Dissecting the Contribution of Vascular Alterations and Aging to Alzheimer’s Disease

Astrocyte Function is Modified by Alzheimer's Disease-like Pathology in Aged Mice

(2017) Oliver Peters et al.   JOURNAL OF ALZHEIMERS DISEASE

Systemic Immune Responses in Alzheimer's Disease: In Vitro Mononuclear Cell Activation and Cytokine Production

(2017) Mariavaleria Pellicanò et al.   JOURNAL OF ALZHEIMERS DISEASE

Vascular contributions to cognitive impairment and dementia including Alzheimer's disease

(2015) Heather M. Snyder et al.   Alzheimers & Dementia

Glio-vascular changes during ageing in wild-type and Alzheimer׳s disease-like APP/PS1 mice

(2015) C.S. Janota et al.   BRAIN RESEARCH

Astrocytosis precedes amyloid plaque deposition in Alzheimer APPswe transgenic mouse brain: a correlative positron emission tomography and in vitro imaging study

(2015) Elena Rodriguez-Vieitez et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Arginine Deprivation and Immune Suppression in a Mouse Model of Alzheimer's Disease

(2015) Matthew J. Kan et al.   JOURNAL OF NEUROSCIENCE

Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment

(2014) A C LeBlanc et al.   CELL DEATH AND DIFFERENTIATION

PACAP Enhances Barrier Properties of Cerebral Microvessels

(2014) Imola Wilhelm et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

RAGE Inhibition in Microglia Prevents Ischemia-Dependent Synaptic Dysfunction in an Amyloid-Enriched Environment

(2014) N. Origlia et al.   JOURNAL OF NEUROSCIENCE

Activity of P-Glycoprotein, a  -Amyloid Transporter at the Blood-Brain Barrier, Is Compromised in Patients with Mild Alzheimer Disease

(2014) A. K. Deo et al.   JOURNAL OF NUCLEAR MEDICINE

Hippocampal Extracellular Matrix Levels and Stochasticity in Synaptic Protein Expression Increase with Age and Are Associated with Age-dependent Cognitive Decline

(2014) Marlene J. Végh et al.   MOLECULAR & CELLULAR PROTEOMICS

Priming of microglia in a DNA-repair deficient model of accelerated aging

(2014) Divya D.A. Raj et al.   NEUROBIOLOGY OF AGING

Clinical trial of an inhibitor of RAGE-A  interactions in Alzheimer disease

(2014) D. Galasko et al.   NEUROLOGY

Altered cerebral vascular volumes and solute transport at the blood–brain barriers of two transgenic mouse models of Alzheimer's disease

(2014) Tuan Minh Do et al.   NEUROPHARMACOLOGY

Mechanisms Involved in Dual Vasopressin/Apelin Neuron Dysfunction during Aging

(2014) Julie Sauvant et al.   PLoS One

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

(2014) L. Katsimpardi et al.   SCIENCE

Neuroinflammation in the pathogenesis of Alzheimer’s disease. A rational framework for the search of novel therapeutic approaches

(2014) Inelia Morales et al.   Frontiers in Cellular Neuroscience

Aging reduces glial uptake and promotes extracellular accumulation of Aβ from a lentiviral vector

(2014) Wenjuan Zhao et al.   Frontiers in Aging Neuroscience

Proteasome dysfunction inDrosophilasignals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging

(2013) Eleni N. Tsakiri et al.   AGING CELL

Homeostatic and injury-induced microglia behavior in the aging brain

(2013) Jasmin K. Hefendehl et al.   AGING CELL

2013 Alzheimer's disease facts and figures

(2013)   Alzheimers & Dementia

Classical activation of microglia in CD200-deficient mice is a consequence of blood brain barrier permeability and infiltration of peripheral cells

(2013) Stephanie Denieffe et al.   BRAIN BEHAVIOR AND IMMUNITY

Synaptic Aging is Associated with Mitochondrial Dysfunction, Reduced Antioxidant Contents and Increased Vulnerability to Amyloid-β Toxicity

(2013) Ricardo Quiroz-Baez et al.   Current Alzheimer Research

Regional Cerebral Blood Flow and Cerebrovascular Reactivity in Alzheimer's Disease and Vascular Dementia Assessed by Arterial Spinlabeling Magnetic Resonance Imaging

(2013) Yong-Zhe Gao et al.   CURRENT NEUROVASCULAR RESEARCH

Age Increase of Estrogen Receptor-α (ERα) in Cortical Astrocytes Impairs Neurotrophic Support in Male and Female Rats

(2013) Jason M. Arimoto et al.   ENDOCRINOLOGY

Age-related decline of myelin proteins is highly correlated with activation of astrocytes and microglia in the rat CNS

(2013) FANG XIE et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Proteolytic Cleavage of Apolipoprotein E4 as the Keystone for the Heightened Risk Associated with Alzheimer’s Disease

(2013) Troy Rohn   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Low-density Lipoprotein Receptor-related Protein 1 (LRP1)-dependent Cell Signaling Promotes Axonal Regeneration

(2013) Choya Yoon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Lipoprotein Receptor Cluster IV Mutant Preferentially Binds Amyloid-β and Regulates Its Clearance from the Mouse Brain

(2013) Abhay P. Sagare et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blood–Brain Barrier Dysfunction as a Cause and Consequence of Alzheimer's Disease

(2013) Michelle A Erickson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Senescence Hypothesis of Disease Progression in Alzheimer Disease: an Integrated Matrix of Disease Pathways for FAD and SAD

(2013) Sally Hunter et al.   MOLECULAR NEUROBIOLOGY

CD33 in Alzheimer's Disease

(2013) Teng Jiang et al.   MOLECULAR NEUROBIOLOGY

Aging enhances classical activation but mitigates alternative activation in the central nervous system

(2013) Daniel C. Lee et al.   NEUROBIOLOGY OF AGING

Critical ages in the life course of the adult brain: nonlinear subcortical aging

(2013) Anders M. Fjell et al.   NEUROBIOLOGY OF AGING

Age-related alteration in cerebral blood flow and energy failure is correlated with cognitive impairment in the senescence-accelerated prone mouse strain 8 (SAMP8)

(2013) Xuezhu Zhang et al.   NEUROLOGICAL SCIENCES

Incidence of stroke in people with Alzheimer disease: A national register-based approach

(2013) A.-M. Tolppanen et al.   NEUROLOGY

Calcium dysregulation in relation to Alzheimer-type pathology in the ageing brain

(2013) C. Garwood et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Pericyte loss influences Alzheimer-like neurodegeneration in mice

(2013) Abhay P. Sagare et al.   Nature Communications

Cessation of Neoangiogenesis in Alzheimer's Disease Follows Amyloid-beta Immunization

(2013) Kaan E. Biron et al.   Scientific Reports

VEGF significantly restores impaired memory behavior in Alzheimer's mice by improvement of vascular survival

(2013) Piotr Religa et al.   Scientific Reports

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Neurovascular Dysfunction and Faulty Amyloid  -Peptide Clearance in Alzheimer Disease

(2013) A. P. Sagare et al.   Cold Spring Harbor Perspectives in Medicine

Role of ABC Transporters in the Pathogenesis of Alzheimer’s Disease

(2012) Alaa H. Abuznait et al.   ACS Chemical Neuroscience

Primate aging in the mammalian scheme: the puzzle of extreme variation in brain aging

(2012) Caleb E. Finch et al.   AGE

Aging brain microenvironment decreases hippocampal neurogenesis through Wnt-mediated survivin signaling

(2012) Carlos J. Miranda et al.   AGING CELL

The links between complex coronary disease, cerebrovascular disease, and degenerative brain disease

(2012) Jason C. Kovacic et al.   Annals of the New York Academy of Sciences

Age-related memory decline is associated with vascular and microglial degeneration in aged rats

(2012) Rong Zhang et al.   BEHAVIOURAL BRAIN RESEARCH

Deficiency in Mural Vascular Cells Coincides with Blood-Brain Barrier Disruption in Alzheimer's Disease

(2012) Jesse D. Sengillo et al.   BRAIN PATHOLOGY

Oligomers of beta-amyloid protein (Aβ1-42) induce the activation of cyclooxygenase-2 in astrocytes via an interaction with interleukin-1beta, tumour necrosis factor-alpha, and a nuclear factor kappa-B mechanism in the rat brain

(2012) I. Carrero et al.   EXPERIMENTAL NEUROLOGY

Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity

(2012) Y. Kim et al.   GENES & DEVELOPMENT

Plasma neopterin level as a marker of peripheral immune activation in amnestic mild cognitive impairment and Alzheimer's disease

(2012) Daniel C. Parker et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

C1q-induced LRP1B and GPR6 Proteins Expressed Early in Alzheimer Disease Mouse Models, Are Essential for the C1q-mediated Protection against Amyloid-β Neurotoxicity

(2012) Marie E. Benoit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Vivo Imaging of Cerebral Microvascular Plasticity from Birth to Death

(2012) Roa Harb et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

(2012) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

LRP1 in Brain Vascular Smooth Muscle Cells Mediates Local Clearance of Alzheimer's Amyloid- 

(2012) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

Reducing Human Apolipoprotein E Levels Attenuates Age-Dependent A  Accumulation in Mutant Human Amyloid Precursor Protein Transgenic Mice

(2012) N. Bien-Ly et al.   JOURNAL OF NEUROSCIENCE

A 1-42-RAGE Interaction Disrupts Tight Junctions of the Blood-Brain Barrier Via Ca2+-Calcineurin Signaling

(2012) S.-Y. Kook et al.   JOURNAL OF NEUROSCIENCE

P-Glycoprotein Function at the Blood–Brain Barrier: Effects of Age and Gender

(2012) Daniëlle M. E. van Assema et al.   MOLECULAR IMAGING AND BIOLOGY

Neurovascular Unit: a Focus on Pericytes

(2012) Inês Sá-Pereira et al.   MOLECULAR NEUROBIOLOGY

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease–like pathology and cognitive decline

(2012) Johannes vom Berg et al.   NATURE MEDICINE

Astrocytes regulate adult hippocampal neurogenesis through ephrin-B signaling

(2012) Randolph S Ashton et al.   NATURE NEUROSCIENCE

The ageing cortical synapse: hallmarks and implications for cognitive decline

(2012) John H. Morrison et al.   NATURE REVIEWS NEUROSCIENCE

Prenatal hypoxia may aggravate the cognitive impairment and Alzheimer’s disease neuropathology in APPSwe/PS1A246E transgenic mice

(2012) Xin Zhang et al.   NEUROBIOLOGY OF AGING

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Decreased serum angiogenin level in Alzheimer's disease

(2012) Yong Nam Kim et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Blood–brain barrier P-glycoprotein function in healthy subjects and Alzheimer's disease patients: effect of polymorphisms in the ABCB1 gene

(2012) Daniëlle ME van Assema et al.   EJNMMI Research

Diffusion tensor imaging of cerebral white matter integrity in cognitive aging

(2011) David J. Madden et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

New Insights into the Roles of Megalin/LRP2 and the Regulation of its Functional Expression

(2011) María-Paz Marzolo et al.   BIOLOGICAL RESEARCH

Brain microbleeds and Alzheimer’s disease: innocent observation or key player?

(2011) Charlotte Cordonnier et al.   BRAIN

Age-related changes in the hippocampus (loss of synaptophysin and glial–synaptic interaction) are modified by systemic treatment with an NCAM-derived peptide, FGL

(2011) Bunmi Ojo et al.   BRAIN BEHAVIOR AND IMMUNITY

Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype

(2011) Antero Salminen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Alzheimer's dementia begins as a disease of small blood vessels, damaged by oxidative-induced inflammation and dysregulated amyloid metabolism: implications for early detection and therapy

(2011) Vincent T. Marchesi   FASEB JOURNAL

Age-related changes in the morphology of cerebral capillaries do not correlate with cognitive decline

(2011) Alan Peters et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Immune profiling of Alzheimer patients

(2011) Mariavaleria Pellicanò et al.   JOURNAL OF NEUROIMMUNOLOGY

The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis

(2011) Jie Zhao et al.   Journal of Neuroinflammation

Binding of Curcumin to Senile Plaques and Cerebral Amyloid Angiopathy in the Aged Brain of Various Animals and to Neurofibrillary Tangles in Alzheimer's Brain

(2011) Mayu MUTSUGA et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

(2011) Marco Prinz et al.   NATURE NEUROSCIENCE

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease

(2011) J. Li et al.   NEUROLOGY

Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia

(2011) M.A. Koike et al.   NEUROSCIENCE LETTERS

Amyloid Triggers Extensive Cerebral Angiogenesis Causing Blood Brain Barrier Permeability and Hypervascularity in Alzheimer's Disease

(2011) Kaan E. Biron et al.   PLoS One

Neurobiology of the aging dog

(2010) Elizabeth Head   AGE

Vascular risk factor detection and control may prevent Alzheimer's disease

(2010) Jack C. de la Torre   AGEING RESEARCH REVIEWS

Brain Endothelial Cells Synthesize Neurotoxic Thrombin in Alzheimer’s Disease

(2010) Xiangling Yin et al.   AMERICAN JOURNAL OF PATHOLOGY

APOE ε4 Genotype and Longitudinal Changes in Cerebral Blood Flow in Normal Aging

(2010) Madhav Thambisetty et al.   ARCHIVES OF NEUROLOGY

The etiology of age-related dementia is more complicated than we think

(2010) Robert J. McDonald et al.   BEHAVIOURAL BRAIN RESEARCH

Proteolytic processing of tau

(2010) Yipeng Wang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Looking at the blood–brain barrier: Molecular anatomy and possible investigation approaches

(2010) Filipa Lourenço Cardoso et al.   BRAIN RESEARCH REVIEWS

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Amyloid Efflux Transporter Expression at the Blood-Brain Barrier Declines in Normal Aging

(2010) Gerald D. Silverberg et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Does Accumulation of Advanced Glycation End Products Contribute to the Aging Phenotype?

(2010) R. D. Semba et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Prevalence and Impact of Cerebrovascular Lesions in Alzheimer and Lewy Body Diseases

(2010) Kurt A. Jellinger   Neurodegenerative Diseases

The Vascular Hypothesis of Alzheimer’s Disease: Bench to Bedside and Beyond

(2010) Jack C. de la Torre   Neurodegenerative Diseases

Distinct cerebral perfusion patterns in FTLD and AD

(2010) W. T. Hu et al.   NEUROLOGY

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

Review: Cerebral microvascular pathology in ageing and neurodegeneration

(2010) W. R. Brown et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Lead-induced accumulation of β-amyloid in the choroid plexus: Role of low density lipoprotein receptor protein-1 and protein kinase C

(2010) Mamta Behl et al.   NEUROTOXICOLOGY

Vascular basis for brain degeneration: faltering controls and risk factors for dementia

(2010) Raj N Kalaria   NUTRITION REVIEWS

Differential effects and rates of normal aging in cerebellum and hippocampus

(2010) D. S. Woodruff-Pak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peripherally Applied A -Containing Inoculates Induce Cerebral  -Amyloidosis

(2010) Y. S. Eisele et al.   SCIENCE

Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease

(2009) Robert D. Bell et al.   ACTA NEUROPATHOLOGICA

Cerebral blood flow in ischemic vascular dementia and Alzheimer's disease, measured by arterial spin-labeling magnetic resonance imaging

(2009) Norbert Schuff et al.   Alzheimers & Dementia

Multiple levels of regulation determine the role of the receptor for AGE (RAGE) as common soil in inflammation, immune responses and diabetes mellitus and its complications

(2009) A. Bierhaus et al.   DIABETOLOGIA

RAGE-dependent signaling in microglia contributes to neuroinflammation, Aβ accumulation, and impaired learning/memory in a mouse model of Alzheimer’s disease

(2009) Fang Fang et al.   FASEB JOURNAL

Age and Neuroinflammation: A Lifetime of Psychoneuroimmune Consequences

(2009) Jonathan P. Godbout et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Amyloid-β-induced occludin down-regulation and increased permeability in human brain endothelial cells is mediated by MAPK activation

(2009) L.M. Tai et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Amyloid Deposition and Influx Transporter Expression at the Blood-Brain Barrier Increase in Normal Aging

(2009) Gerald D. Silverberg et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Matrix metalloproteinases and their multiple roles in neurodegenerative diseases

(2009) Gary A Rosenberg   LANCET NEUROLOGY

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

DECREASED mRNA EXPRESSION OF TIGHT JUNCTION PROTEINS IN LUMBAR SPINAL CORDS OF PATIENTS WITH ALS

(2009) J. S. Henkel et al.   NEUROLOGY

RAGE-mediated signaling contributes to intraneuronal transport of amyloid-  and neuronal dysfunction

(2009) K. Takuma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased β-amyloid levels in the choroid plexus following lead exposure and the involvement of low-density lipoprotein receptor protein-1

(2009) Mamta Behl et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

(2008) Dennis J. Selkoe   BEHAVIOURAL BRAIN RESEARCH

Hypertension and Cerebrovascular Dysfunction

(2008) Costantino Iadecola et al.   Cell Metabolism

Evidence for Altered LRP/RAGE Expression in Alzheimer Lesion Pathogenesis

(2008) Brian Jeynes et al.   Current Alzheimer Research

Microglial degeneration in the aging brain - bad news for neurons?

(2008) Wolfgang et al.   Frontiers in Bioscience-Landmark

SRF and myocardin regulate LRP-mediated amyloid-β clearance in brain vascular cells

(2008) Robert D. Bell et al.   NATURE CELL BIOLOGY

LRP1 modulates APP trafficking along early compartments of the secretory pathway

(2008) Elaine Waldron et al.   NEUROBIOLOGY OF DISEASE

Central obesity and increased risk of dementia more than three decades later

(2008) R. A. Whitmer et al.   NEUROLOGY

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON

New therapeutic targets in the neurovascular pathway in Alzheimer’s disease

(2008) Berislav V. Zlokovic   Neurotherapeutics

 -Secretase Limits the Inflammatory Response Through the Processing of LRP1

(2008) K. Zurhove et al.   Science Signaling

Hypoxia increases Aβ generation by altering β- and γ-cleavage of APP

(2007) Liang Li et al.   NEUROBIOLOGY OF AGING

Blood–brain barrier: Ageing and microvascular disease – systematic review and meta-analysis

(2007) Andrew J. Farrall et al.   NEUROBIOLOGY OF AGING