Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis

Dynamics of chromatin marks and the role of JMJD3 during pancreatic endocrine cell fate commitment

(2018) Xin-Xin Yu et al.   DEVELOPMENT

SIMLR: A Tool for Large-Scale Genomic Analyses by Multi-Kernel Learning

(2018) Bo Wang et al.   PROTEOMICS

FUCCI tracking shows cell-cycle-dependent Neurog3 variation in pancreatic progenitors

(2017) Matthew E. Bechard et al.   GENESIS

Effective detection of variation in single-cell transcriptomes using MATQ-seq

(2017) Kuanwei Sheng et al.   NATURE METHODS

Visualization and analysis of single-cell RNA-seq data by kernel-based similarity learning

(2017) Bo Wang et al.   NATURE METHODS

Single-cell mRNA quantification and differential analysis with Census

(2017) Xiaojie Qiu et al.   NATURE METHODS

Reconstructing human pancreatic differentiation by mapping specific cell populations during development

(2017) Cyrille Ramond et al.   eLife

Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells

(2016) Gioele La Manno et al.   CELL

Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics

(2016) Karthik Shekhar et al.   CELL

Genome Editing of Lineage Determinants in Human Pluripotent Stem Cells Reveals Mechanisms of Pancreatic Development and Diabetes

(2016) Zengrong Zhu et al.   Cell Stem Cell

Precommitment low-levelNeurog3expression defines a long-lived mitotic endocrine-biased progenitor pool that drives production of endocrine-committed cells

(2016) Matthew E. Bechard et al.   GENES & DEVELOPMENT

Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution

(2016) M Ryan Corces et al.   NATURE GENETICS

Cell-cycle-independent transitions in temporal identity of mammalian neural progenitor cells

(2016) Mayumi Okamoto et al.   Nature Communications

DCDC2 Mutations Cause a Renal-Hepatic Ciliopathy by Disrupting Wnt Signaling

(2015) Markus Schueler et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

(2015) Evan Z. Macosko et al.   CELL

Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding

(2015) Shashank Tripathi et al.   Cell Host & Microbe

Human pancreas development

(2015) R. E. Jennings et al.   DEVELOPMENT

Feedback control of growth, differentiation, and morphogenesis of pancreatic endocrine progenitors in an epithelial plexus niche

(2015) Eric D. Bankaitis et al.   GENES & DEVELOPMENT

Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells

(2015) Monika S. Kowalczyk et al.   GENOME RESEARCH

DNA methylation directs functional maturation of pancreatic β cells

(2015) Sangeeta Dhawan et al.   JOURNAL OF CLINICAL INVESTIGATION

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Systematically labeling developmental stage-specific genes for the study of pancreatic β-cell differentiation from human embryonic stem cells

(2014) Haisong Liu et al.   CELL RESEARCH

Taming the young and restless--epigenetic gene regulation in pancreas and beta-cell precursors

(2014) H. A. Russ et al.   EMBO JOURNAL

AmotL2 disrupts apical–basal cell polarity and promotes tumour invasion

(2014) Mahdi Mojallal et al.   Nature Communications

Factors Expressed by Murine Embryonic Pancreatic Mesenchyme Enhance Generation of Insulin-Producing Cells From hESCs

(2013) T. Guo et al.   DIABETES

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

SeeDB: a simple and morphology-preserving optical clearing agent for neuronal circuit reconstruction

(2013) Meng-Tsen Ke et al.   NATURE NEUROSCIENCE

Nkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta Cells

(2013) Brandon L. Taylor et al.   Cell Reports

A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation

(2012) H. P. Shih et al.   DEVELOPMENT

TheAmotl2Gene Inhibits Wnt/β-Catenin Signaling and Regulates Embryonic Development in Zebrafish

(2012) Zhiqiang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lineage determinants in early endocrine development

(2012) Sebastian Rieck et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas

(2011) J. L. Kopp et al.   DEVELOPMENT

Ngn3+ endocrine progenitor cells control the fate and morphogenesis of pancreatic ductal epithelium

(2011) Judith Magenheim et al.   DEVELOPMENTAL BIOLOGY

Competence of failed endocrine progenitors to give rise to acinar but not ductal cells is restricted to early pancreas development

(2011) Anthony Beucher et al.   DEVELOPMENTAL BIOLOGY

Nkx2.2 repressor complex regulates islet  -cell specification and prevents  -to- -cell reprogramming

(2011) J. B. Papizan et al.   GENES & DEVELOPMENT

Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein

(2011) B. Zhao et al.   GENES & DEVELOPMENT

Angiomotin-like2 Gene (amotl2) Is Required for Migration and Proliferation of Endothelial Cells during Angiogenesis

(2011) Yeqi Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neonatal Diabetes and Congenital Malabsorptive Diarrhea Attributable to a Novel Mutation in the Human Neurogenin-3 Gene Coding Sequence

(2011) Sara E. Pinney et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Chromatin "Prepattern" and Histone Modifiers in a Fate Choice for Liver and Pancreas

(2011) C.-R. Xu et al.   SCIENCE

Epithelial dynamics of pancreatic branching morphogenesis

(2010) A. Villasenor et al.   DEVELOPMENT

Nkx6 Transcription Factors and Ptf1a Function as Antagonistic Lineage Determinants in Multipotent Pancreatic Progenitors

(2010) Ashleigh E. Schaffer et al.   DEVELOPMENTAL CELL

Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development

(2009) Josselin Soyer et al.   DEVELOPMENT

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Functional significance of repressor element 1 silencing transcription factor (REST) target genes in pancreatic beta cells

(2008) D. Martin et al.   DIABETOLOGIA

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH