Human stem cell models: lessons for pancreatic development and disease

A Peninsular Structure Coordinates Asynchronous Differentiation with Morphogenesis to Generate Pancreatic Islets

(2019) Nadav Sharon et al.   CELL

Acquisition of Dynamic Function in Human Stem Cell-Derived β Cells

(2019) Leonardo Velazco-Cruz et al.   Stem Cell Reports

GATA6 Cooperates with EOMES/SMAD2/3 to Deploy the Gene Regulatory Network Governing Human Definitive Endoderm and Pancreas Formation

(2019) Crystal Y. Chia et al.   Stem Cell Reports

Point mutations in the PDX1 transactivation domain impair human β-cell development and function

(2019) Xianming Wang et al.   Molecular Metabolism

Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells

(2019) Gopika G. Nair et al.   NATURE CELL BIOLOGY

Charting cellular identity during human in vitro β-cell differentiation

(2019) Adrian Veres et al.   NATURE

Genome-scale screens identify JNK–JUN signaling as a barrier for pluripotency exit and endoderm differentiation

(2019) Qing V. Li et al.   NATURE GENETICS

Wnt Signaling Separates the Progenitor and Endocrine Compartments during Pancreas Development

(2019) Nadav Sharon et al.   Cell Reports

Comprehensive single cell mRNA profiling reveals a detailed roadmap for pancreatic endocrinogenesis

(2019) Aimée Bastidas-Ponce et al.   DEVELOPMENT

YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells

(2019) Edwin A. Rosado-Olivieri et al.   Nature Communications

FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation

(2019) Kihyun Lee et al.   Cell Reports

Modeling Monogenic Diabetes using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A

(2019) Fabian L. Cardenas-Diaz et al.   Cell Stem Cell

Assessing sufficiency and necessity of enhancer activities for gene expression and the mechanisms of transcription activation

(2018) Rui R. Catarino et al.   GENES & DEVELOPMENT

Decoding the dynamic DNA methylation and hydroxymethylation landscapes in endodermal lineage intermediates during pancreatic differentiation of hESC

(2018) Jia Li et al.   NUCLEIC ACIDS RESEARCH

Discovery of a drug candidate for GLIS3-associated diabetes

(2018) Sadaf Amin et al.   Nature Communications

Genetic Testing of Maturity-Onset Diabetes of the Young Current Status and Future Perspectives

(2018) Parveena Firdous et al.   Frontiers in Endocrinology

Understanding human fetal pancreas development using subpopulation sorting, RNA sequencing and single-cell profiling

(2018) Cyrille Ramond et al.   DEVELOPMENT

Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis

(2018) Marissa A. Scavuzzo et al.   Nature Communications

Lineage dynamics of murine pancreatic development at single-cell resolution

(2018) Lauren E. Byrnes et al.   Nature Communications

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

(2018) Jacob O'Brien et al.   Frontiers in Endocrinology

Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic β Cells for In Vitro and In Vivo Analysis

(2018) Diane C. Saunders et al.   Cell Metabolism

Interaction of the GTPase Elongation Factor Like-1 with the Shwachman-Diamond Syndrome Protein and Its Missense Mutations

(2018) Abril Gijsbers et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanosignalling via integrins directs fate decisions of pancreatic progenitors

(2018) Anant Mamidi et al.   NATURE

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

(2018) Anubha Mahajan et al.   NATURE GENETICS

The α-cell in diabetes mellitus

(2018) Jesper Gromada et al.   Nature Reviews Endocrinology

Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

(2018) Diego Balboa et al.   eLife

Single-Cell Transcriptome Profiling of Mouse and hESC-Derived Pancreatic Progenitors

(2018) Nicole A.J. Krentz et al.   Stem Cell Reports

Sequence Determinants for Nuclear Retention and Cytoplasmic Export of mRNAs and lncRNAs

(2018) Alexander F. Palazzo et al.   Frontiers in Genetics

Demethylation of induced pluripotent stem cells from type 1 diabetic patients enhances differentiation into functional pancreatic β cells

(2017) Gohar S. Manzar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Islet inflammation in type 2 diabetes and physiology

(2017) Kosei Eguchi et al.   JOURNAL OF CLINICAL INVESTIGATION

Resealable, optically accessible, PDMS-free fluidic platform for ex vivo interrogation of pancreatic islets

(2017) Giovanni Lenguito et al.   LAB ON A CHIP

Raptor regulates functional maturation of murine beta cells

(2017) Qicheng Ni et al.   Nature Communications

An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation

(2017) Jonna Saarimäki-Vire et al.   Cell Reports

Using hESCs to Probe the Interaction of the Diabetes-Associated Genes CDKAL1 and MT1E

(2017) Min Guo et al.   Cell Reports

Reconstructing human pancreatic differentiation by mapping specific cell populations during development

(2017) Cyrille Ramond et al.   eLife

Single-Cell Gene Expression Analysis of a Human ESC Model of Pancreatic Endocrine Development Reveals Different Paths to β-Cell Differentiation

(2017) Maja Borup Kjær Petersen et al.   Stem Cell Reports

Laser Capture and Deep Sequencing Reveals the Transcriptomic Programmes Regulating the Onset of Pancreas and Liver Differentiation in Human Embryos

(2017) Rachel E. Jennings et al.   Stem Cell Reports

GATA6 Plays an Important Role in the Induction of Human Definitive Endoderm, Development of the Pancreas, and Functionality of Pancreatic β Cells

(2017) Amita Tiyaboonchai et al.   Stem Cell Reports

Identification of islet-enriched long non-coding RNAs contributing to β-cell failure in type 2 diabetes

(2017) Anna Motterle et al.   Molecular Metabolism

Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells

(2017) Heidrun Vethe et al.   Scientific Reports

An Isogenic Human ESC Platform for Functional Evaluation of Genome-wide-Association-Study-Identified Diabetes Genes and Drug Discovery

(2016) Hui Zeng et al.   Cell Stem Cell

Genome Editing of Lineage Determinants in Human Pluripotent Stem Cells Reveals Mechanisms of Pancreatic Development and Diabetes

(2016) Zengrong Zhu et al.   Cell Stem Cell

Divergent lncRNAs Regulate Gene Expression and Lineage Differentiation in Pluripotent Cells

(2016) Sai Luo et al.   Cell Stem Cell

βlinc1encodes a long noncoding RNA that regulates islet β-cell formation and function

(2016) Luis Arnes et al.   GENES & DEVELOPMENT

Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling

(2016) Meike Hohwieler et al.   GUT

Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes

(2016) James Dooley et al.   NATURE GENETICS

Generation of stem cell-derived β-cells from patients with type 1 diabetes

(2016) Jeffrey R. Millman et al.   Nature Communications

DIGIT Is a Conserved Long Noncoding RNA that Regulates GSC Expression to Control Definitive Endoderm Differentiation of Embryonic Stem Cells

(2016) Kaveh Daneshvar et al.   Cell Reports

Modeling Cystic Fibrosis Using Pluripotent Stem Cell-Derived Human Pancreatic Ductal Epithelial Cells

(2016) Senem Simsek et al.   Stem Cells Translational Medicine

Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia

(2016) Adrian Kee Keong Teo et al.   Stem Cell Reports

A suppressor locus for MODY3-diabetes

(2016) Miguel A. Garcia-Gonzalez et al.   Scientific Reports

Epigenetic Priming of Enhancers Predicts Developmental Competence of hESC-Derived Endodermal Lineage Intermediates

(2015) Allen Wang et al.   Cell Stem Cell

Islet formation in mice and men: lessons for the generation of functional insulin-producing β-cells from human pluripotent stem cells

(2015) Gopika Nair et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Human pancreas development

(2015) R. E. Jennings et al.   DEVELOPMENT

Hnf1b controls pancreas morphogenesis and the generation of Ngn3+ endocrine progenitors

(2015) M. G. De Vas et al.   DEVELOPMENT

The Basic Helix-Loop-Helix Transcription Factor NEUROG3 Is Required for Development of the Human Endocrine Pancreas

(2015) Patrick S. McGrath et al.   DIABETES

Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro

(2015) H. A. Russ et al.   EMBO JOURNAL

Embryonic stem cell-derived pancreatic endoderm transplant with MCT1-suppressing miR-495 attenuates type II diabetes in mice

(2015) Dong Liang et al.   ENDOCRINE JOURNAL

miR-410 enhanced hESC-derived pancreatic endoderm transplant to alleviate gestational diabetes mellitus

(2015) Yang Mi et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors

(2015) Inês Cebola et al.   NATURE CELL BIOLOGY

Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids

(2015) Ling Huang et al.   NATURE MEDICINE

Histone exchange, chromatin structure and the regulation of transcription

(2015) Swaminathan Venkatesh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The histone variant H2A.Z is an important regulator of enhancer activity

(2015) Mylène Brunelle et al.   NUCLEIC ACIDS RESEARCH

The biological functions of miRNAs: lessons from in vivo studies

(2015) Joana A. Vidigal et al.   TRENDS IN CELL BIOLOGY

Pancreatic islet cell development and regeneration

(2015) Anthony I. Romer et al.   Current Opinion in Endocrinology Diabetes and Obesity

A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells

(2015) Hung Ping Shih et al.   Cell Reports

The lncRNA DEANR1 Facilitates Human Endoderm Differentiation by Activating FOXA2 Expression

(2015) Wei Jiang et al.   Cell Reports

PDX1 Binds and Represses Hepatic Genes to Ensure Robust Pancreatic Commitment in Differentiating Human Embryonic Stem Cells

(2015) Adrian Kee Keong Teo et al.   Stem Cell Reports

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Analysis of Transcription Factors Key for Mouse Pancreatic Development Establishes NKX2-2 and MNX1 Mutations as Causes of Neonatal Diabetes in Man

(2014) Sarah E. Flanagan et al.   Cell Metabolism

Efficient Endoderm Induction from Human Pluripotent Stem Cells by Logically Directing Signals Controlling Lineage Bifurcations

(2014) Kyle M. Loh et al.   Cell Stem Cell

Dynamics of genomic H3K27me3 domains and role of EZH2 during pancreatic endocrine specification

(2014) C.-R. Xu et al.   EMBO JOURNAL

Long noncoding RNAs are spatially correlated with transcription factors and regulate lung development

(2014) M. J. Herriges et al.   GENES & DEVELOPMENT

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants

(2014) Lorenzo Pasquali et al.   NATURE GENETICS

Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease

(2014) Sarah E Flanagan et al.   NATURE GENETICS

Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus

(2014) Trevor J. Biden et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The pancreatic β cell: recent insights from human genetics

(2014) Soren K. Thomsen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Functional implications of long non-coding RNAs in the pancreatic islets of Langerhans

(2014) Jonathan L. S. Esguerra et al.   Frontiers in Genetics

Pancreas Organogenesis: From Lineage Determination to Morphogenesis

(2013) Hung Ping Shih et al.   Annual Review of Cell and Developmental Biology

Developmental Fate and Cellular Maturity Encoded in Human Regulatory DNA Landscapes

(2013) Andrew B. Stergachis et al.   CELL

FGF7 and cell density are required for final differentiation of pancreatic amylase-positive cells from human ES cells

(2013) Sakiko Takizawa-Shirasawa et al.   CELL AND TISSUE RESEARCH

Dynamic Chromatin Remodeling Mediated by Polycomb Proteins Orchestrates Pancreatic Differentiation of Human Embryonic Stem Cells

(2013) Ruiyu Xie et al.   Cell Stem Cell

Pluripotent Stem Cell Models of Shwachman-Diamond Syndrome Reveal a Common Mechanism for Pancreatic and Hematopoietic Dysfunction

(2013) Asmin Tulpule et al.   Cell Stem Cell

 -Cell Dysfunction Due to Increased ER Stress in a Stem Cell Model of Wolfram Syndrome

(2013) L. Shang et al.   DIABETES

Development of the Human Pancreas From Foregut to Endocrine Commitment

(2013) R. E. Jennings et al.   DIABETES

Transcription factor gene MNX1 is a novel cause of permanent neonatal diabetes in a consanguineous family

(2013) A. Bonnefond et al.   DIABETES & METABOLISM

Matched miRNA and mRNA signatures from an hESC-based in vitro model of pancreatic differentiation reveal novel regulatory interactions

(2013) X. Liao et al.   JOURNAL OF CELL SCIENCE

Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis

(2013) Michael N Weedon et al.   NATURE GENETICS

Neonatal diabetes, gallbladder agenesis, duodenal atresia, and intestinal malrotation caused by a novel homozygous mutation inRFX6

(2013) Jennifer P Concepcion et al.   PEDIATRIC DIABETES

Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells

(2013) A. A. Sigova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-26a targets ten eleven translocation enzymes and is regulated during pancreatic cell differentiation

(2013) X. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired ribosomal subunit association in Shwachman-Diamond syndrome

(2012) N. Burwick et al.   BLOOD

Human β Cell Transcriptome Analysis Uncovers lncRNAs That Are Tissue-Specific, Dynamically Regulated, and Abnormally Expressed in Type 2 Diabetes

(2012) Ignasi Morán et al.   Cell Metabolism

Antisense miR-7 Impairs Insulin Expression in Developing Pancreas and in Cultured Pancreatic Buds

(2012) Margarita Nieto et al.   CELL TRANSPLANTATION

A Sox9/Fgf feed-forward loop maintains pancreatic organ identity

(2012) P. A. Seymour et al.   DEVELOPMENT

CDK5 Regulatory Subunit-associated Protein 1-Like 1 (CDKAL1) Is a Tail-anchored Protein in the Endoplasmic Reticulum (ER) of Insulinoma Cells

(2012) Silvia Brambillasca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis

(2012) Shouhong Xuan et al.   JOURNAL OF CLINICAL INVESTIGATION

GATA4 and GATA6 control mouse pancreas organogenesis

(2012) Manuel Carrasco et al.   JOURNAL OF CLINICAL INVESTIGATION

Intrapatient Variations in Type 1 Diabetes-specific iPS Cell Differentiation Into Insulin-producing Cells

(2012) Tayaramma Thatava et al.   MOLECULAR THERAPY

Transcription factors: from enhancer binding to developmental control

(2012) François Spitz et al.   NATURE REVIEWS GENETICS

Human pluripotent stem cells for disease modelling and drug screening

(2011) Yves Maury et al.   BIOESSAYS

Permanent Neonatal Diabetes and Enteric Anendocrinosis Associated With Biallelic Mutations in NEUROG3

(2011) O. Rubio-Cabezas et al.   DIABETES

Pioneer transcription factors: establishing competence for gene expression

(2011) K. S. Zaret et al.   GENES & DEVELOPMENT

GATA6 haploinsufficiency causes pancreatic agenesis in humans

(2011) Hana Lango Allen et al.   NATURE GENETICS

Identification of microRNAs expressed highly in pancreatic islet-like cell clusters differentiated from human embryonic stem cells

(2010) Bo‑Zhi Chen et al.   CELL BIOLOGY INTERNATIONAL

Homozygous Mutations in NEUROD1 Are Responsible for a Novel Syndrome of Permanent Neonatal Diabetes and Neurological Abnormalities

(2010) O. Rubio-Cabezas et al.   DIABETES

Production of Functional Glucagon-Secreting  -Cells From Human Embryonic Stem Cells

(2010) A. Rezania et al.   DIABETES

Novel GLIS3 mutations demonstrate an extended multisystem phenotype

(2010) P Dimitri et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

High-efficiency derivation of human embryonic stem cell lines following pre-implantation genetic diagnosis

(2010) Philippe Tropel et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Rfx6 directs islet formation and insulin production in mice and humans

(2010) Stuart B. Smith et al.   NATURE

Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth

(2010) Ming Liu et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Transcription Factor Glis3, a Novel Critical Player in the Regulation of Pancreatic  -Cell Development and Insulin Gene Expression

(2009) H. S. Kang et al.   MOLECULAR AND CELLULAR BIOLOGY

Generation of pluripotent stem cells from patients with type 1 diabetes

(2009) R. Maehr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preimplantation genetic diagnosis as a source of human embryonic stem cells for disease research and drug discovery

(2008) EL Stephenson et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Reduction of Ptf1a Gene Dosage Causes Pancreatic Hypoplasia and Diabetes in Mice

(2008) A. Fukuda et al.   DIABETES

Lack of pancreatic body and tail inHNF1Bmutation carriers

(2008) I. S. Haldorsen et al.   DIABETIC MEDICINE

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY

PGD-derived human embryonic stem cell lines as a powerful tool for the study of human genetic disorders

(2007) D. Ben-Yosef et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY