Extracellular Vesicles in Cancer Immune Microenvironment and Cancer Immunotherapy

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

(2019) Mauro Poggio et al.   CELL

Explicating Exosomes: Reclassifying the Rising Stars of Intercellular Communication

(2019) Stefano Pluchino et al.   CELL

Reassessment of Exosome Composition

(2019) Dennis K. Jeppesen et al.   CELL

Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity

(2019) Arash Latifkar et al.   DEVELOPMENTAL CELL

Exosomes

(2019) D. Michiel Pegtel et al.   Annual Review of Biochemistry

PD-1 Blockade Cellular Vesicles for Cancer Immunotherapy

(2018) Xudong Zhang et al.   ADVANCED MATERIALS

NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo

(2018) Gang Jia et al.   BIOMATERIALS

Is the DNA of placental origin packaged in exosomes isolated from plasma and serum of pregnant women?

(2018) Gabriela Repiská et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Regulation and Function of the PD-L1 Checkpoint

(2018) Chong Sun et al.   IMMUNITY

Size matters in nanoscale communication

(2018) Andries Zijlstra et al.   NATURE CELL BIOLOGY

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

(2018) Haiying Zhang et al.   NATURE CELL BIOLOGY

Tumor-derived exosomes antagonize innate antiviral immunity

(2018) Liang Gao et al.   NATURE IMMUNOLOGY

Extracellular vesicles in cancer — implications for future improvements in cancer care

(2018) Rong Xu et al.   Nature Reviews Clinical Oncology

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activated CD8+ T cell extracellular vesicles prevent tumour progression by targeting of lesional mesenchymal cells

(2018) Naohiro Seo et al.   Nature Communications

Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts

(2018) Daniel Torralba et al.   Nature Communications

Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246

(2018) Tomer Cooks et al.   Nature Communications

Exosomes Shuttle TREX1-Sensitive IFN-Stimulatory dsDNA from Irradiated Cancer Cells to DCs

(2018) Julie M. Diamond et al.   Cancer Immunology Research

Exosomes derived from hypoxic epithelial ovarian cancer cells deliver microRNAs to macrophages and elicit a tumor-promoted phenotype

(2018) Xin Chen et al.   CANCER LETTERS

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation

(2017) Seongmin Yoon et al.   IMMUNITY

Role of Lymphocyte Subsets in the Immune Response to Primary B Cell–Derived Exosomes

(2017) Sarah C. Saunderson et al.   JOURNAL OF IMMUNOLOGY

Novel nanosensing technologies for exosome detection and profiling

(2017) Hyungsoon Im et al.   LAB ON A CHIP

Exosomes from M1-Polarized Macrophages Potentiate the Cancer Vaccine by Creating a Pro-inflammatory Microenvironment in the Lymph Node

(2017) Lifang Cheng et al.   MOLECULAR THERAPY

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression

(2017) Fengmei Pi et al.   Nature Nanotechnology

Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

(2017) Pasquale Sansone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipids in exosomes: Current knowledge and the way forward

(2017) Tore Skotland et al.   PROGRESS IN LIPID RESEARCH

T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition

(2017) Enfu Hui et al.   SCIENCE

Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23

(2017) Yao Wei et al.   Nature Communications

Exosomes maintain cellular homeostasis by excreting harmful DNA from cells

(2017) Akiko Takahashi et al.   Nature Communications

Progress in Exosome Isolation Techniques

(2017) Pin Li et al.   Theranostics

Impact of lysosome status on extracellular vesicle content and release

(2016) Erez Eitan et al.   AGEING RESEARCH REVIEWS

Exosome-based tumor antigens–adjuvant co-delivery utilizing genetically engineered tumor cell-derived exosomes with immunostimulatory CpG DNA

(2016) Masaki Morishita et al.   BIOMATERIALS

Tumor Exosomal RNAs Promote Lung Pre-metastatic Niche Formation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils

(2016) Yanfang Liu et al.   CANCER CELL

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

(2016) Annette Becker et al.   CANCER CELL

Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA

(2016) Le Qu et al.   CANCER CELL

Wnt5b-associated exosomes promote cancer cell migration and proliferation

(2016) Takeshi Harada et al.   CANCER SCIENCE

The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity

(2016) Toshiro Moroishi et al.   CELL

Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles

(2016) Jingwei Ma et al.   CELL RESEARCH

Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4+T-cell responses

(2016) Yingping Xu et al.   IMMUNOLOGY

Prostasomes as a source of diagnostic biomarkers for prostate cancer

(2016) Carla Zijlstra et al.   JOURNAL OF CLINICAL INVESTIGATION

Exosomes and tumor-mediated immune suppression

(2016) Theresa L. Whiteside   JOURNAL OF CLINICAL INVESTIGATION

Extracellular vesicle isolation and characterization: toward clinical application

(2016) Rong Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

The biology and function of exosomes in cancer

(2016) Raghu Kalluri   JOURNAL OF CLINICAL INVESTIGATION

Donor dendritic cell–derived exosomes promote allograft-targeting immune response

(2016) Quan Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Extracellular vesicles: masters of intercellular communication and potential clinical interventions

(2016) Jonathan M. Pitt et al.   JOURNAL OF CLINICAL INVESTIGATION

Nano carriers for drug transport across the blood–brain barrier

(2016) Xinming Li et al.   JOURNAL OF DRUG TARGETING

ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins

(2016) Carolina Villarroya-Beltri et al.   Nature Communications

Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1

(2016) Chi Lam Au Yeung et al.   Nature Communications

Exosomes derived from gefitinib-treated EGFR-mutant lung cancer cells alter cisplatin sensitivity via up-regulating autophagy

(2016) Xiao-Qiu Li et al.   Oncotarget

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

(2016) Hongyun Zhao et al.   eLife

Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

(2016) Dinh Ha et al.   Acta Pharmaceutica Sinica B

Digital Detection of Exosomes by Interferometric Imaging

(2016) George G. Daaboul et al.   Scientific Reports

Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes

(2016) Yongchao Dou et al.   Scientific Reports

Diagnostic and therapeutic potentials of exosomes in CNS diseases

(2015) Ivana Kawikova et al.   BRAIN RESEARCH

A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion

(2015) Yuxuan Miao et al.   CELL

Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis

(2015) Yan Li et al.   CELL RESEARCH

Macrophages play an essential role in antigen-specific immune suppression mediated by T CD8+cell-derived exosomes

(2015) Katarzyna Nazimek et al.   IMMUNOLOGY

The lack of type I interferon induces neutrophil-mediated pre-metastatic niche formation in the mouse lung

(2015) Ching-Fang Wu et al.   INTERNATIONAL JOURNAL OF CANCER

ESCRT-0 marks an APPL1-independent transit route for EGFR between the cell surface and the EEA1-positive early endosome

(2015) N. Flores-Rodriguez et al.   JOURNAL OF CELL SCIENCE

Immunosuppressive cells in tumor immune escape and metastasis

(2015) Yang Liu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

(2015) Lin Zhang et al.   NATURE

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

(2015) Sonia A. Melo et al.   NATURE

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

(2015) Seth B. Coffelt et al.   NATURE

YAP and TAZ: a nexus for Hippo signaling and beyond

(2015) Carsten Gram Hansen et al.   TRENDS IN CELL BIOLOGY

Immunosuppression of breast cancer cells mediated by transforming growth factor-β in exosomes from cancer cells

(2015) LEI RONG et al.   Oncology Letters

Exosome-delivered microRNAs modulate the inflammatory response to endotoxin

(2015) Margaret Alexander et al.   Nature Communications

Rab27A regulates exosome secretion from lung adenocarcinoma cells A549: involvement of EPI64

(2014) Wenhai Li et al.   APMIS

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

(2014) Basant Kumar Thakur et al.   CELL RESEARCH

Pancreatic cancer genomics

(2014) David K Chang et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 Cells

(2014) Isobel S. Okoye et al.   IMMUNITY

Identification of Double-stranded Genomic DNA Spanning All Chromosomes with MutatedKRASandp53DNA in the Serum Exosomes of Patients with Pancreatic Cancer

(2014) Christoph Kahlert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Tumor-Derived Exosomes Down-Modulate NKG2D Expression

(2014) A. Clayton et al.   JOURNAL OF IMMUNOLOGY

Hsp70 Translocates into the Plasma Membrane after Stress and Is Released into the Extracellular Environment in a Membrane-Associated Form that Activates Macrophages

(2014) V. L. Vega et al.   JOURNAL OF IMMUNOLOGY

Exosomes As a Short-Range Mechanism to Spread Alloantigen between Dendritic Cells during T Cell Allorecognition

(2014) A. Montecalvo et al.   JOURNAL OF IMMUNOLOGY

Human Urinary Exosomes as Innate Immune Effectors

(2014) T. F. Hiemstra et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A small noncoding RNA signature found in exosomes of GBM patient serum as a diagnostic tool

(2014) Lorea Manterola et al.   NEURO-ONCOLOGY

Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes

(2014) J P Webber et al.   ONCOGENE

Prostate Tumor-Derived Exosomes Down-Regulate NKG2D Expression on Natural Killer Cells and CD8+ T Cells: Mechanism of Immune Evasion

(2014) Marie Lundholm et al.   PLoS One

Immune modulation of T-cell and NK (natural killer) cell activities by TEXs (tumour-derived exosomes)

(2013) Theresa L. Whiteside   BIOCHEMICAL SOCIETY TRANSACTIONS

Molecular lipidomics of exosomes released by PC-3 prostate cancer cells

(2013) Alicia Llorente et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Current methods for the isolation of extracellular vesicles

(2013) Fatemeh Momen-Heravi et al.   BIOLOGICAL CHEMISTRY

MicroRNA-containing microvesicles regulating inflammation in association with atherosclerotic disease

(2013) Maarten Hulsmans et al.   CARDIOVASCULAR RESEARCH

Essential N-Terminal Insertion Motif Anchors the ESCRT-III Filament during MVB Vesicle Formation

(2013) Nicholas J. Buchkovich et al.   DEVELOPMENTAL CELL

CD73 expression on extracellular vesicles derived from CD4+CD25+Foxp3+T cells contributes to their regulatory function

(2013) Lesley Ann Smyth et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1

(2013) Katrin J. Svensson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis

(2013) Jonathan Cools-Lartigue et al.   JOURNAL OF CLINICAL INVESTIGATION

Exosomes Derived from Epstein-Barr Virus-Infected Cells Are Internalized via Caveola-Dependent Endocytosis and Promote Phenotypic Modulation in Target Cells

(2013) A. Nanbo et al.   JOURNAL OF VIROLOGY

Defining the Protein–Protein Interaction Network of the Human Hippo Pathway

(2013) Wenqi Wang et al.   MOLECULAR & CELLULAR PROTEOMICS

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

(2013) Randy Johnson et al.   NATURE REVIEWS DRUG DISCOVERY

Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma

(2013) Hina Kalra et al.   PROTEOMICS

The Hippo Signaling Pathway Interactome

(2013) Y. Kwon et al.   SCIENCE

Protein Interaction Network of the Mammalian Hippo Pathway Reveals Mechanisms of Kinase-Phosphatase Interactions

(2013) A. L. Couzens et al.   Science Signaling

Exosome Secretion Is Enhanced by Invadopodia and Drives Invasive Behavior

(2013) Daisuke Hoshino et al.   Cell Reports

Hijacking Multivesicular Bodies Enables Long-Term and Exosome-Mediated Long-Distance Action of Anthrax Toxin

(2013) Laurence Abrami et al.   Cell Reports

Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials

(2012) Alexander V. Vlassov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Changes in circulating microRNA levels associated with prostate cancer

(2012) R J Bryant et al.   BRITISH JOURNAL OF CANCER

Rab27a Supports Exosome-Dependent and -Independent Mechanisms That Modify the Tumor Microenvironment and Can Promote Tumor Progression

(2012) A. Bobrie et al.   CANCER RESEARCH

Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases

(2012) Shashi Bala et al.   HEPATOLOGY

Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2

(2012) Tadashi Yokosuka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immune Surveillance Properties of Human NK Cell-Derived Exosomes

(2012) L. Lugini et al.   JOURNAL OF IMMUNOLOGY

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Metastatic Pancreatic Cancer Is Dependent on Oncogenic Kras in Mice

(2012) Meredith A. Collins et al.   PLoS One

Drosophila S2 Cells Secrete Wingless on Exosome-Like Vesicles but the Wingless Gradient Forms Independently of Exosomes

(2012) Karen Beckett et al.   TRAFFIC

Interaction and uptake of exosomes by ovarian cancer cells

(2011) Cristina Escrevente et al.   BMC CANCER

Immunosuppressive exosomes from TGF-β1 gene-modified dendritic cells attenuate Th17-mediated inflammatory autoimmune disease by inducing regulatory T cells

(2011) Zhijian Cai et al.   CELL RESEARCH

Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy

(2011) Viktoriya Sokolova et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

(2011) D. Fitzner et al.   JOURNAL OF CELL SCIENCE

Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis

(2011) Rebecca A. Dragovic et al.   Nanomedicine-Nanotechnology Biology and Medicine

Cross-dressed dendritic cells drive memory CD8+ T-cell activation after viral infection

(2011) Linda M. Wakim et al.   NATURE

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

ExoCarta 2012: database of exosomal proteins, RNA and lipids

(2011) S. Mathivanan et al.   NUCLEIC ACIDS RESEARCH

Characterization of extracellular circulating microRNA

(2011) Andrey Turchinovich et al.   NUCLEIC ACIDS RESEARCH

Exosomes/microvesicles: mediators of cancer-associated immunosuppressive microenvironments

(2011) Douglas D. Taylor et al.   Seminars in Immunopathology

Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences

(2011) Leonora Balaj et al.   Nature Communications

Survivin is released from cancer cells via exosomes

(2010) Salma Khan et al.   APOPTOSIS

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

(2010) Sonja I Buschow et al.   IMMUNOLOGY AND CELL BIOLOGY

Dendritic Cells Recruit T Cell Exosomes via Exosomal LFA-1 Leading to Inhibition of CD8+ CTL Responses through Downregulation of Peptide/MHC Class I and Fas Ligand-Mediated Cytotoxicity

(2010) Y. Xie et al.   JOURNAL OF IMMUNOLOGY

Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins

(2010) Caroline Subra et al.   JOURNAL OF LIPID RESEARCH

Exosomes: Extracellular organelles important in intercellular communication

(2010) Suresh Mathivanan et al.   Journal of Proteomics

Cellular Internalization of Exosomes Occurs Through Phagocytosis

(2010) Du Feng et al.   TRAFFIC

Membrane Protein Targeting to the MVB/Lysosome

(2009) Brian A. Davies et al.   CHEMICAL REVIEWS

Exosomes – vesicular carriers for intercellular communication

(2009) Mikael Simons et al.   CURRENT OPINION IN CELL BIOLOGY

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

(2009) Ethan M. Shevach   IMMUNITY

ESCRT ubiquitin-binding domains function cooperatively during MVB cargo sorting

(2009) S. Brookhart Shields et al.   JOURNAL OF CELL BIOLOGY

Membrane-bound HSP70-engineered myeloma cell-derived exosomes stimulate more efficient CD8+ CTL- and NK-mediated antitumour immunity than exosomes released from heat-shocked tumour cells expressing cytoplasmic HSP70

(2009) Yufeng Xie et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Tumor-Derived Microvesicles Promote Regulatory T Cell Expansion and Induce Apoptosis in Tumor-Reactive Activated CD8+ T Lymphocytes

(2009) E. U. Wieckowski et al.   JOURNAL OF IMMUNOLOGY

Astrocytes and Glioblastoma cells release exosomes carrying mtDNA

(2009) Michele Guescini et al.   JOURNAL OF NEURAL TRANSMISSION

Proteomics Analysis of A33 Immunoaffinity-purified Exosomes Released from the Human Colon Tumor Cell Line LIM1215 Reveals a Tissue-specific Protein Signature

(2009) Suresh Mathivanan et al.   MOLECULAR & CELLULAR PROTEOMICS

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Exosomes from human saliva as a source of microRNA biomarkers

(2009) A Michael et al.   ORAL DISEASES

Activated T cells recruit exosomes secreted by dendritic cells via LFA-1

(2008) E. N. M. Nolte-'t Hoen et al.   BLOOD

Targeting Tumor Antigens to Secreted Membrane Vesicles In vivo Induces Efficient Antitumor Immune Responses

(2008) I. S. Zeelenberg et al.   CANCER RESEARCH

MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer

(2008) Douglas D. Taylor et al.   GYNECOLOGIC ONCOLOGY

Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes

(2008) Javier Conde-Vancells et al.   JOURNAL OF PROTEOME RESEARCH

A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

(2008) Yongzhong Liu et al.   NATURE IMMUNOLOGY

Structural heterogeneity and protein composition of exosome-like vesicles (prostasomes) in human semen

(2008) Anton Poliakov et al.   PROSTATE

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE