Anthocyanins: From plant pigments to health benefits at mitochondrial level

Neuroprotective effects of anthocyanins and its major component cyanidin-3-O-glucoside (C3G) in the central nervous system: An outlined review

(2019) Jinlin Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective

(2018) Gary Williamson et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Berries containing anthocyanins with enhanced methylation profiles are more effective at ameliorating high fat diet-induced metabolic damage

(2018) Emily Skates et al.   FOOD AND CHEMICAL TOXICOLOGY

Cyanidin ameliorates endotoxin-induced myocardial toxicity by modulating inflammation and oxidative stress through mitochondria and other factors

(2018) Fang Li et al.   FOOD AND CHEMICAL TOXICOLOGY

Polyelectrolyte microcapsules built on CaCO 3 scaffolds for the integration, encapsulation, and controlled release of copigmented anthocyanins

(2018) Chen Tan et al.   FOOD CHEMISTRY

Encapsulation of anthocyanins from bilberries – Effects on bioavailability and intestinal accessibility in humans

(2018) Dolores Mueller et al.   FOOD CHEMISTRY

Optimized extraction of anthocyanins from Reid Fruits’ Prunus avium ‘Lapins’ cherries

(2018) Melanie L. Blackhall et al.   FOOD CHEMISTRY

Mitochondria: Targeting mitochondrial reactive oxygen species with mitochondriotropic polyphenolic-based antioxidants

(2018) José Teixeira et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Anthocyanins inhibit high glucose-induced renal tubular cell apoptosis caused by oxidative stress in db/db mice

(2018) Jinying Wei et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Radical Scavenging and Anti-Inflammatory Activities of Representative Anthocyanin Groupings from Pigment-Rich Fruits and Vegetables

(2018) Federica Blando et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Overexpression of the Anthocyanidin Synthase Gene in Strawberry Enhances Antioxidant Capacity and Cytotoxic Effects on Human Hepatic Cancer Cells

(2018) Francesca Giampieri et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Discovery of a new mitochondria permeability transition pore (mPTP) inhibitor based on gallic acid

(2018) José Teixeira et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

The C–S–A gene system regulates hull pigmentation and reveals evolution of anthocyanin biosynthesis pathway in rice

(2018) Xingming Sun et al.   JOURNAL OF EXPERIMENTAL BOTANY

Anthocyanins as a potential pharmacological agent to manage memory deficit, oxidative stress and alterations in ion pump activity induced by experimental sporadic dementia of Alzheimer's type

(2018) Simone Muniz Pacheco et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Berry anthocyanin intake and cardiovascular health

(2018) Aedín Cassidy   MOLECULAR ASPECTS OF MEDICINE

Anthocyanins Improve Hippocampus-Dependent Memory Function and Prevent Neurodegeneration via JNK/Akt/GSK3β Signaling in LPS-Treated Adult Mice

(2018) Muhammad Sohail Khan et al.   MOLECULAR NEUROBIOLOGY

Anthocyanin-Rich Grape Pomace Extract (Vitis vinifera L.) from Wine Industry Affects Mitochondrial Bioenergetics and Glucose Metabolism in Human Hepatocarcinoma HepG2 Cells

(2018) Nathalia de Sales et al.   MOLECULES

Cognitive response to fish oil, blueberry, and combined supplementation in older adults with subjective cognitive impairment

(2018) Robert K. McNamara et al.   NEUROBIOLOGY OF AGING

Reduced mortality risk by a polyphenol-rich diet: An analysis from the Moli-sani study

(2018) George Pounis et al.   NUTRITION

Solar UV light regulates flavonoid metabolism in apple (Malus x domestica)

(2018) Rebecca A. Henry-Kirk et al.   PLANT CELL AND ENVIRONMENT

Isolation and Characterization of Key Genes that Promote Flavonoid Accumulation in Purple-leaf Tea (Camellia sinensis L.)

(2018) Xiujuan He et al.   Scientific Reports

Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials

(2018) Lee Hooper et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Cyanidin-3-glucoside enhances mitochondrial function and biogenesis in a human hepatocyte cell line

(2018) Rashad Mogalli et al.   CYTOTECHNOLOGY

Bioactive food and exercise in chronic kidney disease: Targeting the mitochondria

(2018) Denise Mafra et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Protective effects of tricetinidin against oxidative stress inducers in rat kidney cells: A comparison with delphinidin and standard antioxidants

(2018) Ezgi Eyluel Bankoglu et al.   FOOD AND CHEMICAL TOXICOLOGY

Flavonoid biosynthetic pathways in plants: Versatile targets for metabolic engineering

(2018) Seyed Mohammad Nabavi et al.   BIOTECHNOLOGY ADVANCES

Anthocyanin Tissue Bioavailability in Animals: Possible Implications for Human Health. A Systematic Review

(2018) Berner Andrée Sandoval-Ramírez et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Management of anthocyanin amount and composition in genus Ribes using interspecific hybridisation

(2018) Vidmantas Stanys et al.   SCIENTIA HORTICULTURAE

Human intervention study to investigate the intestinal accessibility and bioavailability of anthocyanins from bilberries

(2017) Dolores Mueller et al.   FOOD CHEMISTRY

Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer’s Disease

(2017) Tahir Ali et al.   MOLECULAR NEUROBIOLOGY

Biochemical Properties and Neuroprotective Effects of Compounds in Various Species of Berries

(2017) Erin Kelly et al.   MOLECULES

Dietary cyanidin 3-glucoside from purple corn ameliorates doxorubicin-induced cardiotoxicity in mice

(2017) K. Petroni et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Intraduodenal infusion of cyanidin-3-glucoside transiently promotes triglyceride excretion into bile in rats

(2017) Naoto Hashimoto et al.   NUTRITION RESEARCH

Brassica napus GLABRA3-1 promotes anthocyanin biosynthesis and trichome formation in true leaves when expressed in Arabidopsis thaliana

(2017) C. Gao et al.   PLANT BIOLOGY

The small ubiquitin-like modifier E3 ligase MdSIZ1 promotes anthocyanin accumulation by sumoylating MdMYB1 under low-temperature conditions in apple

(2017) Li-Jie Zhou et al.   PLANT CELL AND ENVIRONMENT

Poplar MYB115 and MYB134 Transcription Factors Regulate Proanthocyanidin Synthesis and Structure

(2017) Amy Midori James et al.   PLANT PHYSIOLOGY

Anthocyanins and Flavanones Are More Bioavailable than Previously Perceived: A Review of Recent Evidence

(2017) Colin D. Kay et al.   Annual Review of Food Science and Technology

Effects of cyanidin 3-0-glucoside on cardiac structure and function in an animal model of myocardial infarction

(2017) Pema Raj et al.   Food & Function

Human anthocyanin bioavailability: effect of intake duration and dosing

(2017) Wilhelmina Kalt et al.   Food & Function

The Effect of Anthocyanin-Rich Foods or Extracts on Vascular Function in Adults: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

(2017) Lucy Fairlie-Jones et al.   Nutrients

The Mitochondrial Basis of Aging and Age-Related Disorders

(2017) Sarika Srivastava   Genes

Development of hydroxybenzoic-based platforms as a solution to deliver dietary antioxidants to mitochondria

(2017) José Teixeira et al.   Scientific Reports

Protective Effects of Selenium, Vitamin E, and Purple Carrot Anthocyanins on d-Galactose-Induced Oxidative Damage in Blood, Liver, Heart and Kidney Rats

(2016) Xia Li et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Interaction between κ- and ι-carrageenan and anthocyanins from Vaccinium myrtillus

(2016) Vesta Navikaite et al.   CARBOHYDRATE POLYMERS

A theoretical physiologically based pharmacokinetic approach for modeling the fate of anthocyanins in vivo

(2016) Giovana Bonat Celli et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Mitochondria and neurodegenerative diseases: the promising role of nanotechnology in targeted drug delivery

(2016) Ilaria Pezzini et al.   Expert Opinion on Drug Delivery

High variability in flavonoid contents and composition between different North-European currant (Ribes spp.) varieties

(2016) Pirjo H. Mattila et al.   FOOD CHEMISTRY

Comparison of polyphenol, anthocyanin and antioxidant capacity in four varieties of Lonicera caerulea berry extracts

(2016) Yuehua Wang et al.   FOOD CHEMISTRY

Mitochondria-Targeted Antioxidants and Uncouplers of Oxidative Phosphorylation in Treatment of the Systemic Inflammatory Response Syndrome (SIRS)

(2016) Vlada V. Zakharova et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Delphinidin prevents high glucose-induced cell proliferation and collagen synthesis by inhibition of NOX-1 and mitochondrial superoxide in mesangial cells

(2016) Seung Eun Song et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Functional identification of MdSIZ1 as a SUMO E3 ligase in apple

(2016) Rui-Fen Zhang et al.   JOURNAL OF PLANT PHYSIOLOGY

Mechanistic insights into the vascular effects of blueberries: Evidence from recent studies

(2016) Brett Ronald Cutler et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Variation of anthocyanins and other major phenolic compounds throughout the ripening of four Portuguese blueberry (Vaccinium corymbosum L) cultivars

(2016) Sara Silva et al.   NATURAL PRODUCT RESEARCH

Fresh Fruit Consumption and Major Cardiovascular Disease in China

(2016) Huaidong Du et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anthocyanins in cardioprotection: A path through mitochondria

(2016) Julius Liobikas et al.   PHARMACOLOGICAL RESEARCH

Chemistry, Pharmacology and Health Benefits of Anthocyanins

(2016) Antonella Smeriglio et al.   PHYTOTHERAPY RESEARCH

Unraveling Anthocyanin Bioavailability for Human Health

(2016) Mary Ann Lila et al.   Annual Review of Food Science and Technology

Determination of cyanidin 3-glucoside in rat brain, liver and kidneys by UPLC/MS-MS and its application to a short-term pharmacokinetic study

(2016) Stefano Fornasaro et al.   Scientific Reports

Molecular Strategies for Targeting Antioxidants to Mitochondria: Therapeutic Implications

(2015) Nadezda Apostolova et al.   ANTIOXIDANTS & REDOX SIGNALING

Cyanidin-3-glucoside inhibits glutamate-induced Zn2+ signaling and neuronal cell death in cultured rat hippocampal neurons by inhibiting Ca2+-induced mitochondrial depolarization and formation of reactive oxygen species

(2015) Ji Seon Yang et al.   BRAIN RESEARCH

Complexes of dextran sulfate and anthocyanins from Vaccinium myrtillus: Formation and stability

(2015) Rima Klimaviciute et al.   CARBOHYDRATE POLYMERS

Estimated intake and major food sources of flavonoids among US adults: changes between 1999–2002 and 2007–2010 in NHANES

(2015) Kijoon Kim et al.   EUROPEAN JOURNAL OF NUTRITION

Anthocyanins as substrates for mitochondrial complex I - protective effect against heart ischemic injury

(2015) Kristina Skemiene et al.   FEBS Journal

A mitochondria-targeted derivative of ascorbate: MitoC

(2015) Peter G. Finichiu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Anthocyanin composition of different wild and cultivated berry species

(2015) Robert Veberic et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Improvement of catechin production in Escherichia coli through combinatorial metabolic engineering

(2015) Shujuan Zhao et al.   METABOLIC ENGINEERING

Plasma bioavailability and regional brain distribution of polyphenols from apple/grape seed and bilberry extracts in a young swine model

(2015) Tzu-Ying Chen et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Synergistic neuroprotection by epicatechin and quercetin: Activation of convergent mitochondrial signaling pathways

(2015) M. Nichols et al.   NEUROSCIENCE

Effects of Cyanidin-3-O-glucoside on Synthetic and Metabolic Activity of Ethanol Stimulated Human Pancreatic Stellate Cells

(2015) Vaidotas Cesna et al.   PHYTOTHERAPY RESEARCH

Characterization of an activation-tagged mutant uncovers a role of GLABRA2 in anthocyanin biosynthesis in Arabidopsis

(2015) Xiaoyu Wang et al.   PLANT JOURNAL

What would be the observable consequences if phospholipid bilayer diffusion of drugs into cells is negligible?

(2015) Douglas B. Kell   TRENDS IN PHARMACOLOGICAL SCIENCES

The chemoprotection of a blueberry anthocyanin extract against the acrylamide-induced oxidative stress in mitochondria: unequivocal evidence in mice liver

(2015) Mengyao Zhao et al.   Food & Function

Post-transcriptional and post-translational regulations of drought and heat response in plants: a spider’s web of mechanisms

(2015) Davide Guerra et al.   Frontiers in Plant Science

Flavonoid Intake in European Adults (18 to 64 Years)

(2015) Anna Vogiatzoglou et al.   PLoS One

Expression and Anthocyanin Biosynthesis-Modulating Potential of Sweet Cherry (Prunus avium L.) MYB10 and bHLH Genes

(2015) Pavel Starkevič et al.   PLoS One

Molecular mechanisms involved in the cardiovascular and neuroprotective effects of anthocyanins

(2014) Sonia de Pascual-Teresa   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Polyphenols and mitochondria: An update on their increasingly emerging ROS-scavenging independent actions

(2014) Cristian Sandoval-Acuña et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Cyanidin-3-O-β-glucoside protects primary mouse hepatocytes against high glucose-induced apoptosis by modulating mitochondrial dysfunction and the PI3K/Akt pathway

(2014) Xinwei Jiang et al.   BIOCHEMICAL PHARMACOLOGY

Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinson׳s disease

(2014) Katherine E. Strathearn et al.   BRAIN RESEARCH

The pharmacokinetics of anthocyanins and their metabolites in humans

(2014) R M de Ferrars et al.   BRITISH JOURNAL OF PHARMACOLOGY

Anthocyanins Protect against Kainic Acid-induced Excitotoxicity and Apoptosis via ROS-activated AMPK Pathway in Hippocampal Neurons

(2014) Ikram Ullah et al.   CNS Neuroscience & Therapeutics

Engineering anthocyanin biosynthesis in plants

(2014) Yang Zhang et al.   CURRENT OPINION IN PLANT BIOLOGY

Antioxidant properties of the anthocyanin-containing ultrasonic extract from blackberry cultivar “Čačanska Bestrna”

(2014) Jasna Ivanovic et al.   INDUSTRIAL CROPS AND PRODUCTS

Cyanidin-3-glucoside isolated from mulberry fruit protects pancreatic β-cells against oxidative stress-induced apoptosis

(2014) JONG SEOK LEE et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Doxorubicin-Induced Oxidative Stress in Rats Is Efficiently Counteracted by Dietary Anthocyanin Differently Enriched Strawberry (Fragaria × ananassa Duch.)

(2014) Jacopo Diamanti et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Some Anthocyanins Could Be Efficiently Absorbed across the Gastrointestinal Mucosa: Extensive Presystemic Metabolism Reduces Apparent Bioavailability

(2014) Jim Fang   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Investigation of Anthocyanin Profile of Four Elderberry Species and Interspecific Hybrids

(2014) Maja Mikulic-Petkovsek et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Structure–activity relationships of anthocyanidin glycosylation

(2014) Chang Ling Zhao et al.   MOLECULAR DIVERSITY

Oxidative Stress and Mitochondrial Dysfunction across Broad-Ranging Pathologies: Toward Mitochondria-Targeted Clinical Strategies

(2014) Giovanni Pagano et al.   Oxidative Medicine and Cellular Longevity

Regulation of anthocyanin biosynthesis in peach fruits

(2014) Md. Abdur Rahim et al.   PLANTA

The Role of Sodium-Dependent Glucose Transporter 1 and Glucose Transporter 2 in the Absorption of Cyanidin-3-O-β-Glucoside in Caco-2 Cells

(2014) Tang-Bin Zou et al.   Nutrients

High Anthocyanin Intake Is Associated With a Reduced Risk of Myocardial Infarction in Young and Middle-Aged Women

(2013) Aedín Cassidy et al.   CIRCULATION

The Case for Anthocyanin Consumption to Promote Human Health: A Review

(2013) Elisa Pojer et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

In the eye of the storm: mitochondrial damage during heart and brain ischaemia

(2013) Vilmante Borutaite et al.   FEBS Journal

Light and the E3 ubiquitin ligase COP1/SPA control the protein stability of the MYB transcription factors PAP1 and PAP2 involved in anthocyanin accumulation in Arabidopsis

(2013) Alexander Maier et al.   PLANT JOURNAL

Regulation of Glucose Transporter Expression in Human Intestinal Caco-2 Cells following Exposure to an Anthocyanin-Rich Berry Extract

(2013) Fawaz Alzaid et al.   PLoS One

Role of endothelial cell membrane transport in red wine polyphenols-induced coronary vasorelaxation: involvement of bilitranslocase

(2013) Lovro Ziberna et al.   Food & Function

Flavonoid intake and cardiovascular disease mortality in a prospective cohort of US adults

(2012) Marjorie L McCullough et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Anthocyanins Extracted from Black Soybean Seed Coat Protect Primary Cortical Neurons against in Vitro Ischemia

(2012) Mohammad Iqbal Hossain Bhuiyan et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Transport and bioactivity of cyanidin 3-glucoside into the vascular endothelium

(2012) Lovro Ziberna et al.   FREE RADICAL BIOLOGY AND MEDICINE

Anthocyanins block ischemia-induced apoptosis in the perfused heart and support mitochondrial respiration potentially by reducing cytosolic cytochrome c

(2012) Kristina Skemiene et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Neuroprotective Potential of Cyanidin-3-glucoside Fraction Extracted from Mulberry Following Oxygen-glucose Deprivation

(2012) Mohammad Iqbal Hossain Bhuiyan et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Habitual intake of dietary flavonoids and risk of Parkinson disease

(2012) X. Gao et al.   NEUROLOGY

Experimental determination and prediction of bilitranslocase transport activity

(2011) Špela Župerl et al.   ANALYTICA CHIMICA ACTA

Complex I and cytochrome c are molecular targets of flavonoids that inhibit hydrogen peroxide production by mitochondria

(2011) Ricardo Lagoa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Exceptionally Fast Uptake and Metabolism of Cyanidin 3-Glucoside by Rat Kidneys and Liver

(2011) Andreja Vanzo et al.   JOURNAL OF NATURAL PRODUCTS

Synaptic failure and adenosine triphosphate imbalance induced by amyloid-β aggregates are prevented by blueberry-enriched polyphenols extract

(2011) Jorge Fuentealba et al.   JOURNAL OF NEUROSCIENCE RESEARCH

There is no evidence that mitochondria are the main source of reactive oxygen species in mammalian cells

(2011) Guy C. Brown et al.   MITOCHONDRION

Neuroprotective effect of cyanidin-3-O-glucoside anthocyanin in mice with focal cerebral ischemia

(2011) Jiangyong Min et al.   NEUROSCIENCE LETTERS

The endothelial plasma membrane transporter bilitranslocase mediates rat aortic vasodilation induced by anthocyanins

(2011) L. Ziberna et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Blueberry Supplementation Improves Memory in Older Adults†

(2010) Robert Krikorian et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pharmacokinetics and Tissue Distribution of 14C-Labeled Grape Polyphenols in the Periphery and the Central Nervous System Following Oral Administration

(2010) Elsa M. Janle et al.   JOURNAL OF MEDICINAL FOOD

Polyphenols and phenolic acids from strawberry and apple decrease glucose uptake and transport by human intestinal Caco-2 cells

(2010) Susana Manzano et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Berry anthocyanins and anthocyanidins exhibit distinct affinities for the efflux transporters BCRP and MDR1

(2009) A Dreiseitel et al.   BRITISH JOURNAL OF PHARMACOLOGY

Expression of bilitranslocase in the vascular endothelium and its function as a flavonoid transporter

(2009) A. Maestro et al.   CARDIOVASCULAR RESEARCH

Bioavailability of Flavonoids: A Review of Their Membrane Transport and the Function of Bilitranslocase in Animal and Plant Organisms

(2009) Sabina Passamonti et al.   CURRENT DRUG METABOLISM

Age-related toxicity of amyloid-beta associated with increased pERK and pCREB in primary hippocampal neurons: reversal by blueberry extract☆

(2009) Gregory J. Brewer et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Mitochondria accumulate large amounts of quercetin: prevention of mitochondrial damage and release upon oxidation of the extramitochondrial fraction of the flavonoid

(2009) Mara Fiorani et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Absorption of anthocyanins through intestinal epithelial cells - Putative involvement of GLUT2

(2009) Ana Faria et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Green Tea Epigallocatechin 3-Gallate Accumulates in Mitochondria and Displays a Selective Antiapoptotic Effect Against Inducers of Mitochondrial Oxidative Stress in Neurons

(2008) Emily K. Schroeder et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of apoptosis by the redox state of cytochrome c

(2008) Guy C. Brown et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Identification of Anthocyanins in the Liver, Eye, and Brain of Blueberry-Fed Pigs

(2008) Wilhelmina Kalt et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Uptake of grape anthocyanins into the rat kidney and the involvement of bilitranslocase

(2008) Andreja Vanzo et al.   MOLECULAR NUTRITION & FOOD RESEARCH