Enzymatic deglycosylation converts pathogenic neuromyelitis optica anti-aquaporin-4 immunoglobulin G into therapeutic antibody

Neuromyelitis optica IgG and natural killer cells produce NMO lesions in mice without myelin loss

(2012) Julien Ratelade et al.   ACTA NEUROPATHOLOGICA

Small-molecule inhibitors of NMO-IgG binding to aquaporin-4 reduce astrocyte cytotoxicity in neuromyelitis optica

(2012) Lukmanee Tradtrantip et al.   FASEB JOURNAL

Complement-dependent Cytotoxicity in Neuromyelitis Optica Requires Aquaporin-4 Protein Assembly in Orthogonal Arrays

(2012) Puay-Wah Phuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aquaporin 4 and neuromyelitis optica

(2012) Marios C Papadopoulos et al.   LANCET NEUROLOGY

Ex vivo spinal cord slice model of neuromyelitis optica reveals novel immunopathogenic mechanisms

(2011) Hua Zhang et al.   ANNALS OF NEUROLOGY

Anti-Aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica

(2011) Lukmanee Tradtrantip et al.   ANNALS OF NEUROLOGY

Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain

(2011) Samira Saadoun et al.   ANNALS OF NEUROLOGY

Binding Affinity and Specificity of Neuromyelitis Optica Autoantibodies to Aquaporin-4 M1/M23 Isoforms and Orthogonal Arrays

(2011) Jonathan M. Crane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Current and future treatment approaches for neuromyelitis optica

(2011) Nicolas Collongues et al.   Therapeutic Advances in Neurological Disorders

Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice

(2010) Samira Saadoun et al.   BRAIN

IgG Glycan Hydrolysis Attenuates ANCA-Mediated Glomerulonephritis

(2010) M. M. van Timmeren et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

AQP4 antibodies in neuromyelitis optica: diagnostic and pathogenetic relevance

(2010) Sven Jarius et al.   Nature Reviews Neurology

Intrathecal pathogenic anti–aquaporin-4 antibodies in early neuromyelitis optica

(2009) Jeffrey L. Bennett et al.   ANNALS OF NEUROLOGY

Neuromyelitis optica: Diagnosis, pathogenesis, and treatment

(2008) Bruce Cree   Current Neurology and Neuroscience Reports

Human IgG/FcγR Interactions Are Modulated by Streptococcal IgG Glycan Hydrolysis

(2008) Maria Allhorn et al.   PLoS One

In vivo enzymatic modulation of IgG glycosylation inhibits autoimmune disease in an IgG subclass-dependent manner

(2008) H. Albert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA