Sprouting angiogenesis is regulated by shedding of the C-type lectin family 14, member A (CLEC14A) ectodomain, catalyzed by rhomboid-like 2 protein (RHBDL2)

Blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and tumour growth

(2015) P J Noy et al.   ONCOGENE

A Subset of Membrane-Altering Agents and γ-Secretase Modulators Provoke Nonsubstrate Cleavage by Rhomboid Proteases

(2014) Siniša Urban et al.   Cell Reports

Emerging role of rhomboid family proteins in mammalian biology and disease

(2013) Nina Bergbold et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A Core Human Primary Tumor Angiogenesis Signature Identifies the Endothelial Orphan Receptor ELTD1 as a Key Regulator of Angiogenesis

(2013) Massimo Masiero et al.   CANCER CELL

SILAC-Based Proteomics of Human Primary Endothelial Cell Morphogenesis Unveils Tumor Angiogenic Markers

(2013) Sara Zanivan et al.   MOLECULAR & CELLULAR PROTEOMICS

Human antibodies targeting the C-type lectin-like domain of the tumor endothelial cell marker clec14a regulate angiogenic properties in vitro

(2013) M K Ki et al.   ONCOGENE

The Epidermal Growth Factor-like Domain of CD93 Is a Potent Angiogenic Factor

(2012) Yuan-Chung Kao et al.   PLoS One

Membrane immersion allows rhomboid proteases to achieve specificity by reading transmembrane segment dynamics

(2012) Syed M Moin et al.   eLife

Developmental and Pathological Angiogenesis

(2011) Alicia S. Chung et al.   Annual Review of Cell and Developmental Biology

The recombinant lectin-like domain of thrombomodulin inhibits angiogenesis through interaction with Lewis Y antigen

(2011) C.-H. Kuo et al.   BLOOD

Cholesterol sequestration by nystatin enhances the uptake and activity of endostatin in endothelium via regulating distinct endocytic pathways

(2011) Y. Chen et al.   BLOOD

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Mammalian EGF receptor activation by the rhomboid protease RHBDL2

(2011) Colin Adrain et al.   EMBO REPORTS

Plasma CD93 concentration is a potential novel biomarker for coronary artery disease

(2011) A. Mälarstig et al.   JOURNAL OF INTERNAL MEDICINE

Functions of Rhomboid Family Protease RHBDL2 and Thrombomodulin in Wound Healing

(2011) Tsung-Lin Cheng et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

MULTIMERIN2 impairs tumor angiogenesis and growth by interfering with VEGF-A/VEGFR2 pathway

(2011) E Lorenzon et al.   ONCOGENE

Identification and angiogenic role of the novel tumor endothelial marker CLEC14A

(2011) M Mura et al.   ONCOGENE

Thrombomodulin and its role in inflammation

(2011) Edward M. Conway   Seminars in Immunopathology

Clec14a is specifically expressed in endothelial cells and mediates cell to cell adhesion

(2010) Seung-Sik Rho et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Soluble CD93 Induces Differentiation of Monocytes and Enhances TLR Responses

(2010) J.-W. Jeon et al.   JOURNAL OF IMMUNOLOGY

Detection and characterization of soluble CD93 released during inflammation

(2009) Mallary C. Greenlee et al.   INFLAMMATION RESEARCH

Sequence-Specific Intramembrane Proteolysis: Identification of a Recognition Motif in Rhomboid Substrates

(2009) Kvido Strisovsky et al.   MOLECULAR CELL

Rhomboid Proteases and their Biological Functions

(2008) Matthew Freeman   Annual Review of Genetics

The PRH/Hex repressor protein causes nuclear retention of Groucho/TLE co-repressors

(2008) Cecile Desjobert et al.   BIOCHEMICAL JOURNAL

Membrane-anchored growth factors, the epidermal growth factor family: Beyond receptor ligands

(2008) Shigeki Higashiyama et al.   CANCER SCIENCE

PCR-mediated deletion of plasmid DNA

(2007) Mattias D. Hansson et al.   ANALYTICAL BIOCHEMISTRY