Circadian Transcription from Beta Cell Function to Diabetes Pathophysiology

Targeting Time in Metabolic Therapeutics

(2016) Joseph Bass   Cell Metabolism

The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome

(2016) Baokun He et al.   Cell Metabolism

A functional circadian clock is required for proper insulin secretion by human pancreatic islet cells

(2016) C. Saini et al.   DIABETES OBESITY & METABOLISM

Bmal1 is required for beta cell compensatory expansion, survival and metabolic adaptation to diet-induced obesity in mice

(2016) Kuntol Rakshit et al.   DIABETOLOGIA

Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival

(2016) Guangrui Yang et al.   Science Translational Medicine

Intrinsic muscle clock is necessary for musculoskeletal health

(2015) Elizabeth A. Schroder et al.   JOURNAL OF PHYSIOLOGY-LONDON

Activation of Melatonin Signaling Promotes β-Cell Survival and Function

(2015) Safia Costes et al.   MOLECULAR ENDOCRINOLOGY

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

(2015) Kyle J Gaulton et al.   NATURE GENETICS

Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans

(2015) Christopher J. Morris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pancreatic   cell enhancers regulate rhythmic transcription of genes controlling insulin secretion

(2015) M. Perelis et al.   SCIENCE

Circadian redox oscillations and metabolism

(2015) Nikolay B. Milev et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The endogenous molecular clock orchestrates the temporal separation of substrate metabolism in skeletal muscle

(2015) Brian A Hodge et al.   Skeletal Muscle

Circadian Enhancers Coordinate Multiple Phases of Rhythmic Gene Transcription In Vivo

(2014) Bin Fang et al.   CELL

Insulin-FOXO3 Signaling Modulates Circadian Rhythms via Regulation of Clock Transcription

(2014) Inês Chaves et al.   CURRENT BIOLOGY

Circadian Secretion of the Intestinal Hormone GLP-1 by the Rodent L Cell

(2014) Manuel Gil-Lozano et al.   DIABETES

Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants

(2014) Lorenzo Pasquali et al.   NATURE GENETICS

The Melatonin Agonist Ramelteon Induces Duration-Dependent Clock Gene Expression through cAMP Signaling in Pancreatic INS-1 β-Cells

(2014) Keiji Nishiyama et al.   PLoS One

Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism

(2014) J. Fadista et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A circadian gene expression atlas in mammals: Implications for biology and medicine

(2014) Ray Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reprogramming of the Circadian Clock by Nutritional Challenge

(2013) Kristin L. Eckel-Mahan et al.   CELL

Blood-Borne Circadian Signal Stimulates Daily Oscillations in Actin Dynamics and SRF Activity

(2013) Alan Gerber et al.   CELL

Consequences of Exposure to Light at Night on the Pancreatic Islet Circadian Clock and Function in Rats

(2013) J. Qian et al.   DIABETES

Melatonin Secretion and the Incidence of Type 2 Diabetes

(2013) Ciaran J. McMullan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Bmal1 and  -Cell Clock Are Required for Adaptation to Circadian Disruption, and Their Loss of Function Leads to Oxidative Stress-Induced  -Cell Failure in Mice

(2013) J. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

The nuclear receptor Rev-erbα controls circadian thermogenic plasticity

(2013) Zachary Gerhart-Hines et al.   NATURE

Circadian Clock NAD+ Cycle Drives Mitochondrial Oxidative Metabolism in Mice

(2013) C. B. Peek et al.   SCIENCE

Molecular architecture of the mammalian circadian clock

(2013) Carrie L. Partch et al.   TRENDS IN CELL BIOLOGY

Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet

(2012) Megumi Hatori et al.   Cell Metabolism

Circadian Oscillations of Protein-Coding and Regulatory RNAs in a Highly Dynamic Mammalian Liver Epigenome

(2012) Christopher Vollmers et al.   Cell Metabolism

The Suprachiasmatic Nucleus Controls Circadian Energy Metabolism and Hepatic Insulin Sensitivity

(2012) C. P. Coomans et al.   DIABETES

Diurnal Pattern to Insulin Secretion and Insulin Action in Healthy Individuals

(2012) A. Saad et al.   DIABETES

Autonomous and self-sustained circadian oscillators displayed in human islet cells

(2012) P. Pulimeno et al.   DIABETOLOGIA

Loss ofmPer2increases plasma insulin levels by enhanced glucose-stimulated insulin secretion and impaired insulin clearance in mice

(2012) Yue Zhao et al.   FEBS LETTERS

Simulated body temperature rhythms reveal the phase-shifting behavior and plasticity of mammalian circadian oscillators

(2012) C. Saini et al.   GENES & DEVELOPMENT

Regulation of core clock genes in human islets

(2012) Jelena A. Stamenkovic et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Circadian topology of metabolism

(2012) Joseph Bass   NATURE

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

(2012) Amélie Bonnefond et al.   NATURE GENETICS

Obesity in mice with adipocyte-specific deletion of clock component Arntl

(2012) Georgios K Paschos et al.   NATURE MEDICINE

Cold-Inducible RNA-Binding Protein Modulates Circadian Gene Expression Posttranscriptionally

(2012) J. Morf et al.   SCIENCE

Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals

(2012) N. Koike et al.   SCIENCE

Brain-Specific Rescue of Clock Reveals System-Driven Transcriptional Rhythms in Peripheral Tissue

(2012) Michael E. Hughes et al.   PLoS Genetics

Nascent-Seq reveals novel features of mouse circadian transcriptional regulation

(2012) Jerome S Menet et al.   eLife

Impairment of Peripheral Circadian Clocks Precedes Metabolic Abnormalities in ob/ob Mice

(2011) Hitoshi Ando et al.   ENDOCRINOLOGY

Dynamics of insulin secretion and the clinical implications for obesity and diabetes

(2011) Susumu Seino et al.   JOURNAL OF CLINICAL INVESTIGATION

Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans

(2011) Rayner Rodriguez-Diaz et al.   NATURE MEDICINE

Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in β-cells

(2011) Jeongkyung Lee et al.   Islets

Genome-Wide and Phase-Specific DNA-Binding Rhythms of BMAL1 Control Circadian Output Functions in Mouse Liver

(2011) Guillaume Rey et al.   PLOS BIOLOGY

The Mammalian Circadian Timing System: Organization and Coordination of Central and Peripheral Clocks

(2010) Charna Dibner et al.   Annual Review of Physiology

Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people

(2010) T. W. Boesgaard et al.   DIABETOLOGIA

An intrinsic circadian clock of the pancreas is required for normal insulin release and glucose homeostasis in mice

(2010) L. A. Sadacca et al.   DIABETOLOGIA

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

(2010) Biliana Marcheva et al.   NATURE

A map of open chromatin in human pancreatic islets

(2010) Kyle J Gaulton et al.   NATURE GENETICS

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis

(2010) Eric E Zhang et al.   NATURE MEDICINE

Variants from GIPR, TCF7L2, DGKB, MADD, CRY2, GLIS3, PROX1, SLC30A8 and IGF1 Are Associated with Glucose Metabolism in the Chinese

(2010) Cheng Hu et al.   PLoS One

Histone H3K27ac separates active from poised enhancers and predicts developmental state

(2010) M. P. Creyghton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temperature as a Universal Resetting Cue for Mammalian Circadian Oscillators

(2010) E. D. Buhr et al.   SCIENCE

Novel insights into the function of β-cell M3 muscarinic acetylcholine receptors: therapeutic implications

(2010) Inigo Ruiz de Azua et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene

(2009) H. Mulder et al.   DIABETOLOGIA

Circadian Timing of Food Intake Contributes to Weight Gain

(2009) Deanna M. Arble et al.   Obesity

Adverse metabolic and cardiovascular consequences of circadian misalignment

(2009) F. A. J. L. Scheer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sleep-wake regulation is altered in leptin-resistant (db/db) genetically obese and diabetic mice

(2008) A. D. Laposky et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

(2008) Nabila Bouatia-Naji et al.   NATURE GENETICS

Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

(2008) Deborah M. Muoio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Polymorphisms within the Novel Type 2 Diabetes Risk Locus MTNR1B Determine β-Cell Function

(2008) Harald Staiger et al.   PLoS One

Physiological significance of a peripheral tissue circadian clock

(2008) K. A. Lamia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anticipatory physiological regulation in feeding biology: Cephalic phase responses

(2007) Michael L. Power et al.   APPETITE