Identification of KCC2 Mutations in Human Epilepsy Suggests Strategies for Therapeutic Transporter Modulation

KCC2 overexpression prevents the paradoxical seizure-promoting action of somatic inhibition

(2019) Vincent Magloire et al.   Nature Communications

Generalizált epilepszia hátterében azonosított ioncsatorna-génmutáció ritka formája

(2019) Ágnes Till et al.   ORVOSI HETILAP

Pharmacological enhancement of KCC2 gene expression exerts therapeutic effects on human Rett syndrome neurons and Mecp2 mutant mice

(2019) Xin Tang et al.   Science Translational Medicine

Potentiating KCC2 activity is sufficient to limit the onset and severity of seizures

(2018) Yvonne E. Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Seizing Control of KCC2: A New Therapeutic Target for Epilepsy

(2017) Yvonne E. Moore et al.   TRENDS IN NEUROSCIENCES

GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl−-sensitive WNK1 kinase

(2017) Martin Heubl et al.   Nature Communications

Discovery and Characterization of Allosteric WNK Kinase Inhibitors

(2016) Ken Yamada et al.   ACS Chemical Biology

Kinase-KCC2 coupling: Cl− rheostasis, disease susceptibility, therapeutic target

(2016) Kristopher T. Kahle et al.   JOURNAL OF NEUROPHYSIOLOGY

Chloride Regulation: A Dynamic Equilibrium Crucial for Synaptic Inhibition

(2016) Nicolas Doyon et al.   NEURON

The KCC2 Cotransporter and Human Epilepsy

(2016) Kristopher T. Kahle et al.   NEUROSCIENTIST

Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition

(2016) Kristopher T. Kahle et al.   Science Signaling

Impaired neuronal KCC2 function by biallelic SLC12A5 mutations in migrating focal seizures and severe developmental delay

(2016) Hirotomo Saitsu et al.   Scientific Reports

Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition

(2016) Kristopher T. Kahle et al.   Science Signaling

Treatment of drug-induced seizures

(2015) Hsien-Yi Chen et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Developmental Expression Patterns of KCC2 and Functionally Associated Molecules in the Human Brain

(2015) Goran Sedmak et al.   CEREBRAL CORTEX

KCC2 regulates actin dynamics in dendritic spines via interaction with β-PIX

(2015) Olaya Llano et al.   JOURNAL OF CELL BIOLOGY

Could tuning of the inhibitory tone involve graded changes in neuronal chloride transport?

(2015) Stefan Titz et al.   NEUROPHARMACOLOGY

WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons

(2015) Perrine Friedel et al.   Science Signaling

Hypoglycemia and risk of seizures: A retrospective cross-sectional study

(2015) Imad Halawa et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures

(2015) Tommy Stödberg et al.   Nature Communications

Seizures and Epilepsy: An Overview for Neuroscientists

(2015) C. E. Stafstrom et al.   Cold Spring Harbor Perspectives in Medicine

WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons

(2015) Perrine Friedel et al.   Science Signaling

Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy

(2014) K. T. Kahle et al.   EMBO REPORTS

A variant of KCC2 from patients with febrile seizures impairs neuronal Cl- extrusion and dendritic spine formation

(2014) M. Puskarjov et al.   EMBO REPORTS

Excitatory Effects of Parvalbumin-Expressing Interneurons Maintain Hippocampal Epileptiform Activity via Synchronous Afterdischarges

(2014) T. J. Ellender et al.   JOURNAL OF NEUROSCIENCE

Cation-chloride cotransporters in neuronal development, plasticity and disease

(2014) Kai Kaila et al.   NATURE REVIEWS NEUROSCIENCE

Chloride extrusion enhancers as novel therapeutics for neurological diseases

(2013) Martin Gagnon et al.   NATURE MEDICINE

Rare copy number variants are an important cause of epileptic encephalopathies

(2011) Heather C. Mefford et al.   ANNALS OF NEUROLOGY

NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor–mediated currents

(2011) Henry H C Lee et al.   NATURE NEUROSCIENCE

Sites of Regulated Phosphorylation that Control K-Cl Cotransporter Activity

(2009) Jesse Rinehart et al.   CELL

The Potassium Chloride Cotransporter KCC-2 Coordinates Development of Inhibitory Neurotransmission and Synapse Structure in Caenorhabditis elegans

(2009) J. E. Tanis et al.   JOURNAL OF NEUROSCIENCE

When drugs and surgery don’t work

(2008) Gregory D. Cascino   EPILEPSIA

Cognitive Effects of Antiepileptic Drugs

(2008) Sung-Pa Park et al.   Journal of Clinical Neurology

Seizures in adults with bacterial meningitis

(2008) E. Zoons et al.   NEUROLOGY