Circulating AQP4-specific auto-antibodies alone can induce neuromyelitis optica spectrum disorder in the rat

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Anti-aquaporin-4 titer is not predictive of disease course in neuromyelitis optica spectrum disorder: A multicenter cohort study

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Subregional structural and connectivity damage in the visual cortex in neuromyelitis optica

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Clinicopathological features in anterior visual pathway in neuromyelitis optica

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Early and extensive spinal white matter involvement in neuromyelitis optica

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Characterization of the binding pattern of human aquaporin-4 autoantibodies in patients with neuromyelitis optica spectrum disorders

(2016) Friederike Tuller et al.   Journal of Neuroinflammation

Complement-independent retinal pathology produced by intravitreal injection of neuromyelitis optica immunoglobulin G

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Experimental Neuromyelitis Optica Induces a Type I Interferon Signature in the Spinal Cord

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Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4

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T-cell responses to distinct AQP4 peptides in patients with neuromyelitis optica (NMO)

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Aquaporin 4-specific T cells and NMO-IgG cause primary retinal damage in experimental NMO/SD

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Highly encephalitogenic aquaporin 4-specific T cells and NMO-IgG jointly orchestrate lesion location and tissue damage in the CNS

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Mutagenesis of the Aquaporin 4 Extracellular Domains Defines Restricted Binding Patterns of Pathogenic Neuromyelitis Optica IgG

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The cerebrospinal fluid immunoglobulin transcriptome and proteome in neuromyelitis optica reveals central nervous system-specific B cell populations

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Role of membrane complement regulators in neuromyelitis optica

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International consensus diagnostic criteria for neuromyelitis optica spectrum disorders

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Role of membrane complement regulators in neuromyelitis optica

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New aspects in fenestrated capillary and tissue dynamics in the sensory circumventricular organs of adult brains

(2015) Seiji Miyata   Frontiers in Neuroscience

Severely exacerbated neuromyelitis optica rat model with extensive astrocytopathy by high affinity anti-aquaporin-4 monoclonal antibody

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Neuromyelitis optica IgG stimulates an immunological response in rat astrocyte cultures

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Aquaporins: important but elusive drug targets

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Pain in neuromyelitis optica—prevalence, pathogenesis and therapy

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Vascular Endothelial Growth Factors Enhance the Permeability of the Mouse Blood-brain Barrier

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Involvement of antibody-dependent cell-mediated cytotoxicity in inflammatory demyelination in a mouse model of neuromyelitis optica

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Presence of six different lesion types suggests diverse mechanisms of tissue injury in neuromyelitis optica

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Establishment of monoclonal antibodies against the extracellular domain that block binding of NMO-IgG to AQP4

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Developing Therapeutic Antibodies for Neurodegenerative Disease

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Why Can’t Rodents Vomit? A Comparative Behavioral, Anatomical, and Physiological Study

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Intrastriatal injection of interleukin-1 beta triggers the formation of neuromyelitis optica-like lesions in NMO-IgG seropositive rats

(2013) Maja Kitic et al.   Acta Neuropathologica Communications

T cell-activation in neuromyelitis optica lesions plays a role in their formation

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Aquaporin 4-specific T cells in neuromyelitis optica exhibit a Th17 bias and recognizeClostridiumABC transporter

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Cognitive impairment and cortical degeneration in neuromyelitis optica

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Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease

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Pathogenic T cell responses against aquaporin 4

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Ex vivo spinal cord slice model of neuromyelitis optica reveals novel immunopathogenic mechanisms

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Binding Affinity and Specificity of Neuromyelitis Optica Autoantibodies to Aquaporin-4 M1/M23 Isoforms and Orthogonal Arrays

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Cerebrospinal fluid findings in aquaporin-4 antibody positive neuromyelitis optica: Results from 211 lumbar punctures

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Neuromyelitis optica unique area postrema lesions: Nausea, vomiting, and pathogenic implications

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Intravenous Neuromyelitis Optica Autoantibody in Mice Targets Aquaporin-4 in Peripheral Organs and Area Postrema

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Anti-aquaporin-4 antibody induces astrocytic cytotoxicity in the absence of CNS antigen-specific T cells

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Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice

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Patterns of Antibody Binding to Aquaporin-4 Isoforms in Neuromyelitis Optica

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Neuromyelitis optica: Pathogenicity of patient immunoglobulin in vivo

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Intrathecal pathogenic anti–aquaporin-4 antibodies in early neuromyelitis optica

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