Functional implications of long non-coding RNAs in the pancreatic islets of Langerhans

Role of non-coding RNAs in pancreatic beta-cell development and physiology

(2014) L. Eliasson et al.   Acta Physiologica

Development of a conditionally immortalized human pancreatic β cell line

(2014) Raphaël Scharfmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants

(2014) Lorenzo Pasquali et al.   NATURE GENETICS

Comparative primate genomics: emerging patterns of genome content and dynamics

(2014) Jeffrey Rogers et al.   NATURE REVIEWS GENETICS

Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre

(2014) Ezgi Hacisuleyman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genome-Wide DNA Methylation Analysis of Human Pancreatic Islets from Type 2 Diabetic and Non-Diabetic Donors Identifies Candidate Genes That Influence Insulin Secretion

(2014) Tasnim Dayeh et al.   PLoS Genetics

Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency

(2014) Yul W Yang et al.   eLife

Regulation of metabolism by long, non-coding RNAs

(2014) Jan-Wilhelm Kornfeld et al.   Frontiers in Genetics

Gene regulation by the act of long non-coding RNA transcription

(2013) Aleksandra E Kornienko et al.   BMC BIOLOGY

Role of genomic architecture in the expression dynamics of long noncoding RNAs during differentiation of human neuroblastoma cells

(2013) Arsen O Batagov et al.   BMC Systems Biology

Imprinted Igf2r silencing depends on continuous Airn lncRNA expression and is not restricted to a developmental window

(2013) F. Santoro et al.   DEVELOPMENT

Role of Reduced  -Cell Mass Versus Impaired  -Cell Function in the Pathogenesis of Type 2 Diabetes

(2013) J. J. Meier et al.   DIABETES CARE

Glucose regulation of glucagon secretion

(2013) Erik Gylfe et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome

(2013) A. C. Nica et al.   GENOME RESEARCH

Inactivation of specific β cell transcription factors in type 2 diabetes

(2013) Shuangli Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Epigenomic plasticity enables human pancreatic α to β cell reprogramming

(2013) Nuria C. Bramswig et al.   JOURNAL OF CLINICAL INVESTIGATION

The islet ghrelin cell

(2013) Nils Wierup et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Regional Differences in Islet Distribution in the Human Pancreas - Preferential Beta-Cell Loss in the Head Region in Patients with Type 2 Diabetes

(2013) Xiaojun Wang et al.   PLoS One

Gastrin: A Distinct Fate of Neurogenin3 Positive Progenitor Cells in the Embryonic Pancreas

(2013) Yaron Suissa et al.   PLoS One

Long noncoding RNAs: fresh perspectives into the RNA world

(2013) Lin Yang et al.   TRENDS IN BIOCHEMICAL SCIENCES

Regulation of Insulin Secretion in Human Pancreatic Islets

(2012) Patrik Rorsman et al.   Annual Review of Physiology

Diabetes Mellitus and the β Cell: The Last Ten Years

(2012) Frances M. Ashcroft et al.   CELL

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Human β Cell Transcriptome Analysis Uncovers lncRNAs That Are Tissue-Specific, Dynamically Regulated, and Abnormally Expressed in Type 2 Diabetes

(2012) Ignasi Morán et al.   Cell Metabolism

Cytotopic localization by long noncoding RNAs

(2012) Pedro J Batista et al.   CURRENT OPINION IN CELL BIOLOGY

Pancreas-enriched miRNA refines endocrine cell differentiation

(2012) S. Kredo-Russo et al.   DEVELOPMENT

Reduced Insulin Exocytosis in Human Pancreatic  -Cells With Gene Variants Linked to Type 2 Diabetes

(2012) A. H. Rosengren et al.   DIABETES

The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression

(2012) T. Derrien et al.   GENOME RESEARCH

Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover

(2012) Roger H. Unger et al.   JOURNAL OF CLINICAL INVESTIGATION

Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes

(2012) Sofia A. Andersson et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Research Resource: RNA-Seq Reveals Unique Features of the Pancreatic β-Cell Transcriptome

(2012) Gregory M. Ku et al.   MOLECULAR ENDOCRINOLOGY

Modular regulatory principles of large non-coding RNAs

(2012) Mitchell Guttman et al.   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Evolution of the human-specific microRNA miR-941

(2012) Hai Yang Hu et al.   Nature Communications

Conserved Function of lincRNAs in Vertebrate Embryonic Development despite Rapid Sequence Evolution

(2011) Igor Ulitsky et al.   CELL

Innervation Patterns of Autonomic Axons in the Human Endocrine Pancreas

(2011) Rayner Rodriguez-Diaz et al.   Cell Metabolism

Transcriptomes of the major human pancreatic cell types

(2011) C. Dorrell et al.   DIABETOLOGIA

Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses

(2011) M. N. Cabili et al.   GENES & DEVELOPMENT

Differences between Human and Rodent Pancreatic Islets

(2011) Michael J. MacDonald et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion

(2011) Philippe Ravassard et al.   JOURNAL OF CLINICAL INVESTIGATION

GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: Implications for understanding genetic association signals at this locus

(2011) Laura J. McCulloch et al.   MOLECULAR GENETICS AND METABOLISM

Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans

(2011) Rayner Rodriguez-Diaz et al.   NATURE MEDICINE

Large human islets secrete less insulin per islet equivalent than smaller islets in vitro

(2011) Yasutaka Fujita et al.   Islets

Long Noncoding RNAs with Enhancer-like Function in Human Cells

(2010) Ulf Andersson Ørom et al.   CELL

Global Epigenomic Analysis of Primary Human Pancreatic Islets Provides Insights into Type 2 Diabetes Susceptibility Loci

(2010) Michael L. Stitzel et al.   Cell Metabolism

Genome-wide analysis of histone modifications in human pancreatic islets

(2010) R. Bhandare et al.   GENOME RESEARCH

A map of open chromatin in human pancreatic islets

(2010) Kyle J Gaulton et al.   NATURE GENETICS

genenames.org: the HGNC resources in 2011

(2010) R. L. Seal et al.   NUCLEIC ACIDS RESEARCH

lncRNAdb: a reference database for long noncoding RNAs

(2010) Paulo P. Amaral et al.   NUCLEIC ACIDS RESEARCH

Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes

(2010) M.-C. Tsai et al.   SCIENCE

Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites

(2010) Doron Betel et al.   GENOME BIOLOGY

Exocytotic Properties of Human Pancreatic β-cells

(2009) Matthias Braun et al.   Annals of the New York Academy of Sciences

Genetic basis of β-cell dysfunction in man

(2009) L. Groop et al.   DIABETES OBESITY & METABOLISM

Cluster analysis of rat pancreatic islet gene mRNA levels after culture in low-, intermediate- and high-glucose concentrations

(2009) M. Bensellam et al.   DIABETOLOGIA

An Architectural Role for a Nuclear Noncoding RNA: NEAT1 RNA Is Essential for the Structure of Paraspeckles

(2009) Christine M. Clemson et al.   MOLECULAR CELL

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

(2009) Mitchell Guttman et al.   NATURE

Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

(2009) Ahmad M. Khalil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin as a physiological modulator of glucagon secretion

(2008) Pritpal Bansal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Voltage-Gated Ion Channels in Human Pancreatic  -Cells: Electrophysiological Characterization and Role in Insulin Secretion

(2008) M. Braun et al.   DIABETES

Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation

(2008) M. E. Dinger et al.   GENOME RESEARCH

Specific expression of long noncoding RNAs in the mouse brain

(2008) T. R. Mercer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

KATP-channels and glucose-regulated glucagon secretion

(2008) Patrik Rorsman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM