Cell Fate Regulation upon DNA Damage: p53 Serine 46 Kinases Pave the Cell Death Road

Ser46 phosphorylation of p53 is an essential event in prolyl-isomerase Pin1-mediated p53-independent apoptosis in response to heat stress

(2019) Li Li et al.   Cell Death & Disease

The multiple mechanisms that regulate p53 activity and cell fate

(2019) Antonina Hafner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AMP-activated protein kinase: the current landscape for drug development

(2019) Gregory R. Steinberg et al.   NATURE REVIEWS DRUG DISCOVERY

The SIAH1–HIPK2–p53ser46 Damage Response Pathway is Involved in Temozolomide-Induced Glioblastoma Cell Death

(2019) Yang He et al.   MOLECULAR CANCER RESEARCH

The functional roles of PML nuclear bodies in genome maintenance

(2018) Hae Ryung Chang et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Genotoxic Damage Activates the AMPK-α1 Isoform in the Nucleus via Ca 2+ /CaMKK2 Signaling to Enhance Tumor Cell Survival

(2017) Diana Vara-Ciruelos et al.   MOLECULAR CANCER RESEARCH

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

(2017) Daniel Garcia et al.   MOLECULAR CELL

The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export

(2017) Jekaterina Vohhodina et al.   NUCLEIC ACIDS RESEARCH

Loss of tumour-specific ATM protein expression is an independent prognostic factor in early resected NSCLC

(2017) Lars F. Petersen et al.   Oncotarget

The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches

(2016) Andreas C. Joerger et al.   Annual Review of Biochemistry

Transcriptional induction of protein kinase C delta by p53 tumor suppressor in the apoptotic response to DNA damage

(2016) Nurmaa Dashzeveg et al.   CANCER LETTERS

The DNA damage-induced cell death response: a roadmap to kill cancer cells

(2016) Sonja Matt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

An African-specific polymorphism in theTP53gene impairs p53 tumor suppressor function in a mouse model

(2016) Matthew Jennis et al.   GENES & DEVELOPMENT

Downregulated DYRK2 expression is associated with poor prognosis and Oxaliplatin resistance in hepatocellular carcinoma

(2016) Xiubing Zhang et al.   PATHOLOGY RESEARCH AND PRACTICE

Multifunctional roles of PKCδ: Opportunities for targeted therapy in human disease

(2016) Mary E. Reyland et al.   PHARMACOLOGY & THERAPEUTICS

AMPKα Is Suppressed in Bladder Cancer through Macrophage-Mediated Mechanisms

(2016) Stavros Kopsiaftis et al.   Translational Oncology

Low Expression of DYRK2 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2) Correlates with Poor Prognosis in Colorectal Cancer

(2016) Haiyan Yan et al.   PLoS One

The Stress Kinase p38  as a Target for Cancer Therapy

(2015) A. Igea et al.   CANCER RESEARCH

HIPK2 restricts SIRT1 activity upon severe DNA damage by a phosphorylation-controlled mechanism

(2015) E Conrad et al.   CELL DEATH AND DIFFERENTIATION

Molecular Pathways: Is AMPK a Friend or a Foe in Cancer?

(2015) D. G. Hardie   CLINICAL CANCER RESEARCH

DYRK protein kinases

(2015) Ulf Soppa et al.   CURRENT BIOLOGY

The Tyrosine Kinase c-Abl Promotes Homeodomain-interacting Protein Kinase 2 (HIPK2) Accumulation and Activation in Response to DNA Damage

(2015) Nina Reuven et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis

(2015) Ariele Viacava Follis et al.   MOLECULAR CELL

A New p53 Target Gene, RKIP, Is Essential for DNA Damage-Induced Cellular Senescence and Suppression of ERK Activation

(2015) Su-Jin Lee et al.   NEOPLASIA

Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing

(2014) Francesca Rossiello et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Inhibiting Tyrosine Phosphorylation of Protein Kinase Cδ (PKCδ) Protects the Salivary Gland from Radiation Damage

(2014) Sten M. Wie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMP-Activated Protein Kinase Suppresses the In Vitro and In Vivo Proliferation of Hepatocellular Carcinoma

(2014) Jidong Cheng et al.   PLoS One

ShaPINg Cell Fate Upon DNA Damage: Role of Pin1 Isomerase in DNA Damage-Induced Cell Death and Repair

(2014) Tilman Polonio-Vallon et al.   Frontiers in Oncology

Human Papillomavirus Load in Eyebrow Hair Follicles and Risk of Cutaneous Squamous Cell Carcinoma

(2013) R. E. Neale et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

DYRK2 controls the epithelial–mesenchymal transition in breast cancer by degrading Snail

(2013) Rei Mimoto et al.   CANCER LETTERS

Src kinase modulates the apoptotic p53 pathway by altering HIPK2 localization

(2013) Timan Polonio-Vallon et al.   CELL CYCLE

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death

(2013) N. Bitomsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis

(2013) A. I. Nieminen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIPK2: A tumour suppressor that controls DNA damage-induced cell fate and cytokinesis

(2012) Thomas G. Hofmann et al.   BIOESSAYS

The prolyl-isomerase Pin1 activates the mitochondrial death program of p53

(2012) G Sorrentino et al.   CELL DEATH AND DIFFERENTIATION

Nuclear Localization of p38 MAPK in Response to DNA Damage

(2012) C. David Wood et al.   International Journal of Biological Sciences

Mutual regulation between SIAH2 and DYRK2 controls hypoxic and genotoxic signaling pathways

(2012) Moisés Pérez et al.   Journal of Molecular Cell Biology

The impact of phosphorylated AMP-activated protein kinase expression on lung cancer survival

(2011) W. N. William et al.   ANNALS OF ONCOLOGY

Zyxin Is a Critical Regulator of the Apoptotic HIPK2-p53 Signaling Axis

(2011) J. Crone et al.   CANCER RESEARCH

Regulated Binding of Importin-α to Protein Kinase Cδ in Response to Apoptotic Signals Facilitates Nuclear Import

(2011) Tariq S. Adwan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutaneous HPV23 E6 Prevents p53 Phosphorylation through Interaction with HIPK2

(2011) Dorothea Muschik et al.   PLoS One

Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin

(2011) A. Grison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms and functions of p38 MAPK signalling

(2010) Ana Cuadrado et al.   BIOCHEMICAL JOURNAL

Increased SIAH expression predicts ductal carcinoma in situ (DCIS) progression to invasive carcinoma

(2010) Kathryn C. Behling et al.   BREAST CANCER RESEARCH AND TREATMENT

Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer

(2010) Y Baba et al.   BRITISH JOURNAL OF CANCER

Siah2-Dependent Concerted Activity of HIF and FoxA2 Regulates Formation of Neuroendocrine Phenotype and Neuroendocrine Prostate Tumors

(2010) Jianfei Qi et al.   CANCER CELL

Dyrk1A Phosphorylates p53 and Inhibits Proliferation of Embryonic Neuronal Cells

(2010) Joongkyu Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Requirement of ATM for Rapid p53 Phosphorylation at Ser46 without Ser/Thr-Gln Sequences

(2010) M. Kodama et al.   MOLECULAR AND CELLULAR BIOLOGY

Histological evaluation of AMPK signalling in primary breast cancer

(2009) Sirwan M Hadad et al.   BMC CANCER

Hypoxia suppresses chemotherapeutic drug-induced p53 Serine 46 phosphorylation by triggering HIPK2 degradation

(2009) Jutta Moehlenbrink et al.   CANCER LETTERS

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

ATM Augments Nuclear Stabilization of DYRK2 by Inhibiting MDM2 in the Apoptotic Response to DNA Damage

(2009) Naoe Taira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of Disrupting Seven-in-Absentia Homolog 2 Function on Lung Cancer Cell Growth

(2008) Atique U. Ahmed et al.   JNCI-Journal of the National Cancer Institute

PML Activates Transcription by Protecting HIPK2 and p300 from SCFFbx3-Mediated Degradation

(2008) Y. Shima et al.   MOLECULAR AND CELLULAR BIOLOGY

UVB-induced Senescence in Human Keratinocytes Requires a Functional Insulin-like Growth Factor-1 Receptor and p53

(2008) Davina A. Lewis et al.   MOLECULAR BIOLOGY OF THE CELL

Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR

(2008) Melanie Winter et al.   NATURE CELL BIOLOGY

An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response

(2008) Marco A. Calzado et al.   NATURE CELL BIOLOGY

Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations

(2008) A. W. MacInnes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA