Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition
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Title
Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition
Authors
Keywords
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Journal
Science Signaling
Volume 9, Issue 421, Pages ra32-ra32
Publisher
American Association for the Advancement of Science (AAAS)
Online
2016-03-30
DOI
10.1126/scisignal.aad0163
References
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Related references
Note: Only part of the references are listed.- Could tuning of the inhibitory tone involve graded changes in neuronal chloride transport?
- (2015) Stefan Titz et al. NEUROPHARMACOLOGY
- WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons
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- WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons
- (2015) Perrine Friedel et al. Science Signaling
- The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+–Cl−co-transporters
- (2014) Paola de los Heros et al. BIOCHEMICAL JOURNAL
- The WNK-SPAK/OSR1 pathway: Master regulator of cation-chloride cotransporters
- (2014) D. R. Alessi et al. Science Signaling
- Kinase Drug Discovery – What’s Next in the Field?
- (2013) Philip Cohen et al. ACS Chemical Biology
- Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy
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- Chloride extrusion enhancers as novel therapeutics for neurological diseases
- (2013) Martin Gagnon et al. NATURE MEDICINE
- Comparative Analysis of the Expression Profile of Wnk1 and Wnk1/Hsn2 Splice Variants in Developing and Adult Mouse Tissues
- (2013) Masoud Shekarabi et al. PLoS One
- Deconstructing the Neuropathic Pain Phenotype to Reveal Neural Mechanisms
- (2012) Christian A. von Hehn et al. NEURON
- TRPV1 is important for mechanical and heat sensitivity in uninjured animals and development of heat hypersensitivity after muscle inflammation
- (2012) Roxanne Y. Walder et al. PAIN
- Peripheral nerve injury produces a sustained shift in the balance between glutamate release and uptake in the dorsal horn of the spinal cord
- (2012) Perrine Inquimbert et al. PAIN
- Sites of Regulated Phosphorylation that Control K-Cl Cotransporter Activity
- (2009) Jesse Rinehart et al. CELL
- T-Cell Infiltration and Signaling in the Adult Dorsal Spinal Cord Is a Major Contributor to Neuropathic Pain-Like Hypersensitivity
- (2009) M. Costigan et al. JOURNAL OF NEUROSCIENCE
- The Prevalence and Impact of Chronic Pain with Neuropathic Pain Symptoms in the General Population
- (2009) Cory Toth et al. PAIN MEDICINE
- Molecular Physiology of the WNK Kinases
- (2007) Kristopher T. Kahle et al. Annual Review of Physiology
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