Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition

Could tuning of the inhibitory tone involve graded changes in neuronal chloride transport?

(2015) Stefan Titz et al.   NEUROPHARMACOLOGY

WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons

(2015) Perrine Friedel et al.   Science Signaling

WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons

(2015) Perrine Friedel et al.   Science Signaling

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+–Cl−co-transporters

(2014) Paola de los Heros et al.   BIOCHEMICAL JOURNAL

The WNK-SPAK/OSR1 pathway: Master regulator of cation-chloride cotransporters

(2014) D. R. Alessi et al.   Science Signaling

Kinase Drug Discovery – What’s Next in the Field?

(2013) Philip Cohen et al.   ACS Chemical Biology

Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy

(2013) Takayasu Mori et al.   BIOCHEMICAL JOURNAL

Chloride extrusion enhancers as novel therapeutics for neurological diseases

(2013) Martin Gagnon et al.   NATURE MEDICINE

Comparative Analysis of the Expression Profile of Wnk1 and Wnk1/Hsn2 Splice Variants in Developing and Adult Mouse Tissues

(2013) Masoud Shekarabi et al.   PLoS One

Deconstructing the Neuropathic Pain Phenotype to Reveal Neural Mechanisms

(2012) Christian A. von Hehn et al.   NEURON

TRPV1 is important for mechanical and heat sensitivity in uninjured animals and development of heat hypersensitivity after muscle inflammation

(2012) Roxanne Y. Walder et al.   PAIN

Peripheral nerve injury produces a sustained shift in the balance between glutamate release and uptake in the dorsal horn of the spinal cord

(2012) Perrine Inquimbert et al.   PAIN

Sites of Regulated Phosphorylation that Control K-Cl Cotransporter Activity

(2009) Jesse Rinehart et al.   CELL

T-Cell Infiltration and Signaling in the Adult Dorsal Spinal Cord Is a Major Contributor to Neuropathic Pain-Like Hypersensitivity

(2009) M. Costigan et al.   JOURNAL OF NEUROSCIENCE

The Prevalence and Impact of Chronic Pain with Neuropathic Pain Symptoms in the General Population

(2009) Cory Toth et al.   PAIN MEDICINE

Molecular Physiology of the WNK Kinases

(2007) Kristopher T. Kahle et al.   Annual Review of Physiology