Article
Clinical Neurology
Yan Xu, Wen-Han Hu, Xiao-Qiu Shao, Yan-Shan Ma, Lin Lou, Kai Zhang, Jian-Guo Zhang
Summary: This study retrospectively analyzed the medical records and surgical features of 31 patients with drug-resistant frontal lobe epilepsy. It found that surgery for SFS-related dysplasia had a favorable outcome, with 80.6% of patients seizure-free after surgery. FDG-PET co-registered with MRI should be performed in patients with suspected SFS-related dysplasia.
FRONTIERS IN NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nicolin Hainc, Mary Pat McAndrews, Taufik Valiante, Danielle M. Andrade, Richard Wennberg, Timo Krings
Summary: This study provides an updated description of the spectrum and frequency of dedicated 3T MRI findings in adult medically refractory epilepsy (MRE) patients at a tertiary epilepsy center, aiming to familiarize radiologists with potential imaging findings in this population.
INSIGHTS INTO IMAGING
(2022)
Review
Pathology
Rajalakshmi Poyuran
Summary: Epilepsy surgery is a well-established treatment modality for medically refractory epilepsy. Advances in neuroimaging have facilitated detection of surgically amenable lesions, with hippocampal sclerosis being the most common pathology encountered. Accurate interpretation and classification of lesions are crucial for defining clinically relevant etiologies.
INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Ceylan Z. Cankurtaran, Jessica Templer, Sarah K. Bandt, Ryan Avery, Tarek Hijaz, Erin N. McComb, Benjamin P. Liu, Stephan Schuele, Alexander J. Nemeth, Alexander W. Korutz
Summary: Surgery is an effective option for treating focal epilepsy, and advanced neuroimaging techniques play a crucial role in the surgical process. This review provides a background and framework for the presurgical evaluation process and discusses commonly used neuroimaging modalities and electrophysiological techniques.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2022)
Article
Medicine, General & Internal
Xiaozhuan Wang, Dabiao Deng, Chengqian Zhou, Honglin Li, Xueqin Guan, Liguang Fang, Qinxin Cai, Wensheng Wang, Quan Zhou
Summary: This study found that MRI-negative finding of FCD lesions and incomplete resection are independent predictors of unfavorable seizure outcomes in patients with FCD type III.
Article
Clinical Neurology
Jie Zheng, Ying-Li Liu, Di Zhang, Xue-Hua Cui, Lin-Xia Sang, Tao Xie, Wen-Ling Li
Summary: A comparison between robot assisted and stereotactic frame based stereoelectroencephalography in patients with medically refractory epilepsy showed that robot assisted SEEG is significantly more efficient, while safety and effectiveness are comparable between the two methods.
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Gavin J. B. Elias, Juergen Germann, Clemens Neudorfer, Andrew A. Namasivayam, Aaron Loh, Robert M. Gramer, George M. Ibrahim, Taufik Valiante, Jennifer C. Tomaszczyk, Mary Pat McAndrews, Walter Kucharczyk, Alexandre Boutet, Andres M. Lozano
Summary: Surgical resection can reduce seizure frequency in medically intractable temporal lobe epilepsy, but its effects on brain circuitry are poorly understood. This study found volume reductions in the contralesional hippocampus and bilateral mammillary bodies after surgery, as well as significant changes in cortical thickness across the brain. Postoperative verbal memory function was associated with cortical thickness changes in specific brain regions.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Abdulla Alawadhi, Juan Pablo Appendino, Walter Hader, Bernard Rosenblatt, Jeremy T. Moreau, Francois Dubeau, Roy W. R. Dudley, Kenneth A. Myers
Summary: This study reviewed the clinical and research databases of patients who had resolution of CSWS following surgical resection and found that DEE-SWAS may be a secondary bilateral network epilepsy syndrome, which can be treated with resection of the inciting focal lesion.
JOURNAL OF CHILD NEUROLOGY
(2022)
Article
Developmental Biology
Felipe I. Chodraui, Camila Araujo B. Garcia, Niele D. Mendes, Marcelo V. Santos, Pamela S. Beggiora, Stephanya C. Silva, Thiago L. Teixeira, Luiza da Silva Lopes, Fabiano P. Saggioro, Luciano Neder, Helio R. Machado
Summary: Tuberous sclerosis complex (TSC), focal cortical dysplasia IIB (FCD IIB), and hemimegalencephaly (HME) share similar molecular features dependent on hyperactivation of the mTOR pathway, associated with refractory epilepsy. Phosphorylated protein S6 (pS6) may serve as a reliable biomarker in epilepsy, with a greater percentage of pS6 marking potentially correlating with more severe forms of mTOR-dependent brain anomalies.
DEVELOPMENTAL NEUROSCIENCE
(2021)
Review
Clinical Neurology
Christopher Markosian, Vincent Dodson, Helen J. Zhang, Rajeshwari S. Mahalingam, Eric B. Geller, Luke D. Tomycz
Summary: A systematic review of 137 patients undergoing posterior quadrant disconnection (PQD) surgery revealed that both total and partial PQD were effective alternatives for managing medically refractory epilepsy. Total PQD patients had a 75% rate of seizure freedom compared to 63% in partial PQD patients. Further studies are needed to explore the utility of preoperative testing modalities and their impact on surgical decision-making.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2021)
Article
Clinical Neurology
Nilesh S. Kurwale, Sandip B. Patil, Sujit A. Jagtap, Aniruddha Joshi, Yogeshwari Deshmukh, Sujit Nilegaonkar, Deepa Bapat, Sonal Chitnis, Nayan Wadhwani
Summary: Surgical outcomes for pharmaco-resistant epilepsy associated with posterior cortex ulegyria secondary to perinatal insults are promising, with excellent seizure control achieved through parieto-occipital resection and temporo-parieto-occipital disconnection, while corpus callosotomy effectively palliates head drops and disabling reflex seizures.
Review
Clinical Neurology
Anne Kitschen, Milda Aleknonyte-Resch, Gabija Sakalyte, Freya Diederich
Summary: This systematic review aims to evaluate the cost-effectiveness of surgical treatment compared to medical treatment for drug-refractory epilepsy patients. The findings suggest that surgical treatment is more cost-effective, especially when considering a long-term perspective.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Anne Kitschen, Milda Aleknonyte-Resch, Gabija Sakalyte, Freya Diederich
Summary: Surgical treatment is cost-effective compared to medical treatment for patients with drug-refractory epilepsy, especially when considering a lifetime perspective. All disease-specific costs should be taken into account when assessing the cost-effectiveness of epilepsy treatment.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Javier A. Lopez-Rivera, Costin Leu, Marie Macnee, Jean Khoury, Lucas Hoffmann, Roland Coras, Katja Kobow, Nisha Bhattarai, Eduardo Perez-Palma, Hajo Hamer, Sebastian Brandner, Karl Roessler, Christian G. Bien, Thilo Kalbhenn, Tom Pieper, Till Hartlieb, Elizabeth Butler, Giulio Genovese, Kerstin Becker, Janine Altmueller, Lisa-Marie Niestroj, Lisa Ferguson, Robyn M. Busch, Peter Nuernberg, Imad Najm, Ingmar Bluemcke, Dennis Lal
Summary: Lopez-Rivera et al. conducted a study on the genetic architecture of different types of epileptic brain lesions. They discovered novel somatic chromosomal alterations, identified new genes and genotype-phenotype associations, and supported the role of genetics in the histopathological diagnosis of epileptic lesions. The findings provide valuable insights for improving treatment of drug-resistant focal epilepsy.
Article
Peripheral Vascular Disease
Arleen Aune, Eva Gerdts, Marina Kokorina, Ester Kringeland, Helga Midtbo, Kristian Lovas, Marianne A. Grytaas
Summary: This study compared persistent cardiac organ damage in patients with primary aldosteronism treated surgically or medically. The results showed that persistent cardiac organ damage was more common in the medical treatment group and was associated with incomplete aldosterone blockade, impaired renal function, and the presence of metabolic comorbidities.
JOURNAL OF HYPERTENSION
(2022)