A Cryptochrome 2 mutation yields advanced sleep phase in humans

APERIOD3variant causes a circadian phenotype and is associated with a seasonal mood trait

(2016) Luoying Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polymorphisms in the circadian expressed genesPER3andARNTL2are associated with diurnal preference andGNβ3with sleep measures

(2014) Michael J. Parsons et al.   JOURNAL OF SLEEP RESEARCH

In Vivo Role of Phosphorylation of Cryptochrome 2 in the Mouse Circadian Clock

(2014) A. Hirano et al.   MOLECULAR AND CELLULAR BIOLOGY

Spatiotemporal separation of PER and CRY posttranslational regulation in the mammalian circadian clock

(2014) Peter C. St. John et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A central role for ubiquitination within a circadian clock protein modification code

(2014) Katarina Stojkovic et al.   Frontiers in Molecular Neuroscience

Structures of Drosophila Cryptochrome and Mouse Cryptochrome1 Provide Insight into Circadian Function

(2013) Anna Czarna et al.   CELL

Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm

(2013) Seung-Hee Yoo et al.   CELL

FBXL21 Regulates Oscillation of the Circadian Clock through Ubiquitination and Stabilization of Cryptochromes

(2013) Arisa Hirano et al.   CELL

Glucose Sensor O-GlcNAcylation Coordinates with Phosphorylation to Regulate Circadian Clock

(2013) Krista Kaasik et al.   Cell Metabolism

Crystal structure of mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase

(2013) Shannon Nangle et al.   CELL RESEARCH

SCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket

(2013) Weiman Xing et al.   NATURE

CRY2 Genetic Variants Associate with Dysthymia

(2013) Leena Kovanen et al.   PLoS One

Dual roles of FBXL3 in the mammalian circadian feedback loops are important for period determination and robustness of the clock

(2013) G. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dopamine dysregulation in a mouse model of paroxysmal nonkinesigenic dyskinesia

(2012) Hsien-yang Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Suppressed cellular oscillations in after-hours mutant mice are associated with enhanced circadian phase-resetting

(2012) Clare Guilding et al.   JOURNAL OF PHYSIOLOGY-LONDON

Identification of Small Molecule Activators of Cryptochrome

(2012) T. Hirota et al.   SCIENCE

Kinases and phosphatases in the mammalian circadian clock

(2011) Silke Reischl et al.   FEBS LETTERS

The Core Circadian Gene Cryptochrome 2 Influences Breast Cancer Risk, Possibly by Mediating Hormone Signaling

(2010) A. E. Hoffman et al.   Cancer Prevention Research

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

CRY2 Is Associated with Depression

(2010) Catharina Lavebratt et al.   PLoS One

CRY2 Is Associated with Rapid Cycling in Bipolar Disorder Patients

(2010) Louise K. Sjöholm et al.   PLoS One

Roles of CLOCK Phosphorylation in Suppression of E-Box-Dependent Transcription

(2009) H. Yoshitane et al.   MOLECULAR AND CELLULAR BIOLOGY

Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes

(2009) K. Hitomi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Transcriptional Repressor DEC2 Regulates Sleep Length in Mammals

(2009) Y. He et al.   SCIENCE

Individual Differences in the Amount and Timing of Salivary Melatonin Secretion

(2008) Helen J. Burgess et al.   PLoS One