The Blood–Brain Barrier and Its Intercellular Junctions in Age-Related Brain Disorders

Claudin-3-deficient C57BL/6J mice display intact brain barriers

(2019) Mariana Castro Dias et al.   Scientific Reports

The emerging role of exosomes in mental disorders

(2019) Saumeh Saeedi et al.   Translational Psychiatry

Targeting pericyte–endothelial cell crosstalk by circular RNA-cPWWP2A inhibition aggravates diabetes-induced microvascular dysfunction

(2019) Chang Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-Associated Changes in the Immune System and Blood–Brain Barrier Functions

(2019) Michelle Erickson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosomes Derived From Pericytes Improve Microcirculation and Protect Blood–Spinal Cord Barrier After Spinal Cord Injury in Mice

(2019) Xiaochen Yuan et al.   Frontiers in Neuroscience

Impairment of pericyte-endothelium crosstalk leads to blood-brain barrier dysfunction following traumatic brain injury

(2019) Saurav Bhowmick et al.   EXPERIMENTAL NEUROLOGY

Single-cell analysis reveals T cell infiltration in old neurogenic niches

(2019) Ben W. Dulken et al.   NATURE

Increased cerebral vascularization and decreased water exchange across the blood-brain barrier in aquaporin-4 knockout mice

(2019) Yifan Zhang et al.   PLoS One

The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’ system?

(2018) N. Joan Abbott et al.   ACTA NEUROPATHOLOGICA

Impact of aging, Alzheimer's disease and Parkinson's disease on the blood-brain barrier transport of therapeutics

(2018) Yijun Pan et al.   ADVANCED DRUG DELIVERY REVIEWS

Proteomic and cellular localisation studies suggest non-tight junction cytoplasmic and nuclear roles for occludin in astrocytes

(2018) Sarah V. Morgan et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The “glymphatic” mechanism for solute clearance in Alzheimer’s disease: game changer or unproven speculation?

(2018) Alex J. Smith et al.   FASEB JOURNAL

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Interaction between blood-brain barrier and glymphatic system in solute clearance

(2018) I.C.M. Verheggen et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Neuroimmune Axes of the Blood–Brain Barriers and Blood–Brain Interfaces: Bases for Physiological Regulation, Disease States, and Pharmacological Interventions

(2018) Michelle A. Erickson et al.   PHARMACOLOGICAL REVIEWS

APOE and Alzheimer’s Disease: Neuroimaging of Metabolic and Cerebrovascular Dysfunction

(2018) Jason A. Brandon et al.   Frontiers in Aging Neuroscience

Decline in Sirtuin-1 expression and activity plays a critical role in blood-brain barrier permeability in aging

(2018) Svetlana M. Stamatovic et al.   NEUROBIOLOGY OF DISEASE

Multicellular Crosstalk Between Exosomes and the Neurovascular Unit After Cerebral Ischemia. Therapeutic Implications

(2018) Ana-Maria Zagrean et al.   Frontiers in Neuroscience

Blood-Brain Barrier Dysfunction and the Pathogenesis of Alzheimer’s Disease

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Occludin regulates glucose uptake and ATP production in pericytes by influencing AMP-activated protein kinase activity

(2017) Victor Castro et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Astrocytic tight junctions control inflammatory CNS lesion pathogenesis

(2017) Sam Horng et al.   JOURNAL OF CLINICAL INVESTIGATION

Dose-dependent expression of claudin-5 is a modifying factor in schizophrenia

(2017) C Greene et al.   MOLECULAR PSYCHIATRY

The blood-brain barrier in Alzheimer's disease

(2017) Elena Zenaro et al.   NEUROBIOLOGY OF DISEASE

Poly(ADP-ribose) polymerase-1 regulates microglia mediated decrease of endothelial tight junction integrity

(2017) Abbas Rezaeian Mehrabadi et al.   NEUROCHEMISTRY INTERNATIONAL

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

(2017) Costantino Iadecola   NEURON

Age-associated changes in the blood-brain barrier: comparative studies in human and mouse

(2017) E. F. Goodall et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

CD146 coordinates brain endothelial cell–pericyte communication for blood–brain barrier development

(2017) Jianan Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Huntington’s Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits

(2017) Ryan G. Lim et al.   Cell Reports

Characteristics and Outcomes of Young Patients with First-Ever Ischemic Stroke Compared to Older Patients: The National Acute Stroke ISraeli Registry

(2017) Miri Lutski et al.   Frontiers in Neurology

The role of APOE in cerebrovascular dysfunction

(2016) Leon M. Tai et al.   ACTA NEUROPATHOLOGICA

Annexin A1 restores Aβ1-42-induced blood-brain barrier disruption through the inhibition of RhoA-ROCK signaling pathway

(2016) Jong-Chan Park et al.   AGING CELL

Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels

(2016) Steve Horvath et al.   Aging-US

β-asarone and levodopa co-administration increase striatal dopamine level in 6-hydroxydopamine induced rats by modulating P-glycoprotein and tight junction proteins at the blood-brain barrier and promoting levodopa into the brain

(2016) Liping Huang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

α-Synuclein pre-formed fibrils impair tight junction protein expression without affecting cerebral endothelial cell function

(2016) Wei-Li Kuan et al.   EXPERIMENTAL NEUROLOGY

Mice deficient in endothelial α5 integrin are profoundly resistant to experimental ischemic stroke

(2016) Jill Roberts et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Age-Associated Resident Memory CD8 T Cells in the Central Nervous System Are Primed To Potentiate Inflammation after Ischemic Brain Injury

(2016) Rodney M. Ritzel et al.   JOURNAL OF IMMUNOLOGY

Coxsackievirus Adenovirus Receptor Loss Impairs Adult Neurogenesis, Synapse Content, and Hippocampus Plasticity

(2016) C. Zussy et al.   JOURNAL OF NEUROSCIENCE

Vascular Cell Senescence Contributes to Blood–Brain Barrier Breakdown

(2016) Yu Yamazaki et al.   STROKE

Regulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions

(2016) Barbara Schlingmann et al.   Nature Communications

Dynamics of the mouse brain cortical synaptic proteome during postnatal brain development

(2016) Miguel A. Gonzalez-Lozano et al.   Scientific Reports

Cerebrovascular and blood-brain barrier impairments in Huntington's disease: Potential implications for its pathophysiology

(2015) Janelle Drouin-Ouellet et al.   ANNALS OF NEUROLOGY

The neuropathology and cerebrovascular mechanisms of dementia

(2015) Limor Raz et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Striatal Blood–Brain Barrier Permeability in Parkinson'S Disease

(2015) Madison T Gray et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Aβ1-42oligomer-induced leakage in anin vitroblood-brain barrier model is associated with up-regulation of RAGE and metalloproteinases, and down-regulation of tight junction scaffold proteins

(2015) Wenbin Wan et al.   JOURNAL OF NEUROCHEMISTRY

Attenuation of acute stroke injury in rat brain by minocycline promotes blood–brain barrier remodeling and alternative microglia/macrophage activation during recovery

(2015) Yirong Yang et al.   Journal of Neuroinflammation

Dissecting the Contribution of Vascular Alterations and Aging to Alzheimer’s Disease

(2015) Cátia Janota et al.   MOLECULAR NEUROBIOLOGY

Deep-brain stimulation associates with improved microvascular integrity in the subthalamic nucleus in Parkinson's disease

(2015) Ilse S. Pienaar et al.   NEUROBIOLOGY OF DISEASE

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Tight junction disruption of blood–brain barrier in white matter lesions in chronic hypertensive rats

(2015) Yuhua Fan et al.   NEUROREPORT

Endothelial depletion of murine SRF/MRTF provokes intracerebral hemorrhagic stroke

(2015) Christine Weinl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Blood–brain barrier dysfunction developed during normal aging is associated with inflammation and loss of tight junctions but not with leukocyte recruitment

(2015) Mina Elahy et al.   Immunity & Ageing

Impairment of paravascular clearance pathways in the aging brain

(2014) Benjamin T. Kress et al.   ANNALS OF NEUROLOGY

Disruption of the blood-brain barrier in parkinson's disease: curse or route to a cure?

(2014) Heyne Lee   Frontiers in Bioscience-Landmark

Inhibition of Src phosphorylation reduces damage to the blood-brain barrier following transient focal cerebral ischemia in rats

(2014) YONGSHENG BAI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Poly(ADP-ribose) Polymerase-1 Inhibition in Brain Endothelium Protects the Blood—Brain Barrier under Physiologic and Neuroinflammatory Conditions

(2014) Slava Rom et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Emerging Roles of Pericytes in the Regulation of the Neurovascular Unit in Health and Disease

(2014) Jeremy Hill et al.   Journal of Neuroimmune Pharmacology

Aging-related differences in cerebral capillary blood flow in anesthetized rats

(2014) Michèle Desjardins et al.   NEUROBIOLOGY OF AGING

Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke

(2014) Daniel Knowland et al.   NEURON

SIRT1 in Neurodevelopment and Brain Senescence

(2014) A. Zara Herskovits et al.   NEURON

Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson's disease mouse model

(2014) Sumit Sarkar et al.   NEUROTOXICOLOGY

EGb761 Provides a Protective Effect against Aβ1-42 Oligomer-Induced Cell Damage and Blood-Brain Barrier Disruption in an In Vitro bEnd.3 Endothelial Model

(2014) Wen-bin Wan et al.   PLoS One

Accelerated Aging in Schizophrenia Patients: The Potential Role of Oxidative Stress

(2014)   Aging and Disease

Highly Conserved Cysteines Are Involved in the Oligomerization of Occludin—Redox Dependency of the Second Extracellular Loop

(2013) Christian Bellmann et al.   ANTIOXIDANTS & REDOX SIGNALING

Cell-specific blood-brain barrier regulation in health and disease: a focus on hypoxia

(2013) S Engelhardt et al.   BRITISH JOURNAL OF PHARMACOLOGY

CK2-dependent phosphorylation of occludin regulates the interaction with ZO-proteins and tight junction integrity

(2013) Max J Dörfel et al.   Cell Communication and Signaling

The potential mechanisms of Aβ-receptor for advanced glycation end-products interaction disrupting tight junctions of the blood-brain barrier in Alzheimer's disease

(2013) Wenbin Wan et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Early Inhibition of MMP Activity in Ischemic Rat Brain Promotes Expression of Tight Junction Proteins and Angiogenesis During Recovery

(2013) Yi Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Blood–Brain Barrier Dysfunction as a Cause and Consequence of Alzheimer's Disease

(2013) Michelle A Erickson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Altered Brain Uptake of Therapeutics in a Triple Transgenic Mouse Model of Alzheimer’s Disease

(2013) Dharmini C. Mehta et al.   PHARMACEUTICAL RESEARCH

Pericyte loss influences Alzheimer-like neurodegeneration in mice

(2013) Abhay P. Sagare et al.   Nature Communications

Vascular Degeneration in Parkinson's Disease

(2012) Jian Guan et al.   BRAIN PATHOLOGY

Deficiency in Mural Vascular Cells Coincides with Blood-Brain Barrier Disruption in Alzheimer's Disease

(2012) Jesse D. Sengillo et al.   BRAIN PATHOLOGY

Cerebral blood flow responses to dorsal and ventral STN DBS correlate with gait and balance responses in Parkinson's disease

(2012) K.K. Hill et al.   EXPERIMENTAL NEUROLOGY

Blood–Spinal Cord Barrier Pericyte Reductions Contribute to Increased Capillary Permeability

(2012) Ethan A Winkler et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease

(2012) Azeb Tadesse Argaw et al.   JOURNAL OF CLINICAL INVESTIGATION

A 1-42-RAGE Interaction Disrupts Tight Junctions of the Blood-Brain Barrier Via Ca2+-Calcineurin Signaling

(2012) S.-Y. Kook et al.   JOURNAL OF NEUROSCIENCE

Relocalization of Junctional Adhesion Molecule A during Inflammatory Stimulation of Brain Endothelial Cells

(2012) S. M. Stamatovic et al.   MOLECULAR AND CELLULAR BIOLOGY

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

Immune surveillance in the central nervous system

(2012) Shalina S Ousman et al.   NATURE NEUROSCIENCE

Neuroinflammation and Blood-Brain Barrier Changes in Capillary Amyloid Angiopathy

(2012) Anna Carrano et al.   Neurodegenerative Diseases

Integrins as receptor targets for neurological disorders

(2012) Xin Wu et al.   PHARMACOLOGY & THERAPEUTICS

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

T Cell Recruitment in the Brain during Normal Aging

(2012) Jickssa M. Gemechu et al.   Frontiers in Cellular Neuroscience

Occludin Protein Family: Oxidative Stress and Reducing Conditions

(2011) Ingolf E. Blasig et al.   ANTIOXIDANTS & REDOX SIGNALING

Amyloid Beta Induces Oxidative Stress-Mediated Blood–Brain Barrier Changes in Capillary Amyloid Angiopathy

(2011) Anna Carrano et al.   ANTIOXIDANTS & REDOX SIGNALING

The impact of pericytes on the blood–brain barrier integrity depends critically on the pericyte differentiation stage

(2011) Gokulan Thanabalasundaram et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Occludin Localizes to Centrosomes and Modifies Mitotic Entry

(2011) E. Aaron Runkle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function

(2011) David R. Raleigh et al.   JOURNAL OF CELL BIOLOGY

Interendothelial Claudin-5 Expression Depends on Cerebral Endothelial Cell–Matrix Adhesion by β1-Integrins

(2011) Takashi Osada et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Quantitative MRI Reveals the Elderly Ischemic Brain is Susceptible to Increased Early Blood—Brain Barrier Permeability Following Tissue Plasminogen Activator Related to Claudin 5 and Occludin Disassembly

(2011) Jaspreet Kaur et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

A Homozygous Mutation in the Tight-Junction Protein JAM3 Causes Hemorrhagic Destruction of the Brain, Subependymal Calcification, and Congenital Cataracts

(2010) Ganeshwaran H. Mochida et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Metalloproteinase mediated occludin cleavage in the cerebral microcapillary endothelium under pathological conditions

(2010) Mira Lischper et al.   BRAIN RESEARCH

Matrix Metalloproteinase-9 Mediates Hypoxia-Induced Vascular Leakage in the Brain via Tight Junction Rearrangement

(2010) Alexander T Bauer et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Protein Kinase C Activation Modulates Reversible Increase in Cortical Blood–Brain Barrier Permeability and Tight Junction Protein Expression during Hypoxia and Posthypoxic Reoxygenation

(2010) Colin L Willis et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Oxidative Stress Increases Blood–Brain Barrier Permeability and Induces Alterations in Occludin during Hypoxia–Reoxygenation

(2010) Jeffrey J Lochhead et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

Review: Cerebral microvascular pathology in ageing and neurodegeneration

(2010) W. R. Brown et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Amyloid-β(1-42) alters structure and function of retinal pigmented epithelial cells

(2009) Julien Bruban et al.   AGING CELL

Regulation of cytokine signaling and T-cell recruitment in the aging mouse brain in response to central inflammatory challenge

(2009) Yuan-Zhong Xu et al.   BRAIN BEHAVIOR AND IMMUNITY

Inhibition of Src Activity Decreases Tyrosine Phosphorylation of Occludin in Brain Capillaries and Attenuates Increase in Permeability of the Blood-Brain Barrier after Transient Focal Cerebral Ischemia

(2009) Yuji Takenaga et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Matrix metalloproteinases and their multiple roles in neurodegenerative diseases

(2009) Gary A Rosenberg   LANCET NEUROLOGY

Reproductive age-related changes in the blood brain barrier: Expression of IgG and tight junction proteins

(2009) Shameena Bake et al.   MICROVASCULAR RESEARCH

Reduction of the cerebrovascular volume in a transgenic mouse model of Alzheimer's disease

(2009) Fanchon Bourasset et al.   NEUROPHARMACOLOGY

Chylomicron amyloid-beta in the aetiology of Alzheimer's disease

(2008) R. Takechi et al.   ATHEROSCLEROSIS SUPPLEMENTS

Reproductive hormones regulate the selective permeability of the blood-brain barrier

(2008) Andrea C. Wilson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Vascular endothelial senescence: from mechanisms to pathophysiology

(2008) Jorge D. Erusalimsky   JOURNAL OF APPLIED PHYSIOLOGY

Normobaric hyperoxia inhibits NADPH oxidase-mediated matrix metalloproteinase-9 induction in cerebral microvessels in experimental stroke

(2008) Wenlan Liu et al.   JOURNAL OF NEUROCHEMISTRY

Caffeine protects against MPTP-induced blood-brain barrier dysfunction in mouse striatum

(2008) Xuesong Chen et al.   JOURNAL OF NEUROCHEMISTRY

Strategies to advance translational research into brain barriers

(2008) Edward Neuwelt et al.   LANCET NEUROLOGY

Induction of Blood Brain Barrier Tight Junction Protein Alterations by CD8 T Cells

(2008) Georgette L. Suidan et al.   PLoS One

Blood–brain barrier: Ageing and microvascular disease – systematic review and meta-analysis

(2007) Andrew J. Farrall et al.   NEUROBIOLOGY OF AGING