Distinct control of PERIOD2 degradation and circadian rhythms by the oncoprotein and ubiquitin ligase MDM2

CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch

(2018) Rajesh Narasimamurthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation

(2016) Xuan Zhao et al.   CELL

Model-driven experimental approach reveals the complex regulatory distribution of p53 by the circadian factor Period 2

(2016) Tetsuya Gotoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of the circadian factor Period 2 to p53 influences p53's function in DNA-damage signaling

(2015) Tetsuya Gotoh et al.   MOLECULAR BIOLOGY OF THE CELL

A Period2 Phosphoswitch Regulates and Temperature Compensates Circadian Period

(2015) Min Zhou et al.   MOLECULAR CELL

The I-TASSER Suite: protein structure and function prediction

(2015) Jianyi Yang et al.   NATURE METHODS

Ubiquitin ligase Siah2 regulates RevErbα degradation and the mammalian circadian clock

(2015) Jason P. DeBruyne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization

(2015) Stephanie J Papp et al.   eLife

Interaction of Circadian Clock Proteins CRY1 and PER2 Is Modulated by Zinc Binding and Disulfide Bond Formation

(2014) Ira Schmalen et al.   CELL

Crafting a career in molecular animation

(2014) Janet Iwasa   MOLECULAR BIOLOGY OF THE CELL

New insights into ubiquitin E3 ligase mechanism

(2014) Christopher E Berndsen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A central role for ubiquitination within a circadian clock protein modification code

(2014) Katarina Stojkovic et al.   Frontiers in Molecular Neuroscience

Glucose Sensor O-GlcNAcylation Coordinates with Phosphorylation to Regulate Circadian Clock

(2013) Krista Kaasik et al.   Cell Metabolism

The circadian clock and cell cycle: interconnected biological circuits

(2013) Selma Masri et al.   CURRENT OPINION IN CELL BIOLOGY

Effect of circadian clock mutations on DNA damage response in mammalian cells

(2012) Shobhan Gaddameedhi et al.   CELL CYCLE

Unwinding the differences of the mammalian PERIOD clock proteins from crystal structure to cellular function

(2012) N. Kucera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NEMO/NLK Phosphorylates PERIOD to Initiate a Time-Delay Phosphorylation Circuit that Sets Circadian Clock Speed

(2011) Joanna C. Chiu et al.   CELL

Casein Kinase 1-dependent Phosphorylation of Familial Advanced Sleep Phase Syndrome-associated Residues Controls PERIOD 2 Stability

(2011) Naval P. Shanware et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1

(2011) H.-m. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E2s: structurally economical and functionally replete

(2010) Dawn M. Wenzel et al.   BIOCHEMICAL JOURNAL

Regulation of BMAL1 Protein Stability and Circadian Function by GSK3β-Mediated Phosphorylation

(2010) Saurabh Sahar et al.   PLoS One

Mdm2-mediated ubiquitylation: p53 and beyond

(2009) J-C Marine et al.   CELL DEATH AND DIFFERENTIATION

Selective Inhibition of Casein Kinase 1  Minimally Alters Circadian Clock Period

(2009) K. M. Walton et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Rhythmic PER Abundance Defines a Critical Nodal Point for Negative Feedback within the Circadian Clock Mechanism

(2009) Rongmin Chen et al.   MOLECULAR CELL

Building ubiquitin chains: E2 enzymes at work

(2009) Yihong Ye et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Essential roles of CKIδ and CKIε in the mammalian circadian clock

(2009) Hyeongmin Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation

(2009) K. A. Lamia et al.   SCIENCE

Small-molecule inhibitors of MDM2 as new anticancer therapeutics

(2009) Michael P. Dickens et al.   SEMINARS IN CANCER BIOLOGY

Targeting Proteins for Destruction by the Ubiquitin System: Implications for Human Pathobiology

(2008) Alan L. Schwartz et al.   Annual Review of Pharmacology and Toxicology

Discovery of new pyridoacridine alkaloids from Lissoclinum cf. badium that inhibit the ubiquitin ligase activity of Hdm2 and stabilize p53

(2008) Jason A. Clement et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK

(2008) Sonja Langmesser et al.   BMC MOLECULAR BIOLOGY

Phase Resetting of the Mammalian Circadian Clock by DNA Damage

(2008) Małgorzata Oklejewicz et al.   CURRENT BIOLOGY

The Role of β-TrCP1 and β-TrCP2 in Circadian Rhythm Generation by Mediating Degradation of Clock Protein PER2

(2008) Kanae Ohsaki et al.   JOURNAL OF BIOCHEMISTRY

A Novel Heme-Regulatory Motif Mediates Heme-Dependent Degradation of the Circadian Factor Period 2

(2008) J. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2

(2008) J. Kitagaki et al.   MOLECULAR CANCER THERAPEUTICS

Setting Clock Speed in Mammals: The CK1ɛ tau Mutation in Mice Accelerates Circadian Pacemakers by Selectively Destabilizing PERIOD Proteins

(2008) Qing-Jun Meng et al.   NEURON

The SWISS-MODEL Repository and associated resources

(2008) F. Kiefer et al.   NUCLEIC ACIDS RESEARCH

Mdm2 Induces Mono-Ubiquitination of FOXO4

(2008) Arjan B. Brenkman et al.   PLoS One