Role and mechanism of ROS scavengers in alleviating NLRP3-mediated inflammation

Hypoxia potentiates LPS-induced inflammatory response and increases cell death by promoting NLRP3 inflammasome activation in pancreatic β cells

(2018) Cheng Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Peperomin E (PepE) protects against high fat diet-induced atherosclerosis in Apolipoprotein E deficient (ApoE −/− ) mice through reducing inflammation via the suppression of NLRP3 signaling pathway

(2018) Jin Yan et al.   BIOMEDICINE & PHARMACOTHERAPY

Involvement of NLRP3 inflammasome in the impacts of sodium and potassium on insulin resistance in normotensive Asians

(2018) Zhaofei Wan et al.   BRITISH JOURNAL OF NUTRITION

Control release of mitochondria-targeted antioxidant by injectable self-assembling peptide hydrogel ameliorated persistent mitochondrial dysfunction and inflammation after acute kidney injury

(2018) Meng Zhao et al.   DRUG DELIVERY

Troxerutin Protects Kidney Tissue against BDE-47-Induced Inflammatory Damage through CXCR4-TXNIP/NLRP3 Signaling

(2018) Qun Shan et al.   Oxidative Medicine and Cellular Longevity

Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis

(2018) Xianxian Wu et al.   Cell Death & Disease

Melatonin Treatment Regulates SIRT3 Expression in Early Brain Injury (EBI) Due to Reactive Oxygen Species (ROS) in a Mouse Model of Subarachnoid Hemorrhage (SAH)

(2018) Song Yang et al.   MEDICAL SCIENCE MONITOR

The Antioxidant Procyanidin Reduces Reactive Oxygen Species Signaling in Macrophages and Ameliorates Experimental Colitis in Mice

(2018) Lu Chen et al.   Frontiers in Immunology

X-11-5-27, a daidzein derivative, inhibits NLRP3 inflammasome activity via promoting autophagy

(2017) Wei Zhou et al.   EXPERIMENTAL CELL RESEARCH

Quercetin suppresses NLRP3 inflammasome activation in epithelial cells triggered by Escherichia coli O157:H7

(2017) Yansong Xue et al.   FREE RADICAL BIOLOGY AND MEDICINE

Irisin Alleviates Advanced Glycation End Products-Induced Inflammation and Endothelial Dysfunction via Inhibiting ROS-NLRP3 Inflammasome Signaling

(2017) Xian Deng et al.   INFLAMMATION

Quercetin and Ascorbic Acid Suppress Fructose-Induced NLRP3 Inflammasome Activation by Blocking Intracellular Shuttling of TXNIP in Human Macrophage Cell Lines

(2017) Jung-Yoon Choe et al.   INFLAMMATION

Melatonin application in targeting oxidative-induced liver injuries: A review

(2017) Keywan Mortezaee et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Involvement of c-Abl Kinase in Microglial Activation of NLRP3 Inflammasome and Impairment in Autolysosomal System

(2017) Vivek Lawana et al.   Journal of Neuroimmune Pharmacology

Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and/or NF-κB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway

(2017) Jun Zeng et al.   Journal of Neuroinflammation

Melatonin alleviates cadmium-induced liver injury by inhibiting the TXNIP-NLRP3 inflammasome

(2017) Zhengwang Cao et al.   JOURNAL OF PINEAL RESEARCH

Activation of NLRP3 inflammasomes contributes to hyperhomocysteinemia-aggravated inflammation and atherosclerosis in apoE-deficient mice

(2017) Renqing Wang et al.   LABORATORY INVESTIGATION

Autophagy and inflammasomes

(2017) James Harris et al.   MOLECULAR IMMUNOLOGY

Dandelion extract suppresses reactive oxidative species and inflammasome in intestinal epithelial cells

(2017) Yansong Xue et al.   Journal of Functional Foods

Melatonin-mediated mitophagy protects against early brain injury after subarachnoid hemorrhage through inhibition of NLRP3 inflammasome activation

(2017) Shenglong Cao et al.   Scientific Reports

Canonical and Non-Canonical Activation of NLRP3 Inflammasome at the Crossroad between Immune Tolerance and Intestinal Inflammation

(2017) Carolina Pellegrini et al.   Frontiers in Immunology

Angiotensin-(1–7) Improves Liver Fibrosis by Regulating the NLRP3 Inflammasome via Redox Balance Modulation

(2016) Shuang-Ming Cai et al.   ANTIOXIDANTS & REDOX SIGNALING

3-(2-Oxo-2-phenylethylidene)-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one (compound 1), a novel potent Nrf2/ARE inducer, protects against DSS-induced colitis via inhibiting NLRP3 inflammasome

(2016) Yajing Wang et al.   BIOCHEMICAL PHARMACOLOGY

Dimethyl fumarate ameliorates dextran sulfate sodium-induced murine experimental colitis by activating Nrf2 and suppressing NLRP3 inflammasome activation

(2016) Xiuting Liu et al.   BIOCHEMICAL PHARMACOLOGY

Effect of extremely low-frequency electromagnetic fields on antioxidant activity in the human keratinocyte cell line NCTC 2544

(2016) Cinzia Calcabrini et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Angiotensin(1–7) attenuated Angiotensin II-induced hepatocyte EMT by inhibiting NOX-derived H 2 O 2 -activated NLRP3 inflammasome/IL-1β/Smad circuit

(2016) Li-Li Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

A low toxicity synthetic cinnamaldehyde derivative ameliorates renal inflammation in mice by inhibiting NLRP3 inflammasome and its related signaling pathways

(2016) Shuk-Man Ka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive oxygen species induce virus-independent MAVS oligomerization in systemic lupus erythematosus

(2016) Iwona A. Buskiewicz et al.   Science Signaling

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ameliorative effects of hispidulin on high glucose-mediated endothelial dysfunction via inhibition of PKCβII-associated NLRP3 inflammasome activation and NF-κB signaling in endothelial cells

(2016) Weiwei Qin et al.   Journal of Functional Foods

Protective effect of different flavonoids against endothelial senescence via NLRP3 inflammasome

(2016) Chunhui Sun et al.   Journal of Functional Foods

Reactive oxygen species induce virus-independent MAVS oligomerization in systemic lupus erythematosus

(2016) Iwona A. Buskiewicz et al.   Science Signaling

Cinnamaldehyde and allopurinol reduce fructose-induced cardiac inflammation and fibrosis by attenuating CD36-mediated TLR4/6-IRAK4/1 signaling to suppress NLRP3 inflammasome activation

(2016) Lin-Lin Kang et al.   Scientific Reports

Stabilization of endogenous Nrf2 by minocycline protects against Nlrp3-inflammasome induced diabetic nephropathy

(2016) Khurrum Shahzad et al.   Scientific Reports

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

(2015) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive Oxygen Species-Induced TXNIP Drives Fructose-Mediated Hepatic Inflammation and Lipid Accumulation Through NLRP3 Inflammasome Activation

(2015) Xian Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

ROS and Autophagy: Interactions and Molecular Regulatory Mechanisms

(2015) Lulu Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Non-transcriptional regulation of NLRP3 inflammasome signaling by IL-4

(2015) Inhwa Hwang et al.   IMMUNOLOGY AND CELL BIOLOGY

Activation of the NLRP3 Inflammasome in Association with Calcium Oxalate Crystal Induced Reactive Oxygen Species in Kidneys

(2015) Sunil Joshi et al.   JOURNAL OF UROLOGY

Mangiferin inhibits endoplasmic reticulum stress-associated thioredoxin-interacting protein/NLRP3 inflammasome activation with regulation of AMPK in endothelial cells

(2015) Junna Song et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Ilexgenin A inhibits endoplasmic reticulum stress and ameliorates endothelial dysfunction via suppression of TXNIP/NLRP3 inflammasome activation in an AMPK dependent manner

(2015) Yi Li et al.   PHARMACOLOGICAL RESEARCH

A novel synthetic derivative of melatonin, 5-hydroxy-2’-isobutyl-streptochlorin (HIS), inhibits inflammatory responses via regulation of TRIF-dependent signaling and inflammasome activation

(2015) Do-Wan Shim et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Citral alleviates an accelerated and severe lupus nephritis model by inhibiting the activation signal of NLRP3 inflammasome and enhancing Nrf2 activation

(2015) Shuk-Man Ka et al.   ARTHRITIS RESEARCH & THERAPY

Helicobacter pylori induces IL-1β and IL-18 production in human monocytic cell line through activation of NLRP3 inflammasome via ROS signaling pathway

(2015) Xiang Li et al.   Pathogens and Disease

A Mitochondrion-Targeted Antioxidant Ameliorates Isoflurane-Induced Cognitive Deficits in Aging Mice

(2015) Jing Wu et al.   PLoS One

TXNIP mediates NLRP3 inflammasome activation in cardiac microvascular endothelial cells as a novel mechanism in myocardial ischemia/reperfusion injury

(2014) Yi Liu et al.   BASIC RESEARCH IN CARDIOLOGY

Quercetin, luteolin and epigallocatechin gallate alleviate TXNIP and NLRP3-mediated inflammation and apoptosis with regulation of AMPK in endothelial cells

(2014) Jianjun Wu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Nod-like Receptor Protein 3 (NLRP3) Inflammasome Activation and Podocyte Injury via Thioredoxin-Interacting Protein (TXNIP) during Hyperhomocysteinemia

(2014) Justine M. Abais et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reactive Oxygen Species Regulate Caspase-11 Expression and Activation of the Non-canonical NLRP3 Inflammasome during Enteric Pathogen Infection

(2014) Christopher R. Lupfer et al.   PLoS Pathogens

Reactive oxygen species at the crossroads of inflammasome and inflammation

(2014) Anantha Harijith et al.   Frontiers in Physiology

Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines

(2013) Amarjargal Dashdorj et al.   BMC Medicine

Effect of N-acetyl cysteine on enterocyte apoptosis and intracellular signalling pathways' response to oxidative stress in weaned piglets

(2013) Lihui Zhu et al.   BRITISH JOURNAL OF NUTRITION

The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

(2013) Naeha Subramanian et al.   CELL

Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation

(2013) Brian J. Bennett et al.   Cell Metabolism

NADPH oxidase derived reactive oxygen species are involved in human neutrophil IL-1β secretion but not in inflammasome activation

(2013) María Laura Gabelloni et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Ruscogenin reduces cerebral ischemic injury via NF-κB-mediated inflammatory pathway in the mouse model of experimental stroke

(2013) Teng Guan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

The Mitochondrial Antiviral Protein MAVS Associates with NLRP3 and Regulates Its Inflammasome Activity

(2013) S. Park et al.   JOURNAL OF IMMUNOLOGY

SirT3 Regulates the Mitochondrial Unfolded Protein Response

(2013) L. Papa et al.   MOLECULAR AND CELLULAR BIOLOGY

S100A8 and S100A9 Induce Cytokine Expression and Regulate the NLRP3 Inflammasome via ROS-Dependent Activation of NF-κB1

(2013) Jean-Christophe Simard et al.   PLoS One

TXNIP shuttling: missing link between oxidative stress and inflammasome activation

(2013) Troy Lane et al.   Frontiers in Physiology

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

Critical functions of priming and lysosomal damage for NLRP3 activation

(2010) Veit Hornung et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

NLRP3 has a sweet tooth

(2010) Beckley K Davis et al.   NATURE IMMUNOLOGY

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Intracellular Shuttling and Mitochondrial Function of Thioredoxin-interacting Protein

(2009) Geetu Saxena et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY