C1q-targeted monoclonal antibody prevents complement-dependent cytotoxicity and neuropathology in in vitro and mouse models of neuromyelitis optica

Eosinophil pathogenicity mechanisms and therapeutics in neuromyelitis optica

(2013) Hua Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical Efficacy of Plasmapheresis in Patients with Neuromyelitis Optica Spectrum Disorder and Effects on Circulating Anti-Aquaporin-4 Antibody Levels

(2013) Su-Hyun Kim et al.   Journal of Clinical Neurology

Eculizumab in AQP4-IgG-positive relapsing neuromyelitis optica spectrum disorders: an open-label pilot study

(2013) Sean J Pittock et al.   LANCET NEUROLOGY

Interleukin 6 Receptor Blockade in Patients With Neuromyelitis Optica Nonresponsive to Anti-CD20 Therapy

(2013) Ilya Ayzenberg et al.   JAMA Neurology

Neuromyelitis optica IgG and natural killer cells produce NMO lesions in mice without myelin loss

(2012) Julien Ratelade et al.   ACTA NEUROPATHOLOGICA

Chapter 22: Hereditary and acquired angioedema

(2012) Mary S. Georgy et al.   ALLERGY AND ASTHMA PROCEEDINGS

Hereditary angioedema treatment options: The availability of new therapies

(2012) Werner Aberer   ANNALS OF MEDICINE

Enzymatic deglycosylation converts pathogenic neuromyelitis optica anti-aquaporin-4 immunoglobulin G into therapeutic antibody

(2012) Lukmanee Tradtrantip et al.   ANNALS OF NEUROLOGY

Treatment of neuromyelitis optica: an evidence based review

(2012) Douglas Sato et al.   ARQUIVOS DE NEURO-PSIQUIATRIA

Small-molecule inhibitors of NMO-IgG binding to aquaporin-4 reduce astrocyte cytotoxicity in neuromyelitis optica

(2012) Lukmanee Tradtrantip et al.   FASEB JOURNAL

Complement-dependent Cytotoxicity in Neuromyelitis Optica Requires Aquaporin-4 Protein Assembly in Orthogonal Arrays

(2012) Puay-Wah Phuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuromyelitis Optica: Potential Roles for Intravenous Immunoglobulin

(2012) Dean M. Wingerchuk   JOURNAL OF CLINICAL IMMUNOLOGY

Increase of complement fragment C5a in cerebrospinal fluid during exacerbation of neuromyelitis optica

(2012) Hiroshi Kuroda et al.   JOURNAL OF NEUROIMMUNOLOGY

Complement-dependent pathogenicity of brain-specific antibodies in cerebrospinal fluid

(2012) Nasrin Asgari et al.   JOURNAL OF NEUROIMMUNOLOGY

Aquaporin 4 and neuromyelitis optica

(2012) Marios C Papadopoulos et al.   LANCET NEUROLOGY

Rituximab dosing and monitoring strategies in neuromyelitis optica patients: creating strategies for therapeutic success

(2012) Benjamin M Greenberg et al.   Multiple Sclerosis Journal

Ex vivo spinal cord slice model of neuromyelitis optica reveals novel immunopathogenic mechanisms

(2011) Hua Zhang et al.   ANNALS OF NEUROLOGY

Anti-Aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica

(2011) Lukmanee Tradtrantip et al.   ANNALS OF NEUROLOGY

Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain

(2011) Samira Saadoun et al.   ANNALS OF NEUROLOGY

Integrative Continuum: Accelerating Therapeutic Advances in Rare Autoimmune Diseases

(2011) Katja Van Herle et al.   Annual Review of Pharmacology and Toxicology

Complement and non-complement activating functions of C1q: A prototypical innate immune molecule

(2011) Annapurna Nayak et al.   Innate Immunity

Binding Affinity and Specificity of Neuromyelitis Optica Autoantibodies to Aquaporin-4 M1/M23 Isoforms and Orthogonal Arrays

(2011) Jonathan M. Crane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complement activating antibodies to myelin oligodendrocyte glycoprotein in neuromyelitis optica and related disorders

(2011) Simone Mader et al.   Journal of Neuroinflammation

Autoimmunity in neuromyelitis optica and opticospinal multiple sclerosis: Astrocytopathy as a common denominator in demyelinating disorders

(2011) Jun-ichi Kira   JOURNAL OF THE NEUROLOGICAL SCIENCES

Antibody effector mechanisms in myasthenia gravis—Pathogenesis at the neuromuscular junction

(2010) Alejandro M. Gomez et al.   AUTOIMMUNITY

Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice

(2010) Samira Saadoun et al.   BRAIN

New pathophysiological insights and treatment of ANCA-associated vasculitis

(2010) Benjamin Wilde et al.   KIDNEY INTERNATIONAL

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

AQP4 antibodies in neuromyelitis optica: diagnostic and pathogenetic relevance

(2010) Sven Jarius et al.   Nature Reviews Neurology

Intrathecal pathogenic anti–aquaporin-4 antibodies in early neuromyelitis optica

(2009) Jeffrey L. Bennett et al.   ANNALS OF NEUROLOGY

Prediction of Neuromyelitis Optica Attack Severity by Quantitation of Complement-Mediated Injury to Aquaporin-4–Expressing Cells

(2009) Shannon R. Hinson et al.   ARCHIVES OF NEUROLOGY

Paths reunited: Initiation of the classical and lectin pathways of complement activation

(2009) Russell Wallis et al.   IMMUNOBIOLOGY

Cytotoxic effect of neuromyelitis optica antibody (NMO-IgG) to astrocytes: An in vitro study

(2009) Lidia Sabater et al.   JOURNAL OF NEUROIMMUNOLOGY

Eculizumab for paroxysmal nocturnal haemoglobinuria

(2009) Charles Parker   LANCET

The role of the anaphylatoxins in health and disease

(2009) Andreas Klos et al.   MOLECULAR IMMUNOLOGY

Drug-induced lupus erythematosus

(2008) Camilla Dalle Vedove et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Interaction of Human C1q with IgG and IgM: Revisited†

(2008) Mihaela G. Gadjeva et al.   BIOCHEMISTRY