Endorepellin Evokes Autophagy in Endothelial Cells

Endorepellin laminin-like globular 1/2 domains bind Ig3-5 of vascular endothelial growth factor (VEGF) receptor 2 and block pro-angiogenic signaling by VEGFA in endothelial cells

(2013) Chris D. Willis et al.   FEBS Journal

Synovial perlecan is required for osteophyte formation in knee osteoarthritis

(2013) Haruka Kaneko et al.   MATRIX BIOLOGY

Border patrol: Insights into the unique role of perlecan/heparan sulfate proteoglycan 2 at cell and tissue borders

(2013) Mary C. Farach-Carson et al.   MATRIX BIOLOGY

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Perlecan Maintains Microvessel Integrity In Vivo and Modulates Their Formation In Vitro

(2013) Erika Gustafsson et al.   PLoS One

Decorin causes autophagy in endothelial cells via Peg3

(2013) S. Buraschi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD47 deficiency confers cell and tissue radioprotection by activation of autophagy

(2012) David R. Soto-Pantoja et al.   Autophagy

Endorepellin Affects Angiogenesis by Antagonizing Diverse Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)-evoked Signaling Pathways

(2012) Atul Goyal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mast Cells Produce Novel Shorter Forms of Perlecan That Contain Functional Endorepellin

(2012) MoonSun Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thrombospondins in physiology and disease: New tricks for old dogs

(2012) Joanne E. Murphy-Ullrich et al.   MATRIX BIOLOGY

Targeting heparanase for cancer therapy at the tumor–matrix interface

(2012) Ralph D. Sanderson et al.   MATRIX BIOLOGY

The matricellular protein thrombospondin-1 globally regulates cardiovascular function and responses to stress via CD47

(2012) David D. Roberts et al.   MATRIX BIOLOGY

Perlecan modulates VEGF signaling and is essential for vascularization in endochondral bone formation

(2012) Muneaki Ishijima et al.   MATRIX BIOLOGY

A biomechanical role for perlecan in the pericellular matrix of articular cartilage

(2012) Rebecca E. Wilusz et al.   MATRIX BIOLOGY

Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion

(2012) Teresa L. M. Thurston et al.   NATURE

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

Decorin Protein Core Affects the Global Gene Expression Profile of the Tumor Microenvironment in a Triple-Negative Orthotopic Breast Carcinoma Xenograft Model

(2012) Simone Buraschi et al.   PLoS One

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Endorepellin, the Angiostatic Module of Perlecan, Interacts with Both the α2β1 Integrin and Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)

(2011) Atul Goyal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Na+-Ca2+ Exchanger (NCX3) Knock-Out Mice Display an Impairment in Hippocampal Long-Term Potentiation and Spatial Learning and Memory

(2011) P. Molinaro et al.   JOURNAL OF NEUROSCIENCE

Morphogenetic roles of perlecan in the tooth enamel organ: An analysis of overexpression using transgenic mice

(2011) Hiroko Ida-Yonemochi et al.   MATRIX BIOLOGY

Heparan Sulfate-Dependent Signaling of Fibroblast Growth Factor 18 by Chondrocyte-Derived Perlecan

(2010) Christine Y. Chuang et al.   BIOCHEMISTRY

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Physiological significance of selective degradation of p62 by autophagy

(2010) Masaaki Komatsu et al.   FEBS LETTERS

The Imprinted GenePEG3Inhibits Wnt Signaling and Regulates Glioma Growth

(2010) Xiuli Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteoglycans in cancer biology, tumour microenvironment and angiogenesis

(2010) Renato V. Iozzo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The multiple functions of collagen XVIII in development and disease

(2010) Lotta Seppinen et al.   MATRIX BIOLOGY

A Key Role for the Integrin α2β1 in Experimental and Developmental Angiogenesis

(2009) James D. San Antonio et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity

(2009) A. Nystrom et al.   BLOOD

Endostatin induces autophagy in endothelial cells by modulating Beclin 1 and β-catenin levels

(2009) Tri Minh Bui Nguyen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis

(2009) Jason J. Zoeller et al.   MATRIX BIOLOGY

p65/RelA Modulates BECN1 Transcription and Autophagy

(2009) T. Copetti et al.   MOLECULAR AND CELLULAR BIOLOGY

Basement membrane proteoglycans: Modulators Par Excellence of cancer growth and angiogenesis

(2009) Renato V. Iozzo et al.   MOLECULES AND CELLS

Diverse Cell Signaling Events Modulated by Perlecan†

(2008) John M. Whitelock et al.   BIOCHEMISTRY

Endothelial Cells Provide Feedback Control for Vascular Remodeling Through a Mechanosensitive Autocrine TGF-β Signaling Pathway

(2008) Aaron B. Baker et al.   CIRCULATION RESEARCH

Parallel Phosphatidylinositol 3-Kinase (PI3K)-dependent and Src-dependent Pathways Lead to CXCL8-mediated Rac2 Activation and Chemotaxis

(2008) Jiqing Sai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A central function for perlecan in skeletal muscle and cardiovascular development

(2008) Jason J. Zoeller et al.   JOURNAL OF CELL BIOLOGY