Experimental animal models of aquaporin‐4‐IgG‐seropositive neuromyelitis optica spectrum disorders: progress and shortcomings

Theranostic Strategy of Focused Ultrasound Induced Blood-Brain Barrier Opening for CNS Disease Treatment

(2019) Ko-Ting Chen et al.   Frontiers in Pharmacology

CD55 upregulation in astrocytes by statins as potential therapy for AQP4-IgG seropositive neuromyelitis optica

(2019) Lukmanee Tradtrantip et al.   Journal of Neuroinflammation

Neuromyelitis optica spectrum disorders

(2019) Saif Huda et al.   CLINICAL MEDICINE

Eculizumab in Aquaporin-4–Positive Neuromyelitis Optica Spectrum Disorder

(2019) Sean J. Pittock et al.   NEW ENGLAND JOURNAL OF MEDICINE

Repetitive intrathecal injection of human NMO-IgG with complement exacerbates disease severity with NMO pathology in experimental allergic encephalomyelitis mice

(2019) Chao-Lin Lee et al.   Multiple Sclerosis and Related Disorders

Complement-independent bystander injury in AQP4-IgG seropositive neuromyelitis optica produced by antibody-dependent cellular cytotoxicity

(2019) Tianjiao Duan et al.   Acta Neuropathologica Communications

Structural and visual functional deficits in a rat model of neuromyelitis optica spectrum disorders related optic neuritis

(2018) Yuxin Zhang et al.   EXPERIMENTAL EYE RESEARCH

Investigational drugs in development to prevent neuromyelitis optica relapses

(2018) Friedemann Paul et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Recombinant IgG1 Fc hexamers block cytotoxicity and pathological changes in experimental in vitro and rat models of neuromyelitis optica

(2018) Lukmanee Tradtrantip et al.   NEUROPHARMACOLOGY

Distinct patterns of glia repair and remyelination in antibody-mediated demyelination models of multiple sclerosis and neuromyelitis optica

(2018) Yiting Liu et al.   GLIA

Circulating AQP4-specific auto-antibodies alone can induce neuromyelitis optica spectrum disorder in the rat

(2018) Sophie Hillebrand et al.   ACTA NEUROPATHOLOGICA

Complement-dependent bystander injury to neurons in AQP4-IgG seropositive neuromyelitis optica

(2018) Tianjiao Duan et al.   Journal of Neuroinflammation

Noninvasive, Targeted Creation of Neuromyelitis Optica Pathology in AQP4-IgG Seropositive Rats by Pulsed Focused Ultrasound

(2018) Xiaoming Yao et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The aquaporin-4 water channel as a potential drug target in neurological disorders

(2017) Alan S. Verkman et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Neuromyelitis Spectrum Disorders

(2017) Brian G. Weinshenker et al.   MAYO CLINIC PROCEEDINGS

Complement regulator CD59 prevents peripheral organ injury in rats made seropositive for neuromyelitis optica immunoglobulin G

(2017) Xiaoming Yao et al.   Acta Neuropathologica Communications

Marked central nervous system pathology in CD59 knockout rats following passive transfer of Neuromyelitis optica immunoglobulin G

(2017) Xiaoming Yao et al.   Acta Neuropathologica Communications

In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology

(2016) Marina Herwerth et al.   ANNALS OF NEUROLOGY

Characterization of the binding pattern of human aquaporin-4 autoantibodies in patients with neuromyelitis optica spectrum disorders

(2016) Friederike Tuller et al.   Journal of Neuroinflammation

Variable sensitivity to complement-dependent cytotoxicity in murine models of neuromyelitis optica

(2016) Yiting Liu et al.   Journal of Neuroinflammation

Complement-independent retinal pathology produced by intravitreal injection of neuromyelitis optica immunoglobulin G

(2016) Christian M. Felix et al.   Journal of Neuroinflammation

Neuromyelitis optica study model based on chronic infusion of autoantibodies in rat cerebrospinal fluid

(2016) R. Marignier et al.   Journal of Neuroinflammation

Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4

(2016) Sharon A. Sagan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clobetasol promotes remyelination in a mouse model of neuromyelitis optica

(2016) Xiaoming Yao et al.   Acta Neuropathologica Communications

Aquaporin 4-specific T cells and NMO-IgG cause primary retinal damage in experimental NMO/SD

(2016) Bleranda Zeka et al.   Acta Neuropathologica Communications

Highly encephalitogenic aquaporin 4-specific T cells and NMO-IgG jointly orchestrate lesion location and tissue damage in the CNS

(2015) Bleranda Zeka et al.   ACTA NEUROPATHOLOGICA

The intrinsic pathogenic role of autoantibodies to aquaporin 4 mediating spinal cord disease in a rat passive-transfer model

(2015) Christian Geis et al.   EXPERIMENTAL NEUROLOGY

Mutagenesis of the Aquaporin 4 Extracellular Domains Defines Restricted Binding Patterns of Pathogenic Neuromyelitis Optica IgG

(2015) Gregory P. Owens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

International consensus diagnostic criteria for neuromyelitis optica spectrum disorders

(2015) Dean M. Wingerchuk et al.   NEUROLOGY

Pathogenic aquaporin-4 reactive T cells are sufficient to induce mouse model of neuromyelitis optica

(2015) Melina V Jones et al.   Acta Neuropathologica Communications

Severely exacerbated neuromyelitis optica rat model with extensive astrocytopathy by high affinity anti-aquaporin-4 monoclonal antibody

(2015) Kazuhiro Kurosawa et al.   Acta Neuropathologica Communications

Human immunoglobulin G reduces the pathogenicity of aquaporin-4 autoantibodies in neuromyelitis optica

(2014) Julien Ratelade et al.   EXPERIMENTAL NEUROLOGY

Longitudinally extensive NMO spinal cord pathology produced by passive transfer of NMO-IgG in mice lacking complement inhibitor CD59

(2014) Hua Zhang et al.   JOURNAL OF AUTOIMMUNITY

Aggregation state determines the localization and function of M1– and M23–aquaporin-4 in astrocytes

(2014) Alex J. Smith et al.   JOURNAL OF CELL BIOLOGY

Functional Consequences of Neuromyelitis Optica-IgG Astrocyte Interactions on Blood-Brain Barrier Permeability and Granulocyte Recruitment

(2014) T. Vincent et al.   JOURNAL OF IMMUNOLOGY

Experimental mouse model of optic neuritis with inflammatory demyelination produced by passive transfer of neuromyelitis optica-immunoglobulin G

(2014) Nithi Asavapanumas et al.   Journal of Neuroinflammation

Inhibitor(s) of the classical complement pathway in mouse serum limit the utility of mice as experimental models of neuromyelitis optica

(2014) Julien Ratelade et al.   MOLECULAR IMMUNOLOGY

Treatment of neuromyelitis optica: state-of-the-art and emerging therapies

(2014) Marios C. Papadopoulos et al.   Nature Reviews Neurology

Potential Therapeutic Benefit of C1-Esterase Inhibitor in Neuromyelitis Optica Evaluated In Vitro and in an Experimental Rat Model

(2014) Lukmanee Tradtrantip et al.   PLoS One

Neuromyelitis optica pathology in rats following intraperitoneal injection of NMO-IgG and intracerebral needle injury

(2014) Nithi Asavapanumas et al.   Acta Neuropathologica Communications

C1q-targeted monoclonal antibody prevents complement-dependent cytotoxicity and neuropathology in in vitro and mouse models of neuromyelitis optica

(2013) Puay-Wah Phuan et al.   ACTA NEUROPATHOLOGICA

Unique neuromyelitis optica pathology produced in naïve rats by intracerebral administration of NMO-IgG

(2013) Nithi Asavapanumas et al.   ACTA NEUROPATHOLOGICA

Involvement of antibody-dependent cell-mediated cytotoxicity in inflammatory demyelination in a mouse model of neuromyelitis optica

(2013) Julien Ratelade et al.   ACTA NEUROPATHOLOGICA

Passively transferred human NMO-IgG exacerbates demyelination in mouse experimental autoimmune encephalomyelitis

(2013) Harleen Saini et al.   BMC Neurology

Sera from patients with seropositive neuromyelitis optica spectral disorders caused the degeneration of rodent optic nerve

(2013) Yoshiko Matsumoto et al.   EXPERIMENTAL EYE RESEARCH

Eosinophil pathogenicity mechanisms and therapeutics in neuromyelitis optica

(2013) Hua Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Aquaporin water channels in the nervous system

(2013) Marios C. Papadopoulos et al.   NATURE REVIEWS NEUROSCIENCE

Neuromyelitis optica IgG and natural killer cells produce NMO lesions in mice without myelin loss

(2012) Julien Ratelade et al.   ACTA NEUROPATHOLOGICA

Enzymatic deglycosylation converts pathogenic neuromyelitis optica anti-aquaporin-4 immunoglobulin G into therapeutic antibody

(2012) Lukmanee Tradtrantip et al.   ANNALS OF NEUROLOGY

Small-molecule inhibitors of NMO-IgG binding to aquaporin-4 reduce astrocyte cytotoxicity in neuromyelitis optica

(2012) Lukmanee Tradtrantip et al.   FASEB JOURNAL

Neuromyelitis optica: Aquaporin-4 based pathogenesis mechanisms and new therapies

(2012) Julien Ratelade et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Complement-dependent Cytotoxicity in Neuromyelitis Optica Requires Aquaporin-4 Protein Assembly in Orthogonal Arrays

(2012) Puay-Wah Phuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Super-resolution imaging of aquaporin-4 orthogonal arrays of particles in cell membranes

(2012) A. Rossi et al.   JOURNAL OF CELL SCIENCE

Aquaporin 4 and neuromyelitis optica

(2012) Marios C Papadopoulos et al.   LANCET NEUROLOGY

Pathogenic T cell responses against aquaporin 4

(2011) Maria Pohl et al.   ACTA NEUROPATHOLOGICA

Ex vivo spinal cord slice model of neuromyelitis optica reveals novel immunopathogenic mechanisms

(2011) Hua Zhang et al.   ANNALS OF NEUROLOGY

Anti-Aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica

(2011) Lukmanee Tradtrantip et al.   ANNALS OF NEUROLOGY

Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain

(2011) Samira Saadoun et al.   ANNALS OF NEUROLOGY

Binding Affinity and Specificity of Neuromyelitis Optica Autoantibodies to Aquaporin-4 M1/M23 Isoforms and Orthogonal Arrays

(2011) Jonathan M. Crane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Characterization of Aquaporin-4 Specific T Cells: Towards a Model for Neuromyelitis Optica

(2011) Sudhakar Reddy Kalluri et al.   PLoS One

Intravenous Neuromyelitis Optica Autoantibody in Mice Targets Aquaporin-4 in Peripheral Organs and Area Postrema

(2011) Julien Ratelade et al.   PLoS One

Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice

(2010) Samira Saadoun et al.   BRAIN

Neuromyelitis optica: Pathogenicity of patient immunoglobulin in vivo

(2009) Monika Bradl et al.   ANNALS OF NEUROLOGY

Intrathecal pathogenic anti–aquaporin-4 antibodies in early neuromyelitis optica

(2009) Jeffrey L. Bennett et al.   ANNALS OF NEUROLOGY

Prediction of Neuromyelitis Optica Attack Severity by Quantitation of Complement-Mediated Injury to Aquaporin-4–Expressing Cells

(2009) Shannon R. Hinson et al.   ARCHIVES OF NEUROLOGY

Neuromyelitis optica: Passive transfer to rats by human immunoglobulin

(2009) Makoto Kinoshita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neuromyelitis optica pathogenesis and aquaporin 4

(2008) David J Graber et al.   Journal of Neuroinflammation