Article
Biochemistry & Molecular Biology
Wan-Jing Chen, I-Hsuan Lin, Chien-Wei Lee, Yi-Fan Chen
Summary: Aging leads to decline in skeletal muscle function, with reduced regenerative capacity and changes in extracellular matrix structure. This can result in increased collagen deposition and decreased ECM degradation in aged skeletal muscle.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Taryn Loomis, Lucas R. Smith
Summary: This review summarizes the role of fibro-adipogenic progenitors (FAPs) in muscle fibrosis, including their activation, heterogeneity, and contribution to muscle fibrotic degeneration, and discusses current research on potential therapeutic avenues targeting FAPs.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Yong How Tan, Haylie R. Helms, Karina H. Nakayama
Summary: Cardiovascular disease and musculoskeletal conditions are major global health burdens with a lack of restorative treatment options. Regenerative medicine and tissue engineering offer potential solutions for repairing damaged tissues. Decellularized tissues and extracellular matrices play vital roles in regenerative biomaterials and their study can drive the development of novel regenerative therapies.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Immunology
Khurshid Ahmad, Sibhghatulla Shaikh, Hee Jin Chun, Shahid Ali, Jeong Ho Lim, Syed Sayeed Ahmad, Eun Ju Lee, Inho Choi
Summary: The regeneration of skeletal muscle is a complex process that involves various cell types and biomolecular factors, with the extracellular matrix playing a fundamental role. This review discusses skeletal muscle myogenesis and regeneration, the role of muscle satellite cells and other cells, and the effects of their dysregulation. It also covers different types of ECM scaffolds and biomaterials used for skeletal muscle regeneration, their applications, recent advancements in ECM scaffold research, and their impact on tissue engineering and severe muscle injuries.
INFLAMMATION AND REGENERATION
(2023)
Article
Biochemistry & Molecular Biology
Hyeonyu Kim, Tatsuya Osaki, Roger D. Kamm, H. Harry Asada
Summary: This study develops an engineered muscle tissue with a coaxial three-layered tubular structure that resembles the architecture of native skeletal muscles. By remodeling the extracellular matrix, the engineered skeletal muscle tissues produced stronger contractile force and improved angiogenesis.
Article
Neurosciences
Sarah E. Brashear, Ross P. Wohlgemuth, Gabriella Gonzalez, Lucas R. Smith
Summary: The amount of fibrotic material in muscle is related to contractile function and passive stiffness, but excessive fibrosis does not directly lead to decreased muscle function. Anti-fibrotic therapies should target collagen architecture, particularly large collagen fibers and their alignment, to enhance muscle function and reduce excessive stiffness.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Endocrinology & Metabolism
Luke C. McIlvenna, Rhiannon K. Patten, Andrew J. McAinch, Raymond J. Rodgers, Nigel K. Stepto, Alba Moreno-Asso
Summary: The study indicates that short-term treatment with TGF beta 1 does not significantly affect skeletal muscle insulin resistance in women with PCOS, but does not rule out the possibility of indirect or long-term effects.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Line Maersk Staunstrup, Cecilie Liv Bager, Peder Frederiksen, Jorn Wulff Helge, Soren Brunak, Claus Christiansen, Morten Karsdal
Summary: Endotrophin levels are associated with multiple chronic diseases, increasing with the number of morbidities, and serve as a predictor of death in older women. This suggests that endotrophin may play a central role in fibroblast function and could be targeted for intervention in various chronic diseases.
Review
Physiology
Marine Theret, Fabio M. V. Rossi, Osvaldo Contreras
Summary: This review explores the function of fibro-adipogenic progenitors in muscle homeostatic integrity, regeneration, repair, and aging, as well as how they control the onset and severity of muscle loss in disease.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Engineering, Biomedical
Chen Wang, Guoyun Li, Kaige Cui, Zihan Chai, Ziyu Huang, Yue Liu, Shang Chen, Haoyan Huang, Kaiyue Zhang, Zhibo Han, Yuhao Li, Guangli Yu, Zhong-Chao Han, Na Liu, Zongjin Li
Summary: In this study, the glycosaminoglycanomics of decellularized extracellular matrices (dECMs) from perinatal tissues were investigated, highlighting the critical roles of sulfated glycosaminoglycans (GAGs) in promoting tissue regeneration. The placenta-derived dECM hydrogel showed superior therapeutic effects due to higher contents of chondroitin sulfate with 6-O-sulfo group (CS-6S) and heparan sulfate with 6-O-sulfo group (HS-6S), which play important roles in inflammation and angiogenesis. This study provides insight into the use of placenta-derived ECM hydrogel for regenerative applications.
ACTA BIOMATERIALIA
(2021)
Article
Biochemistry & Molecular Biology
Naoki Ito, Yuko Miyagoe-Suzuki, Shin'ichi Takeda, Akira Kudo
Summary: In this study, the protective role of periostin, a matricellular protein, in skeletal muscle regeneration was identified. Periostin-null mice showed decreased muscle weight due to the loss of muscle fibers during repeated muscle regeneration. The decrease in CD31-positive blood vessels during muscle regeneration in periostin-null mice suggests that the decreased nutritional supply may be the cause of muscle fiber loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Brendan A. Hilliard, Mamta Amin, Steven N. Popoff, Mary F. Barbe
Summary: The study found that in a rat model of repetitive overuse injury, the high force training group showed a significant increase in FGF2 gene expression, while protein levels of collagen type 1, collagen type 3, and TGF beta 1 were higher in the HFHR group. This suggests that the transcription of fibrogenic genes in muscles with established fibrosis is in steady state, and the increased protein levels are due to post-transcriptional processes.
CONNECTIVE TISSUE RESEARCH
(2021)
Review
Respiratory System
Sakshi Phogat, Fama Thiam, Safiya Al Yazeedi, Filsan Ahmed Abokor, Emmanuel Twumasi Osei
Summary: The pulmonary extracellular matrix (ECM) plays a vital role in lung development, repair, and maintenance of tissue homeostasis. It regulates the function of lung fibroblasts, which are responsible for the production and repair of ECM proteins. In lung injury and chronic lung diseases, an abnormal feedback between fibroblasts and the altered ECM disrupts tissue homeostasis and leads to fibrotic changes and tissue remodeling.
RESPIRATORY RESEARCH
(2023)
Article
Food Science & Technology
Khurshid Ahmad, Jeong-Ho Lim, Eun-Ju Lee, Hee-Jin Chun, Shahid Ali, Syed Sayeed Ahmad, Sibhghatulla Shaikh, Inho Choi
Summary: Cultured meat production is a method that uses tissue engineering techniques to produce animal meat, with key factors including cells, chemical factors, and scaffolds. Scaffolding is crucial for developing organized meat products resembling steaks, with animal-derived polymers like collagen considered the gold standard for producing ECM-like scaffolds.
Article
Geriatrics & Gerontology
Mona Bensalah, Laura Muraine, Alexis Boulinguiez, Lorenzo Giordani, Victorine Albert, Victor Ythier, Jamila Dhiab, Alison Oliver, Valentine Hanique, Teresa Gidaro, Sophie Perie, Jean Lacau St-Guily, Aurelien Corneau, Gillian Butler-Browne, Anne Bigot, Vincent Mouly, Elisa Negroni, Capucine Trollet
Summary: This study explored the role of nonmyogenic cells (fibroadipogenic progenitors, FAPs) in human fibrotic muscles and found that FAPs from fibrotic muscles have a higher proliferation rate compared to those from nonfibrotic muscles, which leads to impaired fusion index when cocultured with muscle cells. The study also identified endothelin as a potential target to counteract human muscle fibrosis through a paracrine signaling pathway.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Hematology
Santoshi Muppala, Ella Frolova, Roy Xiao, Irene Krukovets, Suzy Yoon, George Hoppe, Amit Vasanji, Edward Plow, Olga Stenina-Adognravi
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Irene Krukovets, Matthew Legerski, Pavel Sul, Olga Stenina-Adognravi
Article
Hematology
Priya Raman, Christy Harry, Malory Weber, Irene Krukovets, Olga I. Stenina
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2011)
Article
Cardiac & Cardiovascular Systems
Pankaj Dabir, Tina E. Marinic, Irene Krukovets, Olga I. Stenina
CIRCULATION RESEARCH
(2008)
Article
Cardiac & Cardiovascular Systems
Ella G. Frolova, Elzbieta Pluskota, Irene Krukovets, Tim Burke, Carla Drumm, Jonathan D. Smith, Lauren Blech, Maria Febbraio, Paul Bornstein, Edward F. Plow, Olga I. Stenina
CIRCULATION RESEARCH
(2010)
Review
Biochemistry & Molecular Biology
Olga Stenina-Adognravi
CURRENT OPINION IN LIPIDOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Ella G. Frolova, Nikolai Sopko, Lauren Blech, Zoran B. Popovic, Jianbo Li, Amit Vasanji, Carla Drumm, Irene Krukovets, Mukesh K. Jain, Marc S. Penn, Edward F. Plow, Olga I. Stenina
Review
Biochemistry & Molecular Biology
Olga Stenina-Adognravi
Article
Biochemistry & Molecular Biology
Ella G. Frolova, Judith Drazba, Irene Krukovets, Volodymyr Kostenko, Lauren Blech, Christy Harry, Amit Vasanji, Carla Drumm, Pavel Sul, Guido J. Jenniskens, Edward F. Plow, Olga Stenina-Adognravi
Article
Multidisciplinary Sciences
Raquel Bienes-Martinez, Angel Ordonez, Monica Feijoo-Cuaresma, Maria Corral-Escariz, Gloria Mateo, Olga Stenina, Benilde Jimenez, Maria J. Calzada
SCIENTIFIC REPORTS
(2012)
Article
Cardiac & Cardiovascular Systems
Sanghamitra Bhattacharyya, Kristina Sul, Irene Krukovets, Carla Nestor, Jianbo Li, Olga Stenina Adognravi
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2012)
Article
Biochemistry & Molecular Biology
Sanghamitra Bhattacharyya, Tina E. Marinic, Irene Krukovets, George Hoppe, Olga I. Stenina
JOURNAL OF BIOLOGICAL CHEMISTRY
(2008)
Article
Biochemistry & Molecular Biology
Priya Raman, Irene Krukovets, Tina E. Marinic, Paul Bornstein, Olga I. Stenina
JOURNAL OF BIOLOGICAL CHEMISTRY
(2007)
Review
Hematology
Olga I. Stenina, Eric J. Topol, Edward F. Plow
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2007)