WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+–Cl−co-transporters

(2014) Paola de los Heros et al.   BIOCHEMICAL JOURNAL

Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy

(2014) K. T. Kahle et al.   EMBO REPORTS

A variant of KCC2 from patients with febrile seizures impairs neuronal Cl- extrusion and dendritic spine formation

(2014) M. Puskarjov et al.   EMBO REPORTS

Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism Pathogenesis in Rodent Offspring

(2014) R. Tyzio et al.   SCIENCE

The WNK-SPAK/OSR1 pathway: Master regulator of cation-chloride cotransporters

(2014) D. R. Alessi et al.   Science Signaling

Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation

(2014) A. T. Piala et al.   Science Signaling

Current view on the functional regulation of the neuronal K+-Cl− cotransporter KCC2

(2014) Igor Medina et al.   Frontiers in Cellular Neuroscience

Physiology of SLC12 transporters: lessons from inherited human genetic mutations and genetically engineered mouse knockouts

(2013) Kenneth B. Gagnon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The SLC12 family of electroneutral cation-coupled chloride cotransporters

(2013) Juan Pablo Arroyo et al.   MOLECULAR ASPECTS OF MEDICINE

Comparative Analysis of the Expression Profile of Wnk1 and Wnk1/Hsn2 Splice Variants in Developing and Adult Mouse Tissues

(2013) Masoud Shekarabi et al.   PLoS One

Modulation of neuronal activity by phosphorylation of the K–Cl cotransporter KCC2

(2013) Kristopher T. Kahle et al.   TRENDS IN NEUROSCIENCES

WNK1/HSN2 Mutation in Human Peripheral Neuropathy Deregulates KCC2 Expression and Posterior Lateral Line Development in Zebrafish (Danio rerio)

(2013) Valérie Bercier et al.   PLoS Genetics

Improved method for efficient imaging of intracellular Cl− with Cl-Sensor using conventional fluorescence setup

(2013) Perrine Friedel et al.   Frontiers in Molecular Neuroscience

WNK kinases and the kidney

(2012) Ewout J. Hoorn et al.   EXPERIMENTAL CELL RESEARCH

Taurine Inhibits K+-Cl−Cotransporter KCC2 to Regulate Embryonic Cl−Homeostasis via With-no-lysine (WNK) Protein Kinase Signaling Pathway

(2012) Koichi Inoue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities

(2012) Lynn M. Boyden et al.   NATURE

The GABA Excitatory/Inhibitory Shift in Brain Maturation and Neurological Disorders

(2012) Yehezkel Ben-Ari et al.   NEUROSCIENTIST

Molecular Physiology of SPAK and OSR1: Two Ste20-Related Protein Kinases Regulating Ion Transport

(2012) Kenneth B. Gagnon et al.   PHYSIOLOGICAL REVIEWS

A glial origin for periventricular nodular heterotopia caused by impaired expression of Filamin-A

(2011) Aurelie Carabalona et al.   HUMAN MOLECULAR GENETICS

WNK2 Kinase Is a Novel Regulator of Essential Neuronal Cation-Chloride Cotransporters

(2011) Jesse Rinehart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Knocking down of the KCC2 in rat hippocampal neurons increases intracellular chloride concentration and compromises neuronal survival

(2011) Christophe Pellegrino et al.   JOURNAL OF PHYSIOLOGY-LONDON

NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor–mediated currents

(2011) Henry H C Lee et al.   NATURE NEUROSCIENCE

Enhanced synaptic activity and epileptiform events in the embryonic KCC2 deficient hippocampus

(2011) Ilgam Khalilov   Frontiers in Cellular Neuroscience

Genetically encoded Cl-Sensor as a tool for monitoring of Cl-dependent processes in small neuronal compartments

(2010) Tatyana Waseem et al.   JOURNAL OF NEUROSCIENCE METHODS

Pathophysiological roles of WNK kinases in the kidney

(2010) Shinichi Uchida   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Chloride channelopathies

(2009) Rosa Planells-Cases et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Sites of Regulated Phosphorylation that Control K-Cl Cotransporter Activity

(2009) Jesse Rinehart et al.   CELL

A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene

(2009) Ji Luo et al.   CELL

WNK kinases and blood pressure control

(2009) Staci L. Deaton et al.   CURRENT HYPERTENSION REPORTS

Cation-Chloride Cotransporters and Neuronal Function

(2009) Peter Blaesse et al.   NEURON

NKCC1 and KCC2 prevent hyperexcitability in the mouse hippocampus

(2008) Lei Zhu et al.   EPILEPSY RESEARCH

Molecular Physiology of the WNK Kinases

(2007) Kristopher T. Kahle et al.   Annual Review of Physiology