CH Activation Generates Period-Shortening Molecules That Target Cryptochrome in the Mammalian Circadian Clock

A Concise and Scalable Strategy for the Total Synthesis of Dictyodendrin B Based on Sequential CH Functionalization

(2015) Andrew K. Pitts et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic C–H Imidation of Aromatic Cores of Functional Molecules: Ligand-Accelerated Cu Catalysis and Application to Materials- and Biology-Oriented Aromatics

(2015) Takahiro Kawakami et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Concise Syntheses of Dictyodendrins A and F by a Sequential C–H Functionalization Strategy

(2015) Atsushi D. Yamaguchi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ligand-enabled meta-C–H activation using a transient mediator

(2015) Xiao-Chen Wang et al.   NATURE

Metal-catalysed azidation of tertiary C–H bonds suitable for late-stage functionalization

(2015) Ankit Sharma et al.   NATURE

The direct arylation of allylic sp3 C–H bonds via organic and photoredox catalysis

(2015) James D. Cuthbertson et al.   NATURE

Synthesis and characterization of hexaarylbenzenes with five or six different substituents enabled by programmed synthesis

(2015) Shin Suzuki et al.   Nature Chemistry

One-shot K-region-selective annulative π-extension for nanographene synthesis and functionalization

(2015) Kyohei Ozaki et al.   Nature Communications

Late-stage C–H functionalization of complex alkaloids and drug molecules via intermolecular rhodium-carbenoid insertion

(2015) Jing He et al.   Nature Communications

Stereodivergent Synthesis of Arylcyclopropylamines by Sequential CH Borylation and Suzuki-Miyaura Coupling

(2014) Shin Miyamura et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Extended π-Systems through C-H Activation

(2014) Yasutomo Segawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iridium-Catalyzed C–H Amination with Anilines at Room Temperature: Compatibility of Iridacycles with External Oxidants

(2014) Hyunwoo Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Mild, Ferrocene-Catalyzed C–H Imidation of (Hetero)Arenes

(2014) Klement Foo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective C–H Bond Addition of Pyridines to Alkenes Catalyzed by Chiral Half-Sandwich Rare-Earth Complexes

(2014) Guoyong Song et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Analyzing Site Selectivity in Rh2(esp)2-Catalyzed Intermolecular C–H Amination Reactions

(2014) Elizabeth N. Bess et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β-Selective C–H Arylation of Pyrroles Leading to Concise Syntheses of Lamellarins C and I

(2014) Kirika Ueda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

C–H Methylation of Heteroarenes Inspired by Radical SAM Methyl Transferase

(2014) Jinghan Gui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iridium-Catalyzed Intermolecular Amidation of sp3 C–H Bonds: Late-Stage Functionalization of an Unactivated Methyl Group

(2014) Taek Kang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-catalysed C–H activation of aliphatic amines to give strained nitrogen heterocycles

(2014) Andrew McNally et al.   NATURE

Conformation-induced remote meta-C–H activation of amines

(2014) Ri-Yuan Tang et al.   NATURE

Rhodium-Catalyzed Intermolecular C-H Silylation of Arenes with High Steric Regiocontrol

(2014) C. Cheng et al.   SCIENCE

Room-temperature enantioselective C–H iodination via kinetic resolution

(2014) Ling Chu et al.   SCIENCE

Ligand-Controlled C(sp3)-H Arylation and Olefination in Synthesis of Unnatural Chiral  -Amino Acids

(2014) J. He et al.   SCIENCE

Catalytic Functionalization of C(sp2)H and C(sp3)H Bonds by Using Bidentate Directing Groups

(2013) Guy Rouquet et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Crystal structure of mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase

(2013) Shannon Nangle et al.   CELL RESEARCH

Pd-Catalyzed Aryl C–H Imidation with Arene as the Limiting Reagent

(2013) Gregory B. Boursalian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Direct Arylation of C(sp3)–H Bonds in Aliphatic Amides via Bidentate-Chelation Assistance

(2013) Yoshinori Aihara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

SCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket

(2013) Weiman Xing et al.   NATURE

A grossly warped nanographene and the consequences of multiple odd-membered-ring defects

(2013) Katsuaki Kawasumi et al.   Nature Chemistry

C–H bond activation enables the rapid construction and late-stage diversification of functional molecules

(2013) Joanna Wencel-Delord et al.   Nature Chemistry

Selective C-H Fluorination of Pyridines and Diazines Inspired by a Classic Amination Reaction

(2013) P. S. Fier et al.   SCIENCE

Programmed synthesis of arylthiazoles through sequential C–H couplings

(2013) Satoshi Tani et al.   Chemical Science

Palladium-Catalyzed CH and CN Arylation of Aminothiazoles with Arylboronic Acids

(2013) Takahiro N. Uehara et al.   Asian Journal of Organic Chemistry

CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals

(2012) Junichiro Yamaguchi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed C–H Activation Taken to the Limit. Flattening an Aromatic Bowl by Total Arylation

(2012) Qianyan Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Decarbonylative C–H Coupling of Azoles and Aryl Esters: Unprecedented Nickel Catalysis and Application to the Synthesis of Muscoride A

(2012) Kazuma Amaike et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Activation of remote meta-C–H bonds assisted by an end-on template

(2012) Dasheng Leow et al.   NATURE

Catalytic functionalization of unactivated primary C–H bonds directed by an alcohol

(2012) Eric M. Simmons et al.   NATURE

Practical and innate carbon–hydrogen functionalization of heterocycles

(2012) Yuta Fujiwara et al.   NATURE

Identification of Small Molecule Activators of Cryptochrome

(2012) T. Hirota et al.   SCIENCE

Weak Coordination as a Powerful Means for Developing Broadly Useful C–H Functionalization Reactions

(2011) Keary M. Engle et al.   ACCOUNTS OF CHEMICAL RESEARCH

Oxidative Biaryl Coupling of Thiophenes and Thiazoles with Arylboronic Acids through Palladium Catalysis: Otherwise Difficult C4-Selective CH Arylation Enabled by Boronic Acids

(2011) Sylvia Kirchberg et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Intracellular and intercellular processes determine robustness of the circadian clock

(2011) John B. Hogenesch et al.   FEBS LETTERS

Synthesis of Dragmacidin D via Direct C–H Couplings

(2011) Debashis Mandal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed C–H/C–O Coupling of Azoles with Phenol Derivatives

(2011) Kei Muto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Arylation of Polycyclic Aromatic Hydrocarbons through Palladium Catalysis

(2011) Kenji Mochida et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A General Catalyst for the β-Selective C-H Bond Arylation of Thiophenes with Iodoarenes

(2010) Kirika Ueda et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct detection of CH/π interactions in proteins

(2010) Michael J. Plevin et al.   Nature Chemistry

Transition-Metal-Catalyzed Regioselective Arylation and Vinylation of Carboxylic Acids

(2010) Tetsuya Satoh et al.   SYNTHESIS-STUTTGART

Transition-Metal-Catalyzed Direct Arylation of (Hetero)Arenes by CH Bond Cleavage

(2009) Lutz Ackermann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Programmed Synthesis of Tetraarylthiophenes through Sequential C−H Arylation

(2009) Shuichi Yanagisawa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic C–H functionalization by metal carbenoid and nitrenoid insertion

(2008) Huw M. L. Davies et al.   NATURE

A High-Throughput Assay for siRNA-Based Circadian Screens in Human U2OS Cells

(2008) Christopher Vollmers et al.   PLoS One