Cell-matrix interactions: focus on proteoglycan-proteinase interplay and pharmacological targeting in cancer

Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival

(2015) Aurelie Poli et al.   Oncotarget

Decorin Suppresses Prostate Tumor Growth through Inhibition of Epidermal Growth Factor and Androgen Receptor Pathways

(2015) Yunping Hu et al.   NEOPLASIA

The potential of heparanase as a therapeutic target in cancer

(2014) Claudio Pisano et al.   BIOCHEMICAL PHARMACOLOGY

Cysteine cathepsins and extracellular matrix degradation

(2014) Marko Fonović et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Key roles for the small leucine-rich proteoglycans in renal and pulmonary pathophysiology

(2014) Madalina V. Nastase et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Versican and the regulation of cell phenotype in disease

(2014) Thomas N. Wight et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

MicroRNA regulation of proteoglycan function in cancer

(2014) Sherif A. Ibrahim et al.   FEBS Journal

Epigenetics in extracellular matrix remodeling and hyaluronan metabolism

(2014) Davide Vigetti et al.   FEBS Journal

Heparan sulfate in the regulation of neural differentiation and glioma development

(2014) Anqi Xiong et al.   FEBS Journal

Serglycin Proteoglycan Is Required for Multiple Myeloma Cell Adhesion,in VivoGrowth, and Vascularization

(2014) Anurag Purushothaman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decorin Induces Mitophagy in Breast Carcinoma Cells via Peroxisome Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and Mitostatin

(2014) Thomas Neill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cathepsin B: Multiple roles in cancer

(2014) Neha Aggarwal et al.   Proteomics Clinical Applications

Syndecans as Modulators and Potential Pharmacological Targets in Cancer Progression

(2014) Despoina Barbouri et al.   Frontiers in Oncology

Serglycin: At the Crossroad of Inflammation and Malignancy

(2014) Angeliki Korpetinou et al.   Frontiers in Oncology

Antitumor efficacy of the heparanase inhibitor SST0001 alone and in combination with antiangiogenic agents in the treatment of human pediatric sarcoma models

(2013) G. Cassinelli et al.   BIOCHEMICAL PHARMACOLOGY

The Role of Basic Amino Acid Surface Clusters on the Collagenase Activity of Cathepsin K

(2013) Ferez S. Nallaseth et al.   BIOCHEMISTRY

Binding of Chondroitin 4-Sulfate to Cathepsin S Regulates Its Enzymatic Activity

(2013) Juliette Sage et al.   BIOCHEMISTRY

Preclinical evaluation of zoledronate using an in vitro mimetic cellular model for breast cancer metastatic bone disease

(2013) P.G. Dedes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

CD26 Expression on T-Anaplastic Large Cell Lymphoma (ALCL) Line Karpas 299 is associated with increased expression of Versican and MT1-MMP and enhanced adhesion

(2013) Pamela A Havre et al.   BMC CANCER

TGF-  Modulates Ovarian Cancer Invasion by Upregulating CAF-Derived Versican in the Tumor Microenvironment

(2013) T.-L. Yeung et al.   CANCER RESEARCH

T Lymphocytes Redirected against the Chondroitin Sulfate Proteoglycan-4 Control the Growth of Multiple Solid Tumors both In Vitro and In Vivo

(2013) C. Geldres et al.   CLINICAL CANCER RESEARCH

Cathepsin K Inhibitors: A Novel Target but Promising Approach in the Treatment of Osteoporosis

(2013) Asadul Helali et al.   CURRENT DRUG TARGETS

A novel human anti-syndecan-1 antibody inhibits vascular maturation and tumour growth in melanoma

(2013) Paola Orecchia et al.   EUROPEAN JOURNAL OF CANCER

Mapping of matrix metalloproteinase cleavage sites on syndecan-1 and syndecan-4 ectodomains

(2013) Tina Manon-Jensen et al.   FEBS Journal

Imatinib as a key inhibitor of the platelet-derived growth factor receptor mediated expression of cell surface heparan sulfate proteoglycans and functional properties of breast cancer cells

(2013) Christina J. Malavaki et al.   FEBS Journal

The heparanase/syndecan-1 axis in cancer: mechanisms and therapies

(2013) Vishnu C. Ramani et al.   FEBS Journal

Synstatin: a selective inhibitor of the syndecan-1-coupled IGF1R-αvβ3 integrin complex in tumorigenesis and angiogenesis

(2013) Alan C. Rapraeger   FEBS Journal

Decorin interferes with platelet-derived growth factor receptor signaling in experimental hepatocarcinogenesis

(2013) Kornélia Baghy et al.   FEBS Journal

In vitroreconstitution of complexes between pro-matrix metalloproteinase-9 and the proteoglycans serglycin and versican

(2013) Nabin Malla et al.   FEBS Journal

Cell-surface serglycin promotes adhesion of myeloma cells to collagen type I and affects the expression of matrix metalloproteinases

(2013) Antonis Skliris et al.   FEBS Journal

Decorin induces rapid secretion of thrombospondin-1 in basal breast carcinoma cells via inhibition of Ras homolog gene family, member A/Rho-associated coiled-coil containing protein kinase 1

(2013) Thomas Neill et al.   FEBS Journal

Vascular endothelial-cadherin stimulates syndecan-1-coupled insulin-like growth factor-1 receptor and cross-talk between αVβ3 integrin and vascular endothelial growth factor receptor 2 at the onset of endothelial cell dissemination during angiogenesis

(2013) Alan C. Rapraeger et al.   FEBS Journal

Functional interactions between matrix metalloproteinases and glycosaminoglycans

(2013) Autumn Tocchi et al.   FEBS Journal

Forkhead box Q1 promotes hepatocellular carcinoma metastasis by transactivating ZEB2 and VersicanV1 expression

(2013) Limin Xia et al.   HEPATOLOGY

Effects of novel human cathepsin S inhibitors on cell migration in human cancer cells

(2013) Ju-Ying Tsai et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Cathepsin B: a potential prognostic marker for inflammatory breast cancer

(2013) Mohamed A Nouh et al.   Journal of Translational Medicine

Serglycin (SRGN) overexpression predicts poor prognosis in hepatocellular carcinoma patients

(2013) Lu He et al.   MEDICAL ONCOLOGY

Cathepsin B as a potential prognostic and therapeutic marker for human lung squamous cell carcinoma

(2013) Fengming Gong et al.   Molecular Cancer

Decreased expression of ADAMTS-1 in human breast tumors stimulates migration and invasion

(2013) Vanessa M Freitas et al.   Molecular Cancer

Matrix metalloproteinase and its drug targets therapy in solid and hematological malignancies: An overview

(2013) Ajay Kumar Chaudhary et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Tumor-Produced Versican V1 Enhances hCAP18/LL-37 Expression in Macrophages through Activation of TLR2 and Vitamin D3 Signaling to Promote Ovarian Cancer Progression In Vitro

(2013) Dong Li et al.   PLoS One

Serglycin Is Implicated in the Promotion of Aggressive Phenotype of Breast Cancer Cells

(2013) Angeliki Korpetinou et al.   PLoS One

Decorin causes autophagy in endothelial cells via Peg3

(2013) S. Buraschi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Missing the target: matrix metalloproteinase antitargets in inflammation and cancer

(2013) Antoine Dufour et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

NG2/CSPG4-collagen type VI interplays putatively involved in the microenvironmental control of tumour engraftment and local expansion

(2013) S. Cattaruzza et al.   Journal of Molecular Cell Biology

Decorin

(2012) Thomas Neill et al.   AMERICAN JOURNAL OF PATHOLOGY

Matrix Metalloproteinases

(2012) Laurie A. Shuman Moss et al.   AMERICAN JOURNAL OF PATHOLOGY

Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex

(2012) Linda Troeberg et al.   BIOCHEMICAL JOURNAL

Expression of matrix macromolecules and functional properties of breast cancer cells are modulated by the bisphosphonate zoledronic acid

(2012) P.G. Dedes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cathepsin B Inhibition Limits Bone Metastasis in Breast Cancer

(2012) N. P. Withana et al.   CANCER RESEARCH

Cathepsin B and uPAR regulate self-renewal of glioma-initiating cells through GLI-regulated Sox2 and Bmi1 expression

(2012) Sreelatha Gopinath et al.   CARCINOGENESIS

CSPG4 as a Target of Antibody-Based Immunotherapy for Malignant Mesothelioma

(2012) Z. Rivera et al.   CLINICAL CANCER RESEARCH

Small leucine-rich proteoglycans, at the crossroad of cancer growth and inflammation

(2012) Liliana Schaefer et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Glycosaminoglycans: key players in cancer cell biology and treatment

(2012) Nikos Afratis et al.   FEBS Journal

Expression of matrix macromolecules and functional properties of EGF-responsive colon cancer cells are inhibited by panitumumab

(2012) Ch. Gialeli et al.   INVESTIGATIONAL NEW DRUGS

RhoGDI2 suppresses lung metastasis in mice by reducing tumor versican expression and macrophage infiltration

(2012) Neveen Said et al.   JOURNAL OF CLINICAL INVESTIGATION

Thrombospondins in physiology and disease: New tricks for old dogs

(2012) Joanne E. Murphy-Ullrich et al.   MATRIX BIOLOGY

Altered Expression of Sialylated Glycoproteins in Breast Cancer Using Hydrazide Chemistry and Mass Spectrometry

(2012) Yuan Tian et al.   MOLECULAR & CELLULAR PROTEOMICS

ErbB2-Driven Breast Cancer Cell Invasion Depends on a Complex Signaling Network Activating Myeloid Zinc Finger-1-Dependent Cathepsin B Expression

(2012) Bo Rafn et al.   MOLECULAR CELL

Matrix Metalloproteinases and Their Role in Oncogenesis: A Review

(2012) Marek Pytliak et al.   ONKOLOGIE

Decorin Protein Core Affects the Global Gene Expression Profile of the Tumor Microenvironment in a Triple-Negative Orthotopic Breast Carcinoma Xenograft Model

(2012) Simone Buraschi et al.   PLoS One

Dosimetry results suggest feasibility of radioimmunotherapy using anti-CD138 (B-B4) antibody in multiple myeloma patients

(2012) Caroline Rousseau et al.   TUMOR BIOLOGY

Inhibition of Cathepsin K for Treatment of Osteoporosis

(2012) Steven Boonen et al.   Current Osteoporosis Reports

Emerging Roles of ADAMTSs in Angiogenesis and Cancer

(2012) Saran Kumar et al.   Cancers

Versican but not decorin accumulation is related to malignancy in mammographically detected high density and malignant-appearing microcalcifications in non-palpable breast carcinomas

(2011) Spyros S Skandalis et al.   BMC CANCER

Functional Characterization of an scFv-Fc Antibody that Immunotherapeutically Targets the Common Cancer Cell Surface Proteoglycan CSPG4

(2011) X. Wang et al.   CANCER RESEARCH

Serglycin Is a Theranostic Target in Nasopharyngeal Carcinoma that Promotes Metastasis

(2011) X.-J. Li et al.   CANCER RESEARCH

Integrative Genomic Analyses of Sporadic Clear Cell Renal Cell Carcinoma Define Disease Subtypes and Potential New Therapeutic Targets

(2011) V. R. Dondeti et al.   CANCER RESEARCH

Decorin-mediated inhibition of colorectal cancer growth and migration is associated with E-cadherin in vitro and in mice

(2011) X. Bi et al.   CARCINOGENESIS

Antithetic roles of proteoglycans in cancer

(2011) Elena Garusi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Pathophysiology and Pharmacological Targeting of Tumor-Induced Bone Disease: Current Status and Emerging Therapeutic Interventions

(2011) V.T. Labropoulou et al.   CURRENT MEDICINAL CHEMISTRY

Decorin Antagonizes IGF Receptor I (IGF-IR) Function by Interfering with IGF-IR Activity and Attenuating Downstream Signaling

(2011) Renato V. Iozzo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decorin Antagonizes the Angiogenic Network

(2011) Thomas Neill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Morphea-like skin reactions in patients treated with the cathepsin K inhibitor balicatib

(2011) Thomas M. Rnger et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Syndecan-1 and -4 differentially regulate oncogenic K-ras dependent cell invasion into collagen through α2β1 integrin and MT1-MMP

(2011) Karoliina Vuoriluoto et al.   MATRIX BIOLOGY

Decorin Is a Novel VEGFR-2-Binding Antagonist for the Human Extravillous Trophoblast

(2011) Gausal A. Khan et al.   MOLECULAR ENDOCRINOLOGY

An Updated Patent Therapeutic Agents Targeting MMPs

(2011) Zheng-gao Shi et al.   Recent Patents on Anti-Cancer Drug Discovery

Signaling by the Matrix Proteoglycan Decorin Controls Inflammation and Cancer Through PDCD4 and MicroRNA-21

(2011) R. Merline et al.   Science Signaling

The Calreticulin-Binding Sequence of Thrombospondin 1 Regulates Collagen Expression and Organization During Tissue Remodeling

(2010) Mariya T. Sweetwyne et al.   AMERICAN JOURNAL OF PATHOLOGY

Cathepsin B Expression and Survival in Colon Cancer: Implications for Molecular Detection of Neoplasia

(2010) A. T. Chan et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Targeting MMP-9, uPAR and cathepsin B inhibits invasion, migration and activates apoptosis in prostate cancer cells

(2010) A K Nalla et al.   CANCER GENE THERAPY

Versican induces a pro-metastatic ovarian cancer cell behavior which can be inhibited by small hyaluronan oligosaccharides

(2010) Miranda P. Ween et al.   CLINICAL & EXPERIMENTAL METASTASIS

Molecular Interactions of MMP-13 C-Terminal Domain with Chondrocyte Proteins

(2010) Liang Zhang et al.   CONNECTIVE TISSUE RESEARCH

Serglycin inhibits the classical and lectin pathways of complement via its glycosaminoglycan chains: Implications for multiple myeloma

(2010) Antonis Skliris et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulation of matrix metalloproteinase activity in health and disease

(2010) Elin Hadler-Olsen et al.   FEBS Journal

Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting

(2010) Achilleas D. Theocharis et al.   FEBS Journal

Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans

(2010) Renato V. Iozzo et al.   FEBS Journal

Localizing matrix metalloproteinase activities in the pericellular environment

(2010) Gillian Murphy et al.   FEBS Journal

Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting

(2010) Chrisostomi Gialeli et al.   FEBS Journal

Structure-Activity Analysis of Cathepsin K/Chondroitin 4-Sulfate Interactions

(2010) Maia M. Cherney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteoglycans in cancer biology, tumour microenvironment and angiogenesis

(2010) Renato V. Iozzo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

CSPG4 Protein as a New Target for the Antibody-Based Immunotherapy of Triple-Negative Breast Cancer

(2010) Xinhui Wang et al.   JNCI-Journal of the National Cancer Institute

Heparin-derived heparan sulfate mimics to modulate heparan sulfate-protein interaction in inflammation and cancer

(2010) Benito Casu et al.   MATRIX BIOLOGY

Syndecans as cell surface receptors: Unique structure equates with functional diversity

(2010) Youngsil Choi et al.   MATRIX BIOLOGY

Cathepsin B inhibition interferes with metastatic potential of human melanoma: an in vitro and in vivo study

(2010) Paola Matarrese et al.   Molecular Cancer

Updated Biological Roles for Matrix Metalloproteinases and New “Intracellular” Substrates Revealed by Degradomics

(2009) Georgina S. Butler et al.   BIOCHEMISTRY

Structural and functional bases for allosteric control of MMP activities: Can it pave the path for selective inhibition?

(2009) Netta Sela-Passwell et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Matrix metalloproteinases: What do they not do? New substrates and biological roles identified by murine models and proteomics

(2009) David Rodríguez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

(2009) Laetitia Devy et al.   CANCER RESEARCH

The Monoclonal Antibody nBT062 Conjugated to Cytotoxic Maytansinoids Has Selective Cytotoxicity Against CD138-Positive Multiple Myeloma Cells In vitro and In vivo

(2009) H. Ikeda et al.   CLINICAL CANCER RESEARCH

Matrix metalloproteinase proteomics: substrates, targets, and therapy

(2009) Charlotte J Morrison et al.   CURRENT OPINION IN CELL BIOLOGY

A Review of the ADAMTS Family, Pharmaceutical Targets of the Future

(2009) Micky Tortorella et al.   CURRENT PHARMACEUTICAL DESIGN

Inhibition of cathepsin K reduces bone erosion, cartilage degradation and inflammation evoked by collagen-induced arthritis in mice

(2009) Lena Svelander et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sdc1 negatively modulates carcinoma cell motility and invasion

(2009) Tohru Ishikawa et al.   EXPERIMENTAL CELL RESEARCH

Activation of cathepsin D by glycosaminoglycans

(2009) Marie Beckman et al.   FEBS Journal

Cathepsin L Inactivates Human Trypsinogen, Whereas Cathepsin L-Deletion Reduces the Severity of Pancreatitis in Mice

(2009) Thomas Wartmann et al.   GASTROENTEROLOGY

Versican overexpression in human breast cancer lesions: Known and new isoforms for stromal tumor targeting

(2009) Philippe Kischel et al.   INTERNATIONAL JOURNAL OF CANCER

Syndecan-2 Functions as a Docking Receptor for Pro-matrix Metalloproteinase-7 in Human Colon Cancer Cells

(2009) Heui-Young Ryu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparin Enhances Serpin Inhibition of the Cysteine Protease Cathepsin L

(2009) Wayne J. Higgins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of Promatrilysin (MMP7) Activation and Substrate-specific Activity by Sulfated Glycosaminoglycans

(2009) Hyun-Jeong Ra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decorin is a novel antagonistic ligand of the Met receptor

(2009) Silvia Goldoni et al.   JOURNAL OF CELL BIOLOGY

Syndecan-1 regulates αvβ3and αvβ5integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor

(2009) DeannaLee M. Beauvais et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adamalysins in biology and disease

(2009) Harry van Goor et al.   JOURNAL OF PATHOLOGY

Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis

(2009) Frank Echtermeyer et al.   NATURE MEDICINE

MEROPS: the peptidase database

(2009) Neil D. Rawlings et al.   NUCLEIC ACIDS RESEARCH

An Antimetastatic Role for Decorin in Breast Cancer

(2008) Silvia Goldoni et al.   AMERICAN JOURNAL OF PATHOLOGY

Cleavage of Type II Collagen by Cathepsin K in Human Osteoarthritic Cartilage

(2008) Valeria M. Dejica et al.   AMERICAN JOURNAL OF PATHOLOGY

Cathepsin K deficiency partially inhibits, but does not prevent, bone destruction in human tumor necrosis factor–transgenic mice

(2008) Uta Schurigt et al.   ARTHRITIS AND RHEUMATISM

Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation

(2008) X. Bi et al.   CARCINOGENESIS

Suppression of proHB-EGF Carboxy-Terminal Fragment Nuclear Translocation: A New Molecular Target Therapy for Gastric Cancer

(2008) T. Shimura et al.   CLINICAL CANCER RESEARCH

Versican in Health and Disease

(2008) Achilleas D. Theocharis   CONNECTIVE TISSUE RESEARCH

Syndecan-1 supports integrin α2β1-mediated adhesion to collagen

(2008) Karoliina Vuoriluoto et al.   EXPERIMENTAL CELL RESEARCH

Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases

(2008) Linda Troeberg et al.   FASEB JOURNAL

Matrix Metalloproteinase-9 Associated with Heparan Sulphate Chains of GPI-Anchored Cell Surface Proteoglycans Mediates Motility of Murine Colon Adenocarcinoma Cells

(2008) Y. Koyama et al.   JOURNAL OF BIOCHEMISTRY

Heparan Sulfate Regulates ADAM12 through a Molecular Switch Mechanism

(2008) Hans Peter Sørensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Major Role of Cathepsin L for Producing the Peptide Hormones ACTH, β-Endorphin, and α-MSH, Illustrated by Protease Gene Knockout and Expression

(2008) Lydiane Funkelstein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Special issue: Metzincin metalloproteinases

(2008) E STERCHI   MOLECULAR ASPECTS OF MEDICINE

The ADAM metalloproteinases

(2008) D EDWARDS et al.   MOLECULAR ASPECTS OF MEDICINE

Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoforms

(2008) N. Puri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cathepsin K-Dependent Toll-Like Receptor 9 Signaling Revealed in Experimental Arthritis

(2008) M. Asagiri et al.   SCIENCE

Potential new drug targets for osteoporosis

(2008) Chad Deal   Nature clinical practice. Rheumatology