Promising Pharmacological Directions in the World of Lysophosphatidic Acid Signaling

Inhibition of autotaxin delays breast tumor growth and lung metastasis in mice

(2014) Matthew G. K. Benesch et al.   FASEB JOURNAL

LPA receptor signaling: pharmacology, physiology, and pathophysiology

(2014) Yun C. Yung et al.   JOURNAL OF LIPID RESEARCH

Anti-lysophosphatidic acid antibodies improve traumatic brain injury outcomes

(2014) Peter J Crack et al.   Journal of Neuroinflammation

Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, phase 3 trial

(2014) Peter A Calabresi et al.   LANCET NEUROLOGY

Transforming growth factor β—at the centre of systemic sclerosis

(2014) Robert Lafyatis   Nature Reviews Rheumatology

Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe

(2013) Mitsuyasu Kawaguchi et al.   ACS Chemical Biology

Autotaxin Production of Lysophosphatidic Acid Mediates Allergic Asthmatic Inflammation

(2013) Gye Young Park et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Lysophosphatidic acid receptor inhibition as a new multipronged treatment for rheumatoid arthritis

(2013) Beatriz Orosa et al.   ANNALS OF THE RHEUMATIC DISEASES

PF-8380 and Closely Related Analogs: Synthesis and Structure-Activity Relationship towards Autotaxin Inhibition and Glioma Cell Viability

(2013) Patrick-Denis St-Cœur et al.   ARCHIV DER PHARMAZIE

Autotaxin inhibition: Development and application of computational tools to identify site-selective lead compounds

(2013) Derek D. Norman et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Autotaxin-Lysophosphatidic Acid Signaling Axis Mediates Tumorigenesis and Development of Acquired Resistance to Sunitinib in Renal Cell Carcinoma

(2013) S.-C. Su et al.   CLINICAL CANCER RESEARCH

Lysophosphatidic Acid Stimulates Activation of Focal Adhesion Kinase and Paxillin and Promotes Cell Motility, via LPA1–3, in Human Pancreatic Cancer

(2013) Yan Liao et al.   DIGESTIVE DISEASES AND SCIENCES

Lysophosphatidic acid induces vasodilation mediated by LPA1 receptors, phospholipase C, and endothelial nitric oxide synthase

(2013) Éva Ruisanchez et al.   FASEB JOURNAL

A Metabolically-Stabilized Phosphonate Analog of Lysophosphatidic Acid Attenuates Collagen-Induced Arthritis

(2013) Ioanna Nikitopoulou et al.   PLoS One

Blockage of Lysophosphatidic Acid Signaling Improves Spinal Cord Injury Outcomes

(2012) Yona Goldshmit et al.   AMERICAN JOURNAL OF PATHOLOGY

Lysophosphatidic Acid Increases Proximal Tubule Cell Secretion of Profibrotic Cytokines PDGF-B and CTGF through LPA2- and Gαq-Mediated Rho and αvβ6 Integrin-Dependent Activation of TGF-β

(2012) Hui Geng et al.   AMERICAN JOURNAL OF PATHOLOGY

Pulmonary Autotaxin Expression Contributes to the Pathogenesis of Pulmonary Fibrosis

(2012) Nikos Oikonomou et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Controlling cancer through the autotaxin–lysophosphatidic acid receptor axis

(2012) Mari Gotoh et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Lysophosphatidic acid: Chemical signature of neuropathic pain

(2012) Hiroshi Ueda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo

(2012) Mayumi Komachi et al.   CANCER SCIENCE

The Rho/ROCK pathway for lysophosphatidic acid-induced proteolytic enzyme expression and ovarian cancer cell invasion

(2012) K J Jeong et al.   ONCOGENE

Autotaxin-Lysophosphatidic Acid Axis Is a Novel Molecular Target for Lowering Intraocular Pressure

(2012) Padma Iyer et al.   PLoS One

Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma

(2011) Flavia V. Castelino et al.   ARTHRITIS AND RHEUMATISM

Differential function of lysophosphatidic acid receptors in cell proliferation and migration of neuroblastoma cells

(2011) Mai Hayashi et al.   CANCER LETTERS

Benzyl and Naphthalene Methylphosphonic Acid Inhibitors of Autotaxin with Anti-invasive and Anti-metastatic Activity

(2011) Renuka Gupte et al.   ChemMedChem

LPA1-induced migration requires nonmuscle myosin II light chain phosphorylation in breast cancer cells

(2011) Jong Hyun Kim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

LPA5 Is Abundantly Expressed by Human Mast Cells and Important for Lysophosphatidic Acid Induced MIP-1β Release

(2011) Anders Lundequist et al.   PLoS One

Autotaxin and LPA Receptors Represent Potential Molecular Targets for the Radiosensitization of Murine Glioma through Effects on Tumor Vasculature

(2011) Stephen M. Schleicher et al.   PLoS One

LPA Is a Chemorepellent for B16 Melanoma Cells: Action through the cAMP-Elevating LPA5 Receptor

(2011) Maikel Jongsma et al.   PLoS One

Pharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors

(2010) Dong-Soon Im   ACTA PHARMACOLOGICA SINICA

LPA Receptors: Subtypes and Biological Actions

(2010) Ji Woong Choi et al.   Annual Review of Pharmacology and Toxicology

A novel, orally active LPA1 receptor antagonist inhibits lung fibrosis in the mouse bleomycin model

(2010) JS Swaney et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of tumor growth and angiogenesis by a lysophosphatidic acid antagonist in an engineered three-dimensional lung cancer xenograft model

(2010) Xiaoyu Xu et al.   CANCER

Mechanism of Action of Oral Fingolimod (FTY720) in Multiple Sclerosis

(2010) Jerold Chun et al.   CLINICAL NEUROPHARMACOLOGY

Pharmacokinetic and Pharmacodynamic Characterization of an Oral Lysophosphatidic Acid Type 1 Receptor-Selective Antagonist

(2010) J. S. Swaney et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid Receptor Nomenclature

(2010) J. Chun et al.   PHARMACOLOGICAL REVIEWS

Lysophosphatidic acid (LPA)—a perspective marker in ovarian cancer

(2010) Iva Sedláková et al.   TUMOR BIOLOGY

Dual Activity Lysophosphatidic Acid Receptor Pan-Antagonist/Autotaxin Inhibitor Reduces Breast Cancer Cell Migration In vitro and Causes Tumor Regression In vivo

(2009) Honglu Zhang et al.   CANCER RESEARCH

Identification and Characterization of a Novel Lysophosphatidic Acid Receptor, p2y5/LPA6

(2009) Keisuke Yanagida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide linkage analysis of an autosomal recessive hypotrichosis identifies a novel P2RY5 mutation

(2008) Lynn Petukhova et al.   GENOMICS

Novel mutations in G protein-coupled receptor gene (P2RY5) in families with autosomal recessive hypotrichosis (LAH3)

(2008) Zahid Azeem et al.   HUMAN GENETICS

Role of LPA4/p2y9/GPR23 in Negative Regulation of Cell Motility

(2008) Zendra Lee et al.   MOLECULAR BIOLOGY OF THE CELL

G protein–coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth

(2008) Sandra M Pasternack et al.   NATURE GENETICS

Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs

(2008) Hidenobu Kanda et al.   NATURE IMMUNOLOGY

Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents

(2007) Hilary P. Beck et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS