivski, Aubrey Ibele, Kevin Nurzynski-Loth, Eric Kudlow, T. M. Murali, John J. Tyson, Jean Peccoud
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
(2020)
Article
Biochemical Research Methods
Chunrui Xu, Bronson R. Weston, John J. Tyson, Yang Cao
BMC BIOINFORMATICS
(2020)
Review
Biochemical Research Methods
Jae Kyoung Kim, John J. Tyson
PLOS COMPUTATIONAL BIOLOGY
(2020)
Review
Cell Biology
Bela Novak, John J. Tyson
Summary: Cells must delay progression in the replication-division cycle if threats to genome integrity are detected; once they decide to continue, cells enter a qualitatively different biochemical state, making transitions between cell cycle phases irreversible and switch-like; different cell cycle phases are controlled by unique signalling networks, yet they exhibit bistable behavior as a hallmark of molecular memory devices.
CURRENT OPINION IN CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Bronson R. Weston, John J. Tyson, Yang Cao
Summary: The phosphorylated CtrA can displace the CtrA similar to P on Cori to inhibit DNA replication. Model analysis reveals that this mechanism allows for a faster transition into S phase, stabilizes the timing of chromosome replication, and improves the viability of various mutant strains.
Article
Biochemical Research Methods
Xiangyu Yao, Benjamin L. Heidebrecht, Jing Chen, John J. Tyson
Summary: This paper explores mathematical models of genetic oscillators based on transcription-translation feedback and investigates modifications to improve the accuracy of the models. The study relaxes constraints by introducing multistep reaction chains and replacing rate laws, resulting in more realistic parameter values. Additionally, the addition of a supplementary positive feedback loop enhances the robustness of the oscillations. The results provide testable predictions for future experimental studies.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Mathematics, Applied
Dorjsuren Battogtokh, John J. Tyson
Summary: Shoot apical meristems (SAMs) are responsible for the development of above-ground tissues in plants. The growth and expansion of SAMs rely on the division of stem cells in a central zone, which is regulated by a transcription factor called WUSCHEL. WUSCHEL is self-activating and downregulated by a signaling pathway involving CLAVATA proteins. While most mathematical models of stem cell confinement in the SAM rely on Turing's mechanism, this study proposes a bistable-switch model based on interactions between WUSCHEL and CLAVATA. Comparisons between the two mechanisms demonstrate that the bistable-switch provides a better explanation for the nucleation and confinement of stem cells.
Article
Biology
Rajat Singhania, John J. Tyson
Summary: When a perfume is released in a room, the initial occupants will smell it but become desensitized after a few minutes, while newcomers can still smell it. This adaptation behavior is studied in this paper, which focuses on the molecular basis behind it using an evolutionary search approach.
Review
Biology
John J. Tyson, Bela Novak
Summary: Cell growth, DNA replication, mitosis, and division are fundamental processes for passing on life. The eukaryotic cell cycle is a periodic process that plays a crucial role in maintaining the integrity of the genome. Key factors in cell cycle control include mitosis promoting factor and cyclin-dependent kinases.
Article
Mathematical & Computational Biology
Mansooreh Ahmadian, John J. Tyson, Jean Peccoud, Yang Cao
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
(2020)