Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Microglia emerge as central players in brain disease

(2017) Michael W Salter et al.   NATURE MEDICINE

TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss

(2017) Rosa C. Paolicelli et al.   NEURON

Analgesic effects of novel lysophosphatidic acid receptor 5 antagonist AS2717638 in rodents

(2017) Nobuhito Murai et al.   NEUROPHARMACOLOGY

Microglia Responses in Acute and Chronic Neurological Diseases: What Microglia-Specific Transcriptomic Studies Taught (and did Not Teach) Us

(2017) Hélène E. Hirbec et al.   Frontiers in Aging Neuroscience

An updated assessment of microglia depletion: current concepts and future directions

(2017) Jinming Han et al.   Molecular Brain

Emergency Spatiotemporal Shift: The Response of Protein Kinase D to Stress Signals in the Cardiovascular System

(2017) Brent M. Wood et al.   Frontiers in Pharmacology

Targeting the Microglial Signaling Pathways: New Insights in the Modulation of Neuropathic Pain

(2016) Katarzyna Popiolek-Barczyk et al.   CURRENT MEDICINAL CHEMISTRY

Role of Microglia in Neurological Disorders and Their Potentials as a Therapeutic Target

(2016) Li Du et al.   MOLECULAR NEUROBIOLOGY

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

Protein kinase D1/2 is involved in the maturation of multivesicular bodies and secretion of exosomes in T and B lymphocytes

(2015) C Mazzeo et al.   CELL DEATH AND DIFFERENTIATION

Lysophospholipid receptors in drug discovery

(2015) Yasuyuki Kihara et al.   EXPERIMENTAL CELL RESEARCH

Protein Kinase D2 Assembles a Multiprotein Complex at the Trans-Golgi Network to Regulate Matrix Metalloproteinase Secretion

(2015) Tim Eiseler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Lysophosphatidic Acid Receptor Type 1 Contributes to Pathophysiology of Spinal Cord Injury

(2015) E. Santos-Nogueira et al.   JOURNAL OF NEUROSCIENCE

Lysophosphatidic Acid Signaling in the Nervous System

(2015) Yun C. Yung et al.   NEURON

Glioma-Associated Microglia/Macrophages Display an Expression Profile Different from M1 and M2 Polarization and Highly Express Gpnmb and Spp1

(2015) Frank Szulzewsky et al.   PLoS One

Protein kinase D2 silencing reduced motility of doxorubicin-resistant MCF7 cells

(2015) Aktan Alpsoy et al.   TUMOR BIOLOGY

LPA signaling initiates schizophrenia-like brain and behavioral changes in a mouse model of prenatal brain hemorrhage

(2015) H Mirendil et al.   Translational Psychiatry

Inducible nitric oxide synthase is key to peroxynitrite-mediated, LPS-induced protein radical formation in murine microglial BV2 cells

(2014) Ashutosh Kumar et al.   FREE RADICAL BIOLOGY AND MEDICINE

What is microglia neurotoxicity (Not)?

(2014) Knut Biber et al.   GLIA

Elevated serum levels of lysophosphatidic acid in patients with multiple sclerosis

(2014) Mohammad Balood et al.   HUMAN IMMUNOLOGY

Autotaxin Downregulates LPS-Induced Microglia Activation and Pro-Inflammatory Cytokines Production

(2014) Rana Awada et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

LPA receptor signaling: pharmacology, physiology, and pathophysiology

(2014) Yun C. Yung et al.   JOURNAL OF LIPID RESEARCH

Lipid phosphate phosphatases: more than one way to put the brakes on LPA signaling?

(2014) Andrew J. Morris et al.   JOURNAL OF LIPID RESEARCH

Anti-lysophosphatidic acid antibodies improve traumatic brain injury outcomes

(2014) Peter J Crack et al.   Journal of Neuroinflammation

Morphometric characterization of microglial phenotypes in human cerebral cortex

(2014) Susana G Torres-Platas et al.   Journal of Neuroinflammation

Quantitative Phosphoproteomics of Cytotoxic T Cells to Reveal Protein Kinase D 2 Regulated Networks

(2014) María N. Navarro et al.   MOLECULAR & CELLULAR PROTEOMICS

Silencing of protein kinase D2 induces glioma cell senescence via p53-dependent and -independent pathways

(2014) Eva Bernhart et al.   NEURO-ONCOLOGY

Protein Kinase D Isoforms Differentially Modulate Cofilin-Driven Directed Cell Migration

(2014) Heike Döppler et al.   PLoS One

Protein kinase D: a new player among the signaling proteins that regulate functions in the nervous system

(2014) Gang Li et al.   Neuroscience Bulletin

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Protein kinase D2 regulates migration and invasion of U87MG glioblastoma cells in vitro

(2013) Eva Bernhart et al.   EXPERIMENTAL CELL RESEARCH

Lysophosphatidic acid (LPA) and its receptor, LPA1, influence embryonic schwann cell migration, myelination, and cell-to-axon segregation

(2013) Brigitte Anliker et al.   GLIA

Classical and unconventional pathways of vesicular release in microglia

(2013) Ilaria Prada et al.   GLIA

Protein Kinase D1-mediated Phosphorylations Regulate Vasodilator-stimulated Phosphoprotein (VASP) Localization and Cell Migration

(2013) Heike R. Döppler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapid and Reversible Enhancement of Blood–Brain Barrier Permeability Using Lysophosphatidic Acid

(2013) Ngoc H On et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Microglia: New Roles for the Synaptic Stripper

(2013) Helmut Kettenmann et al.   NEURON

Phospholipase Cɛ links G protein-coupled receptor activation to inflammatory astrocytic responses

(2013) Stephanie S. Dusaban et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Factors regulating microglia activation

(2013) Katrin Kierdorf et al.   Frontiers in Cellular Neuroscience

Lysophospholipids and their receptors in the central nervous system

(2012) Ji Woong Choi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lysophosphatidic acid: Chemical signature of neuropathic pain

(2012) Hiroshi Ueda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Selective non-lipid modulator of LPA5 activity in human platelets

(2012) Detlef H. Kozian et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

PKD Controls αvβ3 Integrin Recycling and Tumor Cell Invasive Migration through Its Substrate Rabaptin-5

(2012) Claudine Christoforides et al.   DEVELOPMENTAL CELL

Targeted Deletion of LPA5Identifies Novel Roles for Lysophosphatidic Acid Signaling in Development of Neuropathic Pain

(2012) Mu-En Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microglial Cathepsin B Contributes to the Initiation of Peripheral Inflammation-Induced Chronic Pain

(2012) L. Sun et al.   JOURNAL OF NEUROSCIENCE

Lipid phosphate phosphatase inhibitors locally amplify lysophosphatidic acid LPA1 receptor signalling in rat brain cryosections without affecting global LPA degradation

(2012) Niina Aaltonen et al.   BMC Pharmacology & Toxicology

A dialog between glioma and microglia that promotes tumor invasiveness through the CCL2/CCR2/interleukin-6 axis

(2011) J. Zhang et al.   CARCINOGENESIS

Protein kinase D1: A novel regulator of actin-driven directed cell migration

(2011) Peter Storz   CELL CYCLE

Protein kinase D: coupling extracellular stimuli to the regulation of cell physiology

(2011) Ya Fu et al.   EMBO REPORTS

Autotaxin protects microglial cells against oxidative stress

(2011) Rana Awada et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protein Kinase D Signaling: Multiple Biological Functions in Health and Disease

(2011) Enrique Rozengurt   PHYSIOLOGY

Lysophosphatidic Acid Signaling May Initiate Fetal Hydrocephalus

(2011) Y. C. Yung et al.   Science Translational Medicine

Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells

(2010) Sharon A. Matthews et al.   BIOCHEMICAL JOURNAL

N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor

(2010) Douglas McHugh et al.   BMC NEUROSCIENCE

ATX-LPA receptor axis in inflammation and cancer

(2010) Shuying Liu et al.   CELL CYCLE

Microglia in the CNS: Immigrants from another world

(2010) Marco Prinz et al.   GLIA

Protein kinase D2 is a crucial regulator of tumour cell-endothelial cell communication in gastrointestinal tumours

(2010) N. Azoitei et al.   GUT

Protein Kinase D Controls Actin Polymerization and Cell Motility through Phosphorylation of Cortactin

(2010) Tim Eiseler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinase D1 Is Essential for the Proinflammatory Response Induced by Hypersensitivity Pneumonitis-Causing Thermophilic Actinomycetes Saccharopolyspora rectivirgula

(2010) Y.-I. Kim et al.   JOURNAL OF IMMUNOLOGY

Microglial activation mediates de novo lysophosphatidic acid production in a model of neuropathic pain

(2010) Lin Ma et al.   JOURNAL OF NEUROCHEMISTRY

Evidence for De Novo Synthesis of Lysophosphatidic Acid in the Spinal Cord through Phospholipase A2 and Autotaxin in Nerve Injury-Induced Neuropathic Pain

(2010) L. Ma et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A Novel Small-Molecule Inhibitor of Protein Kinase D Blocks Pancreatic Cancer Growth In vitro and In vivo

(2010) K. B. Harikumar et al.   MOLECULAR CANCER THERAPEUTICS

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

Lysophosphatidylcholine Activates a Novel PKD2-Mediated Signaling Pathway That Controls Monocyte Migration

(2009) Mingqi Tan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Regulation of PKD by the MAPK p38δ in Insulin Secretion and Glucose Homeostasis

(2009) Grzegorz Sumara et al.   CELL

High affinity receptor for IgE stimulation activates protein kinase D augmenting activator protein-1 activity for cytokine producing in mast cells

(2009) Kyoko Yamashita et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Role of VASP phosphorylation for the regulation of microglia chemotaxis via the regulation of focal adhesion formation/maturation

(2009) S. Lee et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Lysophosphatidic Acid-3 Receptor-Mediated Feed-Forward Production of Lysophosphatidic Acid: an Initiator of Nerve Injury-Induced Neuropathic Pain

(2009) Lin Ma et al.   Molecular Pain

Immune Activation in Brain Aging and Neurodegeneration: Too Much or Too Little?

(2009) Kurt M. Lucin et al.   NEURON

Lysophosphatidic acid (LPA) receptors: Signaling properties and disease relevance

(2009) Mu-En Lin et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Lysophosphatidic acid receptor activation affects the C13NJ microglia cell line proteome leading to alterations in glycolysis, motility, and cytoskeletal architecture

(2009) Eva Bernhart et al.   PROTEOMICS

PKD prevents H2O2-induced apoptosis via NF-κB and p38 MAPK in RIE-1 cells

(2008) Jun Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neuroinflammation and microglia: considerations and approaches for neurotoxicity assessment

(2008) Gaylia Jean Harry et al.   Expert Opinion on Drug Metabolism & Toxicology

Identification of Protein Kinase D2 as a Pivotal Regulator of Endothelial Cell Proliferation, Migration, and Angiogenesis

(2008) Qin Hao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction between protein kinase D1 and transient receptor potential V1 in primary sensory neurons is involved in heat hypersensitivity

(2007) Haihao Zhu et al.   PAIN