Pharmacological enhancement of KCC2 gene expression exerts therapeutic effects on human Rett syndrome neurons and Mecp2 mutant mice

Total RNA Sequencing of Rett Syndrome Autopsy Samples Identifies the M4Muscarinic Receptor as a Novel Therapeutic Target

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MeCP2 as an Activator of Gene Expression

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The KCC3 cotransporter as a therapeutic target for peripheral neuropathy

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NKCC1 Chloride Importer Antagonists Attenuate Many Neurological and Psychiatric Disorders

(2017) Yehezkel Ben-Ari   TRENDS IN NEUROSCIENCES

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Reduced GABAergic Action in the Autistic Brain

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Chloride co-transporters as possible therapeutic targets for stroke

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Diminished KCC2 confounds synapse specificity of LTP during senescence

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Compromising KCC2 transporter activity enhances the development of continuous seizure activity

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The KCC2 Cotransporter and Human Epilepsy

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KCC2 rescues functional deficits in human neurons derived from patients with Rett syndrome

(2016) Xin Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Jointly reduced inhibition and excitation underlies circuit-wide changes in cortical processing in Rett syndrome

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Restoration of Mecp2 expression in GABAergic neurons is sufficient to rescue multiple disease features in a mouse model of Rett syndrome

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Conserved hippocampal cellular pathophysiology but distinct behavioural deficits in a new rat model of FXS

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Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome

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A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease

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Dendritic spine dysgenesis in autism related disorders

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Properties of Resveratrol:In VitroandIn VivoStudies about Metabolism, Bioavailability, and Biological Effects in Animal Models and Humans

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Resveratrol via sirtuin-1 downregulates RE1-silencing transcription factor (REST) expression preventing PCB-95-induced neuronal cell death

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Ameliorating effect of piperine on behavioral abnormalities and oxidative markers in sodium valproate induced autism in BALB/C mice

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Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy

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A variant of KCC2 from patients with febrile seizures impairs neuronal Cl- extrusion and dendritic spine formation

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Targeting FLT3 to treat leukemia

(2014) Heiko Konig et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The Developmental Switch in GABA Polarity Is Delayed in Fragile X Mice

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Cation-chloride cotransporters in neuronal development, plasticity and disease

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Functional recovery with recombinant human IGF1 treatment in a mouse model of Rett Syndrome

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Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism Pathogenesis in Rodent Offspring

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Treating Fragile X syndrome with the diuretic bumetanide: a case report

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Global Transcriptional and Translational Repression in Human-Embryonic-Stem-Cell-Derived Rett Syndrome Neurons

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Visualization of Synaptic Inhibition with an Optogenetic Sensor Developed by Cell-Free Protein Engineering Automation

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Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering

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Chloride extrusion enhancers as novel therapeutics for neurological diseases

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Abnormal Expression of Cerebrospinal Fluid Cation Chloride Cotransporters in Patients with Rett Syndrome

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Astroglial cells regulate the developmental timeline of human neurons differentiated from induced pluripotent stem cells

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MeCP2 Is Critical for Maintaining Mature Neuronal Networks and Global Brain Anatomy during Late Stages of Postnatal Brain Development and in the Mature Adult Brain

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Transcript-Specific Associations of SLC12A5 (KCC2) in Human Prefrontal Cortex with Development, Schizophrenia, and Affective Disorders

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(2012) Oscar Marín   NATURE REVIEWS NEUROSCIENCE

Reversal of Disease-Related Pathologies in the Fragile X Mouse Model by Selective Activation of GABAB Receptors with Arbaclofen

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Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmission

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Seizures in Alzheimer Disease: Clinical and Epidemiological Data

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A randomised controlled trial of bumetanide in the treatment of autism in children

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Expression of GABA Signaling Molecules KCC2, NKCC1, and GAD1 in Cortical Development and Schizophrenia

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Neocortical excitation/inhibition balance in information processing and social dysfunction

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A role for glia in the progression of Rett’s syndrome

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Dendritic spine pathology in neuropsychiatric disorders

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Differential GABAergic disinhibition during the development of painful peripheral neuropathy

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The neuronal K-Cl cotransporter KCC2 influences postsynaptic AMPA receptor content and lateral diffusion in dendritic spines

(2011) G. Gauvain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS

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Altered Expression of Regulators of the Cortical Chloride Transporters NKCC1 and KCC2 in Schizophrenia

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A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

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Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

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Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury

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Regenerating cortical connections in a dish: the entorhino-hippocampal organotypic slice co-culture as tool for pharmacological screening of molecules promoting axon regeneration

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Epilepsy and the natural history of Rett syndrome

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Downregulation of Potassium Chloride Cotransporter KCC2 After Transient Focal Cerebral Ischemia

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Novel Repression of Kcc2 Transcription by REST-RE-1 Controls Developmental Switch in Neuronal Chloride

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Intact Long-Term Potentiation but Reduced Connectivity between Neocortical Layer 5 Pyramidal Neurons in a Mouse Model of Rett Syndrome

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Dendritic spine pathologies in hippocampal pyramidal neurons from Rett syndrome brain and after expression of Rett-associated MECP2 mutations

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Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2

(2009) E. Delpire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rett Syndrome and the Impact of MeCP2 Associated Transcriptional Mechanisms on Neurotransmission

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A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response

(2008) K. W. Pratz et al.   BLOOD

MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription

(2008) M. Chahrour et al.   SCIENCE