Endorepellin laminin-like globular 1/2 domains bind Ig3-5 of vascular endothelial growth factor (VEGF) receptor 2 and block pro-angiogenic signaling by VEGFA in endothelial cells

Perlecan Maintains Microvessel Integrity In Vivo and Modulates Their Formation In Vitro

(2013) Erika Gustafsson et al.   PLoS One

Anti-VEGF/VEGFR Therapy for Cancer: Reassessing the Target

(2012) B. Sitohy et al.   CANCER RESEARCH

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Endorepellin Affects Angiogenesis by Antagonizing Diverse Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)-evoked Signaling Pathways

(2012) Atul Goyal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Perlecan modulates VEGF signaling and is essential for vascularization in endochondral bone formation

(2012) Muneaki Ishijima et al.   MATRIX BIOLOGY

Signal transduction by vascular endothelial growth factor receptors

(2011) Sina Koch et al.   BIOCHEMICAL JOURNAL

Endorepellin, the Angiostatic Module of Perlecan, Interacts with Both the α2β1 Integrin and Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)

(2011) Atul Goyal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner

(2011) L. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antagonistic VEGF variants engineered to simultaneously bind to and inhibit VEGFR2 and  v 3 integrin

(2011) N. Papo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stromal Endothelial Cells Directly Influence Cancer Progression

(2011) J. W. Franses et al.   Science Translational Medicine

Heparan Sulfate-Dependent Signaling of Fibroblast Growth Factor 18 by Chondrocyte-Derived Perlecan

(2010) Christine Y. Chuang et al.   BIOCHEMISTRY

Soluble Perlecan Domain I Enhances Vascular Endothelial Growth Factor-165 Activity and Receptor Phosphorylation in Human Bone Marrow Endothelial Cells

(2010) Arivalagan Muthusamy et al.   BMC BIOCHEMISTRY

Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans

(2010) Renato V. Iozzo et al.   FEBS Journal

Proteoglycans in cancer biology, tumour microenvironment and angiogenesis

(2010) Renato V. Iozzo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

TIMP-2 modulates VEGFR-2 phosphorylation and enhances phosphodiesterase activity in endothelial cells

(2010) Seo-Jin Lee et al.   LABORATORY INVESTIGATION

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

(2010) Cory M. Johannessen et al.   NATURE

A Key Role for the Integrin α2β1 in Experimental and Developmental Angiogenesis

(2009) James D. San Antonio et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity

(2009) A. Nystrom et al.   BLOOD

Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level

(2009) Xuefeng Zhang et al.   FASEB JOURNAL

Decorin is a novel antagonistic ligand of the Met receptor

(2009) Silvia Goldoni et al.   JOURNAL OF CELL BIOLOGY

Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis

(2009) Jason J. Zoeller et al.   MATRIX BIOLOGY

Myeloperoxidase-derived oxidants selectively disrupt the protein core of the heparan sulfate proteoglycan perlecan

(2009) Martin D. Rees et al.   MATRIX BIOLOGY

Basement membrane proteoglycans: Modulators Par Excellence of cancer growth and angiogenesis

(2009) Renato V. Iozzo et al.   MOLECULES AND CELLS

Diverse Cell Signaling Events Modulated by Perlecan†

(2008) John M. Whitelock et al.   BIOCHEMISTRY

Endothelial Cells Provide Feedback Control for Vascular Remodeling Through a Mechanosensitive Autocrine TGF-β Signaling Pathway

(2008) Aaron B. Baker et al.   CIRCULATION RESEARCH

Integrins team up with tyrosine kinase receptors and plexins to control angiogenesis

(2008) Guido Serini et al.   CURRENT OPINION IN HEMATOLOGY

Caspase-3 Activation Triggers Extracellular Cathepsin L Release and Endorepellin Proteolysis

(2008) Jean-François Cailhier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A central function for perlecan in skeletal muscle and cardiovascular development

(2008) Jason J. Zoeller et al.   JOURNAL OF CELL BIOLOGY

Novel interactions of perlecan: Unraveling perlecan's role in angiogenesis

(2008) Gregory Bix et al.   MICROSCOPY RESEARCH AND TECHNIQUE

Sustained VEGF Blockade Results in Microenvironmental Sequestration of VEGF by Tumors and Persistent VEGF Receptor-2 Activation

(2008) A. Kadenhe-Chiweshe et al.   MOLECULAR CANCER RESEARCH