Cation-chloride cotransporters in neuronal development, plasticity and disease

A novel prodrug-based strategy to increase effects of bumetanide in epilepsy

(2014) Kathrin Töllner et al.   ANNALS OF NEUROLOGY

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+–Cl−co-transporters

(2014) Paola de los Heros et al.   BIOCHEMICAL JOURNAL

Beyond inhibition: GABA synapses tune the neuroendocrine stress axis

(2014) Wataru Inoue et al.   BIOESSAYS

Early GABAergic circuitry in the cerebral cortex

(2014) Heiko J Luhmann et al.   CURRENT OPINION IN NEUROBIOLOGY

Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy

(2014) K. T. Kahle et al.   EMBO REPORTS

Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizures

(2014) Martin Puskarjov et al.   EPILEPSIA

Impairment of kindling development in phospholipase Cγ1 heterozygous mice

(2014) Xiao Ping He et al.   EPILEPSIA

Contributions of the Na+/K+-ATPase, NKCC1, and Kir4.1 to hippocampal K+clearance and volume responses

(2014) Brian Roland Larsen et al.   GLIA

A Novel Regulatory Locus of Phosphorylation in the C Terminus of the Potassium Chloride Cotransporter KCC2 That Interferes withN-Ethylmaleimide or Staurosporine-mediated Activation

(2014) Maren Weber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characteristics of the Cation Cotransporter NKCC1 in Human Brain: Alternate Transcripts, Expression in Development, and Potential Relationships to Brain Function and Schizophrenia

(2014) Y. Morita et al.   JOURNAL OF NEUROSCIENCE

Gephyrin Clusters Are Absent from Small Diameter Primary Afferent Terminals Despite the Presence of GABAA Receptors

(2014) L.-E. Lorenzo et al.   JOURNAL OF NEUROSCIENCE

Inhibition of Carbonic Anhydrase Augments GABAA Receptor-Mediated Analgesia via a Spinal Mechanism of Action

(2014) Marina N. Asiedu et al.   JOURNAL OF PAIN

Erythropoietin attenuates loss of potassium chloride co-transporters following prenatal brain injury

(2014) L.L. Jantzie et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Sensory-evoked synaptic integration in cerebellar and cerebral cortical neurons

(2014) Paul Chadderton et al.   NATURE REVIEWS NEUROSCIENCE

Gephyrin: a master regulator of neuronal function?

(2014) Shiva K. Tyagarajan et al.   NATURE REVIEWS NEUROSCIENCE

Comment on "Local impermeant anions establish the neuronal chloride concentration"

(2014) J. Voipio et al.   SCIENCE

Response to Comments on "Local impermeant anions establish the neuronal chloride concentration"

(2014) J. Glykys et al.   SCIENCE

Local Impermeant Anions Establish the Neuronal Chloride Concentration

(2014) J. Glykys et al.   SCIENCE

The WNK-SPAK/OSR1 pathway: Master regulator of cation-chloride cotransporters

(2014) D. R. Alessi et al.   Science Signaling

Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation

(2014) A. T. Piala et al.   Science Signaling

Kainate Receptors Coexist in a Functional Complex with KCC2 and Regulate Chloride Homeostasis in Hippocampal Neurons

(2014) Vivek Mahadevan et al.   Cell Reports

Physiology of SLC12 transporters: lessons from inherited human genetic mutations and genetically engineered mouse knockouts

(2013) Kenneth B. Gagnon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Enhancing K–Cl co-transport restores normal spinothalamic sensory coding in a neuropathic pain model

(2013) Guillaume Lavertu et al.   BRAIN

Regional differences in the expression of K+–Cl− 2 cotransporter in the developing rat cortex

(2013) Krisztina Kovács et al.   Brain Structure & Function

General anaesthetics do not impair developmental expression of the KCC2 potassium-chloride cotransporter in neonatal rats during the brain growth spurt

(2013) C.-M. Lacoh et al.   BRITISH JOURNAL OF ANAESTHESIA

A Molecular Analysis of the Na+-Independent Cation Chloride Cotransporters

(2013) Kenneth B. Gagnon et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

GABAergic Excitation of Vasopressin Neurons

(2013) Young-Beom Kim et al.   CIRCULATION RESEARCH

GABA actions and ionic plasticity in epilepsy

(2013) Kai Kaila et al.   CURRENT OPINION IN NEUROBIOLOGY

Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures

(2013) Eva Ruusuvuori et al.   EMBO JOURNAL

Treating pathological pain: is KCC2 the key to the gate?

(2013) Nicolas Doyon et al.   Expert Review of Neurotherapeutics

Visualization of Synaptic Inhibition with an Optogenetic Sensor Developed by Cell-Free Protein Engineering Automation

(2013) J. S. Grimley et al.   JOURNAL OF NEUROSCIENCE

Activity-Dependent Regulation of the K/Cl Transporter KCC2 Membrane Diffusion, Clustering, and Function in Hippocampal Neurons

(2013) I. Chamma et al.   JOURNAL OF NEUROSCIENCE

Conditional Disruption of Calpain in the CNS Alters Dendrite Morphology, Impairs LTP, and Promotes Neuronal Survival following Injury

(2013) M. Amini et al.   JOURNAL OF NEUROSCIENCE

NMDA Receptor Activation and Calpain Contribute to Disruption of Dendritic Spines by the Stress Neuropeptide CRH

(2013) Adrienne L. Andres et al.   JOURNAL OF NEUROSCIENCE

Chloride extrusion enhancers as novel therapeutics for neurological diseases

(2013) Martin Gagnon et al.   NATURE MEDICINE

Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl− homeostasis

(2013) Francesco Ferrini et al.   NATURE NEUROSCIENCE

Network state-dependent inhibition of identified hippocampal CA3 axo-axonic cells in vivo

(2013) Tim J Viney et al.   NATURE NEUROSCIENCE

Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction

(2013) Ethan M. Goldberg et al.   NATURE REVIEWS NEUROSCIENCE

Altered rate-dependent depression of the spinal H-reflex as an indicator of spinal disinhibition in models of neuropathic pain

(2013) Corinne A.G. Lee-Kubli et al.   PAIN

Physiology and pathophysiology of SLC12A1/2 transporters

(2013) Nicolas Markadieu et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Neto2 is a KCC2 interacting protein required for neuronal Cl−regulation in hippocampal neurons

(2013) Evgueni A. Ivakine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Compartmentalization of GABAergic Inhibition by Dendritic Spines

(2013) C. Q. Chiu et al.   SCIENCE

Modulation of neuronal activity by phosphorylation of the K–Cl cotransporter KCC2

(2013) Kristopher T. Kahle et al.   TRENDS IN NEUROSCIENCES

A genetically-encoded chloride and pH sensor for dissociating ion dynamics in the nervous system

(2013) Joseph Raimondo   Frontiers in Cellular Neuroscience

KCC2-dependent subcellular ECl difference of ON-OFF retinal ganglion cells in larval zebrafish

(2013) Rong-wei Zhang et al.   Frontiers in Neural Circuits

An unexpected role of neuroligin-2 in regulating KCC2 and GABA functional switch

(2013) Chicheng Sun et al.   Molecular Brain

Microglia Control Neuronal Network Excitability via BDNF Signalling

(2013) Francesco Ferrini et al.   NEURAL PLASTICITY

Interplay between DISC1 and GABA Signaling Regulates Neurogenesis in Mice and Risk for Schizophrenia

(2012) Ju Young Kim et al.   CELL

An Ion Transport-Independent Role for the Cation-Chloride Cotransporter KCC2 in Dendritic Spinogenesis In Vivo

(2012) H. Fiumelli et al.   CEREBRAL CORTEX

Raising cytosolic Cl−in cerebellar granule cells affects their excitability and vestibulo-ocular learning

(2012) Patricia Seja et al.   EMBO JOURNAL

Are you in or out? Leukocyte, ion, and neurotransmitter permeability across the epileptic blood-brain barrier

(2012) Damir Janigro   EPILEPSIA

Stress, seizures, and hypothalamic–pituitary–adrenal axis targets for the treatment of epilepsy

(2012) Jamie Maguire et al.   EPILEPSY & BEHAVIOR

N-Methyl-d-aspartate Receptor- and Calpain-mediated Proteolytic Cleavage of K+-Cl−Cotransporter-2 Impairs Spinal Chloride Homeostasis in Neuropathic Pain

(2012) Hong-Yi Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Taurine Inhibits K+-Cl−Cotransporter KCC2 to Regulate Embryonic Cl−Homeostasis via With-no-lysine (WNK) Protein Kinase Signaling Pathway

(2012) Koichi Inoue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular and functional expression of cation-chloride cotransporters in dorsal root ganglion neurons during postnatal maturation

(2012) Shihong Mao et al.   JOURNAL OF NEUROPHYSIOLOGY

Loss of Neuronal Potassium/Chloride Cotransporter 3 (KCC3) Is Responsible for the Degenerative Phenotype in a Conditional Mouse Model of Hereditary Motor and Sensory Neuropathy Associated with Agenesis of the Corpus Callosum

(2012) M. Shekarabi et al.   JOURNAL OF NEUROSCIENCE

Transcript-Specific Associations of SLC12A5 (KCC2) in Human Prefrontal Cortex with Development, Schizophrenia, and Affective Disorders

(2012) R. Tao et al.   JOURNAL OF NEUROSCIENCE

Activity-Dependent Cleavage of the K-Cl Cotransporter KCC2 Mediated by Calcium-Activated Protease Calpain

(2012) M. Puskarjov et al.   JOURNAL OF NEUROSCIENCE

GABAergic Synaptic Transmission Triggers Action Potentials in Thalamic Reticular Nucleus Neurons

(2012) Y.-G. Sun et al.   JOURNAL OF NEUROSCIENCE

Cortical inhibition, pH and cell excitability in epilepsy: what are optimal targets for antiepileptic interventions?

(2012) Ivan Pavlov et al.   JOURNAL OF PHYSIOLOGY-LONDON

Synchronization and desynchronization in epilepsy: controversies and hypotheses

(2012) Premysl Jiruska et al.   JOURNAL OF PHYSIOLOGY-LONDON

KCC3-dependent chloride extrusion in adult sensory neurons

(2012) Olivier Lucas et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons

(2012) Hawon Cho et al.   NATURE NEUROSCIENCE

Principles Governing the Operation of Synaptic Inhibition in Dendrites

(2012) Albert Gidon et al.   NEURON

Extrasynaptic GABAA Receptors: Their Function in the CNS and Implications for Disease

(2012) Stephen G. Brickley et al.   NEURON

Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments

(2012) Wolfgang Löscher et al.   NEUROPHARMACOLOGY

The Responsiveness of TrkB to BDNF and Antidepressant Drugs Is Differentially Regulated during Mouse Development

(2012) Antonio Di Lieto et al.   PLoS One

Activation of 5-HT2A receptors upregulates the function of the neuronal K-Cl cotransporter KCC2

(2012) R. Bos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical feedback between membrane tension and dynamics

(2012) Nils C. Gauthier et al.   TRENDS IN CELL BIOLOGY

Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmission

(2012) Ingrid Chamma et al.   Frontiers in Cellular Neuroscience

Altered inhibition in tuberous sclerosis and type IIb cortical dysplasia

(2011) Delia M. Talos et al.   ANNALS OF NEUROLOGY

Neuronal chloride accumulation and excitatory GABA underlie aggravation of neonatal epileptiform activities by phenobarbital

(2011) Romain Nardou et al.   BRAIN

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

(2011) Beatrice M Filippi et al.   EMBO JOURNAL

Positive shifts of the GABAA receptor reversal potential due to altered chloride homeostasis is widespread after status epilepticus

(2011) Gleb Barmashenko et al.   EPILEPSIA

Epilepsy as a spectrum disorder: Implications from novel clinical and basic neuroscience

(2011) Frances E. Jensen   EPILEPSIA

Contribution of the potassium-chloride co-transporter KCC2 to the modulation of lumbar spinal networks in mice

(2011) Aurélie Stil et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Identification and functional characterization of rare mutations of the neuroligin-2 gene ( NLGN2 ) associated with schizophrenia

(2011) Chicheng Sun et al.   HUMAN MOLECULAR GENETICS

ClC-2 Channels Regulate Neuronal Excitability, Not Intracellular Chloride Levels

(2011) S. Ratte et al.   JOURNAL OF NEUROSCIENCE

Expression of GABA Signaling Molecules KCC2, NKCC1, and GAD1 in Cortical Development and Schizophrenia

(2011) T. M. Hyde et al.   JOURNAL OF NEUROSCIENCE

Early Growth Response 4 Mediates BDNF Induction of Potassium Chloride Cotransporter 2 Transcription

(2011) A. Ludwig et al.   JOURNAL OF NEUROSCIENCE

Spatio-temporal transcriptome of the human brain

(2011) Hyo Jung Kang et al.   NATURE

NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor–mediated currents

(2011) Henry H C Lee et al.   NATURE NEUROSCIENCE

The neuronal K-Cl cotransporter KCC2 influences postsynaptic AMPA receptor content and lateral diffusion in dendritic spines

(2011) G. Gauvain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extraordinary neoteny of synaptic spines in the human prefrontal cortex

(2011) Zdravko Petanjek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fear Erasure in Mice Requires Synergy Between Antidepressant Drugs and Extinction Training

(2011) N. N. Karpova et al.   SCIENCE

Enhanced synaptic activity and epileptiform events in the embryonic KCC2 deficient hippocampus

(2011) Ilgam Khalilov   Frontiers in Cellular Neuroscience

Efficacy of Synaptic Inhibition Depends on Multiple, Dynamically Interacting Mechanisms Implicated in Chloride Homeostasis

(2011) Nicolas Doyon et al.   PLoS Computational Biology

Spatial and Temporal Dynamics in the Ionic Driving Force for GABAAReceptors

(2011) R. Wright et al.   NEURAL PLASTICITY

Cellular expression of the K+–Cl− cotransporter KCC3 in the central nervous system of mouse

(2010) Masoud Shekarabi et al.   BRAIN RESEARCH

Premature expression of KCC2 in embryonic mice perturbs neural development by an ion transport-independent mechanism

(2010) Zachi Horn et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Differential distribution of KCC2 along the axo-somato-dendritic axis of hippocampal principal cells

(2010) Rita Báldi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Multiple Pathways for Protein Phosphatase 1 (PP1) Regulation of Na-K-2Cl Cotransporter (NKCC1) Function

(2010) Kenneth B. Gagnon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of Cation-Chloride Cotransporter Expression in Preterm Infants With White Matter Lesions: Implications for the Pathogenesis of Epilepsy

(2010) Shenandoah Robinson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

ClC-2 Voltage-Gated Channels Constitute Part of the Background Conductance and Assist Chloride Extrusion

(2010) I. Rinke et al.   JOURNAL OF NEUROSCIENCE

Disruption of TrkB-Mediated Phospholipase C  Signaling Inhibits Limbic Epileptogenesis

(2010) X. P. He et al.   JOURNAL OF NEUROSCIENCE

A Single Seizure Episode Leads to Rapid Functional Activation of KCC2 in the Neonatal Rat Hippocampus

(2010) S. Khirug et al.   JOURNAL OF NEUROSCIENCE

Genetically encoded Cl-Sensor as a tool for monitoring of Cl-dependent processes in small neuronal compartments

(2010) Tatyana Waseem et al.   JOURNAL OF NEUROSCIENCE METHODS

The K+-Cl−cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampus

(2010) Tero Viitanen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Tyrosine phosphorylation regulates the membrane trafficking of the potassium chloride co-transporter KCC2

(2010) Henry H.C. Lee et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke

(2010) Andrew N. Clarkson et al.   NATURE

Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury

(2010) Pascale Boulenguez et al.   NATURE MEDICINE

Developmental localization of potassium chloride co-transporter 2 (KCC2), GABA and vesicular GABA transporter (VGAT) in the postnatal mouse somatosensory cortex

(2010) Chitoshi Takayama et al.   NEUROSCIENCE RESEARCH

Role of the NKCC1 co-transporter in sensitization of spinal nociceptive neurons

(2010) Mark H. Pitcher et al.   PAIN

Downregulation of Potassium Chloride Cotransporter KCC2 After Transient Focal Cerebral Ischemia

(2010) Nadine Jaenisch et al.   STROKE

Chloride regulation in the pain pathway

(2009) Theodore J. Price et al.   BRAIN RESEARCH REVIEWS

Sites of Regulated Phosphorylation that Control K-Cl Cotransporter Activity

(2009) Jesse Rinehart et al.   CELL

Coexpression and Heteromerization of Two Neuronal K-Cl Cotransporter Isoforms in Neonatal Brain

(2009) Pavel Uvarov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NKCC1-Dependent GABAergic Excitation Drives Synaptic Network Maturation during Early Hippocampal Development

(2009) C. K. Pfeffer et al.   JOURNAL OF NEUROSCIENCE

Novel Repression of Kcc2 Transcription by REST-RE-1 Controls Developmental Switch in Neuronal Chloride

(2009) M. Yeo et al.   JOURNAL OF NEUROSCIENCE

Compensatory Enhancement of Intrinsic Spiking upon NKCC1 Disruption in Neonatal Hippocampus

(2009) S. T. Sipila et al.   JOURNAL OF NEUROSCIENCE

Selective Expression of Ligand-Gated Ion Channels in L5 Pyramidal Cell Axons

(2009) J. M. Christie et al.   JOURNAL OF NEUROSCIENCE

Quantitative dynamics and spatial profile of perisomatic GABAergic input during epileptiform synchronization in the CA1 hippocampus

(2009) Ivan Marchionni et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cation-Chloride Cotransporters and Neuronal Function

(2009) Peter Blaesse et al.   NEURON

Rapid Neocortical Dynamics: Cellular and Network Mechanisms

(2009) Bilal Haider et al.   NEURON

Acetazolamide and midazolam act synergistically to inhibit neuropathic pain

(2009) Marina Asiedu et al.   PAIN

X-ray Structure of the C-Terminal Domain of a Prokaryotic Cation-Chloride Cotransporter

(2009) Stefan Warmuth et al.   STRUCTURE

SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells

(2008) Eric Delpire et al.   BIOCHEMICAL JOURNAL

Role of upstream stimulating factors in the transcriptional regulation of the neuron-specific K–Cl cotransporter KCC2

(2008) Marika Markkanen et al.   BRAIN RESEARCH

Sexually dimorphic expression of KCC2 and GABA function

(2008) Aristea S. Galanopoulou   EPILEPSY RESEARCH

HMSN/ACC truncation mutations disrupt brain-type creatine kinase-dependant activation of K+/Cl− co-transporter 3

(2008) Adèle Salin-Cantegrel et al.   HUMAN MOLECULAR GENETICS

AnkyrinG is required for maintenance of the axon initial segment and neuronal polarity

(2008) Kristian L. Hedstrom et al.   JOURNAL OF CELL BIOLOGY

Glycine Receptors Mediate Excitation of Subplate Neurons in Neonatal Rat Cerebral Cortex

(2008) W. Kilb et al.   JOURNAL OF NEUROPHYSIOLOGY

Altered Synaptic Dynamics and Hippocampal Excitability but Normal Long-Term Plasticity in Mice Lacking Hyperpolarizing GABAA Receptor-Mediated Inhibition in CA1 Pyramidal Neurons

(2008) Ruusu Riekki et al.   JOURNAL OF NEUROPHYSIOLOGY

Neurogenic Role of the Depolarizing Chloride Gradient Revealed by Global Overexpression of KCC2 from the Onset of Development

(2008) A. Reynolds et al.   JOURNAL OF NEUROSCIENCE

Posttraumatic GABAA-Mediated [Ca2+]i Increase Is Essential for the Induction of Brain-Derived Neurotrophic Factor-Dependent Survival of Mature Central Neurons

(2008) A. Shulga et al.   JOURNAL OF NEUROSCIENCE

GABAergic Depolarization of the Axon Initial Segment in Cortical Principal Neurons Is Caused by the Na-K-2Cl Cotransporter NKCC1

(2008) S. Khirug et al.   JOURNAL OF NEUROSCIENCE

Exon Loss Accounts for Differential Sorting of Na-K-Cl Cotransporters in Polarized Epithelial Cells

(2008) Monica Carmosino et al.   MOLECULAR BIOLOGY OF THE CELL

Interneurons hyperpolarize pyramidal cells along their entire somatodendritic axis

(2008) Lindsey L Glickfeld et al.   NATURE NEUROSCIENCE

Relationship between neuronal vulnerability and potassium-chloride cotransporter 2 immunoreactivity in hippocampus following transient forebrain ischemia

(2008) E. Papp et al.   NEUROSCIENCE

Allodynia and hyperalgesia in diabetic rats are mediated by GABA and depletion of spinal potassium-chloride co-transporters

(2008) Corinne G. Jolivalt et al.   PAIN

Dendritic Excitability and Synaptic Plasticity

(2008) P. Jesper Sjöström et al.   PHYSIOLOGICAL REVIEWS

Neuronal Diversity and Temporal Dynamics: The Unity of Hippocampal Circuit Operations

(2008) T. Klausberger et al.   SCIENCE

Roles of the cation–chloride cotransporters in neurological disease

(2008) Kristopher T Kahle et al.   Nature clinical practice. Neurology